MAP kinases in chondrocyte differentiation

Developmental Biology

Volumn 263, Issue 2, 2003, Pages 165-175

  Stanton, Lee Anne ^a   Underhill, T Michael ^a   Beier, Frank ^a  

^a UNIVERSITY OF WESTERN ONTARIO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ANTIINFLAMMATORY AGENT; GROWTH FACTOR; HORMONE DERIVATIVE; MITOGEN ACTIVATED PROTEIN KINASE;

BIOLOGY; CARTILAGE CELL; CELL DIFFERENTIATION; CELL PROLIFERATION; CHONDROGENESIS; DATA ANALYSIS; DOWNSTREAM PROCESSING; ENCHONDRAL OSSIFICATION; ENVIRONMENTAL FACTOR; GENE MUTATION; GROWTH DISORDER; HYPOCHONDROPLASIA; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN FAMILY; PROTEIN TARGETING; REGULATORY MECHANISM; REVIEW;

VERTEBRATA;

EID: 0242334002     PISSN: 00121606     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0012-1606(03)00321-X     Document Type: Review

References (115)

1. Adams C.S., Shapiro I.M. The fate of the terminally differentiated chondrocyte evidence for microenvironmental regulation of chondrocyte apoptosis . Crit. Rev. Oral. Biol. Med. 13:2002;465-473.
2. Adams J.L., Badger A.M., Kumar S., Lee J.C. p38 MAP kinase molecular target for the inhibition of pro-inflammatory cytokines . Prog. Med. Chem. 38:2001;1-60.
3. Ambrosino C., Nebreda A.R. Cell cycle regulation by p38 MAP kinases. Biol. Cell. 93:2001;47-51.
4. Atfi A., Djelloul S., Chastre E., Davis R., Gespach C. Evidence for a role of Rho-like GTPases and stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) in transforming growth factor beta-mediated signaling. J. Biol. Chem. 272:1997;1429-1432.
5. Avruch J., Zhang X.F., Kyriakis J.M. Raf meets Ras completing the framework of a signal transduction pathway . Trends Biochem. Sci. 19:1994;279-283.
6. Beier F., Ali Z., Mok D., Taylor A.C., Leask T., Albanese C., Pestell R.G., LuValle P. TGFbeta and PTHrP control chondrocyte proliferation by activating cyclin D1 expression. Mol. Biol. Cell. 12:2001;3852-3863.
7. Beier F., Lee R.J., Taylor A.C., Pestell R.G., LuValle P. Identification of the cyclin D1 gene as a target of activating transcription factor 2 in chondrocytes. Proc. Natl. Acad. Sci. USA. 96:1999;1433-1438.
8. Beier F., LuValle P. Serum induction of the collagen X promoter requires the Raf/MEK/ERK and p38 pathways. Biochem. Biophys. Res. Commun. 262:1999;50-54.
9. Beier F., Taylor A.C., LuValle P. Raf signaling stimulates and represses the human collagen X promoter through distinguishable elements. J. Cell Biochem. 72:1999;549-557.
10. Beier F., Taylor A.C., LuValle P. The Raf-1/MEK/ERK pathway regulates the expression of the p21 (Cip1/Waf1) gene in chondrocytes. J. Biol. Chem. 274:1999;30273-30279.
11. Beier F., Taylor A.C., LuValle P. Activating transcription factor 2 is necessary for maximal activity and serum induction of the cyclin A promoter in chondrocytes. J. Biol. Chem. 275:2000;12948-12953.
12. Bellus G.A., McIntosh I., Smith E.A., Aylsworth A.S., Kaitila I., Horton W.A., Greenhaw G.A., Hecht J.T., Francomano C.A. A recurrent mutation in the tyrosine kinase domain of fibroblast growth factor receptor 3 causes hypochondroplasia. Nat. Genet. 10:1995;357-359.
