p120-ctn: A nexus for contextual signaling via Rho GTPases

Biochimica et Biophysica Acta - Molecular Cell Research

Volumn 1773, Issue 1, 2007, Pages 34-46

  Anastasiadis, Panos Z ^a  

^a MAYO CLINIC   (United States)

Author keywords

Cadherin; Cell adhesion; Cell motility; Cognition; Microenvironment; p120; Rac1; RhoA

Indexed keywords

PROTEIN P120; RHO GUANINE NUCLEOTIDE BINDING PROTEIN;

CELL ADHESION; CELL GROWTH; CELL MIGRATION; CELL MOTILITY; CELL STRUCTURE; COGNITION; DROSOPHILA; HUMAN; INFLAMMATION; MEMBRANE VESICLE; MICROENVIRONMENT; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVIEW; SIGNAL TRANSDUCTION;

ANIMALS; CADHERINS; CELL ADHESION; CELL ADHESION MOLECULES; HUMANS; INFLAMMATION; MICROTUBULES; NEOPLASMS; PHOSPHOPROTEINS; RHO GTP-BINDING PROTEINS; SIGNAL TRANSDUCTION;

ARMADILLO;

EID: 33845477045     PISSN: 01674889     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbamcr.2006.08.040     Document Type: Review

References (129)

1. Reynolds A.B., Roesel D.J., Kanner S.B., and Parsons J.T. Transformation-specific tyrosine phosphorylation of a novel cellular protein in chicken cells expressing oncogenic variants of the avian cellular src gene. Mol. Cell. Biol. 9 (1989) 629-638
2. Ireton R.C., Davis M.A., van Hengel J., Mariner D.J., Barnes K., Thoreson M.A., Anastasiadis P.Z., Matrisian L., Bundy L.M., Sealy L., Gilbert B., van Roy F., and Reynolds A.B. A novel role for p120 catenin in E-cadherin function. J. Cell Biol. 159 (2002) 465-476
3. Davis M.A., Ireton R.C., and Reynolds A.B. A core function for p120-catenin in cadherin turnover. J. Cell Biol. 163 (2003) 525-534
4. Xiao K., Allison D.F., Buckley K.M., Kottke M.D., Vincent P.A., Faundez V., and Kowalczyk A.P. Cellular levels of p120 catenin function as a set point for cadherin expression levels in microvascular endothelial cells. J. Cell Biol. 163 (2003) 535-545
5. Davis M.A., and Reynolds A.B. Blocked acinar development, E-cadherin reduction, and intraepithelial neoplasia upon ablation of p120-catenin in the mouse salivary gland. Dev. Cell 10 (2006) 21-31
6. Kowalczyk A.P., and Reynolds A.B. Protecting your tail: regulation of cadherin degradation by p120-catenin. Curr. Opin. Cell Biol. 16 (2004) 522-527
7. Aono S., Nakagawa S., Reynolds A.B., and Takeichi M. p120(ctn) acts as an inhibitory regulator of cadherin function in colon carcinoma cells. J. Cell Biol. 145 (1999) 551-562
8. Ozawa M., and Kemler R. The membrane-proximal region of the E-cadherin cytoplasmic domain prevents dimerization and negatively regulates adhesion activity. J. Cell Biol. 142 (1998) 1605-1613
9. Ohkubo T., and Ozawa M. p120(ctn) binds to the membrane-proximal region of the E-cadherin cytoplasmic domain and is involved in modulation of adhesion activity. J. Biol. Chem. 274 (1999) 21409-21415
10. Takeichi M. Morphogenetic roles of classic cadherins. Curr. Opin. Cell Biol. 7 (1995) 619-627
11. Tepass U., Truong K., Godt D., Ikura M., and Peifer M. Cadherins in embryonic and neural morphogenesis. Nat. Rev., Mol. Cell Biol. 1 (2000) 91-100
12. Yap A.S. The morphogenetic role of cadherin cell adhesion molecules in human cancer: a thematic review. Cancer Investig. 16 (1998) 252-261
13. Nollet F., Berx G., and Roy F.v. The role of the E-cadherin/catenin adhesion complex in the development and progression of cancer. Mol. Cell. Biol. Res. Comm. 2 (1999) 77-85
14. Yap A.S., Niessen C.M., and Gumbiner B.M. The juxtamembrane region of the cadherin cytoplasmic tail supports lateral clustering, adhesive strengthening, and interaction with p120ctn. J. Cell Biol. 141 (1998) 779-789
15. Thoreson M.A., Anastasiadis P.Z., Daniel J.M., Ireton R.C., Wheelock M.J., Johnson K.R., Hummingbird D.K., and Reynolds A.B. Selective uncoupling of p120(ctn) from E-cadherin disrupts strong adhesion. J. Cell Biol. 148 (2000) 189-202
