-
6
-
-
0034613320
-
Structure of the protease domain of memapsin 2 (β-secretase) complexed with inhibitor
-
(2000)
Science
, vol.290
, pp. 150-153
-
-
Hong, L.1
Koelsch, G.2
Lin, X.L.3
Wu, S.L.4
Terzyan, S.5
Ghosh, A.K.6
Zhang, X.C.7
Tang, J.8
-
7
-
-
0034844346
-
Secreted aspartic proteases of Candida albicans, Candida tropicalis, Candida parapsilosis and Candida lusitaniae. Inhibition with peptidomimetic inhibitors
-
(2001)
Eur. J. Biochem
, vol.268
, pp. 2669-2677
-
-
Pichová, I.1
Pavlíková, L.2
Dostál, J.3
Dolejí, E.4
Hruvá-Heidingsfeldová, O.5
Weber, J.6
Ruml, T.7
Souek, M.8
-
11
-
-
16044374702
-
Structure and inhibition of plasmepsin II, a hemoglobin-degrading enzyme from Plasmodium falciparum
-
(1996)
Proc. Natl. Acad. Sci. USA
, vol.93
, pp. 10034-10039
-
-
Silva, A.M.1
Lee, A.Y.2
Gulnik, S.V.3
Majer, P.4
Collins, J.5
Bhat, T.N.6
Collins, P.J.7
Cachau, R.E.8
Luker, K.E.9
Gluzman, I.Y.10
Francis, S.E.11
Oksman, A.12
Goldberg, D.E.13
Erickson, J.E.14
-
12
-
-
0032497354
-
Identification of potent inhibitors of Plasmodium falciparum plasmepsin II from an encoded statine combinatorial library
-
(1998)
Bioorg. Med. Chem. Lett
, vol.8
, pp. 2315-2320
-
-
Carroll, C.D.1
Patel, H.2
Johnson, T.O.3
Guo, T.4
Orlowski, M.5
He, Z.M.6
Cavallaro, C.L.7
Guo, J.8
Oksman, A.9
Gluzman, I.Y.10
Connelly, J.11
Chelsky, D.12
Goldberg, D.E.13
Dolle, E.14
-
15
-
-
0026683982
-
X-ray analyses of peptide-inhibitor complexes define the structural basis of specificity for human and mouse renins
-
(1992)
Nature (Lond.)
, vol.357
, pp. 466-472
-
-
Dhanaraj, V.1
Dealwis, C.2
Frazao, C.3
Badasso, M.4
Sibanda, B.L.5
Tickle, I.J.6
Cooper, J.B.7
Driessen, H.P.C.8
Newman, M.9
Aguilar, C.10
Wood, S.P.11
Blundell, T.L.12
Hobart, P.M.13
Geoghegan, K.F.14
Ammirati, M.J.15
Danley, D.E.16
O'Connor, B.A.17
Hoover, D.J.18
-
17
-
-
0008788371
-
-
(Johnson, J. A., Anderson, R. R., Ed.), Plenum press, New York
-
(1980)
The Renin-Angiotensin System
-
-
Skeggs, L.T.1
Dover, F.E.2
Levine, M.3
Lentz, K.E.4
Kahn, J.R.5
-
21
-
-
0023238799
-
High resolution X-ray analyses of renin inhibitor-aspartic proteinase complexes
-
(1987)
Nature (Lond.)