13. Bulavin D.V., Saito S., Hollander M.C., Sakaguchi K., Anderson C.W., Appella E., Fornace A.J. Jr. Phosphorylation of human p53 by p38 kinase coordinates N-terminal phosphorylation and apoptosis in response to UV radiation. EMBO J. 18:1999;6845-6854.
14. Cancedda R., Castagnola P., Cancedda F.D., Dozin B., Quarto R. Developmental control of chondrogenesis and osteogenesis. Int. J. Dev. Biol. 44:2000;707-714.
15. Cancedda R., Descalzi Cancedda F., Castagnola P. Chondrocyte differentiation. Int. Rev. Cytol. 159:1995;265-358.
16. Casanovas O., Miro F., Estanyol J.M., Itarte E., Agell N., Bachs O. Osmotic stress regulates the stability of cyclin D1 in a p38SAPK2-dependent manner. J. Biol. Chem. 275:2000;35091-35097.
17. Chen J.K., Shapiro H.S., Wrana J.L., Reimers S., Heersche J.N., Sodek J. Localization of bone sialoprotein (BSP) expression to sites of mineralized tissue formation in fetal rat tissues by in situ hybridization. Matrix. 11:1991;133-143.
18. Chen Z., Gibson T.B., Robinson F., Silvestro L., Pearson G., Xu B., Wright A., Vanderbilt C., Cobb M.H. MAP kinases. Chem. Rev. 101:2001;2449-2476.
19. Cobb M.H. MAP kinase pathways. Prog. Biophys. Mol. Biol. 71:1999;479-500.
20. Cook S.J., Aziz N., McMahon M. The repertoire of fos and jun proteins expressed during the G1 phase of the cell cycle is determined by the duration of mitogen-activated protein kinase activation. Mol. Cell. Biol. 19:1999;330-341.
21. Cuenda A., Rouse J., Doza Y.N., Meier R., Cohen P., Gallagher T.F., Young P.R., Lee J.C. SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1. FEBS Lett. 364:1995;229-233.
22. Davis R.J. Signal transduction by the JNK group of MAP kinases. Cell. 103:2000;239-252.
23. de Crombrugghe B., Lefebvre V., Nakashima K. Regulatory mechanisms in the pathways of cartilage and bone formation. Curr. Opin. Cell Biol. 13:2001;721-727.
24. Dean J.L., Brook M., Clark A.R., Saklatvala J. p38 mitogen-activated protein kinase regulates cyclooxygenase-2 mRNA stability and transcription in lipopolysaccharide-treated human monocytes. J. Biol. Chem. 274:1999;264-269.
25. DeLise A.M., Fischer L., Tuan R.S. Cellular interactions and signaling in cartilage development. Osteoarthritis Cartilage. 8:2000;309-334.
26. Elder S.H., Goldstein S.A., Kimura J.H., Soslowsky L.J., Spengler D.M. Chondrocyte differentiation is modulated by frequency and duration of cyclic compressive loading. Ann. Biomed. Eng. 29:2001;476-482.
27. English J.M., Cobb M.H. Pharmacological inhibitors of MAPK pathways. Trends Pharmacol. Sci. 23:2002;40-45.
28. Frost H.M., Schonau E. On longitudinal bone growth, short stature, and related matters insights about cartilage physiology from the Utah paradigm . J. Pediatr. Endocrinol. Metab. 14:2001;481-496.
29. Gack S., Vallon R., Schmidt J., Grigoriadis A., Tuckermann J., Schenkel J., Weiher H., Wagner E.F., Angel P. Expression of interstitial collagenase during skeletal development of the mouse is restricted to osteoblast-like cells and hypertrophic chondrocytes. Cell Growth Differ. 6:1995;759-767.
30. Gallo K.A., Johnson G.L. Mixed-lineage kinase control of JNK and p38 MAPK pathways. Nat. Rev. Mol. Cell Biol. 3:2002;663-672.
31. Ganiatsas S., Kwee L., Fujiwara Y., Perkins A., Ikeda T., Labow M.A., Zon L.I. SEK1 deficiency reveals mitogen-activated protein kinase cascade crossregulation and leads to abnormal hepatogenesis. Proc. Natl. Acad. Sci. USA. 95:1998;6881-6886.