16. Kuroda S., Fukata M., Nakagawa M., Fujii K., Nakamura T., Ookubo T., Izawa I., Nagase T., Nomura N., Tani H., Shoji I., Matsuura Y., Yonehara S., and Kaibuchi K. Role of IQGAP1, a target of the small GTPases Cdc42 and Rac1, in regulation of E-cadherin- mediated cell-cell adhesion. Science 281 (1998) 832-835
17. Daniel J.M., and Reynolds A.B. The tyrosine kinase substrate p120cas binds directly to E-cadherin but not to the adenomatous polyposis coli protein or alpha-catenin. Mol. Cell. Biol. 15 (1995) 4819-4824
18. van Roy F.M., and McCrea P.D. A role for Kaiso-p120ctn complexes in cancer?. Nat. Rev., Cancer 5 (2005) 956-964
19. Hall A. Rho GTPases and the actin cytoskeleton. Science 279 (1998) 509-514
20. Braga V.M., Machesky L.M., Hall A., and Hotchin N.A. The small GTPases Rho and Rac are required for the establishment of cadherin-dependent cell-cell contacts. J. Cell Biol. 137 (1997) 1421-1431
21. Takaishi K., Sasaki T., Kotani H., Nishioka H., and Takai Y. Regulation of cell-cell adhesion by rac and rho small G proteins in MDCK cells. J. Cell Biol. 139 (1997) 1047-1059
22. Hordijk P.L., ten Klooster J.P., van der Kammen R.A., Michiels F., Oomen L.C., and Collard J.G. Inhibition of invasion of epithelial cells by Tiam1-Rac signaling. Science 278 (1997) 1464-1466
23. Jou T.S., and Nelson W.J. Effects of regulated expression of mutant RhoA and Rac1 small GTPases on the development of epithelial (MDCK) cell polarity. J. Cell Biol. 142 (1998) 85-100
24. Fox D.T., Homem C.C., Myster S.H., Wang F., Bain E.E., and Peifer M. Rho1 regulates Drosophila adherens junctions independently of p120ctn. Development 132 (2005) 4819-4831
25. Anastasiadis P.Z., Moon S.Y., Thoreson M.A., Mariner D.J., Crawford H.C., Zheng Y., and Reynolds A.B. Inhibition of RhoA by p120 catenin. Nat. Cell Biol. 2 (2000) 637-644
26. Noren N.K., Liu B.P., Burridge K., and Kreft B. p120 catenin regulates the actin cytoskeleton via Rho family GTPases. J. Cell Biol. 150 (2000) 567-580
27. Grosheva I., Shtutman M., Elbaum M., and Bershadsky A.D. p120 catenin affects cell motility via modulation of activity of Rho-family GTPases: a link between cell-cell contact formation and regulation of cell locomotion. J. Cell. Sci. 114 (2001) 695-707
28. Reynolds A.B., Daniel J.M., Mo Y.Y., Wu J., and Zhang Z. The novel catenin p120cas binds classical cadherins and induces an unusual morphological phenotype in NIH3T3 fibroblasts. Exp. Cell Res. 225 (1996) 328-337
29. Anastasiadis P.Z., and Reynolds A.B. The p120 catenin family: complex roles in adhesion, signaling and cancer. J. Cell Sci. 113 (2000) 1319-1334
30. Martinez M.C., Ochiishi T., Majewski M., and Kosik K.S. Dual regulation of neuronal morphogenesis by a delta-catenin-cortactin complex and Rho. J. Cell Biol. 162 (2003) 99-111
31. Hatzfeld M., Haffner C., Schulze K., and Vinzens U. The function of plakophilin 1 in desmosome assembly and actin filament organization. J. Cell Biol. 149 (2000) 209-222
32. Fang X., Ji H., Kim S.W., Park J.I., Vaught T.G., Anastasiadis P.Z., Ciesiolka M., and McCrea P.D. Vertebrate development requires ARVCF and p120 catenins and their interplay with RhoA and Rac. J. Cell Biol. 165 (2004) 87-98
33. Mariner D.J., Wang J., and Reynolds A.B. ARVCF localizes to the nucleus and adherens junction and is mutually exclusive with p120(ctn) in E-cadherin complexes [In Process Citation]. J. Cell. Sci. 113 (2000) 1481-1490
34. A. Wolf, R. Keil, O. Gotzl, A. Mun, K. Schwarze, M. Lederer, S. Huttelmaier and M. Hatzfeld, The armadillo-protein p0071 regulates Rho-signaling during cytokinesis, Nat. Cell Biol. (in press).
