DrlCE is an essential caspase required for apoptotic activity in Drosophila cells

EMBO Journal

Volumn 16, Issue 20, 1997, Pages 6192-6199

  Fraser, Andrew G ^a   McCarthy, Nicola J ^a   Evan, Gerard I ^a  

^a IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

Author keywords

Apoptosis; Caspase; D.melanogaster; drICE; S2 cells

Indexed keywords

CYCLOHEXIMIDE; ENZYME ANTIBODY; PROTEINASE; CASPASE; CYSTEINE PROTEINASE; DROSOPHILA PROTEIN; ICE PROTEIN, DROSOPHILA; INSECT PROTEIN; OLIGOPEPTIDE;

APOPTOSIS; ARTICLE; CELL LYSATE; CELL NUCLEUS; CHROMATIN CONDENSATION; CONTROLLED STUDY; DROSOPHILA MELANOGASTER; ENZYME ACTIVITY; ENZYME SPECIFICITY; GENE; GENE EXPRESSION; NONHUMAN; PRIORITY JOURNAL; AMINO ACID SEQUENCE; ANIMAL; CELL FREE SYSTEM; CELL LINE; CHROMATIN; COMPARATIVE STUDY; CYTOLOGY; IMMUNOLOGY; METABOLISM; MOLECULAR GENETICS; PHYSIOLOGY; SEQUENCE HOMOLOGY;

CAENORHABDITIS ELEGANS; DROSOPHILA MELANOGASTER; MAMMALIA; MELANOGASTER; VERTEBRATA;

AMINO ACID SEQUENCE; ANIMALS; APOPTOSIS; CASPASES; CELL LINE; CELL-FREE SYSTEM; CHROMATIN; CYSTEINE ENDOPEPTIDASES; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; INSECT PROTEINS; MOLECULAR SEQUENCE DATA; OLIGOPEPTIDES; SEQUENCE HOMOLOGY, AMINO ACID; SUBSTRATE SPECIFICITY;

EID: 0030683619     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/16.20.6192     Document Type: Article

References (32)