32. Goedert M., Cuenda A., Craxton M., Jakes R., Cohen P. Activation of the novel stress-activated protein kinase SAPK4 by cytokines and cellular stresses is mediated by SKK3 (MKK6); comparison of its substrate specificity with that of other SAP kinases. EMBO. J. 16:1997;3563-3571.
33. Gupta S., Barrett T., Whitmarsh A.J., Cavanagh J., Sluss H.K., Derijard B., Davis R.J. Selective interaction of JNK protein kinase isoforms with transcription factors. EMBO. J. 15:1996;2760-2770.
34. Hagemann C., Blank J.L. The ups and downs of MEK kinase interactions. Cell Signal. 13:2001;863-875.
35. Han J., Lee J.D., Bibbs L., Ulevitch R.J. A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells. Science. 265:1994;808-811.
36. Han J., Lee J.D., Tobias P.S., Ulevitch R.J. Endotoxin induces rapid protein tyrosine phosphorylation in 70Z/3 cells expressing CD14. J. Biol. Chem. 268:1993;25009-25014.
37. Hanauer A., Young I.D. Coffin-Lowry syndrome clinical and molecular features . J. Med. Genet. 39:2002;705-713.
38. Harada S., Sampath T.K., Aubin J.E., Rodan G.A. Osteogenic protein-1 up-regulation of the collagen X promoter activity is mediated by a MEF-2-like sequence and requires an adjacent AP-1 sequence. Mol. Endocrinol. 11:1997;1832-1845.
39. Hocevar B.A., Brown T.L., Howe P.H. TGF-beta induces fibronectin synthesis through a c-Jun N-terminal kinase-dependent, Smad4-independent pathway. EMBO J. 18:1999;1345-1356.
40. Hung C.T., Henshaw D.R., Wang C.C., Mauck R.L., Raia F., Palmer G., Chao P.H., Mow V.C., Ratcliffe A., Valhmu W.B. Mitogen-activated protein kinase signaling in bovine articular chondrocytes in response to fluid flow does not require calcium mobilization. J. Biomech. 33:2000;73-80.
41. Hunziker E.B. Mechanism of longitudinal bone growth and its regulation by growth plate chondrocytes. Microsc. Res. Tech. 28:1994;505-519.
42. Ionescu A.M., Schwarz E.M., Vinson C., Puzas J.E., Rosier R., Reynolds P.R., O'Keefe R.J. PTHrP modulates chondrocyte differentiation through AP-1 and CREB signaling. J. Biol. Chem. 276:2001;11639-11647.
43. Ionescu A.M., Schwarz E.M., Vinson C., Puzas J.E., Rosier R.N., Reynolds P.R., O'Keefe R.J. PTHrP modulates chondrocyte differentiation through AP-1 and CREB signaling. J. Biol. Chem. 2:2001;2.
44. Jimenez M.J., Balbin M., Alvarez J., Komori T., Bianco P., Holmbeck K., Birkedal-Hansen H., Lopez J.M., Lopez-Otin C. A regulatory cascade involving retinoic acid, Cbfa1, matrix metalloproteinases is coupled to the development of a process of perichondrial invasion and osteogenic differentiation during bone formation. J. Cell. Biol. 155:2001;1333-1344.
45. Jin G., Sah R.L., Li Y.S., Lotz M., Shyy J.Y., Chien S. Biomechanical regulation of matrix metalloproteinase-9 in cultured chondrocytes. J. Orthop. Res. 18:2000;899-908.
46. Johnson G.L., Lapadat R. Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases. Science. 298:2002;1911-1912.
47. Kameda T., Watanabe H., Iba H. C-Jun and JunD suppress maturation of chondrocytes. Cell Growth Differ. 8:1997;495-503.