35. Magie C.R., Pinto-Santini D., and Parkhurst S.M. Rho1 interacts with p120ctn and alpha-catenin, and regulates cadherin-based adherens junction components in Drosophila. Development 129 (2002) 3771-3782
36. Bellovin D.I., Bates R.C., Muzikansky A., Rimm D.L., and Mercurio A.M. Altered localization of p120 catenin during epithelial to mesenchymal transition of colon carcinoma is prognostic for aggressive disease. Cancer Res. 65 (2005) 10938-10945
37. Shibata T., Kokubu A., Sekine S., Kanai Y., and Hirohashi S. Cytoplasmic p120ctn regulates the invasive phenotypes of E-cadherin-deficient breast cancer. Am. J. Pathol. 164 (2004) 2269-2278
38. Yanagisawa M., and Anastasiadis P.Z. p120 catenin is essential for mesenchymal cadherin-mediated regulation of cell motility and invasiveness. J. Cell Biol. 174 (2006) 1087-1096
39. Sander E.E., ten Klooster J.P., van Delft S., van der Kammen R.A., and Collard J.G. Rac downregulates Rho activity: reciprocal balance between both GTPases determines cellular morphology and migratory behavior. J. Cell Biol. 147 (1999) 1009-1022
40. Nimnual A.S., Taylor L.J., and Bar-Sagi D. Redox-dependent downregulation of Rho by Rac. Nat. Cell Biol. 5 (2003) 236-241
41. Abe K., Rossman K.L., Liu B., Ritola K.D., Chiang D., Campbell S.L., Burridge K., and Der C.J. Vav2 is an activator of Cdc42, Rac1, and RhoA. J. Biol. Chem. 275 (2000) 10141-10149
42. Weed S.A., Du Y., and Parsons J.T. Translocation of cortactin to the cell periphery is mediated by the small GTPase Rac1. J. Cell. Sci. 111 Pt. 16 (1998) 2433-2443
43. Cozzolino M., Stagni V., Spinardi L., Campioni N., Fiorentini C., Salvati E., Alema S., and Salvatore A.M. p120 Catenin Is Required for Growth Factor-dependent Cell Motility and Scattering in Epithelial Cells. Mol. Biol. Cell 14 (2003) 1964-1977
44. Perez-Moreno M., Davis M.A., Wong E., Pasolli H.A., Reynolds A.B., and Fuchs E. p120-catenin mediates inflammatory responses in the skin. Cell 124 (2006) 631-644
45. Servitja J.M., Marinissen M.J., Sodhi A., Bustelo X.R., and Gutkind J.S. Rac1 function is required for Src-induced transformation. Evidence of a role for Tiam1 and Vav2 in Rac activation by Src. J. Biol. Chem. 278 (2003) 34339-34346
46. Tamas P., Solti Z., Bauer P., Illes A., Sipeki S., Bauer A., Farago A., Downward J., and Buday L. Mechanism of epidermal growth factor regulation of Vav2, a guanine nucleotide exchange factor for Rac. J. Biol. Chem. 278 (2003) 5163-5171
47. Goodwin M., Kovacs E.M., Thoreson M.A., Reynolds A.B., and Yap A.S. Minimal mutation of the cytoplasmic tail inhibits the ability of E-cadherin to activate Rac but not phosphatidylinositol 3-kinase: direct evidence of a role for cadherin-activated Rac signaling in adhesion and contact formation. J. Biol. Chem. 278 (2003) 20533-20539
48. Myster S.H., Cavallo R., Anderson C.T., Fox D.T., and Peifer M. Drosophila p120catenin plays a supporting role in cell adhesion but is not an essential adherens junction component. J. Cell Biol. 160 (2003) 433-449
49. Vidal M., Larson D.E., and Cagan R.L. Csk-deficient boundary cells are eliminated from normal Drosophila epithelia by exclusion, migration, and apoptosis. Dev. Cell 10 (2006) 33-44
