New potent C2-Symmetric malaria plasmepsin I and II inhibitors

Bioorganic and Medicinal Chemistry

Volumn 11, Issue 7, 2003, Pages 1235-1246

  Oscarsson, Karin ^a   Oscarson, Stefan ^a   Vrang, Lotta ^b   Hamelink, Elizabeth ^b   Hallberg, Anders ^c   Samuelsson, Bertil ^a,b  

^a STOCKHOLM UNIVERSITY   (Sweden)

^b MEDIVIR AB   (Sweden)

^c UPPSALA UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

CATHEPSIN D; ENZYME INHIBITOR; PLASMEPSIN I; PLASMEPSIN II; ANTIMALARIAL AGENT; ASPARTIC PROTEINASE; DYES, REAGENTS, INDICATORS, MARKERS AND BUFFERS; PLASMEPSIN; PROTEINASE INHIBITOR;

ARTICLE; DRUG ACTIVITY; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME INHIBITION; MALARIA; ACYLATION; ANIMAL; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; HUMAN; HYDROLYSIS; PLASMODIUM FALCIPARUM; STRUCTURE ACTIVITY RELATION; SYNTHESIS; THERMODYNAMICS;

ACYLATION; ANIMALS; ANTIMALARIALS; ASPARTIC ENDOPEPTIDASES; CATHEPSIN D; HUMANS; HYDROLYSIS; INDICATORS AND REAGENTS; PLASMODIUM FALCIPARUM; PROTEASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP; THERMODYNAMICS;

EID: 0037375846     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(02)00643-0     Document Type: Article

References (35)

1. Weiss U. Nature. 415:2002;669.
2. World Health Report, World Health Organization, 1999.
3. Greenwood B., Mutabingwa T. Nature. 415:2002;760.
4. Westling J., Cipullo P., Hung S.-H., Saft H., Dame J.B., Dunn B.M. Protein Sci. 1999;2001.
5. Peters W. British Medicinal Bulletin. 38:1982;187.
6. Francis S.E., Sullivan D.J., Goldberg D.E. Annu. Rev. Microbiol. 51:1997;97.
7. Rosenthal P.J. Advances in Parasitology. 43:1999;106.
8. Berry C. Curr. Opin. Drug Discov. Devel. 3:2000;624.
9. Mineno T., Avery M.A. Chemtracts-Organic Chemistry. 14:2001;518.
10. Westling J., Yowell C.A., Majer P., Erickson J.W., Dame J.B., Dunn B.M. Experimental Parasitology. 87:1997;185.
11. Haque T.S., Skillman A.G., Lee C.E., Habashita H., Gluzman I.Y., Ewing T.J.A., Goldberg D.E., Kuntz I.D., Ellman J.A. J. Med. Chem. 42:1999;1428.
12. Banerjee R., Liu J., Beatty W., Pelosof L., Klemba M., Goldberg D.E. Proc. Natl. Acad. Sci. U.S.A. 19:2002;990.
13. Francis S.E., Gluzman I.Y., Oksman A., Knickerbocker A., Mueller R., Bryant M.L., Sherman D.R., Russell D.H., Goldberg D.E. EMBO J. 13:1994;306.
14. Wyatt D., Berry C. FEBS Lett. 513:2002;159.
15. Rosenthal P.J. Experimental Parasitology. 80:1995;272.
16. Coombs G.H., Goldberg D.E., Klemba M., Berry C., Kay J., Mottram J.C. Trends in Parasitology. 17:2001;532.
17. Khazanovich Bernstein N., Cherney M.M., Loetscher H., Ridley R.G., James M.N.G. Nature Structural Biology. 6:1999;32.
18. Silva A.M., Lee A.Y., Gulnik S.V., Majer P., Collins J., Bhat T.N., Collins P.J., Cachau R.E., Luker K.E., Gluzman I.Y., Francis S.E., Oksman A., Goldberg D.E., Erickson J.W. Proc. Natl. Acad. Sci. U.S.A. 93:1996;10034.
19. Caroll C.D., Patel H., Johnson T.O., Guo T., Orlowski M., He Z.-M., Cavallaro C.L., Guo J., Oksman A., Gluzman I.Y., Connelly J., Chelsky D., Goldberg D.E., Dolle R.E. Bioorg. Med. Chem. Lett. 8:1998;2315.
20. Nezami A., Luque I., Kimura T., Kiso Y., Freire E. Biochem. 41:2002;2273.
21. Jiang S., Prigge S.T., Wei L., Gao Y.-E., Hudson T.H., Gerena L., Dame J.B., Kyle D.E. Antimicrob. Agents Chemother. 2001;2577.
22. Tyas L., Gluzman I.Y., Moon R.P., Rupp K., Westling J., Ridley R.G., Kay J., Goldberg D.E., Berry C. FEBS Lett. 454:1999;210.
23. Zuccarello G., Bouzide A., Kvarnström I., Niklasson G., Svensson S.C.T., Brisander M., Danielsson H., Nillroth U., Karlén A., Hallberg A., Classon B., Samuelsson B. J. Org. Chem. 63:1998;4898.
24. Le Merrer Y., Duréault A., Greck C., Micas-Languin D., Gravier C., Depezay J.-C. Heterocycles. 25:1987;541.
25. Lal B., Pramanik B.N., Manhas M.S., Bose A.K. Tetrahedron Lett. 1977;1977.
26. Ogawa Y., Kovac P. Glycoconjugate J. 14:1997;433.
27. Dondoni A., Mastellari A.R., Medici A., Negrini E., Pedrini P. Synthesis. 1986;757.
28. Scott W.J., Crisp G.T., Stille J.K. J. Am. Chem. Soc. 106:1984;4630.
29. Bold G., Fässler A., Capraro H.-G., Cozens R., Klimkait T., Lazidins J., Mestan J., Poncioni B., Rösel J., Stover D., Tintelnot-Blomley M., Acemoglu F., Ucci-Stoll K., Wyss D., Lang M. J. Med. Chem. 41:1998;3387.
30. Sakaitani M., Hori K., Ohfune Y. Tetrahedron Lett. 29:1988;2983.
31. Frérot E., Coste J., Pantaloni A., Dufour M.-N., Jouin P. Tetrahedron. 47:1991;259.
32. Kocz R., Roestamadji J., Mobashery S. J. Org. Chem. 59:1994;2913.
33. Unpublished test methods by Medivir AB, Manuscript in preparation.
34. Copeland, R.A. Enzymes, 2nd ed.; Wiley-VHC: New York.
35. Cheng Y., Prusoff W.H. Biochem. Pharmacol. 22:1973;3099.