48. Kaneko Y., Tanzawa H., Sato K. The proto-oncogene C-raf-1 is highly expressed only in the hypertrophic zone of the growth plate. Calcif. Tissue Int. 54:1994;426-430.
49. Kantomaa T., Tuominen M., Pirttiniemi P. Effect of mechanical forces on chondrocyte maturation and differentiation in the mandibular condyle of the rat. J. Dent. Res. 73:1994;1150-1156.
50. Karsenty G. Minireview transcriptional control of osteoblast differentiation . Endocrinology. 142:2001;2731-2733.
51. Kielty C.M., Kwan A.P., Holmes D.F., Schor S.L., Grant M.E. Type X collagen, a product of hypertrophic chondrocytes. Biochem. J. 227:1985;545-554.
52. Kumar S., McDonnell P.C., Gum R.J., Hand A.T., Lee J.C., Young P.R. Novel homologues of CSBP/p38 MAP kinase activation, substrate specificity and sensitivity to inhibition by pyridinyl imidazoles . Biochem. Biophys. Res. Commun. 235:1997;533-538.
53. Kyriakis J.M., Avruch J. Protein kinase cascades activated by stress and inflammatory cytokines. Bioessays. 18:1996;567-577.
54. Kyriakis J.M., Avruch J. Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation. Physiol. Rev. 81:2001;807-869.
55. Kyriakis J.M., Banerjee P., Nikolakaki E., Dai T., Rubie E.A., Ahmad M.F., Avruch J., Woodgett J.R. The stress-activated protein kinase subfamily of c-Jun kinases. Nature. 369:1994;156-160.
56. Lali F.V., Hunt A.E., Turner S.J., Foxwell B.M. The pyridinyl imidazole inhibitor SB203580 blocks phosphoinositide-dependent protein kinase activity, protein kinase B phosphorylation, and retinoblastoma hyperphosphorylation in interleukin-2-stimulated T cells independently of p38 mitogen-activated protein kinase. J. Biol. Chem. 275:2000;7395-7402.
57. Legeai-Mallet L., Benoist-Lasselin C., Delezoide A.L., Munnich A., Bonaventure J. Fibroblast growth factor receptor 3 mutations promote apoptosis but do not alter chondrocyte proliferation in thanatophoric dysplasia. J. Biol. Chem. 273:1998;13007-13014.
58. Loeser R.F. Integrins and cell signaling in chondrocytes. Biorheology. 39:2002;119-124.
59. Long F., Schipani E., Asahara H., Kronenberg H., Montminy M. The CREB family of activators is required for endochondral bone development. Development. 128:2001;541-550.
60. Marais R., Marshall C.J. Control of the ERK MAP kinase cascade by Ras and Raf. Cancer Surv. 27:1996;101-125.
61. Marshall C.J. Specificity of receptor tyrosine kinase signaling transient versus sustained extracellular signal-regulated kinase activation . Cell. 80:1995;179-185.
62. Mobasheri A., Carter S.D., Martin-Vasallo P., Shakibaei M. Integrins and stretch activated ion channels; putative components of functional cell surface mechanoreceptors in articular chondrocytes. Cell Biol. Int. 26:2002;1-18.
63. Morrison D.K., Cutler R.E. The complexity of Raf-1 regulation. Curr. Opin. Cell Biol. 9:1997;174-179.
64. Mundlos S., Olsen B.R. Heritable diseases of the skeleton.Part I Molecular insights into skeletal development-transcription factors and signaling pathways . FASEB J. 11:1997;125-132.
65. Mundlos S., Olsen B.R. Heritable diseases of the skeleton. Part II Molecular insights into skeletal development-matrix components and their homeostasis . FASEB J. 11:1997;227-233.
66. Murakami S., Kan M., McKeehan W.L., de Crombrugghe B. Up-regulation of the chondrogenic Sox9 gene by fibroblast growth factors is mediated by the mitogen-activated protein kinase pathway. Proc. Natl. Acad. Sci. USA. 97:2000;1113-1118.