50. Brumby A.M., and Richardson H.E. scribble mutants cooperate with oncogenic Ras or Notch to cause neoplastic overgrowth in Drosophila. EMBO J. 22 (2003) 5769-5779
51. Zeitler J., Hsu C.P., Dionne H., and Bilder D. Domains controlling cell polarity and proliferation in the Drosophila tumor suppressor Scribble. J. Cell Biol. 167 (2004) 1137-1146
52. Bilder D., Li M., and Perrimon N. Cooperative regulation of cell polarity and growth by Drosophila tumor suppressors. Science 289 (2000) 113-116
53. Qin Y., Capaldo C., Gumbiner B.M., and Macara I.G. The mammalian Scribble polarity protein regulates epithelial cell adhesion and migration through E-cadherin. J. Cell Biol. 171 (2005) 1061-1071
54. Pettitt J., Cox E.A., Broadbent I.D., Flett A., and Hardin J. The Caenorhabditis elegans p120 catenin homologue, JAC-1, modulates cadherin-catenin function during epidermal morphogenesis. J. Cell Biol. 162 (2003) 15-22
55. Israely I., Costa R.M., Xie C.W., Silva A.J., Kosik K.S., and Liu X. Deletion of the neuron-specific protein delta-catenin leads to severe cognitive and synaptic dysfunction. Curr. Biol. 14 (2004) 1657-1663
56. Noren N.K., Arthur W.T., and Burridge K. Cadherin engagement inhibits RhoA via p190RhoGAP. J. Biol. Chem. 278 (2003) 13615-13618
57. Anwar K.N., Fazal F., Malik A.B., and Rahman A. RhoA/Rho-associated kinase pathway selectively regulates thrombin-induced intercellular adhesion molecule-1 expression in endothelial cells via activation of I kappa B kinase beta and phosphorylation of RelA/p65. J. Immunol. 173 (2004) 6965-6972
58. Segain J.P., Raingeard de la Bletiere D., Sauzeau V., Bourreille A., Hilaret G., Cario-Toumaniantz C., Pacaud P., Galmiche J.P., and Loirand G. Rho kinase blockade prevents inflammation via nuclear factor kappa B inhibition: evidence in Crohn's disease and experimental colitis. Gastroenterology 124 (2003) 1180-1187
59. Kodama A., Takaishi K., Nakano K., Nishioka H., and Takai Y. Involvement of Cdc42 small G protein in cell-cell adhesion, migration and morphology of MDCK cells. Oncogene 18 (1999) 3996-4006
60. Zhong C., Kinch M.S., and Burridge K. Rho-stimulated contractility contributes to the fibroblastic phenotype of Ras-transformed epithelial cells. Mol. Biol. Cell 8 (1997) 2329-2344
61. Shewan A.M., Maddugoda M., Kraemer A., Stehbens S.J., Verma S., Kovacs E.M., and Yap A.S. Myosin 2 is a key Rho kinase target necessary for the local concentration of E-cadherin at cell-cell contacts. Mol. Biol. Cell 16 (2005) 4531-4542
62. Calautti E., Grossi M., Mammucari C., Aoyama Y., Pirro M., Ono Y., Li J., and Dotto G.P. Fyn tyrosine kinase is a downstream mediator of Rho/PRK2 function in keratinocyte cell-cell adhesion. J. Cell Biol. 156 (2002) 137-148
63. Charrasse S., Meriane M., Comunale F., Blangy A., and Gauthier-Rouviere C. N-cadherin-dependent cell-cell contact regulates Rho GTPases and beta-catenin localization in mouse C2C12 myoblasts. J. Cell Biol. 158 (2002) 953-965
64. Kotani H., Takaishi K., Sasaki T., and Takai Y. Rho regulates association of both the ERM family and vinculin with the plasma membrane in MDCK cells. Oncogene 14 (1997) 1705-1713
