-
1
-
-
0026507126
-
A novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytes
-
Thomberry NA, Bull HG, Calaycay JR, Chapman KT, Howard AD, Kostura MJ et al. (1992) A novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytes. Nature 356: 768-774.
-
(1992)
Nature
, vol.356
, pp. 768-774
-
-
Thornberry, N.A.1
Bull, H.G.2
Calaycay, J.R.3
Chapman, K.T.4
Howard, A.D.5
Kostura, M.J.6
-
2
-
-
0026517239
-
Molecular cloning of the interleukin-1 beta converting enzyme
-
Cerretti DP, Kozlosky CJ, Mosley B, Nelson N, Van Ness K, Greenstreet TA et al. (1992) Molecular cloning of the interleukin-1 beta converting enzyme. Science 256: 97-100.
-
(1992)
Science
, vol.256
, pp. 97-100
-
-
Cerretti, D.P.1
Kozlosky, C.J.2
Mosley, B.3
Nelson, N.4
Van Ness, K.5
Greenstreet, T.A.6
-
3
-
-
0027525104
-
The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1 beta-converting enzyme
-
Yuan J, Shaham S, Ledoux S, Ellis HM, Horvitz HR (1993) The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1 beta-converting enzyme. Cell 75: 641-652.
-
(1993)
Cell
, vol.75
, pp. 641-652
-
-
Yuan, J.1
Shaham, S.2
Ledoux, S.3
Ellis, H.M.4
Horvitz, H.R.5
-
4
-
-
0027449187
-
Induction of apoptosis in fibroblasts by IL-1 beta-converting enzyme, a mammalian homolog of the C. elegans cell death gene ced-3
-
Miura M, Zhu H, Rotello R, Hartwieg EA, Yuan J (1993) Induction of apoptosis in fibroblasts by IL-1 beta-converting enzyme, a mammalian homolog of the C. elegans cell death gene ced-3. Cell 75: 653-660.
-
(1993)
Cell
, vol.75
, pp. 653-660
-
-
Miura, M.1
Zhu, H.2
Rotello, R.3
Hartwieg, E.A.4
Yuan, J.5
-
5
-
-
0026763128
-
Identification of a set of genes with developmentally down-regulated expression in the mouse brain
-
Kumar S, Tomooka Y, Noda M (1992) Identification of a set of genes with developmentally down-regulated expression in the mouse brain. Biochem Biophys Res Commun 185: 1155-1161.
-
(1992)
Biochem Biophys Res Commun
, vol.185
, pp. 1155-1161
-
-
Kumar, S.1
Tomooka, Y.2
Noda, M.3
-
6
-
-
0027990778
-
Induction of apoptosis by mouse Nedd2 gene, which encodes a protein similar to the product of the Caenorhabditis elegans cell death gene ced-3 and the mammalian IL-1 β-converting enzyme
-
Kumar S, Kinoshita M, Noda M, Copeland NG, Jenkins NA (1994) Induction of apoptosis by mouse Nedd2 gene, which encodes a protein similar to the product of the Caenorhabditis elegans cell death gene ced-3 and the mammalian IL-1 β-converting enzyme. Genes Dev 8: 1613-1626.
-
(1994)
Genes Dev
, vol.8
, pp. 1613-1626
-
-
Kumar, S.1
Kinoshita, M.2
Noda, M.3
Copeland, N.G.4
Jenkins, N.A.5
-
7
-
-
0036312069
-
Alice in caspase land. A phylogenetic analysis of caspases from worm to man
-
Lamkanfi M, Declercq W, Kalai M, Saelens X, Vandenabeele P (2002) Alice in caspase land. A phylogenetic analysis of caspases from worm to man. Cell Death Differ 9: 358-361.
-
(2002)
Cell Death Differ
, vol.9
, pp. 358-361
-
-
Lamkanfi, M.1
Declercq, W.2
Kalai, M.3
Saelens, X.4
Vandenabeele, P.5
-
8
-
-
10644282148
-
The protein structures that shape caspase activity, specificity, activation and inhibition
-
Fuentes-Prior P, Salvesen GS (2004) The protein structures that shape caspase activity, specificity, activation and inhibition. Biochem J 384: 201-232.
-
(2004)
Biochem J
, vol.384
, pp. 201-232
-
-
Fuentes-Prior, P.1
Salvesen, G.S.2
-
10
-
-
0022497852
-
Genetic control of programmed cell death in the nematode C. elegans
-
Ellis HM, Horvitz HR (1986) Genetic control of programmed cell death in the nematode C. elegans. Cell 44: 817-829.
-
(1986)
Cell
, vol.44
, pp. 817-829
-
-
Ellis, H.M.1
Horvitz, H.R.2
-
11
-
-
0032567405
-
Identification of multiple Caenorhabditis elegans caspases and their potential roles in proteolytic cascades
-
Shaham S (1998) Identification of multiple Caenorhabditis elegans caspases and their potential roles in proteolytic cascades. J Biol Chem 273: 35109-35117.
-
(1998)
J Biol Chem
, vol.273
, pp. 35109-35117
-
-
Shaham, S.1
-
12
-
-
33244471589
-
Developmental apoptosis in C. elegans: A complex CEDnario
-
Lettre G, Hengartner MO (2006) Developmental apoptosis in C. elegans: A complex CEDnario. Nat Rev Mol Cell Biol 7: 97-108.
-
(2006)
Nat Rev Mol Cell Biol
, vol.7
, pp. 97-108
-
-
Lettre, G.1
Hengartner, M.O.2
-
13
-
-
26844485563
-
Structure of the CED-4-CED-9 complex provides insights into programmed cell death in Caenorhabditis elegans
-
Yan N, Chai J, Lee ES, Gu L, Liu Q, He J et al. (2005) Structure of the CED-4-CED-9 complex provides insights into programmed cell death in Caenorhabditis elegans. Nature 437: 831-837.
-
(2005)
Nature
, vol.437
, pp. 831-837
-
-
Yan, N.1
Chai, J.2
Lee, E.S.3
Gu, L.4
Liu, Q.5
He, J.6
-
14
-
-
0031023782
-
DCP-1, a Drosophila cell death protease essential for development
-
Song Z, McCall K, Steller H (1997) DCP-1, a Drosophila cell death protease essential for development. Science 275: 536-540.
-
(1997)
Science
, vol.275
, pp. 536-540
-
-
Song, Z.1
McCall, K.2
Steller, H.3
-
15
-
-
0032530359
-
Dredd, a novel effector of the apoptosis activators reaper, grim and hid in Drosophila
-
Chen P, Rodriguez A, Erskine R, Thach T, Abrams JM (1998) Dredd, a novel effector of the apoptosis activators reaper, grim and hid in Drosophila. Dev Biol 201: 202-216.
-
(1998)
Dev Biol
, vol.201
, pp. 202-216
-
-
Chen, P.1
Rodriguez, A.2
Erskine, R.3
Thach, T.4
Abrams, J.M.5
-
16
-
-
0031001092
-
Identification of a Drosophila melanogaster ICE/CED-3-related protease, drlCE
-
Fraser AG, Evan GI (1997) Identification of a Drosophila melanogaster ICE/CED-3-related protease, drlCE. EMBO J 16: 2805-2813.
-
(1997)
EMBO J
, vol.16
, pp. 2805-2813
-
-
Fraser, A.G.1
Evan, G.I.2
-
17
-
-
0033551239
-
DRONC, a novel ecdysone-inducible Drosophila caspase
-
Dorstyn L, Colussi PA, Quinn LM, Richardson H, Kumar S (1999) DRONC, a novel ecdysone-inducible Drosophila caspase. Proc Natl Acad Sci USA 96: 4307-4312.
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 4307-4312
-
-
Dorstyn, L.1
Colussi, P.A.2
Quinn, L.M.3
Richardson, H.4
Kumar, S.5
-
18
-
-
0032718887
-
DECAY, a novel Drosophila caspase related to mammalian caspase-3 and caspase-7
-
Dorstyn L, Read SH, Quinn LM, Richardson H, Kumar S (1999) DECAY, a novel Drosophila caspase related to mammalian caspase-3 and caspase-7. J Biol Chem 274: 30778-30783.
-
(1999)
J Biol Chem
, vol.274
, pp. 30778-30783
-
-
Dorstyn, L.1
Read, S.H.2
Quinn, L.M.3
Richardson, H.4
Kumar, S.5
-
19
-
-
0035816667
-
Characterization of the Drosophila caspase, DAMM
-
Harvey NL, Daish T, Mills K, Dorstyn L, Quinn LM, Read SH et al. (2001) Characterization of the Drosophila caspase, DAMM. J Biol Chem 276: 25342-25350.