67. Nakamura K., Shirai T., Morishita S., Uchida S., Saeki-Miura K., Makishima F. p38 mitogen-activated protein kinase functionally contributes to chondrogenesis induced by growth/differentiation factor-5 in ATDC5 cells. Exp. Cell Res. 250:1999;351-363.
68. Naski M.C., Ornitz D.M. FGF signaling in skeletal development. Front. Biosci. 3:1998;D781-D794.
69. Nebreda A.R., Porras A. p38 MAP kinases beyond the stress response . Trends Biochem. Sci. 25:2000;257-260.
70. Nilsson A., Ohlsson C., Isaksson O.G., Lindahl A., Isgaard J. Hormonal regulation of longitudinal bone growth. Eur. J. Clin. Nutr. 48:1994;S150-S158. discussionS158-S160.
71. Oh C.D., Chang S.H., Yoon Y.M., Lee S.J., Lee Y.S., Kang S.S., Chun J.S. Opposing role of mitogen-activated protein kinase subtypes, erk-1/2 and p38, in the regulation of chondrogenesis of mesenchymes. J. Biol. Chem. 275:2000;5613-5619.
72. Oh C.D., Kim S.J., Ju J.W., Song W.K., Kim J.H., Yoo Y.J., Chun J.S. Immunosuppressant rapamycin inhibits protein kinase C alpha and p38 itogen-activated protein kinase leading to the inhibition of chondrogenesis. Eur. J. Pharmacol. 427:2001;175-185.
73. Ohlsson C., Isgaard J., Tornell J., Nilsson A., Isaksson O.G., Lindahl A. Endocrine regulation of longitudinal bone growth. Acta Paediatr. Suppl. 82:1993;33-40. discussion 41.
74. Olsen B.R., Reginato A.M., Wang W. Bone development. Annu. Rev. Cell Dev. Biol. 16:2000;191-220.
75. Ono K., Han J. The p38 signal transduction pathway activation and function . Cell Signal. 12:2000;1-13.
76. Ornitz D.M., Marie P.J. FGF signaling pathways in endochondral and intramembranous bone development and human genetic disease. Genes Dev. 16:2002;1446-1465.
77. Palmer G., Guicheux J., Bonjour J.P., Caverzasio J. Transforming growth factor-beta stimulates inorganic phosphate transport and expression of the type III phosphate transporter Glvr-1 in chondrogenic ATDC5 cells. Endocrinology. 141:2000;2236-2243.
78. Pearson G., Robinson F., Beers Gibson T., Xu B.E., Karandikar M., Berman K., Cobb M.H. Mitogen-activated protein (MAP) kinase pathways regulation and physiological functions . Endocr. Rev. 22:2001;153-183.
79. Pombo C.M., Bonventre J.V., Avruch J., Woodgett J.R., Kyriakis J.M., Force T. The stress-activated protein kinases are major c-Jun amino-terminal kinases activated by ischemia and reperfusion. J. Biol. Chem. 269:1994;26546-26551.
80. Price J.S., Oyajobi B.O., Russell R.G. The cell biology of bone growth. Eur. J. Clin. Nutr. 48:1994;S131-S149.
81. Raingeaud J., Whitmarsh A.J., Barrett T., Derijard B., Davis R.J. MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway. Mol. Cell. Biol. 16:1996;1247-1255.
82. Reichenberger E., Aigner T., von der Mark K., Stoss H., Bertling W. In situ hybridization studies on the expression of type X collagen in fetal human cartilage. Dev. Biol. 148:1991;562-572.
83. Reimold A.M., Grusby M.J., Kosaras B., Fries J.W., Mori R., Maniwa S., Clauss I.M., Collins T., Sidman R.L., Glimcher M.J., Glimcher L.H. Chondrodysplasia and neurological abnormalities in ATF-2-deficient mice. Nature. 379:1996;262-265.
84. Ridley S.H., Dean J.L., Sarsfield S.J., Brook M., Clark A.R., Saklatvala J. A p38 MAP kinase inhibitor regulates stability of interleukin-1-induced cyclooxygenase-2 mRNA. FEBS Lett. 439:1998;75-80.
