Cyclic sulfamide HIV-1 protease inhibitors, with sidechains spanning from P2/P2′ to P1/P1′

Bioorganic and Medicinal Chemistry

Volumn 13, Issue 3, 2005, Pages 755-764

  Ax, Anna ^a   Schaal, Wesley ^a   Vrang, Lotta ^b   Samuelsson, Bertil ^b   Hallberg, Anders ^a   Karlén, Anders ^a  

^a UPPSALA UNIVERSITY   (Sweden)

^b MEDIVIR AB   (Sweden)

Author keywords

AIDS; Cyclic sulfamide; HIV 1 protease inhibitors; Molecular modeling

Indexed keywords

2,7 BIS(2 PHENYLBENZYL) 4,5 DIHYDROXY 1,2,7 THIADIAZEPINE 1,1 DIOXIDE; 2,7 BIS[2 (2 METHOXYPHENYL)BENZYL] 4,5 DIHYDROXY 1,2,7 THIADIAZEPINE 1,1 DIOXIDE; 2,7 BIS[2 (3 ISOPROPYLPHENYL)BENZYL] 4,5 DIHYDROXY 1,2,7 THIADIAZEPINE 1,1 DIOXIDE; 2,7 BIS[2 (3 METHYLPHENYL)BENZYL] 4,5 DIHYDROXY 1,2,7 THIADIAZEPINE 1,1 DIOXIDE; 2,7 BIS[2 (3 NITROPHENYL)BENZYL] 4,5 DIHYDROXY 1,2,7 THIADIAZEPINE 1,1 DIOXIDE; 2,7 BIS[2 (3 THIENYL)BENZYL] 4,5 DIHYDROXY 1,2,7 THIADIAZEPINE 1,1 DIOXIDE; 2,7 BIS[2 (3,4 DIMETHOXYPHENYL)BENZYL] 4,5 DIHYDROXY 1,2,7 THIADIAZEPINE 1,1 DIOXIDE; 2,7 BIS[2 (4 ACETYLPHENYL)BENZYL] 4,5 DIHYDROXY 1,2,7 THIADIAZEPINE 1,1 DIOXIDE; 2,7 BIS[2 (4 BUTYLPHENYL)BENZYL] 4,5 DIHYDROXY 1,2,7 THIADIAZEPINE 1,1 DIOXIDE; 2,7 BIS[2 (4 FLUOROPHENYL)BENZYL] 4,5 DIHYDROXY 1,2,7 THIADIAZEPINE 1,1 DIOXIDE; 2,7 BIS[2 (4 METHOXYPHENYL)BENZYL] 4,5 DIHYDROXY 1,2,7 THIADIAZEPINE 1,1 DIOXIDE; 2,7 BIS[2 (4 METHYLPHENYL)BENZYL] 4,5 DIHYDROXY 1,2,7 THIADIAZEPINE 1,1 DIOXIDE; 2,7 BIS[2 (BENZO[B]FURAN 2 YL)BENZYL] 4,5 DIHYDROXY 1,2,7 THIADIAZEPINE 1,1 DIOXIDE; 2,7 BIS[2 [(3 TRIFLUOROMETHYL)PHENYL]BENZYL] 4,5 DIHYDROXY 1,2,7 THIADIAZEPINE 1,1 DIOXIDE; 2,7 BIS[2 [(4 ETHYLSULFONYL)PHENYL]BENZYL] 4,5 DIHYDROXY 1,2,7 THIADIAZEPINE 1,1 DIOXIDE; 2,7 BIS[2 [2 (METHYLTHIO)PHENYL]BENZYL] 4,5 DIHYDROXY 1,2,7 THIADIAZEPINE 1,1 DIOXIDE; PROTEINASE INHIBITOR; SULFAMIDE DERIVATIVE; TARTARIC ACID; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; COMPLEX FORMATION; DRUG CONJUGATION; DRUG STRUCTURE; DRUG SYNTHESIS; ENANTIOMER; ENZYME INHIBITION; MOLECULAR MODEL; PHARMACODYNAMICS; STRUCTURE ACTIVITY RELATION;

HIV PROTEASE INHIBITORS; HIV-1; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; SULFONIC ACIDS;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 11844261443     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2004.10.042     Document Type: Article

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