-
(2001)
J Biol Chem
, vol.276
, pp. 25342-25350
-
-
Harvey, N.L.1
Daish, T.2
Mills, K.3
Dorstyn, L.4
Quinn, L.M.5
Read, S.H.6
-
20
-
-
0035037628
-
STRICA, a novel Drosophila caspase with an unusual serine/threonine-rich prodomain, interacts with DIAP1 and DIAP2
-
Doumanis J, Quinn L, Richardson H, Kumar S (2001) STRICA, a novel Drosophila caspase with an unusual serine/threonine-rich prodomain, interacts with DIAP1 and DIAP2. Cell Death Diff 8: 387-394.
-
(2001)
Cell Death Diff
, vol.8
, pp. 387-394
-
-
Doumanis, J.1
Quinn, L.2
Richardson, H.3
Kumar, S.4
-
22
-
-
0034305744
-
The Drosophila caspase Dredd is required to resist gram-negative bacterial infection
-
Leulier F, Rodriguez A, Khush RS, Abrams JM, Lemaitre B (2000) The Drosophila caspase Dredd is required to resist gram-negative bacterial infection. EMBO Rep 1: 353-358.
-
(2000)
EMBO Rep
, vol.1
, pp. 353-358
-
-
Leulier, F.1
Rodriguez, A.2
Khush, R.S.3
Abrams, J.M.4
Lemaitre, B.5
-
23
-
-
0034613376
-
dFADD, a novel death domain-containing adapter protein for the Drosophila caspase DREDD
-
Hu S, Yang X (2000) dFADD, a novel death domain-containing adapter protein for the Drosophila caspase DREDD. J Biol Chem 275: 30761-30764.
-
(2000)
J Biol Chem
, vol.275
, pp. 30761-30764
-
-
Hu, S.1
Yang, X.2
-
24
-
-
26644432726
-
The role of ubiquitination in Drosophila innate immunity
-
Zhou R, Silverman N, Hong M, Liao DS, Chung Y, Chen ZJ et al. (2005) The role of ubiquitination in Drosophila innate immunity. J Biol Chem 260: 34048-34055.
-
(2005)
J Biol Chem
, vol.260
, pp. 34048-34055
-
-
Zhou, R.1
Silverman, N.2
Hong, M.3
Liao, D.S.4
Chung, Y.5
Chen, Z.J.6
-
25
-
-
19344368275
-
Multiple apoptotic caspase cascades are required in nonapoptotic roles for Drosophila spermatid individualization
-
Huh JR, Vemooy SY, Yu H, Yan N, Shi Y, Guo M et al. (2004) Multiple apoptotic caspase cascades are required in nonapoptotic roles for Drosophila spermatid individualization. PLoS Biol 2: E15.
-
(2004)
PLoS Biol
, vol.2
-
-
Huh, J.R.1
Vemooy, S.Y.2
Yu, H.3
Yan, N.4
Shi, Y.5
Guo, M.6
-
26
-
-
10644288480
-
Drosophila caspase DRONC is required for specific developmental cell death pathways and stress-induced apoptosis
-
Daish TJ, Mills K, Kumar S (2004) Drosophila caspase DRONC is required for specific developmental cell death pathways and stress-induced apoptosis. Dev Cell 7: 909-915.
-
(2004)
Dev Cell
, vol.7
, pp. 909-915
-
-
Daish, T.J.1
Mills, K.2
Kumar, S.3
-
27
-
-
10644290827
-
The apical caspase dronc governs programmed and unprogrammed cell death in Drasophila
-
Chew SK, Akdemir F, Chen P, Lu WJ, Mills K, Daish T et al. (2004) The apical caspase dronc governs programmed and unprogrammed cell death in Drasophila. Dev Cell 7: 897-907.
-
(2004)
Dev Cell
, vol.7
, pp. 897-907
-
-
Chew, S.K.1
Akdemir, F.2
Chen, P.3
Lu, W.J.4
Mills, K.5
Daish, T.6
-
28
-
-
19444366944
-
The CARD-carrying caspase Dronc is essential for most, but not all, developmental cell death in Drosophila
-
Xu D, Li Y, Arcaro M, Lackey M, Bergmann A (2005) The CARD-carrying caspase Dronc is essential for most, but not all, developmental cell death in Drosophila. Development 132: 2125-2134.
-
(2005)
Development
, vol.132
, pp. 2125-2134
-
-
Xu, D.1
Li, Y.2
Arcaro, M.3
Lackey, M.4
Bergmann, A.5
-
29
-
-
21844449428
-
The Drosophila caspase DRONC is required for metamorphosis and cell death in response to irradiation and developmental signals
-
Waldhuber M, Emoto K, Petritsch C (2005) The Drosophila caspase DRONC is required for metamorphosis and cell death in response to irradiation and developmental signals. Mech Dev 122: 914-927.
-
(2005)
Mech Dev
, vol.122
, pp. 914-927
-
-
Waldhuber, M.1
Emoto, K.2
Petritsch, C.3
-
30
-
-
33749173274
-
DRONC coordinates cell death and compensatory proliferation
-
Kondo S, Senoo-Matsuda N, Hiromi Y, Miura M (2006) DRONC coordinates cell death and compensatory proliferation. Mol Cell Biol 26: 7258-7268.
-
(2006)
Mol Cell Biol
, vol.26
, pp. 7258-7268
-
-
Kondo, S.1
Senoo-Matsuda, N.2
Hiromi, Y.3
Miura, M.4
-
31
-
-
25144488086
-
The function of the Drosophila caspase DRONC in cell death and development
-
Mills K, Daish T, Kumar S (2005) The function of the Drosophila caspase DRONC in cell death and development. Cell Cycle 4: 744-746.
-
(2005)
Cell Cycle
, vol.4
, pp. 744-746
-
-
Mills, K.1
Daish, T.2
Kumar, S.3
-
32
-
-
8444228997
-
Migrate, differentiate, proliferate, or die: Pleiotropic functions of an apical 'apoptotic caspase'
-
Kumar S (2004) Migrate, differentiate, proliferate, or die: Pleiotropic functions of an apical 'apoptotic caspase'. Sci STKE 2004: Pe49.
-
(2004)
Sci STKE
, vol.2004
-
-
Kumar, S.1
-
33
-
-
0034651987
-
The Drosophila caspase DRONC is regulated by DIAP1
-
Meier P, Silke J, Leevers SJ, Evan GI (2000) The Drosophila caspase DRONC is regulated by DIAP1. EMBO J 19: 598-611.
-
(2000)
EMBO J
, vol.19
, pp. 598-611
-
-
Meier, P.1
Silke, J.2
Leevers, S.J.3
Evan, G.I.4
-
34
-
-
0034704098
-
An essential role for the caspase Dronc in developmentally programmed cell death in Drosophila
-
Quinn LM, Dorstyn L, Mills K, Colussi PA, Chen P, Coombe M et al. (2000) An essential role for the caspase Dronc in developmentally programmed cell death in Drosophila. J Biol Chem 275: 40416-40424.
-
(2000)
J Biol Chem
, vol.275
, pp. 40416-40424
-
-
Quinn, L.M.1
Dorstyn, L.2
Mills, K.3
Colussi, P.A.4
Chen, P.5
Coombe, M.6
-
35
-
-
0034282666
-
The Drosophila caspase Dronc cleaves following glutamate or aspartate and is regulated by Diap1, Hid and Grim
-
Hawkins CJ, Yoo SJ, Peterson EP, Wang SL, Vemooy SY, Hay BA (2000) The Drosophila caspase Dronc cleaves following glutamate or aspartate and is regulated by Diap1, Hid and Grim. J Biol Chem 275: 27084-27093.
-
(2000)
J Biol Chem
, vol.275
, pp. 27084-27093
-
-
Hawkins, C.J.1
Yoo, S.J.2
Peterson, E.P.3
Wang, S.L.4
Vemooy, S.Y.5
Hay, B.A.6
-
36
-
-
33748713053
-
Systematic in vivo RNAi analysis of putative components of the Drosophila cell death machinery
-
Leulier F, Ribeiro PS, Palmer E, Tenev T, Takahashi K, Robertson D et al. (2006) Systematic in vivo RNAi analysis of putative components of the Drosophila cell death machinery. Cell Death Differ 13: 1663-1674.
-
(2006)
Cell Death Differ
, vol.13
, pp. 1663-1674
-
-
Leulier, F.1
Ribeiro, P.S.2
Palmer, E.3
Tenev, T.4
Takahashi, K.5
Robertson, D.6
-
37
-
-
0037054544
-
Ecdysone-induced expression of the caspase DRONC during hormone dependent programmed cell death in Drosophila is regulated by Broad-Complex
-
Cakouros D, Daish T, Martin D, Baehrecke EH, Kumar S (2002) Ecdysone-induced expression of the caspase DRONC during hormone dependent programmed cell death in Drosophila is regulated by Broad-Complex. J Cell Biol 157: 985-995.