85. Robinson M.J., Cobb M.H. Mitogen-activated protein kinase pathways. Curr. Opin. Cell Biol. 9:1997;180-186.
86. Roovers K., Assoian R.K. Integrating the MAP kinase signal into the G1 phase cell cycle machinery. Bioessays. 22:2000;818-826.
87. Rozenblatt-Rosen O., Mosonego-Ornan E., Sadot E., Madar-Shapiro L., Sheinin Y., Ginsberg D., Yayon A. Induction of chondrocyte growth arrest by FGF transcriptional and cytoskeletal alterations . J. Cell Sci. 115:2002;553-562.
88. Schaeffer H.J., Weber M.J. Mitogen-activated protein kinases specific messages from ubiquitous messengers . Mol. Cell. Biol. 19:1999;2435-2444.
89. Schramek H. MAP kinases from intracellular signals to physiology and disease . News Physiol. Sci. 17:2002;62-67.
90. Segat D., Comai R., Di Marco E., Strangio A., Cancedda R., Franzi A.T., Tacchetti C. Integrins alpha(6A)beta 1 and alpha(6B)beta 1 promote different stages of chondrogenic cell differentiation. J. Biol. Chem. 277:2002;31612- 31622.
91. Sewing A., Wiseman B., Lloyd A.C., Land H. High-intensity Raf signal causes cell cycle arrest mediated by p21Cip1. Mol. Cell. Biol. 17:1997;5588-5597.
92. Shi Y., Gaestel M. In the cellular garden of forking paths how p38 MAPKs signal for downstream assistance . Biol. Chem. 383:2002;1519-1536.
93. Shiang R., Thompson L.M., Zhu Y.Z., Church D.M., Fielder T.J., Bocian M., Winokur S.T., Wasmuth J.J. Mutations in the transmembrane domain of FGFR3 cause the most common genetic form of dwarfism, achondroplasia. Cell. 78:1994;335-342.
94. Shimoaka T., Ogasawara T., Yonamine A., Chikazu D., Kawano H., Nakamura K., Itoh N., Kawaguchi H. Regulation of osteoblast, chondrocyte, and osteoclast functions by fibroblast growth factor (FGF)-18 in comparison with FGF-2 and FGF-10. J. Biol. Chem. 277:2002;7493-7500.
95. Siebler T., Robson H., Shalet S.M., Williams G.R. Glucocorticoids, thyroid hormone and growth hormone interactions implications for the growth plate . Horm. Res. 56:2001;7-12.
96. Siebler T., Shalet S.M., Robson H. Effects of chemotherapy on bone metabolism and skeletal growth. Horm. Res. 58:2002;80-85.
97. Thomas D.P., Sunters A., Gentry A., Grigoriadis A.E. Inhibition of chondrocyte differentiation in vitro by constitutive and inducible overexpression of the c-fos proto-oncogene. J. Cell Sci. 113:2000;439-450.
98. Treisman R. Regulation of transcription by MAP kinase cascades. Curr. Opin. Cell Biol. 8:1996;205-215.
99. Trivier E., De Cesare D., Jacquot S., Pannetier S., Zackai E., Young I., Mandel J.L., Sassone-Corsi P., Hanauer A. Mutations in the kinase Rsk-2 associated with Coffin-Lowry syndrome. Nature. 384:1996;567-570.
100. van Leeuwen B.L., Kamps W.A., Jansen H.W., Hoekstra H.J. The effect of chemotherapy on the growing skeleton. Cancer Treat. Rev. 26:2000;363-376.
101. Wagner E.F., Karsenty G. Genetic control of skeletal development. Curr. Opin. Genet. Dev. 11:2001;527-532.
102. Wang W., Zhou G., Hu M.C., Yao Z., Tan T.H. Activation of the hematopoietic progenitor kinase-1 (HPK1)-dependent, stress-activated c-Jun N-terminal kinase (JNK) pathway by transforming growth factor beta (TGF-beta)-activated kinase (TAK1), a kinase mediator of TGF beta signal transduction. J. Biol. Chem. 272:1997;22771-22775.
