Statins suppress THP-1 cell migration and secretion of matrix metalloproteinase 9 by inhibiting geranylgeranylation

Journal of Leukocyte Biology

Volumn 69, Issue 6, 2001, Pages 959-962

  Wong, B ^a   Lumma, W C ^a   Smith, A M ^a   Sisko, J T ^a   Wright, S D ^a   Cai, T Q ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

HMG CoA reductase; Inhibitors; Monocytes

Indexed keywords

ALPHA HYDROXYFARNESYLPHOSPHONIC ACID; BACTERIUM LIPOPOLYSACCHARIDE; ENZYME INHIBITOR; FARNESYL DIPHOSPHATE; GERANYLTRANSFERASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; L 839867; MATRIX METALLOPROTEINASE; MEVALONIC ACID; MONOCYTE CHEMOTACTIC PROTEIN 1; RHO FACTOR; SIMVASTATIN; UBIQUINONE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; ATHEROSCLEROTIC PLAQUE; CELL MIGRATION; CONTROLLED STUDY; DOSE RESPONSE; ENZYME INHIBITION; HYPERCHOLESTEROLEMIA; MONOCYTE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PRIORITY JOURNAL;

ADP RIBOSE TRANSFERASES; ALKYL AND ARYL TRANSFERASES; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BOTULINUM TOXINS; CELL MOVEMENT; CHEMOKINE CCL2; CHEMOTAXIS; DEPRESSION, CHEMICAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; LEUKEMIA, MONOCYTIC, ACUTE; LIPOPOLYSACCHARIDES; MATRIX METALLOPROTEINASE 9; MEVALONIC ACID; MONOCYTES; NEOPLASM PROTEINS; ORGANIC CHEMICALS; POLYISOPRENYL PHOSPHATES; PROTEIN ISOPRENYLATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; SIMVASTATIN; TUMOR CELLS, CULTURED;

EID: 0034978984     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (24)

1. Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: The Scandinavian Simvastatin Survival Study (4S)
2. Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia
3. HMG CoA reductase inhibitors: In vivo effects on carotid intimal thickening in normocholesterolemic rabbits
4. Stroke protection by 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase inhibitors mediated by endothelial nitric oxide synthase
5. Simvastatin has anti-inflammatory and anti-atherosclerotic activities independent of plasma cholesterol-lowering
6. Regulation of the mevalonate pathway
7. Protein lipidation in cell signaling
8. Post-transcriptional regulation of endothelial nitric oxide synthase mRNA stability by Rho GTPase
9. 3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors increase fibrinolytic activity in rat aortic endothelial cells. Role of geranylgeranylation and Rho proteins
10. 3-Hydroxy-3-methylglutaryl coenzyme a reductase and isoprenylation inhibitors induce apoptosis of vascular smooth muscle cells in culture
11. Macrophages and atherosclerotic plaque stability
12. Atherosclerosis - An inflammatory disease
13. Biochemical evaluation of specific geranylgeranyltransferase inhibitors
14. Activation of PPARα or γ reduces secretion of matrix metalloproteinase 9 but not interleukin 8 from human monocytic THP-1 cells
15. Protein prenyltransferases
16. Posttranslational modifications of p21rho proteins
17. The rho gene product expressed in E. coli is a substrate of botulinum ADP-ribosyltransferase C3
18. HMG CoA reductase inhibitors reduce plasminogen activator inhibitor-1 expression by human vascular smooth muscle and endothelial cells
19. HMG-CoA reductase inhibitors reduce MMP-9 secretion by macrophages
20. Rab GTPases in vesicular transport
21. Rho GTPases and signaling networks
22. Rho GTPases and the actin cytoskeleton
23. Protein prenyltransferases
24. Inhibitors of Ras farnesyltransferases