-
(2002)
J Cell Biol
, vol.157
, pp. 985-995
-
-
Cakouros, D.1
Daish, T.2
Martin, D.3
Baehrecke, E.H.4
Kumar, S.5
-
38
-
-
2942696793
-
Ecdysone receptor directly binds the promoter of the Drosophila caspase dronc regulating its expression in specific tissues
-
Cakouros D, Daish TJ, Kumar S (2004) Ecdysone receptor directly binds the promoter of the Drosophila caspase dronc regulating its expression in specific tissues. J Cell Biol 165: 631-640.
-
(2004)
J Cell Biol
, vol.165
, pp. 631-640
-
-
Cakouros, D.1
Daish, T.J.2
Kumar, S.3
-
39
-
-
2442614108
-
An arginine-histone methyl transferase, Carmer, coordinates ecdysone-mediated apoptosis in Drosophila cells
-
Cakouros D, Daish TJ, Mills K, Kumar S (2004) An arginine-histone methyl transferase, Carmer, coordinates ecdysone-mediated apoptosis in Drosophila cells. J Biol Chem 279: 18467-18471.
-
(2004)
J Biol Chem
, vol.279
, pp. 18467-18471
-
-
Cakouros, D.1
Daish, T.J.2
Mills, K.3
Kumar, S.4
-
40
-
-
0346777314
-
Distinct promoter regions regulate spatial and temporal expression of the Drosophila caspase dronc
-
Daish T, Cakouros D, Kumar S (2003) Distinct promoter regions regulate spatial and temporal expression of the Drosophila caspase dronc. Cell Death Differ 10: 1348-1356.
-
(2003)
Cell Death Differ
, vol.10
, pp. 1348-1356
-
-
Daish, T.1
Cakouros, D.2
Kumar, S.3
-
41
-
-
1842813931
-
Transcriptional control of the core cell death machinery
-
Kumar S, Cakouros D (2004) Transcriptional control of the core cell death machinery. Trends Biochem Sci 29: 193-199.
-
(2004)
Trends Biochem Sci
, vol.29
, pp. 193-199
-
-
Kumar, S.1
Cakouros, D.2
-
42
-
-
0037128924
-
The role of cytochrome c in caspase activation in Drosophila cells
-
Dorstyn L, Read S, Cakouros D, Huh JR, Hay BA, Kumar S (2002) The role of cytochrome c in caspase activation in Drosophila cells. J Cell Biol 156: 1089-1098.
-
(2002)
J Cell Biol
, vol.156
, pp. 1089-1098
-
-
Dorstyn, L.1
Read, S.2
Cakouros, D.3
Huh, J.R.4
Hay, B.A.5
Kumar, S.6
-
43
-
-
33746570157
-
Drosophila IKK-related kinase regulates nonapoptotic function of caspases via degradation of IAPs
-
Kuranaga E, Kanuka H, Tonoki A, Takemoto K, Tomioka T, Kobayashi M et al. (2006) Drosophila IKK-related kinase regulates nonapoptotic function of caspases via degradation of IAPs. Cell 126: 583-596.
-
(2006)
Cell
, vol.126
, pp. 583-596
-
-
Kuranaga, E.1
Kanuka, H.2
Tonoki, A.3
Takemoto, K.4
Tomioka, T.5
Kobayashi, M.6
-
44
-
-
33749392341
-
The Drosophila caspase Ice is important for many apoptotic cell deaths and for spermatid individualization, a nonapoptotic process
-
Muro I, Berry DL, Huh JR, Chen CH, Huang H, Yoo SJ et al. (2006) The Drosophila caspase Ice is important for many apoptotic cell deaths and for spermatid individualization, a nonapoptotic process. Development 133: 3305-3315.
-
(2006)
Development
, vol.133
, pp. 3305-3315
-
-
Muro, I.1
Berry, D.L.2
Huh, J.R.3
Chen, C.H.4
Huang, H.5
Yoo, S.J.6
-
45
-
-
33748676654
-
The effector caspases drlCE and dcp-1 have partially overlapping functions in the apoptotic pathway in Drosophila
-
Xu D, Wang Y, Willecke R, Chen Z, Ding T, Bergmann A (2006) The effector caspases drlCE and dcp-1 have partially overlapping functions in the apoptotic pathway in Drosophila. Cell Death Differ 13: 1697-1706.
-
(2006)
Cell Death Differ
, vol.13
, pp. 1697-1706
-
-
Xu, D.1
Wang, Y.2
Willecke, R.3
Chen, Z.4
Ding, T.5
Bergmann, A.6
-
46
-
-
15744394371
-
Ecdysone-mediated up-regulation of the effector caspase DRICE is required for hormone-dependent apoptosis in Drosophila cells
-
Kilpatrick ZE, Cakouros D, Kumar S (2005) Ecdysone-mediated up-regulation of the effector caspase DRICE is required for hormone-dependent apoptosis in Drosophila cells. J Biol Chem 280: 11981-11986.
-
(2005)
J Biol Chem
, vol.280
, pp. 11981-11986
-
-
Kilpatrick, Z.E.1
Cakouros, D.2
Kumar, S.3
-
47
-
-
0030683619
-
drlCE is an essential caspase required for apoptotic activity in Drosophila cells
-
Fraser AG, McCarthy NJ, Evan GI (1997) drlCE is an essential caspase required for apoptotic activity in Drosophila cells. EMBO J 16: 6192-6199.
-
(1997)
EMBO J
, vol.16
, pp. 6192-6199
-
-
Fraser, A.G.1
McCarthy, N.J.2
Evan, G.I.3
-
48
-
-
0031888955
-
A caspase activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD
-
Enari M, Sakahira H, Yokoyama H, Okawa K, Iwamatsu A, Nagata S (1998) A caspase activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD. Nature 391: 43-50.
-
(1998)
Nature
, vol.391
, pp. 43-50
-
-
Enari, M.1
Sakahira, H.2
Yokoyama, H.3
Okawa, K.4
Iwamatsu, A.5
Nagata, S.6
-
49
-
-
0034724949
-
A novel activation mechanism of caspase-activated DNase from Drosophila melanogaster
-
Yokoyama H, Mukae N, Sakahira H, Okawa K, Iwamatsu A, Nagata S (2000) A novel activation mechanism of caspase-activated DNase from Drosophila melanogaster. J Biol Chem 275: 12978-12986.
-
(2000)
J Biol Chem
, vol.275
, pp. 12978-12986
-
-
Yokoyama, H.1
Mukae, N.2
Sakahira, H.3
Okawa, K.4
Iwamatsu, A.5
Nagata, S.6
-
50
-
-
0032498138
-
Requirement for DCP-1 caspase during Drosophila oogenesis
-
McCall K, Steller H (1998) Requirement for DCP-1 caspase during Drosophila oogenesis. Science 279: 230-234.
-
(1998)
Science
, vol.279
, pp. 230-234
-
-
McCall, K.1
Steller, H.2
-
51
-
-
0347361690
-
Germline cell death is inhibited by P-element insertions disrupting the dcp-1/pita nested gene pair in Drosophila
-
Laundrie B, Peterson JS, Baum JS, Chang JC, Fileppo D, Thompson SR et al. (2003) Germline cell death is inhibited by P-element insertions disrupting the dcp-1/pita nested gene pair in Drosophila. Genetics 165: 1881-1888.
-
(2003)
Genetics
, vol.165
, pp. 1881-1888
-
-
Laundrie, B.1
Peterson, J.S.2
Baum, J.S.3
Chang, J.C.4
Fileppo, D.5
Thompson, S.R.6
-
52
-
-
0037452653
-
Genome-wide analyses of steroid- and radiation-triggered programmed cell death in Drosophila
-
Lee CY, Clough EA, Yellon P, Teslovich TM, Stephan DA, Baehrecke EH (2003) Genome-wide analyses of steroid- and radiation-triggered programmed cell death in Drosophila. Curr, Biol 13: 350-357.
-
(2003)
Curr, Biol
, vol.13
, pp. 350-357
-
-
Lee, C.Y.1
Clough, E.A.2
Yellon, P.3
Teslovich, T.M.4
Stephan, D.A.5
Baehrecke, E.H.6
-
53
-
-
0033588273
-
The Drosophila caspase inhibitor DIAP1 is essential for cell survival and is negatively regulated by HID
-
Wang SL, Hawkins CJ, Yoo SJ, Muller HA, Hay BA (1999) The Drosophila caspase inhibitor DIAP1 is essential for cell survival and is negatively regulated by HID. Cell 98: 453-463.
-
(1999)
Cell
, vol.98
, pp. 453-463
-
-
Wang, S.L.1
Hawkins, C.J.2
Yoo, S.J.3
Muller, H.A.4
Hay, B.A.5
-
54
-
-
0034651791
-
Induction of apoptosis by Drosophila reaper, hid and grim through inhibition of IAP function
-
Goyal L, McCall K, Agapite J, Hartwieg E, Steller H (2000) Induction of apoptosis by Drosophila reaper, hid and grim through inhibition of IAP function. EMBO J 19: 589-597.