65. Takaishi K., Sasaki T., Kameyama T., Tsukita S., and Takai Y. Translocation of activated Rho from the cytoplasm to membrane ruffling area, cell-cell adhesion sites and cleavage furrows. Oncogene 11 (1995) 39-48
66. Nakagawa M., Fukata M., Yamaga M., Itoh N., and Kaibuchi K. Recruitment and activation of Rac1 by the formation of E-cadherin-mediated cell-cell adhesion sites. J. Cell. Sci. 114 (2001) 1829-1838
67. Hoshino T., Sakisaka T., Baba T., Yamada T., Kimura T., and Takai Y. Regulation of E-cadherin endocytosis by nectin through afadin, Rap1, and p120ctn. J. Biol. Chem. 280 (2005) 24095-24103
68. Balzac F., Avolio M., Degani S., Kaverina I., Torti M., Silengo L., Small J.V., and Retta S.F. E-cadherin endocytosis regulates the activity of Rap1: a traffic light GTPase at the crossroads between cadherin and integrin function. J. Cell. Sci. 118 (2005) 4765-4783
69. Symons M., and Rusk N. Control of vesicular trafficking by Rho GTPases. Curr. Biol. 13 (2003) R409-R418
70. Ellis S., and Mellor H. Regulation of endocytic traffic by rho family GTPases. Trends Cell Biol. 10 (2000) 85-88
71. Lamaze C., Chuang T.H., Terlecky L.J., Bokoch G.M., and Schmid S.L. Regulation of receptor-mediated endocytosis by Rho and Rac. Nature 382 (1996) 177-179
72. Jou T.S., Leung S.M., Fung L.M., Ruiz W.G., Nelson W.J., and Apodaca G. Selective alterations in biosynthetic and endocytic protein traffic in Madin-Darby canine kidney epithelial cells expressing mutants of the small GTPase Rac1. Mol. Biol. Cell 11 (2000) 287-304
73. Izumi G., Sakisaka T., Baba T., Tanaka S., Morimoto K., and Takai Y. Endocytosis of E-cadherin regulated by Rac and Cdc42 small G proteins through IQGAP1 and actin filaments. J. Cell Biol. 166 (2004) 237-248
74. Akhtar N., and Hotchin N.A. RAC1 regulates adherens junctions through endocytosis of E-cadherin. Mol. Biol. Cell 12 (2001) 847-862
75. Sander E.E., van Delft S., ten Klooster J.P., Reid T., van der Kammen R.A., Michiels F., and Collard J.G. Matrix-dependent Tiam1/Rac signaling in epithelial cells promotes either cell-cell adhesion or cell migration and is regulated by phosphatidylinositol 3-kinase. J. Cell Biol. 143 (1998) 1385-1398
76. Leung S.M., Rojas R., Maples C., Flynn C., Ruiz W.G., Jou T.S., and Apodaca G. Modulation of endocytic traffic in polarized Madin-Darby canine kidney cells by the small GTPase RhoA. Mol. Biol. Cell 10 (1999) 4369-4384
77. Kim S.H., Li Z., and Sacks D.B. E-cadherin-mediated cell-cell attachment activates Cdc42. J. Biol. Chem. 275 (2000) 36999-37005
78. Kawakatsu T., Ogita H., Fukuhara T., Fukuyama T., Minami Y., Shimizu K., and Takai Y. Vav2 as a Rac-GDP/GTP exchange factor responsible for the nectin-induced, c-Src- and Cdc42-mediated activation of Rac. J. Biol. Chem. 280 (2005) 4940-4947
79. Fukuhara T., Shimizu K., Kawakatsu T., Fukuyama T., Minami Y., Honda T., Hoshino T., Yamada T., Ogita H., Okada M., and Takai Y. Activation of Cdc42 by trans interactions of the cell adhesion molecules nectins through c-Src and Cdc42-GEF FRG. J. Cell Biol. 166 (2004) 393-405
80. Fukuyama T., Ogita H., Kawakatsu T., Fukuhara T., Yamada T., Sato T., Shimizu K., Nakamura T., Matsuda M., and Takai Y. Involvement of the c-Src-Crk-C3G-Rap1 signaling in the nectin-induced activation of Cdc42 and formation of adherens junctions. J. Biol. Chem. 280 (2005) 815-825
