Potent Inhibitors of the Plasmodium falciparum Enzymes Plasmepsin I and II Devoid of Cathepsin D Inhibitory Activity

Journal of Medicinal Chemistry

Volumn 47, Issue 1, 2004, Pages 110-122

  Ersmark, Karolina ^a   Feierberg, Isabella ^a   Bjelic, Sinisa ^a   Hamelink, Elizabeth ^c   Hackett, Fiona ^b   Blackman, Michael J ^b   Hultén, Johan ^a   Samuelsson, Bertil ^c   Åqvist, Johan ^a   Hallberg, Anders ^a  

^a UPPSALA UNIVERSITY   (Sweden)

^b NATIONAL INSTITUTE FOR MEDICAL RESEARCH   (United Kingdom)

^c MEDIVIR AB   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

2,5 BIS(ALLYLOXY) 3,4 DIHYDROXY 6 (2 HYDROXY 1 INDANYLAMINO) N1 (2 HYDROXY 1 INDANYL)HEXANAMIDE; 2,5 O BIS(3 BROMO 2 PROPEN 1 YL) LEVO MANNARO 1,4:3,6 DI GAMMA LACTONE; 3 BROMO 2 PROPEN 1 YL 2,2,2 TRICHLOROETHANIMIDATE; ASPARTIC PROTEINASE; CATHEPSIN D; ENZYME INHIBITOR; ETHYLENE DERIVATIVE; HEMOGLOBIN; N1,N6 BIS(2 HYDROXY 1 INDANYL) 2,5 BIS(3 BROMO 2 PROPENYLOXY) 3,4 DIHYDROXYHEXANE 1,6 DIAMIDE; N1,N6 BIS(2 HYDROXY 1 INDANYL) 2,5 BIS(3 PHENYL 2 PROPENYLOXY) 3,4 DIHYDROXYHEXANE 1,6 DIAMIDE; N1,N6 BIS(2 HYDROXY 1 INDANYL) 2,5 BIS(5 PHENYLPENT 2 EN 4 YNYL) 3,4 DIHYDROXYHEXANE 1,6 DIAMIDE; N1,N6 BIS(2 HYDROXY 1 INDANYL) 2,5 BIS(5 PHENYLPENTADIENYLOXY) 3,4 DIHYDROXYHEXANE 1,6 DIAMIDE; N1,N6 BIS(2 HYDROXY 1 INDANYL) 2,5 BIS(5 TRIMETHYLSILYLPENT 2 EN 4 YNYL) 3,4 DIHYDROXYHEXANE 1,6 DIAMIDE; N1,N6 BIS(2 HYDROXY 1 INDANYL) 2,5 BIS(PENT 2 EN 4 YNYL) 3,4 DIHYDROXYHEXANE 1,6 DIAMIDE; N1,N6 BIS(2 HYDROXY 1 INDANYL) 2,5 BIS[3 (2,4 DIMETHOXY 3,5 PYRIMIDIN) 2 PROPENYLOXY] 3,4 DIHYDROXYHEXANE 1,6 DIAMIDE; N1,N6 BIS(2 HYDROXY 1 INDANYL) 2,5 BIS[3 (2,5 DIMETHYL 3,4 OXAZOL) 2 PROPENYLOXY] 3,4 DIHYDROXYHEXANE 1,6 DIAMIDE; N1,N6 BIS(2 HYDROXY 1 INDANYL) 2,5 BIS[3 (3 THIENYL) 2 PROPENYLOXY] 3,4 DIHYDROXYHEXANE 1,6 DIAMIDE; N1,N6 BIS(2 HYDROXY 1 INDANYL) 2,5 BIS[3 (3,4 METHYLENEDIOXYPHENYL) 2 PROPENYLOXY] 3,4 DIHYDROXYHEXANE 1,6 DIAMIDE; N1,N6 BIS(2 HYDROXY 1 INDANYL) 2,5 BIS[3 (4 ACETYLPHENYL) 2 PROPENYLOXY] 3,4 DIHYDROXYHEXANE 1,6 DIAMIDE; N1,N6 BIS(2 HYDROXY 1 INDANYL) 2,5 BIS[3 (4 FLUOROPHENYL) 2 PROPENYLOXY] 3,4 DIHYDROXYHEXANE 1,6 DIAMIDE; N1,N6 BIS(2 HYDROXY 1 INDANYL) 2,5 BIS[3 (4 TOLYL) 2 PROPENYLOXY] 3,4 DIHYDROXYHEXANE 1,6 DIAMIDE; N1,N6 BIS(HYDROXY 1 INDANYL) 2,5 BIS[5 (METHOXYCARBONYL)PENT 2,4 DIENYLOXY] 3,4 DIHYDROXYHEXANE 1,6 DIAMIDE; PALLADIUM; PLASMEPSIN I; PLASMEPSIN II; UNCLASSIFIED DRUG;

ACCURACY; ARTICLE; BINDING AFFINITY; CALCULATION; CATALYSIS; CELL CULTURE; DATA ANALYSIS; DRUG ACTIVITY; DRUG BINDING; DRUG CONFORMATION; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; ENERGY; ENZYME ASSAY; ENZYME INHIBITION; EXPERIMENT; GROWTH INHIBITION; INHIBITION KINETICS; MEASUREMENT; MICROWAVE RADIATION; MOLECULAR DYNAMICS; PLASMODIUM FALCIPARUM; PREDICTION; PROTEIN DEGRADATION; PROTEIN TARGETING; REACTION ANALYSIS; SIMULATION; STRUCTURE ANALYSIS; X RAY ANALYSIS;

AMIDES; ANIMALS; ASPARTIC ENDOPEPTIDASES; CATHEPSIN D; CELLS, CULTURED; COMPUTER SIMULATION; ERYTHROCYTES; ETHYLENES; HUMANS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PLASMODIUM FALCIPARUM; PROTEIN BINDING; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; THERMODYNAMICS;

EID: 9144243695     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm030933g     Document Type: Article

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