-
(2000)
EMBO J
, vol.19
, pp. 589-597
-
-
Goyal, L.1
McCall, K.2
Agapite, J.3
Hartwieg, E.4
Steller, H.5
-
55
-
-
0034695914
-
Debcl, a pro-apoptotic Bcl-2 homologue, is a component of the Drosophila cell death machinery
-
Colussi PA, Quinn LM, Huang DCS, Coombe M, Read SH, Richardson H et al (2000) Debcl, a pro-apoptotic Bcl-2 homologue, is a component of the Drosophila cell death machinery. J Cell Biol 148: 703-714.
-
(2000)
J Cell Biol
, vol.148
, pp. 703-714
-
-
Colussi, P.A.1
Quinn, L.M.2
Huang, D.C.S.3
Coombe, M.4
Read, S.H.5
Richardson, H.6
-
56
-
-
0041813273
-
Buffy, a Drosophila Bcl-2 related protein, has anti-apoptotic and cell cycle inhibitory function
-
Quinn L, Coomb M, Mills K, Daish T, Colussi P, Kumar S et al. (2003) Buffy, a Drosophila Bcl-2 related protein, has anti-apoptotic and cell cycle inhibitory function. EMBO J 22: 3568-3579.
-
(2003)
EMBO J
, vol.22
, pp. 3568-3579
-
-
Quinn, L.1
Coomb, M.2
Mills, K.3
Daish, T.4
Colussi, P.5
Kumar, S.6
-
58
-
-
0030715323
-
Cylochrome c and dATP-dependent formation of Apaf1/caspase-9 complex initiates the apoptotic protease cascade
-
Li P, Nijhawan D, Budihardjo I, Srinivasula SM, Ahmad M, Alnemri ES et al. (1997) Cylochrome c and dATP-dependent formation of Apaf1/caspase-9 complex initiates the apoptotic protease cascade. Cell 91: 479-489.
-
(1997)
Cell
, vol.91
, pp. 479-489
-
-
Li, P.1
Nijhawan, D.2
Budihardjo, I.3
Srinivasula, S.M.4
Ahmad, M.5
Alnemri, E.S.6
-
59
-
-
33745186883
-
A cytochrome c-free fly apoptosome
-
Dorstyn L, Kumar S (2006) A cytochrome c-free fly apoptosome. Cell Death Differ 13: 1049-1051.
-
(2006)
Cell Death Differ
, vol.13
, pp. 1049-1051
-
-
Dorstyn, L.1
Kumar, S.2
-
60
-
-
33644885423
-
The Drosophila melanogaster Apaf-1 homologue ARK is required for most, but not all, programmed cell death
-
Mills K, Daish T, Harvey KF, Pfleger CM, Hariharan IK, Kumar S (2006) The Drosophila melanogaster Apaf-1 homologue ARK is required for most, but not all, programmed cell death. J Cell Biol 172: 809-815.
-
(2006)
J Cell Biol
, vol.172
, pp. 809-815
-
-
Mills, K.1
Daish, T.2
Harvey, K.F.3
Pfleger, C.M.4
Hariharan, I.K.5
Kumar, S.6
-
61
-
-
33845510345
-
ARK, the Apaf-1 related killer in Drosophila, requires diverse domains for its apoptotic activity
-
(in press)
-
Srivastava M, Scherr H, Lackey M, Xu D, Chen Z, Lu J et al (2006) ARK, the Apaf-1 related killer in Drosophila, requires diverse domains for its apoptotic activity. Cell Death Differ (in press).
-
(2006)
Cell Death Differ
-
-
Srivastava, M.1
Scherr, H.2
Lackey, M.3
Xu, D.4
Chen, Z.5
Lu, J.6
-
62
-
-
33646696937
-
Autophagy occurs upstream or parallel to the apoptosome during histolytic cell death
-
Akdemir F, Farkas R, Chen P, Juhasz G, Medved'ova L, Sass M et al. (2006) Autophagy occurs upstream or parallel to the apoptosome during histolytic cell death. Development 133: 1457-1465.
-
(2006)
Development
, vol.133
, pp. 1457-1465
-
-
Akdemir, F.1
Farkas, R.2
Chen, P.3
Juhasz, G.4
Medved'ova, L.5
Sass, M.6
-
63
-
-
0033593791
-
Altered cytochrome c display precedes apoptotic cell death in Drosophila
-
Varkey J, Chen P, Jemmerson R, Abrams JM (1999) Altered cytochrome c display precedes apoptotic cell death in Drosophila. J Cell Biol 144: 701-710.
-
(1999)
J Cell Biol
, vol.144
, pp. 701-710
-
-
Varkey, J.1
Chen, P.2
Jemmerson, R.3
Abrams, J.M.4
-
64
-
-
0037128923
-
The role of ARK in stress-induced apoptosis in Drosophila cells
-
Zimmermann KC, Ricci JE, Droin NM, Green DR (2002) The role of ARK in stress-induced apoptosis in Drosophila cells. J Cell Biol 156: 1077-1087.
-
(2002)
J Cell Biol
, vol.156
, pp. 1077-1087
-
-
Zimmermann, K.C.1
Ricci, J.E.2
Droin, N.M.3
Green, D.R.4
-
65
-
-
8444227809
-
The two cytochrome c species, DC3 and DC4, are not required for caspase activation and apoptosis in Drosophila cells
-
Dorstyn L, Mills K, Lazebnik Y, Kumar S (2004) The two cytochrome c species, DC3 and DC4, are not required for caspase activation and apoptosis in Drosophila cells. J Cell Biol 167: 405-410.
-
(2004)
J Cell Biol
, vol.167
, pp. 405-410
-
-
Dorstyn, L.1
Mills, K.2
Lazebnik, Y.3
Kumar, S.4
-
66
-
-
33745220731
-
Lack of involvement of mitochondrial factors in caspase activation in a Drosophila oell-free system
-
Means JC, Muro I, Clem RJ (2006) Lack of involvement of mitochondrial factors in caspase activation in a Drosophila oell-free system. Cell Death Differ 13: 1222-1234.
-
(2006)
Cell Death Differ
, vol.13
, pp. 1222-1234
-
-
Means, J.C.1
Muro, I.2
Clem, R.J.3
-
67
-
-
28944443033
-
Three-dimensional structure of a double apoptosome formed by the Drosophila Apaf-1 related killer
-
Yu X, Wang L, Acehan D, Wang X, Akey CW (2006) Three-dimensional structure of a double apoptosome formed by the Drosophila Apaf-1 related killer. J Mol Biol 355: 577-589.
-
(2006)
J Mol Biol
, vol.355
, pp. 577-589
-
-
Yu, X.1
Wang, L.2
Acehan, D.3
Wang, X.4
Akey, C.W.5
-
68
-
-
0036187036
-
Three-dimensional structure of the apoptosome. Implications for assembly, procaspase-9 binding, and activation
-
Acehan D, Jiang X, Morgan DG, Heuser JE, Wang X, Akey CW (2002) Three-dimensional structure of the apoptosome. Implications for assembly, procaspase-9 binding, and activation. Mol Cell 9: 423-432.
-
(2002)
Mol Cell
, vol.9
, pp. 423-432
-
-
Acehan, D.1
Jiang, X.2
Morgan, D.G.3
Heuser, J.E.4
Wang, X.5
Akey, C.W.6
-
69
-
-
0032493870
-
Differential requirement for caspase-9 in apoptotic pathways in vivo
-
Hakem R, Hakem A, Duncan GS, Henderson JT, Woo M, Soengas MS et al. (1998) Differential requirement for caspase-9 in apoptotic pathways in vivo. Cell 94: 339-352.
-
(1998)
Cell
, vol.94
, pp. 339-352
-
-
Hakem, R.1
Hakem, A.2
Duncan, G.S.3
Henderson, J.T.4
Woo, M.5
Soengas, M.S.6
-
70
-
-
0032493910
-
Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase 9
-
Kuida K, Haydar TF, Kuan C-Y, Gu Y, Taya C, Karasuyama H et al. (1998) Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase 9. Cell 94: 325-337.
-
(1998)
Cell
, vol.94
, pp. 325-337
-
-
Kuida, K.1
Haydar, T.F.2
Kuan, C.-Y.3
Gu, Y.4
Taya, C.5
Karasuyama, H.6
-
71
-
-
0029956641
-
Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice
-
Kuida K, Zheng TS, Na S, Kuan C, Yang D, Karasuyama H et al (1996) Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice. Nature 384: 368-372.
-
(1996)
Nature
, vol.384
, pp. 368-372
-
-
Kuida, K.1
Zheng, T.S.2
Na, S.3
Kuan, C.4
Yang, D.5
Karasuyama, H.6
-
72
-
-
0032544449
-
Apaf1 (CED-4 homolog) regulates programmed cell death in mammalian development
-
Cecconi F, Alvarez-Bolado G, Meyer BI, Roth KA, Gruss P (1998) Apaf1 (CED-4 homolog) regulates programmed cell death in mammalian development Cell 94: 727-737.