103. Wang Z.Q., Ovitt C., Grigoriadis A.E., Mohle-Steinlein U., Ruther U., Wagner E.F. Bone and haematopoietic defects in mice lacking c-fos. Nature. 360:1992;741-745.
104. Watanabe H., de Caestecker M.P., Yamada Y. Transcriptional cross-talk between Smad, ERK1/2, and p38 mitogen-activated protein kinase pathways regulates transforming growth factor-beta-induced aggrecan gene expression in chondrogenic ATDC5 cells. J. Biol. Chem. 276:2001;14466-14473.
105. Weston A.D., Chandraratna R.A., Torchia J., Underhill T.M. Requirement for RAR-mediated gene repression in skeletal progenitor differentiation. J. Cell Biol. 158:2002;39-51.
106. Weston C.R., Davis R.J. The JNK signal transduction pathway. Curr. Opin. Genet. Dev. 12:2002;14-21.
107. Winzen R., Kracht M., Ritter B., Wilhelm A., Chen C.Y., Shyu A.B., Muller M., Gaestel M., Resch K., Holtmann H. The p38 MAP kinase pathway signals for cytokine-induced mRNA stabilization via MAP kinase-activated protein kinase 2 and an AU-rich region-targeted mechanism. EMBO J. 18:1999;4969-4980.
108. Wojnowski L., Stancato L.F., Zimmer A.M., Hahn H., Beck T.W., Larner A.C.R., Rapp U., Zimmer A. Craf-1 protein kinase is essential for mouse development. Mech. Dev. 76:1998;141-149.
109. Woods D., Parry D., Cherwinski H., Bosch E., Lees E., McMahon M. Raf-induced proliferation or cell cycle arrest is determined by the level of Raf activity with arrest mediated by p21Cip1. Mol. Cell. Biol. 17:1997;5598-5611.
110. Wu Q., Zhang Y., Chen Q. Indian hedgehog is an essential component of mechanotransduction complex to stimulate chondrocyte proliferation. J. Biol. Chem. 276:2001;35290-35296.
111. Wu Q.Q., Chen Q. Mechanoregulation of chondrocyte proliferation, maturation, and hypertrophy ion-channel dependent transduction of matrix deformation signals . Exp. Cell Res. 256:2000;383-391.
112. Yoon Y.M., Oh C.D., Kim D.Y., Lee Y.S., Park J.W., Huh T.L., Kang S.S., Chun J.S. Epidermal growth factor negatively regulates chondrogenesis of mesenchymal cells by modulating the protein kinase C-alpha, Erk-1, and p38 MAPK signaling pathways. J. Biol. Chem. 275:2000;12353-12359.
113. Yosimichi G., Nakanishi T., Nishida T., Hattori T., Takano-Yamamoto T., Takigawa M. CTGF/Hcs24 induces chondrocyte differentiation through a p38 mitogen-activated protein kinase (p38MAPK), and proliferation through a p44/42 MAPK/extracellular-signal regulated kinase (ERK). Eur. J. Biochem. 268:2001;6058-6065.
114. Young P.R., McLaughlin M.M., Kumar S., Kassis S., Doyle M.L., McNulty D., Gallagher T.F., Fisher S., McDonnell P.C., Carr S.A., Huddleston M.J., Seibel G., Porter T.G., Livi G.P., Adams J.L., Lee J.C. Pyridinyl imidazole inhibitors of p38 mitogen-activated protein kinase bind in the ATP site. J. Biol. Chem. 272:1997;12116-12121.
115. Zhen X., Wei L., Wu Q., Zhang Y., Chen Q. Mitogen-activated protein kinase p38 mediates regulation of chondrocyte differentiation by parathyroid hormone. J. Biol. Chem. 275:2000;15.