1. Beidler,D., Tewari,M., Friesen,P. Poirer,G. Diit,V. (1995) The baculovirus p35 protein inhibits Fas- and lumour Necrosis Factor-induccd apoptosis. J. Biol. Chem., 270, 1652616528
2. Bump,N. et al. (1995) Inhibition of ICH family proteases by baculovirus antiapoptotic protein p35. Science. 269, 1885-1888.
3. Clem,R.J., Fechheimer,M. and Miller,L.K. (1991) Prevention of apoplosi by a baculovirus gene during infection of insect cells. Science. 254, 1388-1390.
4. Cotter,T.G. and Martin,S.J. Techniques in Apoptosis: a User's Guide. Portland Press.
5. Ellis,R.E., Yuan,J.Y. and Horbitz,H.R. (1991) Mechanisms and functions of cell death. Annu. Rev. Cell Biol., 7, 663-698.
6. Fraser,A. and Evan,G. (1996) A license to kill. Cell. 85, 781-784.
7. Fraser,A. and Evan,G. ( 1997) Identification of a Drosophila melagaster ICE/CED-3-related protease. drICE. EMBO J., 16, 2805-2813.
8. Gagliardini,V., Fernandez,P.A., Lee,R.K., Drexler,H.C., Rotello,R.J., Fishman,M.C. and Yuan,J. (1994) Prevention of Vertebrate neuronal death by the cA gene. Science. 263, 826-828.
9. Grether,M.E., Ahrams,J.M., Asapite,J., White,K. and Steller,H. (1995) The head involution defective gene of Drosophila melanogaster functions in programmed cell death, Genes Dev., 9, 1694-1708.
10. Gruenbaum,Y. et al. (1988) Drosophila nuclear lamin precursor DmO is translated from either of two developmentally regulated mRNA species upparently encoded by a single gene. J. Cell. Biol. 106, 585596.
11. Hay,B.A., Wolff,T. and Rubin,G.M. (1994) Expression of baculovirus P35 prevents cell death in Drosophila. Developement. 120, 21212129.
12. Hengartner,M. and Horvitz,H. (1944) Celegans cell survival gene ced-9 encodes a functional homolog of the mammalian proto-oncogene bcl-2. Cell. 76, 665-676.
13. James,C., Gschmeissner,S., Fraser,A. and Evan,G (1997) Ced-4 induces chromatin condensation in S.pomebe and is inhibited by direct physical assiociation with Ced-9. Curr. Biol., 7, 246-252.
14. Lazebruk,Y., Cole,S., Cooke,C., Nelson,W. and Earnshaw,W. (1993) Nuclear events of apoptosis in-vitro in cell-free mitotic extracts -a model system for analysis of the active phase of apoptosis. J. Cell Biol., 123, 7-22.
15. Lazebnik,Y., Kaufmann,S., Desnoyers,S., Poirioi,G. and Earnshaw,W. (1994) Cleavage of polytadp-ribose polymerase by a proteinase with properties like ICE. Nature. 371, 346-347.
16. Liu,X., Zou,H., Slaughter,C. and Wang,X. (1997) DFE a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis. Cell. 89, 174184.
17. Martinou,I. et al. (1995) Viral protein E1B 19K and p35 protect sympathetic neurons from cell death induced by NGF deprivation. J. Cell Biol., 128, 201-208.
18. Nicholson,D. et al. (1995) Identification and inhibition of the ICE/ CED-3 protease necessary for mammalian apoptosis. Nature. 375, 37-43.
19. Oberhammer,E.A., Hochegger,K., Froschl,G., Tiefenhacher,R. and Pavelka,M. (1994) Chromatin condensation during apoptosis is accompanied by degradation of lamin A-B. without enhanced activation of cdc2 kinase. J. Cell Biol., 126, 827837.
20. Rabizadeh,S., LuCount,D., Friesen,P. und Bredesen,D. (1993) Expression of the baculovirus p35 gene inhibits mammalian neural cell death. Neurochem., 61, 23182321.
21. Ray,C.A., Black,R.A., Kronheim,S.R., Greenstreet,T.A., Sleath,P.R., Salvesen,G.S. and Pickup,D.J (1992) Viral inhibition of inflammation: cowpox virus encodes an inhibitor of the interleukin-1 beta converting enzyme. Cell. 69, 597-604.
22. Shaham,S. and Horviz,H. (1996) Develpping Canorhabditis elegans neurons may contain both cell-death protective and killer activities. Genes Dev., 10, 578591.
23. Slee,E., Zhu,H., Chow,S., MacFarlane,M., Nicholson,D. and Cohen,G. (1996) Benezyloxycarbonyl-Val-Ala-Asp (O-Me) fluoromethylketone (ZVAD.) inhibits anoptosis by blocking the processing of CPP32. Biomchem. J. 315, 21-24.
24. Song,Z., McCall,K. and Steller,H. (1997) DCP-L a Drosophila cell death protease essential for development. Science. 275, 536539.
25. Steller,H., Abrams,J.M. Grether,M.E. and White,K. (1994) Programmed cell death in Drosophila. Philos. Trans. R. Soc. Lond. B. Biol. Sci., 345, 247-250.
26. Takahashi,A. and Earnshaw,W. (1996) Ice-related proteases in apoptosis. Curr. Opin. Genet. Dev., 6, 5055.
27. Vucic,D., Seshagiri,S. and Miller,L.K. (1997) Characterization of reaperand EADD-induced apoptosis in a lepidopteran cell line. Mol. Cell. Biol., 17, 667-676.
28. White,K., Grether,M.E., Abrams,J.M., Young,L., Farrell,K. and Steller.H. (1494) Genetic control of prngrammed cell death in Drosophila (see comments). Science. 264, 677-683.
29. Xue,D. and Horvitz,H.R. (1995) Inhibition of the Caenorhabditis elegans cell-death protease CED-3 by a CED-3 cleavage site in baculovirus p35 protein, Nature. 377, 248-251.
30. Yin,C., Knudson,C.M., Korsmeyer,S.J. and Van Dyke,T. (1997) Bax suppresses tumorigenesis and stimulates apoptosis in vivo. Nature. 385, 637640
31. Yuan,J. and Horvitz,H.R. (1992) The Caernorhabditis elegans cell death gene ced-4 encodes a novel protein and is expressed during the period of extensive programmed cell death, Development. 116, 309-320.
32. Yuan,J.Y., Shaham,S., Ledoux,S., Ellis,H.M. and Horvitz,H.R. (1993) The C.elegans cell-death gene ced-3 encodes a protein similar to mammalian interleukin-1 beta converting enzyme. Cell. 75, 641-652.