81. Fukuyama T., Ogita H., Kawakatsu T., Inagaki M., and Takai Y. Activation of Rac by cadherin through the c-Src-Rap1-phosphatidylinositol 3-kinase-Vav2 pathway. Oncogene 25 (2006) 8-19
82. Palovuori R., Sormunen R., and Eskelinen S. SRC-induced disintegration of adherens junctions of Madin-Darby canine kidney cells is dependent on endocytosis of cadherin and antagonized by Tiam-1. Lab. Invest. 83 (2003) 1901-1915
83. Fujikawa K., Miletic A.V., Alt F.W., Faccio R., Brown T., Hoog J., Fredericks J., Nishi S., Mildiner S., Moores S.L., Brugge J., Rosen F.S., and Swat W. Vav1/2/3-null mice define an essential role for Vav family proteins in lymphocyte development and activation but a differential requirement in MAPK signaling in T and B cells. J. Exp. Med. 198 (2003) 1595-1608
84. Hogan C., Serpente N., Cogram P., Hosking C.R., Bialucha C.U., Feller S.M., Braga V.M., Birchmeier W., and Fujita Y. Rap1 regulates the formation of E-cadherin-based cell-cell contacts. Mol. Cell. Biol. 24 (2004) 6690-6700
85. Gavard J., Lambert M., Grosheva I., Marthiens V., Irinopoulou T., Riou J.F., Bershadsky A., and Mege R.M. Lamellipodium extension and cadherin adhesion: two cell responses to cadherin activation relying on distinct signalling pathways. J. Cell. Sci. 117 (2004) 257-270
86. Clark E.A., King W.G., Brugge J.S., Symons M., and Hynes R.O. Integrin-mediated signals regulated by members of the rho family of GTPases. J. Cell Biol. 142 (1998) 573-586
87. Schwartz M.A., and Shattil S.J. Signaling networks linking integrins and rho family GTPases. Trends Biochem. Sci. 25 (2000) 388-391 8_00001605 8_00001605
88. Sastry S.K., and Burridge K. Focal adhesions: a nexus for intracellular signaling and cytoskeletal dynamics. Exp. Cell Res. 261 (2000) 25-36
89. Nobes C.D., and Hall A. Rho GTPases control polarity, protrusion, and adhesion during cell movement. J. Cell Biol. 144 (1999) 1235-1244
90. Rottner K., Hall A., and Small J.V. Interplay between Rac and Rho in the control of substrate contact dynamics. Curr. Biol. 9 (1999) 640-648
91. Wittmann T., and Waterman-Storer C.M. Cell motility: can Rho GTPases and microtubules point the way?. J. Cell. Sci. 114 (2001) 3795-3803
92. Hollenbeck P. Cytoskeleton: microtubules get the signal. Curr. Biol. 11 (2001) R820-R823
93. Waterman-Storer C.M., and Salmon E. Positive feedback interactions between microtubule and actin dynamics during cell motility. Curr. Opin. Cell Biol. 11 (1999) 61-67
94. Small J.V., Kaverina I., Krylyshkina O., and Rottner K. Cytoskeleton cross-talk during cell motility. FEBS Lett. 452 (1999) 96-99
95. Palazzo A.F., and Gundersen G.G. Microtubule-actin cross-talk at focal adhesions. Sci. STKE 2002 (2002) PE31
96. Waterman-Storer C.M., Worthylake R.A., Liu B.P., Burridge K., and Salmon E.D. Microtubule growth activates Rac1 to promote lamellipodial protrusion in fibroblasts. Nat. Cell Biol. 1 (1999) 45-50
97. Kaverina I., Krylyshkina O., and Small J.V. Microtubule targeting of substrate contacts promotes their relaxation and dissociation. J. Cell Biol. 146 (1999) 1033-1044