, vol.327
, pp. 349-352
-
-
Foundling, S.I.1
Cooper, J.2
Watson, F.E.3
Cleasby, A.4
Pearl, L.H.5
Sibanda, B.L.6
Hemmings, A.7
Wood, S.P.8
Blundell, T.L.9
Valler, M.J.10
Norey, C.G.11
Kay, J.12
Boger, J.13
Dunn, B.M.14
Leckie, B.J.15
Jones, D.M.16
Atrash, B.17
Hallett, A.18
Szelke, M.19
-
22
-
-
0023880207
-
1 site
-
(1988)
J. Med. Chem
, vol.31
, pp. 532-539
-
-
Luly, J.R.1
Bolis, G.2
Bamaung, N.3
Soderquist, J.4
Dellaria, J.F.5
Stein, H.6
Cohen, J.7
Thomas, J.P.8
Greer, J.9
Plattner, J.J.10
-
26
-
-
0021839127
-
Highly potent and specific inhibitors of human renin
-
(1985)
Hypertension
, vol.7
, Issue.SUPPL. 1
, pp. 8-11
-
-
Kokubu, T.1
Hiwada, K.2
Murakami, E.3
Imamura, Y.4
Matsueda, R.5
Yabe, Y.6
Koike, H.7
Iijima, Y.8
-
27
-
-
0022473099
-
Statine containing dipeptide and tripeptide inhibitors of human renin
-
(1986)
Hypertension
, vol.8
, Issue.SUPPL. II
, pp. 1-5
-
-
Kokubu, T.1
Hiwada, K.2
Nagae, A.3
Murakami, E.4
Morisawa, Y.5
Yabe, Y.6
Koike, H.7
Iijima, Y.8
-
32
-
-
0022869306
-
Novel renin inhibitors: Synthesis of aminostatine and comparison with statine-containing analogues
-
(1986)
J. Chem. Soc. Chem. Commun
, vol.10
, pp. 755-757
-
-
Arrowsmith, R.J.1
Carter, K.2
Dann, J.G.3
Davies, D.E.4
Harris, C.J.5
Morton, J.A.6
Lister, P.7
Robinson, J.A.8
Williams, D.J.9
-
33
-
-
0001781199
-
Renin inhibitors containing the novel amino-acid 3-amino-deoxystatine
-
(Deber, C. M., Hruby, V. J. and Kopple, K. D. Ed.), Pierce Chemical Company, Rockford, Illinois
-
(1985)
Peptides: Structure and Function
, pp. 759-762
-
-
Jones, M.1
Sueiras-Diaz, J.2
Szelke, M.3
Leckie, B.4
Beattie, S.5
-
38
-
-
0000435021
-
A rational approach to the design of antihypertensives: X-ray studies of complexes between aspartic proteinases and aminoalcohol inhibitors
-
(Leeming, P.R., Ed.), London, Royal Society of Chemistry, London
-
(1988)
Topics in Medicinal Chemistry
, pp. 308-313
-
-
Cooper, J.B.1
Foundling, S.I.2
Blundell, T.L.3
Arrowsmith, R.J.4
Harris, C.J.5
Champness, J.N.6
-
39
-
-
0027144106
-
Analyses of ligand binding in five endothiapepsin crystal complexes and their use in the design and evaluation of novel renin inhibitors
-
(1993)
J. Med. Chem
, vol.36
, pp. 3809-3820
-
-
Lunney, E.A.1
Hamilton, H.W.2
Hodges, J.C.3
Kaltenbrohn, J.S.4
Repine, J.T.5
Badasso, M.6
Cooper, J.7
Dealwis, C.8
Wallace, B.9
Lowther, W.T.10
Dunn, B.M.11
Humblet, C.12
-
45
-
-
0029160445
-
How the molten globule became
-
(1995)
TIBS
, vol.20
, pp. 376-379
-
-
Ptitsyn, O.B.1
-
49
-
-
0034634367
-
X-ray structures of five renin inhibitors bound to saccharopepsin: Exploration of active-site specificity
-
(2000)
J. Mol. Biol
, vol.303
, pp. 745-750
-
-
Cronin, N.B.1
Badasso, M.O.2
Tickle, I.J.3
Dreyer, T.4
Hoover, D.J.5
Rosati, R.L.6
Humblet, C.C.7
Lunney, E.A.8
Cooper, J.B.9
-
51
-
-
0009130116
-
Renin inhibitors. Design and synthesis of a new class of conformationally restricted analogues of angiotensinogen
-
(1988)
J. Med. Chem
, vol.31
, pp. 284-295
-
-
Sham, H.L.1
Bolis, G.2
Stein, H.H.3
Fesik, S.W.4
Marcott, P.A.5
Plattner, J.J.6
Rempel, C.A.7
Greer, J.8
-
53
-
-
0008787549
-
Protection groups increase the in vivo stability of a statine-containing renin inhibitor
-
(Kostka, V., Ed.), Walter de Gruyter, Berlin
-
(1985)
Aspartic Proteinases and their Inhibitors
, pp. 463-466
-
-
Wood, J.M.1
Fuhrer, W.2
Buhlmayer, P.3
Riniker, B.4
Hofbauer, K.G.5
-
54