-
(1998)
Cell
, vol.94
, pp. 727-737
-
-
Cecconi, F.1
Alvarez-Bolado, G.2
Meyer, B.I.3
Roth, K.A.4
Gruss, P.5
-
73
-
-
0032544564
-
Apaf1 is required for mitochondrial pathways of apoptosis and brain development
-
Yoshida H, Kong YY, Yoshida R, Elia AJ, Hakem A, Hakem R et al. (1998) Apaf1 is required for mitochondrial pathways of apoptosis and brain development. Cell 94: 739-750.
-
(1998)
Cell
, vol.94
, pp. 739-750
-
-
Yoshida, H.1
Kong, Y.Y.2
Yoshida, R.3
Elia, A.J.4
Hakem, A.5
Hakem, R.6
-
74
-
-
0034652010
-
Adult Apaf-1-deficient mice exhibit male infertility
-
Honarpour N, Du C, Richardson JA, Hammer RE, Wang X, Herz J (2000) Adult Apaf-1-deficient mice exhibit male infertility. Dev Biol 218: 248-258.
-
(2000)
Dev Biol
, vol.218
, pp. 248-258
-
-
Honarpour, N.1
Du, C.2
Richardson, J.A.3
Hammer, R.E.4
Wang, X.5
Herz, J.6
-
75
-
-
33644938544
-
Histological analyses of normally grown, fertile Apat1-deficient mice
-
Okamoto H, Shiraishi H, Yoshida H (2006) Histological analyses of normally grown, fertile Apat1-deficient mice. Cell Death Differ 13: 668-671.
-
(2006)
Cell Death Differ
, vol.13
, pp. 668-671
-
-
Okamoto, H.1
Shiraishi, H.2
Yoshida, H.3
-
76
-
-
0037057629
-
Apoptosis initiated by Bcl-2-regulated caspase activation independently of the cytochrome c/Apaf-1/caspase-9 apoptosome
-
Marsden VS, O'Connor L, O'Reilly LA, Silke J, Metcalf D, Ekert PG et al. (2002) Apoptosis initiated by Bcl-2-regulated caspase activation independently of the cytochrome c/Apaf-1/caspase-9 apoptosome. Nature 419: 634-637.
-
(2002)
Nature
, vol.419
, pp. 634-637
-
-
Marsden, V.S.1
O'Connor, L.2
O'Reilly, L.A.3
Silke, J.4
Metcalf, D.5
Ekert, P.G.6
-
77
-
-
3042592579
-
Bcl-2-regulated apoptosis and cytochrome c release can occur independently of both caspase-2 and caspase-9
-
Marsden VS, Ekert PG, Van Delft M, Vaux DL, Adams JM, Strasser A (2004) Bcl-2-regulated apoptosis and cytochrome c release can occur independently of both caspase-2 and caspase-9. J Cell Biol 165: 775-780.
-
(2004)
J Cell Biol
, vol.165
, pp. 775-780
-
-
Marsden, V.S.1
Ekert, P.G.2
Van Delft, M.3
Vaux, D.L.4
Adams, J.M.5
Strasser, A.6
-
78
-
-
3042687605
-
Apaf-1 and caspase-9 accelerate apoptosis, but do not determine whether factor-deprived or drug-treated cells die
-
Ekert PG, Read SH, Silke J, Marsden VS, Kaufmann H, Hawkins CJ et al. (2004) Apaf-1 and caspase-9 accelerate apoptosis, but do not determine whether factor-deprived or drug-treated cells die. J Cell Biol 165: 835-842.
-
(2004)
J Cell Biol
, vol.165
, pp. 835-842
-
-
Ekert, P.G.1
Read, S.H.2
Silke, J.3
Marsden, V.S.4
Kaufmann, H.5
Hawkins, C.J.6
-
79
-
-
0037279648
-
The Apat-1/cytochrome c apoptosome: An essential initiator of caspase activation or just a sideshow?
-
Baliga C, Kumar S (2003) The Apat-1/cytochrome c apoptosome: An essential initiator of caspase activation or just a sideshow? Cell Death Differ 10: 15-17.
-
(2003)
Cell Death Differ
, vol.10
, pp. 15-17
-
-
Baliga, C.1
Kumar, S.2
-
80
-
-
21144451097
-
Specific ablation of the apoptotic functions of cytochrome c reveals a differential requirement for cytochrome c and Apaf-1 in apoptosis
-
Hao Z, Duncan GS, Chang CC, Elia A, Fang M, Wakeham A et al. (2005) Specific ablation of the apoptotic functions of cytochrome c reveals a differential requirement for cytochrome c and Apaf-1 in apoptosis. Cell 121: 579-591.
-
(2005)
Cell
, vol.121
, pp. 579-591
-
-
Hao, Z.1
Duncan, G.S.2
Chang, C.C.3
Elia, A.4
Fang, M.5
Wakeham, A.6
-
81
-
-
0030011398
-
Involvement of MACH, a novel Mort1/FADD-interacting protease, in Fas/APO1- and TNF receptor-induced cell death
-
Boldin MP, Goncharov TM, Gottsev YV, Wallach D (1996) Involvement of MACH, a novel Mort1/FADD-interacting protease, in Fas/APO1- and TNF receptor-induced cell death. Cell 85: 803-815.
-
(1996)
Cell
, vol.85
, pp. 803-815
-
-
Boldin, M.P.1
Goncharov, T.M.2
Gottsev, Y.V.3
Wallach, D.4
-
82
-
-
15844412409
-
FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death-inducing signaling complex
-
Muzio M, Chinnaiyan AM, Kischkel FC, O'Rourke K, Shevchenko A, Scaffidi C et al. (1996) FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death-inducing signaling complex. Cell 85: 817-827.
-
(1996)
Cell
, vol.85
, pp. 817-827
-
-
Muzio, M.1
Chinnaiyan, A.M.2
Kischkel, F.C.3
O'Rourke, K.4
Shevchenko, A.5
Scaffidi, C.6
-
83
-
-
0032143986
-
Targeted disruption of the mouse caspase 8 gene ablates cell death induction by the TNF receptors, Fas/Apo1, and DR3 and is lethal prenatally
-
Varfolomeev EE, Schuchmann M, Luna V, Chiannilkulchai N, Beckmann JS, Mett IL et al. (1998) Targeted disruption of the mouse caspase 8 gene ablates cell death induction by the TNF receptors, Fas/Apo1, and DR3 and is lethal prenatally. Immunity 9: 267-276.
-
(1998)
Immunity
, vol.9
, pp. 267-276
-
-
Varfolomeev, E.E.1
Schuchmann, M.2
Luna, V.3
Chiannilkulchai, N.4
Beckmann, J.S.5
Mett, I.L.6
-
84
-
-
4344560197
-
Caspase-8 serves both apoptotic and nonapoptotic roles
-
Kang TB, Ben-Moshe T, Varfolomeev EE, Pewzner-Jung Y, Yogev N, Jurewicz A et al. (2004) Caspase-8 serves both apoptotic and nonapoptotic roles. J Immunol 173: 2976-2984.
-
(2004)
J Immunol
, vol.173
, pp. 2976-2984
-
-
Kang, T.B.1
Ben-Moshe, T.2
Varfolomeev, E.E.3
Pewzner-Jung, Y.4
Yogev, N.5
Jurewicz, A.6
-
85
-
-
18544383460
-
Pleiotropic defects in lymphocyte activation caused by caspase-8 mutations lead to human immunodeficiency
-
Chun HJ, Zheng L, Ahmad M, Wang J, Speirs CK, Siegel RM et al. (2002) Pleiotropic defects in lymphocyte activation caused by caspase-8 mutations lead to human immunodeficiency. Nature 419: 395-399.
-
(2002)
Nature
, vol.419
, pp. 395-399
-
-
Chun, H.J.1
Zheng, L.2
Ahmad, M.3
Wang, J.4
Speirs, C.K.5
Siegel, R.M.6
-
86
-
-
7144263731
-
FADD: Essential for embryo development and signaling from some, but not all, inducers of apoptosis
-
Yeh WC, de la Pompa JL, McCurrach ME, Shu H-B, Elia AJ, Shahinian A et al. (1998) FADD: Essential for embryo development and signaling from some, but not all, inducers of apoptosis. Science 279: 1954-1958.
-
(1998)
Science
, vol.279
, pp. 1954-1958
-
-
Yeh, W.C.1
de la Pompa, J.L.2
McCurrach, M.E.3
Shu, H.-B.4
Elia, A.J.5
Shahinian, A.6
-
87
-
-
0032546387
-
Fas-mediated apoptosis and activation-induced T-cell proliferation are detective in mice lacking FADD/MORT1
-
Zhang J, Cado D, Kabra NH, Winoto A (1998) Fas-mediated apoptosis and activation-induced T-cell proliferation are detective in mice lacking FADD/MORT1. Nature 392: 296-299.