98. Kaverina I., Krylyshkina O., and Small J.V. Regulation of substrate adhesion dynamics during cell motility. Int. J. Biochem. Cell Biol. 34 (2002) 746-761
99. Yanagisawa M., Kaverina I.N., Wang A., Fujita Y., Reynolds A.B., and Anastasiadis P.Z. A novel interaction between kinesin and p120 modulates p120 localization and function. J. Biol. Chem. 279 (2004) 9512-9521
100. Franz C.M., and Ridley A.J. p120 catenin associates with microtubules: inverse relationship between microtubule binding and Rho GTPase regulation. J. Biol. Chem. 279 (2004) 6588-6594
101. Chen X., Kojima S., Borisy G.G., and Green K.J. p120 catenin associates with kinesin and facilitates the transport of cadherin-catenin complexes to intercellular junctions. J. Cell Biol. 163 (2003) 547-557
102. Thoreson M.A., and Reynolds A.B. Altered expression of the catenin p120 in human cancer: implications for tumor progression. Differentiation 70 (2002) 583-589
103. Thiery J.P. Epithelial-mesenchymal transitions in tumour progression. Nat. Rev., Cancer 2 (2002) 442-454
104. Nieman M.T., Prudoff R.S., Johnson K.R., and Wheelock M.J. N-cadherin promotes motility in human breast cancer cells regardless of their E-cadherin expression. J. Cell Biol. 147 (1999) 631-644
105. Suyama K., Shapiro I., Guttman M., and Hazan R.B. A signaling pathway leading to metastasis is controlled by N-cadherin and the FGF receptor. Cancer Cell 2 (2002) 301-314
106. Hazan R.B., Phillips G.R., Qiao R.F., Norton L., and Aaronson S.A. Exogenous expression of N-cadherin in breast cancer cells induces cell migration, invasion, and metastasis. J. Cell Biol. 148 (2000) 779-790
107. Feltes C.M., Kudo A., Blaschuk O., and Byers S.W. An alternatively spliced cadherin-11 enhances human breast cancer cell invasion. Cancer Res. 62 (2002) 6688-6697
108. Dillon D.A., D'Aquila T., Reynolds A.B., Fearon E.R., and Rimm D.L. The expression of p120ctn protein in breast cancer is independent of alpha- and beta-catenin and E-cadherin. Am. J. Pathol. 152 (1998) 75-82
109. Karayiannakis A.J., Syrigos K.N., Efstathiou J., Valizadeh A., Noda M., Playford R.J., Kmiot W., and Pignatelli M. Expression of catenins and E-cadherin during epithelial restitution in inflammatory bowel disease. J. Pathol. 185 (1998) 413-418
110. Kallakury B.V., Sheehan C.E., Winn-Deen E., Oliver J., Fisher H.A., Kaufman Jr. R.P., and Ross J.S. Decreased expression of catenins (alpha and beta), p120 CTN, and E- cadherin cell adhesion proteins and E-cadherin gene promoter methylation in prostatic adenocarcinomas. Cancer 92 (2001) 2786-2795
111. Baki L., Marambaud P., Efthimiopoulos S., Georgakopoulos A., Wen P., Cui W., Shioi J., Koo E., Ozawa M., Friedrich Jr. V.L., and Robakis N.K. Presenilin-1 binds cytoplasmic epithelial cadherin, inhibits cadherin/p120 association, and regulates stability and function of the cadherin/catenin adhesion complex. Proc. Natl. Acad. Sci. U. S. A. 98 (2001) 2381-2386
112. Marambaud P., Shioi J., Serban G., Georgakopoulos A., Sarner S., Nagy V., Baki L., Wen P., Efthimiopoulos S., Shao Z., Wisniewski T., and Robakis N.K. A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions. EMBO J. 21 (2002) 1948-1956