-
-
2142652751
-
Renin inhibitors. Dipeptide analogues of angiotensinogen incorporating transition-state, nonpeptidic replacements at the scissile bond
-
(1987)
J. Med. Chem
, vol.30
, pp. 1729-1737
-
-
Bolis, G.1
Fung, A.K.L.2
Greer, J.3
Kleinert, H.D.4
Marcotte, P.A.5
Perun, T.J.6
Plattner, J.J.7
Stein, H.H.8
-
56
-
-
0024538619
-
Structure of recombinant human renin, a target for cardiovascular-active drugs, at 2.5 Å resolution
-
(1989)
Science
, vol.243
, pp. 1346-1351
-
-
Sielecki, A.R.1
Hayakawa, K.2
Fujinaga, M.3
Murphy, M.E.P.4
Fraser, M.5
Muir, A.K.6
Carilli, C.T.7
Lewicki, J.A.8
Baxter, J.D.9
James, M.N.G.10
-
57
-
-
0028278857
-
X-ray analysis at 2.0 Å resolution of mouse submaxillary renin complexed with a decapeptide inhibitor CH-66, based on the 4-16 fragment of rat angiotensinogen
-
(1994)
J. Molec. Biol
, vol.236
, pp. 342-360
-
-
Dealwis, C.G.1
Frazao, C.2
Badasso, M.3
Cooper, J.B.4
Tickle, I.J.5
Driessen, H.6
Blundell, T.L.7
Murakami, K.8
Miyazaki, H.9
Sueiras-Diaz, J.10
Jones, D.M.11
Szelke, M.12
-
59
-
-
0033941893
-
Structure-based drug design: The discovery of novel nonpeptide orally active inhibitors of human renin
-
(2000)
Chemistry and Biology
, vol.7
, pp. 493-504
-
-
Rahuel, J.1
Rasetti, V.2
Maibaum, J.3
Rueger, H.4
Goschke, R.5
Cohen, N.C.6
Stutz, S.7
Cumin, F.8
Fuhrer, W.9
Wood, J.M.10
Grutter, M.G.11
-
60
-
-
0024412506
-
Conserved folding in retroviral proteinases: Crystal structure of synthetic HIV-1 proteinase
-
(1989)
Science
, vol.245
, pp. 616-621
-
-
Wlodawer, A.1
Miller, M.2
Jaskolski, M.3
Sathyanarayana, B.K.4
Baldwin, E.5
Weber, I.T.6
Selk, L.M.7
Clawson, L.8
Schneider, J.9
Kent, S.10
-
61
-
-
20244373125
-
X-ray analysis of HIV-1 proteinase at 2.7 Å resolution confirms structural homology among retroviral enzymes
-
(1989)
Nature (Lond.)
, vol.342
, pp. 299-302
-
-
Lapatto, R.1
Blundell, T.L.2
Hemmings, A.3
Overington, J.4
Wilderspin, A.5
Wood, S.P.6
Merson, J.R.7
Whittle, P.J.8
Danley, D.E.9
Geoghegan, K.F.10
Hawrylik, S.J.11
Lee, S.E.12
Scheld, K.G.13
Hobart, P.M.14
-
67
-
-
0026018244
-
Characterisation of recombinant human renin - Kinetics, pH-stability and peptidomimetic inhibitor binding
-
(1991)
J. Protein Chem
, vol.10
, pp. 553-563
-
-
Holzman, T.F.1
Chung, C.C.2
Edalji, R.3
Egan, D.A.4
Martin, M.5
Gubbins, E.J.6
Krafft, G.A.7
Wang, G.T.8
Thomas, A.M.9
Rosenberg, S.H.10
Hutchins, C.11
-
69
-
-
85037007777
-
-
The HIV protease database, National Cancer Institute, Frederick, USA
-
-
-
-
71
-
-
0029935527
-
Structure of a secreted aspartic protease from C. Albicans complexed with a potent inhibitor: Implications for the design of antifungal agents
-
(1996)
Protein Science
, vol.5
, pp. 640-652
-
-
Abad-Zapatero, C.1
Goldman, R.2
Muchmore, S.W.3
Hutchins, C.4
Stewart, K.5
Navaza, J.6
Payne, C.D.7
Ray, T.L.8
-
76
-
-
0033950453
-
The aspartic proteinase from Saccharomyces cerevisiae folds its own inhibitor into a helix
-
(2000)
Nat. Struct. Biol
, vol.7
, pp. 113-117
-
-
Li, M.1
Phylip, L.H.2
Lees, W.E.3
Winther, J.R.4
Dunn, B.M.5
Wlodawer, A.6
Kay, J.7
Gustchina, A.8
-
77
-
-
0033882029
-
Structural basis for the inhibition of porcine pepsin by Ascaris pepsin inhibitor-3
-
(2000)
Nat. Struct. Biol
, vol.7
, pp. 653-657
-
-
Ng, K.K.S.1
Petersen, J.F.W.2
Cherney, M.M.3
Garen, C.4
Zalatoris, J.J.5
Rao-Naik, C.6
Dunn, B.M.7
Martzen, M.R.8
Peanasky, R.J.9
James, M.N.G.10
|