Vastatins inhibit tissue factor in cultured human macrophages: A novel mechanism of protection against atherothrombosis

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 17, Issue 2, 1997, Pages 265-272

  Colli, Susanna ^a   Eligini, Sonia ^a   Lalli, Mariagrazia ^a   Camera, Marina ^a   Paoletti, Rodolfo ^a   Tremoli, Elena ^a  

^a UNIVERSITY OF MILAN   (Italy)

Author keywords

3 hydroxy 3 methylglutaryl coenzyme A reductase inhibitors; atherosclerosis; isoprenoids; procoagulant activity; thrombosis

Indexed keywords

DOLICHOL; FARNESOL; FLUINDOSTATIN; GERANIOL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; LOW DENSITY LIPOPROTEIN; MEVALONIC ACID; SIMVASTATIN; THROMBOPLASTIN;

ARTICLE; ATHEROSCLEROTIC PLAQUE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSE RESPONSE; DRUG MECHANISM; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPERLIPIDEMIA; IMMUNOMODULATION; MACROPHAGE ACTIVATION; PRIORITY JOURNAL; PROMOTER REGION; THROMBOSIS PREVENTION;

EID: 0031025656     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.ATV.17.2.265     Document Type: Article

References (6)

1. Alberts AW, Chen J, Kuron G, Hunt V, Huff J, Huffman C, Rothrock J, Lopez M, Joshua H, Harris E, Patchett A, Monaghan R, Currie S, Stapley E, Albers-Schoenberg G, Hensens O, Hirshfield J, Hoogsteen K, Liesch J, Springer J. Mevinolin: a highly potent competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase and a cholesterol-lowering agent. Proc Natl Acad Sci U S A. 1980;77:3957-3961.
2. Grundy SM. HMG-CoA reductase inhibitors for treatment of hypercholesterolemia. N Engl J Med. 1988;319:24-33.
3. Sirtori CR. Tissue selectivity of hydroxymethylglutaryl coenzyme A (HMG-CoA) reductase inhibitors. Pharmacol Ther. 1993;60:431-459.
4. Brown G, Albers JJ, Fisher LD, Schaeffer SM, Lin JT, Kaplan C, Zhao XQ, Bisson BD, Fitzpatrick VF, Dodge HT. Regression of coronary artery disease as a result of intensive lipid-lowering therapy in men with high levels of apolipoprotein B. N Engl J Med. 1990;323:1289-1298.
5. Blankenhorn DH. Blood lipids and human atherosclerosis regression: the angiographic evidence. Curr Opin Lipidol. 1991;2:2324-2329.
6. Gellman J, Ezekowitz MD, Sarembock IJ, Azrin A, Nochomowitz LE, Lerner E, Haudenschild CC. Effect of lovastatin on intimal hyperplasia after balloon angioplasty: a study in an atherosclerotic hypercholesterolemic rabbit. J Am Coll Cardiol. 1991;17:251-259.