113. Fujita Y., Krause G., Scheffner M., Zechner D., Leddy H.E., Behrens J., Sommer T., and Birchmeier W. Hakai, a c-Cbl-like protein, ubiquitinates and induces endocytosis of the E-cadherin complex. Nat. Cell Biol. 4 (2002) 222-231
114. Hou J.C., Shigematsu S., Crawford H.C., Anastasiadis P.Z., and Pessin J.E. Dual regulation of Rho and Rac by p120 catenin controls adipocyte plasma membrane trafficking. J. Biol. Chem. (2006)
115. Kawamura Y., Fan Q.W., Hayashi H., Michikawa M., Yanagisawa K., and Komano H. Expression of the mRNA for two isoforms of neural plakophilin-related arm-repeat protein/delta-catenin in rodent neurons and glial cells. Neurosci. Lett. 277 (1999) 185-188
116. Paffenholz R., and Franke W.W. Identification and localization of a neurally expressed member of the plakoglobin/armadillo multigene family. Differentiation 61 (1997) 293-304
117. Ho C., Zhou J., Medina M., Goto T., Jacobson M., Bhide P.G., and Kosik K.S. delta-catenin is a nervous system-specific adherens junction protein which undergoes dynamic relocalization during development. J. Comp. Neurol. 420 (2000) 261-276
118. Ulfig N., and Chan W.Y. Expression of ARVCF in the human ganglionic eminence during fetal development. Dev. Neurosci. 26 (2004) 38-44
119. Chauvet N., Privat A., and Prieto M. Differential expression of p120 catenin in glial cells of the adult rat brain. J. Comp. Neurol. 479 (2004) 15-29
120. Chauvet N., Prieto M., Fabre C., Noren N.K., and Privat A. Distribution of p120 catenin during rat brain development: potential role in regulation of cadherin-mediated adhesion and actin cytoskeleton organization. Mol. Cell. Neurosci. 22 (2003) 467-486
121. Sanai N., Alvarez-Buylla A., and Berger M.S. Neural stem cells and the origin of gliomas. N. Engl. J. Med. 353 (2005) 811-822
122. Ciesiolka M., Delvaeye M., Van Imschoot G., Verschuere V., McCrea P., van Roy F., and Vleminckx K. p120 catenin is required for morphogenetic movements involved in the formation of the eyes and the craniofacial skeleton in Xenopus. J. Cell. Sci. 117 (2004) 4325-4339
123. van Galen E.J., and Ramakers G.J. Rho proteins, mental retardation and the neurobiological basis of intelligence. Prog. Brain Res. 147 (2005) 295-317
124. Newey S.E., Velamoor V., Govek E.E., and Van Aelst L. Rho GTPases, dendritic structure, and mental retardation. J. Neurobiol. 64 (2005) 58-74
125. Li W., Li Y., and Gao F.B. Abelson, enabled, and p120 catenin exert distinct effects on dendritic morphogenesis in Drosophila. Dev. Dyn. 234 (2005) 512-522
126. Elia L.P., Yamamoto M., Zang K., and Reichardt L.F. p120 catenin regulates dendritic spine and synapse development through Rho-family GTPases and cadherins. Neuron 51 (2006) 43-56
127. Piccoli G., Rutishauser U., and Bruses J.L. N-cadherin juxtamembrane domain modulates voltage-gated Ca2+ current via RhoA GTPase and Rho-associated kinase. J. Neurosci. 24 (2004) 10918-10923
128. Tricaud N., Perrin-Tricaud C., Bruses J.L., and Rutishauser U. Adherens junctions in myelinating Schwann cells stabilize Schmidt-Lanterman incisures via recruitment of p120 catenin to E-cadherin. J. Neurosci. 25 (2005) 3259-3269
129. Anastasiadis P.Z., and Reynolds A.B. Regulation of Rho GTPases by p120-catenin. Curr. Opin. Cell Biol. 13 (2001) 604-610