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Volumn 7, Issue 4, 2005, Pages 611-617

High-speed synthesis of potent C2-symmetric HIV-1 protease inhibitors by in-situ aminocarbonylations

Author keywords

[No Author keywords available]

Indexed keywords

PROTEINASE INHIBITOR;

EID: 22844442612     PISSN: 15204766     EISSN: None     Source Type: Journal    
DOI: 10.1021/cc050016r     Document Type: Article
Times cited : (40)

References (22)
  • 5
    • 4744361049 scopus 로고    scopus 로고
    • UNAIDS, Geneva
    • Joint United Nations Programme on HIV/AIDS (UNAIDS). 2004 Report on the Global AIDS Epidemic. http://www.unaids.org (UNAIDS, Geneva, 2004).
    • (2004) 2004 Report on the Global AIDS Epidemic
  • 18
    • 22844451537 scopus 로고    scopus 로고
    • note
    • Employing the o-iodo starting material 4, competing mono dehalogenation resulted in small amounts (<10%) of non-symmetric monoamidation products.
  • 19
    • 22844448144 scopus 로고    scopus 로고
    • note
    • Full conversion of 10 was not achieved with 3-chloroaniline as the nucleophile, which explains the relatively low isolated yield of 61 (24%).
  • 20
    • 22844448612 scopus 로고    scopus 로고
    • note
    • No traces of inhibitor 4 or the corresponding dehalogenated arene was detected by LC/MS or NMR of the purified compounds.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.