Controlled microwave heating as an enabling technology: Expedient synthesis of protease inhibitors in perspective

QSAR and Combinatorial Science

Volumn 26, Issue 1, 2007, Pages 51-68

  Larhed, Mats ^a   Wannberg, Johan ^a   Hallberg, Anders ^a  

^a UPPSALA UNIVERSITY   (Sweden)

Author keywords

Carbonylation; Cross coupling; Drug discovery; Microwave; Protease inhibitor

Indexed keywords

CONTROLLED DRUG DELIVERY; LEAD COMPOUNDS; MICROWAVE HEATING; MICROWAVE IRRADIATION;

CARBONYLATIONS; CROSS-COUPLINGS; DRUG DISCOVERY; ENABLING TECHNOLOGIES; HOT PLATES; METAL BLOCKS; MICROWAVE-HEATING; OIL BATHS; ORGANIC CHEMISTRY; PROTEASE INHIBITOR;

CARBONYLATION;

ANTIHYPERTENSIVE AGENT; ANTIMALARIAL AGENT; ASPARTIC PROTEINASE INHIBITOR; ATAZANAVIR; BENZOFURAN DERIVATIVE; BLOOD CLOTTING FACTOR 10A INHIBITOR; CYCLIC 1,2 DIHYDROXYETHYLENE; CYCLIC SULFAMIDE DERIVATIVE; CYSTEINE PROTEINASE INHIBITOR; ETHYLAMINE; HYDROXYETHYLAMINE DERIVATIVE; HYDROXYL GROUP; INDINAVIR; LINEAR 1,2 DIHYDROXYETHYLENE INHIBITOR; MATRIX METALLOPROTEINASE INHIBITOR; MMP 13 INHIBITOR; MMP2 INHIBITOR; OXAZOLIDINONE DERIVATIVE; PLASMEPSIN 1 INHIBITOR; PLASMEPSIN 2 INHIBITOR; PLASMEPSIN I; PLASMEPSIN II; PLASMEPSIN INHIBITOR; PROTEINASE INHIBITOR; RENIN INHIBITOR; RNA DIRECTED DNA POLYMERASE INHIBITOR; SERINE PROTEINASE INHIBITOR; SULFAMIDE DERIVATIVE; THROMBIN INHIBITOR; TRYPTASE INHIBITOR; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; CHEMICAL REACTION; CHEMICAL STRUCTURE; COMPUTER MODEL; DRUG ACTIVITY; DRUG BIOAVAILABILITY; DRUG COST; DRUG DEVELOPMENT; DRUG ISOLATION; DRUG METABOLISM; DRUG PROTEIN BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; ENERGY RESOURCE; HEATING; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MICROWAVE RADIATION; PRIORITY JOURNAL; PROTEIN SYNTHESIS; QUALITY OF LIFE; QUANTITATIVE STRUCTURE ACTIVITY RELATION; REACTION TIME; REVIEW; SONOGASHIRA REACTION; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION; SUZUKI REACTION; UNSPECIFIED SIDE EFFECT;

EID: 33846794718     PISSN: 1611020X     EISSN: 16110218     Source Type: Journal    
DOI: 10.1002/qsar.200620028     Document Type: Review

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