Novel pyrazinone inhibitors of mast cell tryptase: Synthesis and SAR evaluation

Bioorganic and Medicinal Chemistry Letters

Volumn 14, Issue 19, 2004, Pages 4819-4823

  Hopkins, Corey ^a   Neuenschwander, Kent ^a   Scotese, Anthony ^a   Jackson, Sharon ^a   Nieduzak, Thaddeus ^a   Pauls, Henry ^a   Liang, Guyan ^a   Sides, Keith ^a   Cramer, Dona ^a   Cairns, Jennifer ^a   Maignan, Sebastien ^a   Mathieu, Magali ^a  

^a SANOFI   (France)

Author keywords

Mast cell tryptase; Pyrazinone; SAR

Indexed keywords

ANTIINFLAMMATORY AGENT; BRONCHODILATING AGENT; PYRAZINE DERIVATIVE; TRYPTASE; TRYPTASE INHIBITOR;

ARTICLE; CYCLIZATION; DRUG SYNTHESIS; ENZYME INHIBITION; INHIBITION KINETICS; STRUCTURAL HOMOLOGY; STRUCTURE ACTIVITY RELATION;

PYRAZINES; SERINE ENDOPEPTIDASES; SERINE PROTEINASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP; TRYPTASES;

EID: 4444286148     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2004.07.051     Document Type: Article

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