-
(1998)
Nature
, vol.392
, pp. 296-299
-
-
Zhang, J.1
Cado, D.2
Kabra, N.H.3
Winoto, A.4
-
88
-
-
0035933115
-
T cell-specific FADD-deficient mice: FADD is required for early T cell development
-
Kabra NH, Kang C, Hsing LC, Zhang J, Winoto A (2001) T cell-specific FADD-deficient mice: FADD is required for early T cell development. Proc Natl Acad Sci USA 98: 6307-6312.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 6307-6312
-
-
Kabra, N.H.1
Kang, C.2
Hsing, L.C.3
Zhang, J.4
Winoto, A.5
-
89
-
-
23844548539
-
Conditional Fasassociated death domain protein (FADD): GFP knockout mice reveal FADD is dispensable in thymic development but essential in peripheral T cell homeostasis
-
Zhang Y, Rosenberg S, Wang H, Imtiyaz HZ, Hou YJ, Zhang J (2005) Conditional Fasassociated death domain protein (FADD): GFP knockout mice reveal FADD is dispensable in thymic development but essential in peripheral T cell homeostasis. J Immunol 175: 3033-3044.
-
(2005)
J Immunol
, vol.175
, pp. 3033-3044
-
-
Zhang, Y.1
Rosenberg, S.2
Wang, H.3
Imtiyaz, H.Z.4
Hou, Y.J.5
Zhang, J.6
-
90
-
-
0035824635
-
Death receptor recruitment of endogenous caspase-10 and apoptosis initiation in the absence of caspase-8
-
Kischkel FC, Lawrence DA, Tinel A, LeBlanc H, Virmani A, Schow P et al. (2001) Death receptor recruitment of endogenous caspase-10 and apoptosis initiation in the absence of caspase-8. J Biol Chem 276: 46639-46646.
-
(2001)
J Biol Chem
, vol.276
, pp. 46639-46646
-
-
Kischkel, F.C.1
Lawrence, D.A.2
Tinel, A.3
LeBlanc, H.4
Virmani, A.5
Schow, P.6
-
91
-
-
21244502158
-
Caspase-10 triggers Bid cleavage and caspase cascade activation in FasL-induced apoptosis
-
Milhas D, Cuvillier O, Therville N, Clave P, Thomsen M, Levade T et al (2005) Caspase-10 triggers Bid cleavage and caspase cascade activation in FasL-induced apoptosis. J Biol Chem 280: 19836-19842.
-
(2005)
J Biol Chem
, vol.280
, pp. 19836-19842
-
-
Milhas, D.1
Cuvillier, O.2
Therville, N.3
Clave, P.4
Thomsen, M.5
Levade, T.6
-
92
-
-
15044354180
-
Caspase-10 sensitizes breast carcinoma cells to TRAIL-induced but not tumor necrosis factor-induced apoptosis in a caspase-3-dependent manner
-
Engels IH, Totzke G, Fischer U, Schulze-Osthoff K, Janicke RU (2005) Caspase-10 sensitizes breast carcinoma cells to TRAIL-induced but not tumor necrosis factor-induced apoptosis in a caspase-3-dependent manner. Mol Cell Biol 25: 2808-2818.
-
(2005)
Mol Cell Biol
, vol.25
, pp. 2808-2818
-
-
Engels, I.H.1
Totzke, G.2
Fischer, U.3
Schulze-Osthoff, K.4
Janicke, R.U.5
-
93
-
-
33645786318
-
Roles of caspase-8 and caspase-10 in innate immune responses to double-stranded RNA
-
Takahashi K, Kawai T, Kumar H, Sato S, Yonehara S, Akira S (2006) Roles of caspase-8 and caspase-10 in innate immune responses to double-stranded RNA. J Immunol 176: 4520-4524.
-
(2006)
J Immunol
, vol.176
, pp. 4520-4524
-
-
Takahashi, K.1
Kawai, T.2
Kumar, H.3
Sato, S.4
Yonehara, S.5
Akira, S.6
-
94
-
-
33645015401
-
Genetic alterations in caspase-10 may be causative or protective in autoimmune lymphoproliferative syndrome
-
Zhu S, Hsu AP, Vacek MM, Zheng L, Schaffer AA, Dale JK et al. (2006) Genetic alterations in caspase-10 may be causative or protective in autoimmune lymphoproliferative syndrome. Hum Genet 119: 284-294.
-
(2006)
Hum Genet
, vol.119
, pp. 284-294
-
-
Zhu, S.1
Hsu, A.P.2
Vacek, M.M.3
Zheng, L.4
Schaffer, A.A.5
Dale, J.K.6
-
95
-
-
0036624925
-
Inactivating mutations of CASP10 gene in non-Hodgkin lymphomas
-
Shin MS, Kim HS, Kang CS, Park WS, Kim SY, Lee SN et al. (2002) Inactivating mutations of CASP10 gene in non-Hodgkin lymphomas. Blood 99: 4094-4099.
-
(2002)
Blood
, vol.99
, pp. 4094-4099
-
-
Shin, M.S.1
Kim, H.S.2
Kang, C.S.3
Park, W.S.4
Kim, S.Y.5
Lee, S.N.6
-
96
-
-
18344386198
-
Inactivating mutations of the caspase-10 gene in gastric cancer
-
Park WS, Lee JH, Shin MS, Park JY, Kim HS, Lee JH et al. (2002) Inactivating mutations of the caspase-10 gene in gastric cancer. Oncogene 21: 2919-2925.
-
(2002)
Oncogene
, vol.21
, pp. 2919-2925
-
-
Park, W.S.1
Lee, J.H.2
Shin, M.S.3
Park, J.Y.4
Kim, H.S.5
Lee, J.H.6
-
97
-
-
0032549652
-
Dimerization and autoprocessing of the Nedd2(caspase-2) precursor requires both the prodomain and the carboxyl-terminal regions
-
Butt AJ, Harvey NL, Parasivam G, Kumar S (1998) Dimerization and autoprocessing of the Nedd2(caspase-2) precursor requires both the prodomain and the carboxyl-terminal regions. J Biol Chem 273: 6763-6768.
-
(1998)
J Biol Chem
, vol.273
, pp. 6763-6768
-
-
Butt, A.J.1
Harvey, N.L.2
Parasivam, G.3
Kumar, S.4
-
98
-
-
8844224859
-
The biochemical mechanism of caspase-2 activation
-
Baliga BC, Read SH, Kumar S (2004) The biochemical mechanism of caspase-2 activation. Cell Death Differ 11: 1234-1241.
-
(2004)
Cell Death Differ
, vol.11
, pp. 1234-1241
-
-
Baliga, B.C.1
Read, S.H.2
Kumar, S.3
-
99
-
-
0034097347
-
Subcellular localization and CARD-dependent oligomerization of the death adaptor RAIDD
-
Shearwin-Whyatt LM, Harvey NL, Kumar S (2000) Subcellular localization and CARD-dependent oligomerization of the death adaptor RAIDD. Cell Death Diff 7: 155-165.
-
(2000)
Cell Death Diff
, vol.7
, pp. 155-165
-
-
Shearwin-Whyatt, L.M.1
Harvey, N.L.2
Kumar, S.3
-
100
-
-
0037049549
-
A novel Apaf-1-independent putative caspase-2 activation complex
-
Read SH, Baliga BB, Ekert P, Vaux DL, Kumar S (2002) A novel Apaf-1-independent putative caspase-2 activation complex. J Cell Biol 159: 739-745.
-
(2002)
J Cell Biol
, vol.159
, pp. 739-745
-
-
Read, S.H.1
Baliga, B.B.2
Ekert, P.3
Vaux, D.L.4
Kumar, S.5
-
101
-
-
2442453730
-
The PIDDosome, a protein complex implicated in activation of caspase-2 in response to genotoxic stress
-
Tinel A, Tschopp J (2004) The PIDDosome, a protein complex implicated in activation of caspase-2 in response to genotoxic stress. Science 304: 843-846.
-
(2004)
Science
, vol.304
, pp. 843-846
-
-
Tinel, A.1
Tschopp, J.2
-
102
-
-
0036024020
-
Caspase-2 is not required for thymocyte or neuronal apoptosis even though cleavage of caspase-2 is mediated by Apaf-1 and caspase-9
-
O'Reilly, LA, Ekert P, Harvey N, Marsden V, Cullen L, Vaux DL et al. (2002) Caspase-2 is not required for thymocyte or neuronal apoptosis even though cleavage of caspase-2 is mediated by Apaf-1 and caspase-9. Cell Death Diff 9: 832-841.
-
(2002)
Cell Death Diff
, vol.9
, pp. 832-841
-
-
O'Reilly, L.A.1
Ekert, P.2
Harvey, N.3
Marsden, V.4
Cullen, L.5
Vaux, D.L.6
-
103
-
-
0032544397
-
Kumar S Prodomain-dependent nuclear localization of the caspase-2(Nedd2) precursor
-
Colussi PA, Harvey NL, Kumar S (1998) Prodomain-dependent nuclear localization of the caspase-2(Nedd2) precursor. J Biol Chem 273: 24535-24542.
