Association between enhanced soluble CD40L and prothrombotic state in hypercholesterolemia: Effects of statin therapy

Circulation

Volumn 106, Issue 4, 2002, Pages 399-402

  Cipollone, Francesco ^a   Mezzetti, Andrea ^a   Porreca, Ettore ^a   Di Febbo, Concetta ^a   Nutini, Michele ^a   Fazia, Maria ^a   Falco, Angela ^a   Cuccurullo, Franco ^a   Davì, Giovanni ^a  

^a Dipto Med/Sci dell'Invecchiamento   (Italy)

Author keywords

Atherosclerosis; Hypercholesterolemia; Inflammation; Risk factors

Indexed keywords

11 OXOTHROMBOXANE B2; BLOOD CLOTTING FACTOR 7A; CD40 ANTIGEN; CD40 LIGAND; CERIVASTATIN; CHOLESTEROL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PADGEM PROTEIN; PRAVASTATIN; PROTHROMBIN;

ADULT; AGED; ARTICLE; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL SYNTHESIS; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE ASSOCIATION; DOUBLE BLIND PROCEDURE; DRUG EFFECT; DRUG EFFICACY; FEMALE; HUMAN; HUMAN TISSUE; HYPERCHOLESTEROLEMIA; ITALY; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RANDOMIZED CONTROLLED TRIAL; THROMBOCYTE ACTIVATION; THROMBOSIS;

CD40 LIGAND; DOUBLE-BLIND METHOD; FACTOR VIIA; FEMALE; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; HYPERCHOLESTEROLEMIA; INFLAMMATION; MALE; MIDDLE AGED; P-SELECTIN; PEPTIDE FRAGMENTS; PLATELET ACTIVATION; PROTEIN PRECURSORS; PROTHROMBIN; THROMBOXANE B2;

EID: 0037162340     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.0000025419.95769.F0     Document Type: Article

References (12)

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2. Thromboxane biosynthesis, neutrophil and coagulative activation in type IIa hypercholesterolemia
3. Inhibition of thromboxane biosynthesis and platelet function by simvastatin in type IIa hypercholesterolemia
4. CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cells
5. Role of platelet P-selectin and CD40 ligand in the induction of monocytic tissue factor expression
6. Reduction of atherosclerosis in mice by inhibition of CD40 signaling
7. Inhibition of CD40 signaling limits evolution of established atherosclerosis in mice
8. Enhanced levels of soluble and membrane-bound CD40 ligand in patients with unstable angina
9. Soluble CD40L and cardiovascular risk in women
10. Upregulation of CD40 and CD40 ligand (CD154) in patients with moderate hypercholesterolemia
11. Increased levels of soluble P-selectin in hypercholesterolemic patients
12. Cox-2 and osteopontin in cocultured platelets and mesangial cells: Role of glucocorticoids