Interaction of papain-like cysteine proteases with dipeptide-derived nitriles

Journal of Medicinal Chemistry

Volumn 48, Issue 24, 2005, Pages 7688-7707

  Löser, Reik ^a   Schilling, Klaus ^b   Dimmig, Elke ^b   Gütschow, Michael ^a  

^a UNIVERSITY OF BONN   (Germany)

^b JENA UNIVERSITY HOSPITAL   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ACETONE; ALDEHYDE; AMINOACETONITRILE; BROMINE; CATHEPSIN K; CATHEPSIN L; CATHEPSIN S; CYSTEINE PROTEINASE; CYSTEINE PROTEINASE INHIBITOR; DIPEPTIDE; ENZYME INHIBITOR; FLUORINE; N (BENZYLOXYCARBONYL)GLYCYLGLYCINE NITRILE; N (BENZYLOXYCARBONYL)LEUCYLGLYCINE NITRILE; N (TERT BUTOXYCARBONYL) 2 AMINOBUTANOYLGLYCINE NITRILE; N (TERT BUTOXYCARBONYL)ALANYLGLYCINE NITRILE; N (TERT BUTOXYCARBONYL)CYCLOHEXYLALANYLGLYCINE NITRILE; N (TERT BUTOXYCARBONYL)CYCLOPROPYLALANYLGLYCINE NITRILE; N (TERT BUTOXYCARBONYL)GLYCYLGLYCINE NITRILE; N (TERT BUTOXYCARBONYL)ISOLEUCYLGLYCINE NITRILE; N (TERT BUTOXYCARBONYL)LEUCYLGLYCINE NITRILE; N (TERT BUTOXYCARBONYL)METHIONYLGLYCINE NITRILE; N (TERT BUTOXYCARBONYL)NORLEUCYLGLYCINE NITRILE; N (TERT BUTOXYCARBONYL)NORVALYLGLYCINE NITRILE; N (TERT BUTOXYCARBONYL)PHENYLALANYLGLYCINE NITRILE; N (TERT BUTOXYCARBONYL)VALYLGLYCINE NITRLE; NITRILE; PAPAIN; PHENYLALANINE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; CHEMICAL REACTION KINETICS; DRUG SYNTHESIS; ENZYME INHIBITOR COMPLEX; ENZYME SPECIFICITY; METHYLATION; STRUCTURE ACTIVITY RELATION;

CATHEPSINS; CYSTEINE ENDOPEPTIDASES; CYSTEINE PROTEINASE INHIBITORS; DIPEPTIDES; KINETICS; NITRILES; PAPAIN; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

EID: 28144443719     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm050686b     Document Type: Article

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