-
(1998)
J Biol Chem
, vol.273
, pp. 24535-24542
-
-
Colussi, P.A.1
Harvey, N.L.2
-
104
-
-
0034194338
-
Caspase-2 is localized at the Golgi complex and cleaves golgin-160 during apoptosis
-
Mancini M, Machamer CE, Roy S, Nicholson DW, Thomberry NA, Casciola-Rosen LA et al. (2000) Caspase-2 is localized at the Golgi complex and cleaves golgin-160 during apoptosis. J Cell Biol 149: 603-612.
-
(2000)
J Cell Biol
, vol.149
, pp. 603-612
-
-
Mancini, M.1
Machamer, C.E.2
Roy, S.3
Nicholson, D.W.4
Thornberry, N.A.5
Casciola-Rosen, L.A.6
-
105
-
-
0038136890
-
Role of prodomain in importin-mediated nuclear localization and activation of caspase-2
-
Baliga BC, Colussi PA, Read SH, Dias MM, Jans DA, Kumar S (2003) Role of prodomain in importin-mediated nuclear localization and activation of caspase-2. J Biol Chem 278: 4899-4905.
-
(2003)
J Biol Chem
, vol.278
, pp. 4899-4905
-
-
Baliga, B.C.1
Colussi, P.A.2
Read, S.H.3
Dias, M.M.4
Jans, D.A.5
Kumar, S.6
-
107
-
-
4544274785
-
Caspase-2 can function upstream of bid cleavage in the TRAIL apoptosis pathway
-
Wagner KW, Engels IH, Deveraux QL (2004) Caspase-2 can function upstream of bid cleavage in the TRAIL apoptosis pathway. J Biol Chem 279: 35047-35052.
-
(2004)
J Biol Chem
, vol.279
, pp. 35047-35052
-
-
Wagner, K.W.1
Engels, I.H.2
Deveraux, Q.L.3
-
108
-
-
27144512715
-
Caspase-2 primes cancer cells for TRAIL-mediated apoptosis by processing procaspase-8
-
Shin S, Lee Y, Kim W, Ko H, Choi H, Kim K (2005) Caspase-2 primes cancer cells for TRAIL-mediated apoptosis by processing procaspase-8. EMBO J 24: 3532-3542.
-
(2005)
EMBO J
, vol.24
, pp. 3532-3542
-
-
Shin, S.1
Lee, Y.2
Kim, W.3
Ko, H.4
Choi, H.5
Kim, K.6
-
109
-
-
30344459150
-
In situ trapping of activated initiator caspases reveals a role for caspase-2 in heat shock-induced apoptosis
-
Tu S, McStay GP, Boucher LM, Mak T, Beere HM, Green DR (2006) In situ trapping of activated initiator caspases reveals a role for caspase-2 in heat shock-induced apoptosis. Nat Cell Biol 8: 72-77.
-
(2006)
Nat Cell Biol
, vol.8
, pp. 72-77
-
-
Tu, S.1
McStay, G.P.2
Boucher, L.M.3
Mak, T.4
Beere, H.M.5
Green, D.R.6
-
110
-
-
33745739717
-
Caspase-2-induced apoptosis requires bid cleavage: A physiological role for bid in heat shock-induced death
-
Bonzon C, Bouchier-Hayes L, Pagliari LJ, Green DR, Newmeyer DD (2006) Caspase-2-induced apoptosis requires bid cleavage: A physiological role for bid in heat shock-induced death. Mol Biol Cell 17: 2150-2157.
-
(2006)
Mol Biol Cell
, vol.17
, pp. 2150-2157
-
-
Bonzon, C.1
Bouchier-Hayes, L.2
Pagliari, L.J.3
Green, D.R.4
Newmeyer, D.D.5
-
111
-
-
26244453715
-
Metabolic regulation of oocyte cell death through the CaMKII-mediated phosphorylation of caspase-2
-
Nutt LK, Margolis SS, Jensen M, Herman CE, Dunphy WG, Rathmell JC et al. (2005) Metabolic regulation of oocyte cell death through the CaMKII-mediated phosphorylation of caspase-2. Cell 123: 89-103.
-
(2005)
Cell
, vol.123
, pp. 89-103
-
-
Nutt, L.K.1
Margolis, S.S.2
Jensen, M.3
Herman, C.E.4
Dunphy, W.G.5
Rathmell, J.C.6
-
112
-
-
33745932874
-
Caspase-2 is activated at the CD95 death-inducing signaling complex in the course of CD95-induced apoptosis
-
Lavrik IN, Golks A, Baumann S, Krammer PH (2006) Caspase-2 is activated at the CD95 death-inducing signaling complex in the course of CD95-induced apoptosis. Blood 108: 559-565.
-
(2006)
Blood
, vol.108
, pp. 559-565
-
-
Lavrik, I.N.1
Golks, A.2
Baumann, S.3
Krammer, P.H.4
-
113
-
-
0030915095
-
Functional activation of Nedd2/ICH-1 (caspase-2) is an early process in apoptosis
-
Harvey NL, Butt A, Kumar S (1997) Functional activation of Nedd2/ICH-1 (caspase-2) is an early process in apoptosis. J Biol Chem 272: 13134-13139.
-
(1997)
J Biol Chem
, vol.272
, pp. 13134-13139
-
-
Harvey, N.L.1
Butt, A.2
Kumar, S.3
-
114
-
-
0028998012
-
Inhibition of apoptosis by antisense Nedd2 expression
-
Kumar S (1995) Inhibition of apoptosis by antisense Nedd2 expression. FEBS Lett 368: 69-72.
-
(1995)
FEBS Lett
, vol.368
, pp. 69-72
-
-
Kumar, S.1
-
115
-
-
0037134495
-
Caspase-2-induces apoptosis by releasing proapoptotic proteins from mitochondria
-
Guo Y, Srinivasula SM, Druilhe A, Fernandes-Alnemri T, Alnemri ES (2002) Caspase-2-induces apoptosis by releasing proapoptotic proteins from mitochondria. J Biol Chem 277: 13430-13437.
-
(2002)
J Biol Chem
, vol.277
, pp. 13430-13437
-
-
Guo, Y.1
Srinivasula, S.M.2
Druilhe, A.3
Fernandes-Alnemri, T.4
Alnemri, E.S.5
-
117
-
-
0037177809
-
Caspase-2 can trigger cytochrome c release and apoptosis from the nucleus
-
Paroni G, Henderson C, Schneider C, Brancolini C (2002) Caspase-2 can trigger cytochrome c release and apoptosis from the nucleus. J Biol Chem 277: 15147-15161.
-
(2002)
J Biol Chem
, vol.277
, pp. 15147-15161
-
-
Paroni, G.1
Henderson, C.2
Schneider, C.3
Brancolini, C.4
-
118
-
-
0032500552
-
Conversion of procaspase-3 to an autoactivating caspase by fusion to the caspase-2 prodomain
-
Colussi PA, Harvey NL, Shearwin-Whyatt LM, Kumar S (1998) Conversion of procaspase-3 to an autoactivating caspase by fusion to the caspase-2 prodomain. J Biol Chem 273: 26566-26570.
-
(1998)
J Biol Chem
, vol.273
, pp. 26566-26570
-
-
Colussi, P.A.1
Harvey, N.L.2
Shearwin-Whyatt, L.M.3
Kumar, S.4
-
119
-
-
0037162833
-
Requirement for caspase-2 in stress-induced apoptosis before mitochondrial permeabilization
-
Lassus P, Opitz-Araya X, Lazebnik Y (2002) Requirement for caspase-2 in stress-induced apoptosis before mitochondrial permeabilization. Science 297: 1352-1354.
-
(2002)
Science
, vol.297
, pp. 1352-1354
-
-
Lassus, P.1
Opitz-Araya, X.2
Lazebnik, Y.3
-
120
-
-
0037119491
-
Caspase-2 acts upstream of mitochondria to promote cytochrome c release during etoposide-induced apoptosis
-
Robertson JD, Enoksson M, Suomela M, Zhivotovsky B, Orrenius S (2002) Caspase-2 acts upstream of mitochondria to promote cytochrome c release during etoposide-induced apoptosis. J Biol Chem 277: 29803-29809.
-
(2002)
J Biol Chem
, vol.277
, pp. 29803-29809
-
-
Robertson, J.D.1
Enoksson, M.2
Suomela, M.3
Zhivotovsky, B.4
Orrenius, S.5
-
121
-
-
0032080197
-
Defects in regulation of apoptosis in caspase-2-deficient mice
-
Bergeron L, Perez GI, Macdonald G, Shi L, Sun Y, Jurisicova A et al. (1998) Defects in regulation of apoptosis in caspase-2-deficient mice. Genes Dev 12: 1304-1314.
