The mevalonate pathway as a therapeutic target in the Ph-Negative chronic myeloproliferative disorders

Current Drug Targets

Volumn 8, Issue 2, 2007, Pages 247-256

  Hasselsbalch, Hans Carl ^a   Riley, Caroline H ^a  

^a ODENSE UNIVERSITY HOSPITAL   (Denmark)

Author keywords

Antiangiogenic; Farnesyl transferase inhibitors (FTI); Idiopathic myelofibrosis; Proapoptotic; Zoledronic acid

Indexed keywords

ACETYLSALICYLIC ACID; ALENDRONIC ACID; CD34 ANTIGEN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; IMATINIB; LONAFARNIB; MEVALONIC ACID; PAMIDRONIC ACID; PROTEIN FARNESYLTRANSFERASE INHIBITOR; TIPIFARNIB; ZOLEDRONIC ACID;

ANGIOGENESIS; ANTICOAGULATION; ANTIINFLAMMATORY ACTIVITY; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; BLEEDING; BONE MARROW; BONE MARROW CELL; CELL PROLIFERATION; CELL TRANSPORT; CHRONIC MYELOID LEUKEMIA; DRUG EFFECT; DRUG MECHANISM; DRUG POTENTIATION; DRUG TARGETING; EXTRACELLULAR MATRIX; HISTOPATHOLOGY; HUMAN; IN VITRO STUDY; IN VIVO STUDY; MORBIDITY; MORTALITY; MYELOFIBROSIS; MYELOID METAPLASIA; MYELOPROLIFERATIVE DISORDER; PATHOPHYSIOLOGY; PHILADELPHIA CHROMOSOME NEGATIVE CELL; POLYCYTHEMIA VERA; PROTEIN DEGRADATION; REVIEW; SPLEEN; THROMBOCYTOSIS; THROMBOSIS;

ANTIGENS, CD34; CHRONIC DISEASE; HUMANS; MEVALONIC ACID; MYELOPROLIFERATIVE DISORDERS; PHILADELPHIA CHROMOSOME;

EID: 33847179088     PISSN: 13894501     EISSN: None     Source Type: Journal    
DOI: 10.2174/138945007779940133     Document Type: Review

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