Inhibition of interleukin-1-stimulated MAP kinases, activating protein-1 (AP-1) and nuclear factor kappa B (NF-κB) transcription factors down-regulates matrix metalloproteinase gene expression in articular chondrocytes

Matrix Biology

Volumn 21, Issue 3, 2002, Pages 251-262

  Liacini, Abdelhamid ^a   Sylvester, Judith ^a   Li, Wen Qing ^a   Zafarullah, Muhammad ^a  

^a NOTRE DAME HOSPITAL   (Canada)

Author keywords

Arthritis; Chondrocytes; Interleukin 1; Matrix metalloproteinases; Signal transduction

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ACTIVATING PROTEIN 1; COLLAGENASE 3; CURCUMIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1; MATRIX METALLOPROTEINASE; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN; PYRROLIDINE DITHIOCARBAMATE; RNA; STRESS ACTIVATED PROTEIN KINASE; STROMELYSIN; SYNAPTOPHYSIN; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTHRITIS; ARTICLE; CARTILAGE CELL; CATTLE; CHONDROLYSIS; CONTROLLED STUDY; DOWN REGULATION; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME ANALYSIS; ENZYME INHIBITION; ENZYME REPRESSION; FEMUR HEAD; GENE EXPRESSION; GENE INDUCTION; HUMAN; HUMAN CELL; MOLECULAR BIOLOGY; NONHUMAN; OSTEOARTHRITIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; SIGNAL TRANSDUCTION;

ANIMALS; CARTILAGE, ARTICULAR; CATTLE; CELLS, CULTURED; CHONDROCYTES; COLLAGENASES; CURCUMIN; DOWN-REGULATION; ENZYME ACTIVATION; ENZYME INHIBITORS; FEMUR HEAD; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; IMIDAZOLES; INTERLEUKIN-1; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MATRIX METALLOPROTEINASE 13; MATRIX METALLOPROTEINASE 3; MITOGEN-ACTIVATED PROTEIN KINASES; NF-KAPPA B; OSTEOARTHRITIS, HIP; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PYRIDINES; PYRROLIDINES; THIOCARBAMATES; TIME FACTORS; TRANSCRIPTION FACTOR AP-1;

BOVINAE;

EID: 0036252640     PISSN: 0945053X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0945-053X(02)00007-0     Document Type: Article

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