-
(1998)
Genes Dev
, vol.12
, pp. 1304-1314
-
-
Bergeron, L.1
Perez, G.I.2
Macdonald, G.3
Shi, L.4
Sun, Y.5
Jurisicova, A.6
-
122
-
-
33745223497
-
Heat shock induces apoptosis independently of any known initiator caspase-activating complex
-
Milleron RS, Bratton SB (2006) Heat shock induces apoptosis independently of any known initiator caspase-activating complex. J Biol Chem 281: 16991-17000.
-
(2006)
J Biol Chem
, vol.281
, pp. 16991-17000
-
-
Milleron, R.S.1
Bratton, S.B.2
-
123
-
-
0035879074
-
Death in the balance: Alternative participation of the caspase-2 and -9 pathways in neuronal death induced by nerve growth factor deprivation
-
Troy CM, Rabacchi SA, Hohl JB, Angelastro JM, Greene LA, Shelanski ML (2001) Death in the balance: Alternative participation of the caspase-2 and -9 pathways in neuronal death induced by nerve growth factor deprivation. J Neurosci 21: 5007-5016.
-
(2001)
J Neurosci
, vol.21
, pp. 5007-5016
-
-
Troy, C.M.1
Rabacchi, S.A.2
Hohl, J.B.3
Angelastro, J.M.4
Greene, L.A.5
Shelanski, M.L.6
-
124
-
-
0344142396
-
Emerging roles of caspase-3 in apoptosis
-
Porter AG, Janicke RU (1999) Emerging roles of caspase-3 in apoptosis. Cell Death Differ 6: 99-104.
-
(1999)
Cell Death Differ
, vol.6
, pp. 99-104
-
-
Porter, A.G.1
Janicke, R.U.2
-
125
-
-
32444434664
-
Caspases 3 and 7: Key mediators of mitochondrial events of apoptosis
-
Lakhani SA, Masud A, Kuida K, Porter Jr GA, Booth CJ, Mehal WZ et al. (2006) Caspases 3 and 7: Key mediators of mitochondrial events of apoptosis. Science 311: 847-851.
-
(2006)
Science
, vol.311
, pp. 847-851
-
-
Lakhani, S.A.1
Masud, A.2
Kuida, K.3
Porter Jr., G.A.4
Booth, C.J.5
Mehal, W.Z.6
-
126
-
-
0030849093
-
A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis
-
Thornberry NA, Rano TA, Peterson EP, Rasper DM, Timkey T, Garcia-Calvo M et al. (1997) A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis. J Biol Chem 272: 17907-17911.
-
(1997)
J Biol Chem
, vol.272
, pp. 17907-17911
-
-
Thornberry, N.A.1
Rano, T.A.2
Peterson, E.P.3
Rasper, D.M.4
Timkey, T.5
Garcia-Calvo, M.6
-
127
-
-
0029758833
-
Cleavage of lamin A by Mch2 alpha but not CPP32: Multiple interleukin 1 beta-converting enzyme-related proteases with distinct substrate recognition properties are active in apoptosis
-
Takahashi A, Alnemri ES, Lazebnik YA, Fernandes-Alnemri T, Litwack G, Moir RD et al. (1996) Cleavage of lamin A by Mch2 alpha but not CPP32: multiple interleukin 1 beta-converting enzyme-related proteases with distinct substrate recognition properties are active in apoptosis. Proc Natl Acad Sci USA 93: 8395-9400.
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 8395-9400
-
-
Takahashi, A.1
Alnemri, E.S.2
Lazebnik, Y.A.3
Fernandes-Alnemri, T.4
Litwack, G.5
Moir, R.D.6
-
130
-
-
0030970013
-
Viral FLICE- inhibitory proteins (FLIPs) prevent apoptosis induced by death receptors
-
Thorne M, Schneider P, Hofmann K, Fickenscher H, Meinl E, Neipel F et al. (1997) Viral FLICE- inhibitory proteins (FLIPs) prevent apoptosis induced by death receptors. Nalum 386: 517-521.
-
(1997)
Nalum
, vol.386
, pp. 517-521
-
-
Thorne, M.1
Schneider, P.2
Hofmann, K.3
Fickenscher, H.4
Meinl, E.5
Neipel, F.6
-
131
-
-
0030800070
-
Inhibition of death receptor signals by cellular FLIP
-
Irmler M, Thorne M, Hahne M, Schneider P, Hofmann K, Steiner V et al. (1997) Inhibition of death receptor signals by cellular FLIP. Nature 388: 190-195.
-
(1997)
Nature
, vol.388
, pp. 190-195
-
-
Irmler, M.1
Thorne, M.2
Hahne, M.3
Schneider, P.4
Hofmann, K.5
Steiner, V.6
-
132
-
-
0035496099
-
Regulation of lymphocyte proliferation and death by FLIP
-
Thorne M, Tschopp J (2001) Regulation of lymphocyte proliferation and death by FLIP. Nat Rev Immunol 1: 50-58.
-
(2001)
Nat Rev Immunol
, vol.1
, pp. 50-58
-
-
Thorne, M.1
Tschopp, J.2
-
133
-
-
0041853690
-
Induction of TNF receptor 1-mediated apoptosis via two sequential signaling complexes
-
Micheau O, Tschopp J (2003) Induction of TNF receptor 1-mediated apoptosis via two sequential signaling complexes. Cell 114: 181-190.
-
(2003)
Cell
, vol.114
, pp. 181-190
-
-
Micheau, O.1
Tschopp, J.2
-
134
-
-
32044447161
-
The E3 ubiquitin ligase itch couples JNK activation to TNFalpha-induced cell death by inducing c-FLIP(L) turnover
-
Chang L, Kamata H, Solinas G, Luo JL, Maeda S, Venuprasad K et al. (2006) The E3 ubiquitin ligase itch couples JNK activation to TNFalpha-induced cell death by inducing c-FLIP(L) turnover. Cell 124: 601-613.
-
(2006)
Cell
, vol.124
, pp. 601-613
-
-
Chang, L.1
Kamata, H.2
Solinas, G.3
Luo, J.L.4
Maeda, S.5
Venuprasad, K.6
-
135
-
-
0033662341
-
Requirement for Casper (c-FLIP) in regulation of death receptor-induced apoptosis and embryonic development
-
Yeh WC, Itie A, Elia AJ, Ng M, Shu HB, Wakeham A et al. (2000) Requirement for Casper (c-FLIP) in regulation of death receptor-induced apoptosis and embryonic development. Immunity 12: 633-642.
-
(2000)
Immunity
, vol.12
, pp. 633-642
-
-
Yeh, W.C.1
Itie, A.2
Elia, A.J.3
Ng, M.4
Shu, H.B.5
Wakeham, A.6
-
136
-
-
0037427441
-
Mammalian mitochondrial IAP binding proteins
-
Vaux DL, Silke J (2003) Mammalian mitochondrial IAP binding proteins. Biochem Biophys Res Commun 304: 499-504.
-
(2003)
Biochem Biophys Res Commun
, vol.304
, pp. 499-504
-
-
Vaux, D.L.1
Silke, J.2
-
137
-
-
0036233590
-
Generation and characterization of Smac/DIABLO-deficient mice
-
Okada H, Suh WK, Jin J, Woo M, Du C, Elia A et al. (2002) Generation and characterization of Smac/DIABLO-deficient mice. Mol Cell Blol 22: 3509-3517.
-
(2002)
Mol Cell Biol
, vol.22
, pp. 3509-3517
-
-
Okada, H.1
Suh, W.K.2
Jin, J.3
Woo, M.4
Du, C.5
Elia, A.6
-
138
-
-
7644230386
-
Neuroprotective role of the Reaper-related serine protease HtrA2/Omi revealed by targeted deletion in mice
-
Martins LM, Morrison A, Klupsch K, Fedele V, Moisoi N, Teismann P et al. (2004) Neuroprotective role of the Reaper-related serine protease HtrA2/ Omi revealed by targeted deletion in mice. Mol Cell Biol 24: 9848-9862.
-
(2004)
Mol Cell Biol
, vol.24
, pp. 9848-9862
-
-
Martins, L.M.1
Morrison, A.2
Klupsch, K.3
Fedele, V.4
Moisoi, N.5
Teismann, P.6
-
139
-
-
0035037802
-
Characterization of XIAP-deficient mice
-
Harlin H, Reffey SB, Duckett CS, Lindsten T, Thompson CB (2001) Characterization of XIAP-deficient mice. Mol Cell Biol 21: 3604-3608.
-
(2001)
Mol Cell Biol
, vol.21
, pp. 3604-3608
-
-
Harlin, H.1
Reffey, S.B.2
Duckett, C.S.3
Lindsten, T.4
Thompson, C.B.5
-
140
-
-
0037344678
-
Therapeutic activation of caspases in cancer: A question of selectivity
-
Beauparlant P, Shore GC (2003) Therapeutic activation of caspases in cancer: A question of selectivity. Curr Opin Drug Discov Devel 6: 179-187.
-
(2003)
Curr Opin Drug Discov Devel
, vol.6
, pp. 179-187
-
-
Beauparlant, P.1
Shore, G.C.2
|