Lovastatin induces a pronounced differentiation response in acute myeloid leukemias

Leukemia and Lymphoma

Volumn 40, Issue 1-2, 2000, Pages 167-178

  Dimitroulakos, J ^a   Thai, S ^a   Wasfy, G H ^a   Hedley, D W ^a   Minden, M D ^a   Penn, L Z ^a  

^a PRINCESS MARGARET HOSPITAL   (Canada)

Author keywords

AML; Apoptosis; Bcl 2; Differentiation; Lovastatin; Retinoic acid

Indexed keywords

CD11B ANTIGEN; CD18 ANTIGEN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; MESSENGER RNA; MEVINOLIN; PROTEIN BCL 2; RETINOIC ACID;

ACUTE LYMPHOCYTIC LEUKEMIA; APOPTOSIS; ARTICLE; CANCER CHEMOTHERAPY; CELL DIFFERENTIATION; CELL LINEAGE; CELL MATURATION; CONCENTRATION (PARAMETERS); CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; DRUG SENSITIVITY; DRUG TARGETING; GENE CONTROL; GENE EXPRESSION; HUMAN; HUMAN CELL; LEUKEMIA CELL; MYELOID LEUKEMIA; NEUROBLASTOMA CELL; PRIORITY JOURNAL; TUMOR CELL LINE;

EID: 0035145821     PISSN: 10428194     EISSN: None     Source Type: Journal    
DOI: 10.3109/10428190009054894     Document Type: Article

References (34)

1. Improved survival for patients with acute myelogenous leukemia
2. Adult acute leukemia
3. Differentiation therapy with all-trans retinoic acid in acute myeloid leukemia
4. Retinoids and their receptors in differentiation, embryogenesis and neoplasia
5. Use of all-trans retinoic acid in the treatment of acute promyelocytic leukemia
6. All-trans retinoic acid in hematological malignancies, an update. GER (Gruppo Ematologica Retinoidi)
7. Chromosomal translocation t(15;17) in human acute promyelocytic leukemia fuses RARα with a novel putative transcription factor, PML
8. Differentiation therapy of acute promyelocytic leukemia with tretinoin (all-trans retinoic acid)
9. The acute promyelocytic leukemia- specific PML-RARα fusion protein inhibits differentiation and promotes survival of myeloid precursor cells
10. Identification of a novel zinc finger gene, zf5-3, ás a potential mediator of neuroblastoma differentiation
11. HMG-CoA reductase mediates the biological effects of retinoic acid on human neuroblastoma cells: Lovastatin specifically targets P-glyco-protein-expressing cells
12. Regulation of the mevalonate pathway
13. Pharmacology of competitive inhibitors of HMG-CoA reductase
14. Increased sensitivity of acute myeloid leukemias to lovastatin-induced apoptosis: A potential therapeutic approach
15. Phosphorylation of BCL-2 after exposure of human leukemic cells to retinoic acid
16. Effect of all-trans retinoic acid on chemotherapy induced apoptosis and down-regulation of Bcl-2 in human myeloid leukaemia CD34 positive cells
17. Identification and sequence analysis of the promoter for the leukocyte integrin b-subunit (CD18): A retinoic acid-inducible gene
18. Dysregulated bcl-2 expression inhibits apoptosis but not differentiation of retinoic acid-induced HL-60 granulocytes
19. Autocrine and paracrine growth control by granulocyte-monocyte colony-stimulating factor of acute lymphoblastic leukemia cells
20. Expression of a retinoic acid receptor gene in myeloid leukemia cells
21. Synchronization of tumor and normal cells from G1 to multiple cell cycles by lovastatin
22. Bcl-2 mutants with restricted subcellular location reveal spatially distinct pathways for apoptosis in different cell types
23. Bcl-2 targeted to the endoplasmic reticulum can inhibit apoptosis induced by Myc but not etoposide in Rat-1 fibroblasts
24. Lovastatin induction of cyclin-dependant kinase inhibitors in human breast cells occurs in a cell cycle dependent fashion
25. NUB-7: A stable I-type human neuroblastoma cell line inducible along N- and S-type cell lineages
26. Phase 1 study of lovastatin, an inhibitor of the mevalonate pathway, in patients with cancer
27. Combined vitamin D3/retinoic acid induction of human promyelocytic cell lines: Enhanced phagocytic cell maturation and hybrid granulomonocytic phenotype
28. All-trans retinoic acid and hematopoietic growth factors regulating the growth and differentiation of blast progenitors in acute promyelocytic leukemia
29. Direct evidence for the participation of bcl-2 in the regulation by retinoic acid of the Ara-C sensitivity of leukemic stem cells
30. Bcl-2 proto-ongogene expression in normal and neoplastic human myeloid cells
31. Rapid retroviral infection of human haemopoietic cells of different lineages: Efficient transfer in fresh T cells
32. Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays
33. Features of apoptotic cells measured by flow cytometry
34. The biochemistry of programmed cell death