An alternatively spliced cadherin-11 enhances human breast cancer cell invasion

Cancer Research

Volumn 62, Issue 22, 2002, Pages 6688-6697

  Feltes, Carolyn M ^a   Kudo, Akira ^b   Blaschuk, Orest ^c   Byers, Stephen W ^a  

^a GEORGETOWN UNIVERSITY   (United States)

^b TOKYO INSTITUTE OF TECHNOLOGY   (Japan)

^c MCGILL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; CADHERIN; CADHERIN 11; MATRIGEL; PROTEIN P120; UNCLASSIFIED DRUG; UVOMORULIN;

ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CANCER INVASION; CARBOXY TERMINAL SEQUENCE; CELL DIFFERENTIATION; CELL GROWTH; CELL PROLIFERATION; CELL STRAIN MCF 7; CONTROLLED STUDY; HUMAN; HUMAN CELL; MESENCHYME; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; RNA SPLICING; WILD TYPE;

ADHERENS JUNCTIONS; ALTERNATIVE SPLICING; ANTIBODIES, MONOCLONAL; ANTIBODY SPECIFICITY; BREAST NEOPLASMS; CADHERINS; CELL ADHESION; CELL DIVISION; HUMANS; NEOPLASM INVASIVENESS; TRANSFECTION;

EID: 0037112443     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (28)

1. Yagi, T., and Takeichi, M. Cadherin superfamily genes: Functions, genomic organization, and neurologic diversity. Genes Dev., 14: 1169-1180, 2000
2. Yap, A. S., Brieher, W. M., and Gumbiner, B. M. Molecular and functional analysis of cadherin-based adherens junctions. Annu. Rev. Cell Dev. Biol., 13: 119-146, 1997
3. Troyanovsky, S. M. Mechanism of cell-cell adhesion complex assembly. Curr. Opin. Cell Biol., 11: 561-566, 1999
4. Provost, E., and Rimm, D. L. Controversies at the cytoplasmic face of the cadherin-based adhesion complex. Curr. Opin. Cell Biol., 11: 567-572, 1999
5. Steinberg, M. S., and McNutt, P. M. Cadherins and their connections: Adhesion junctions have broader functions. Curr. Opin. Cell Biol., 11: 554-560, 1999
6. McNeill, H., Ozawa, M., Kemler, R., and Nelson, W. J. Novel function of the cell adhesion molecule uvomorulin as an inducer of cell surface polarity. Cell, 62: 309-316, 1990
7. Hermiston, M. L., Wong, M. H., and Gordon, J. I. Forced expression of E-cadherin in the mouse intestinal epithelium slows cell migration and provides evidence for non-autonomous regulation of cell fate in a self renewing system. Genes Dev., 10: 985-996, 1996
8. Ji, X., Woodard, A. S., Rimm, D. L., and Fearon, E. R. Transcriptional defects underlie loss of E-cadherin expression in breast cancer. Cell Growth Differ., 8: 773-778, 1997
9. Hazan, R. B., Phillips, G. R., Qiao, R. F., Norton, L. and Aaronson, S. A. Exogenous expression of N-cadherin in breast cancer cells induces cell migration, invasion, and metastasis [published erratum appears in J. Cell Biol., 149: 236, 2000]. J. Cell Biol., 148: 779-790, 2000
10. Peralta, S. A., Knudsen, K. A., Salazar, H., Han, A. C., and Keshgegian, A. A. P-cadherin expression in breast carcinoma indicates poor survival. Cancer (Phila.), 86: 1263-1272, 1999
11. Okazaki, M., Takeshita, S., Kawai, S., Kikuno, R., Tsujimura, A., Kudo, A., and Amann, E. Molecular cloning and characterization of OB-cadherin, a new member of cadherin family expressed in osteoblasts. J. Biol. Chem., 269: 12092-12098, 1994
12. Hoffmann, I., and Balling, R. Cloning and expression analysis of a novel mesodermally expressed cadherin. Dev. Biol., 169: 337-346, 1995
13. Kawaguchi, J., Takeshita, S., Kashima, T., Imai, T., Machinami, R., and Kudo, A. Expression and function of the splice variant of the human cadherin-11 gene in subordination to intact cadherin-11. J. Bone Miner. Res., 14: 764-775, 1999
14. Pishvaian, M. J., Feltes, C. M., Thompson, P., Bussemakers, M. J., Schalken, J. A., and Byers, S. W. Cadherin-11 is expressed in invasive breast cancer cell lines. Cancer Res., 59: 947-952, 1999
15. Kashima, T., Kawaguchi, J., Takeshita, S., Kuroda, M., Takanashi, M., Horiuchi, H., Imamura, T., Ishikawa, Y., Ishida, T., Mori, S., Machinami, R., and Kudo, A. Anomalous cadherin expression in osteosarcoma. Possible relationships to metastasis and morphogenesis. Am. J. Pathol., 155: 1549-1555, 1999
16. Munro, S. B., Turner, I. M., Farookhi, R., Blaschuk, O. W., and Jothy, S. E-cadherin and OB-cadherin mRNA levels in normal human colon and colon carcinoma. Exp. Mol. Pathol., 62: 118-122, 1995
17. Shibata, T., Ochiai, A., Gotoh, M., Machinami, R., and Hirohashi, S. Simultaneous expression of cadherin-11 in signet-ring cell carcinoma and stromal cells of diffuse type gastric cancer. Cancer Lett., 99: 147-153, 1996
18. Shimazui, T., Giroldi, L. A., Bringuier, P. P., Oosterwijk, E., and Schlaken, J. A. Complex cadherin expression in renal cell carcinoma. Cancer Res., 56: 3234-3237, 1996
19. Orford, K., Orford, C. C., and Byers, S. W. Exogenous expression of β-catenin regulates contact inhibition, anchorage-independent growth, anoikis and radiation-induced cell-cycle arrest. J. Cell Biol., 146: 1-13, 1999
20. Sommers, C. L., Byers, S. W., Thompson, E. W., Torri, J. A., and Gelmann, E. P. Differentiation state and invasiveness of human breast cancer cell lines. Breast Cancer Res. Treat., 31: 325-335, 1994
21. Pierceall, W. E., Woodard, A. S., Morrow, J. S., Rimm, D., and Fearon, E. R. Frequent alterations in E-cadherin and α and β catenin expression in human breast cancer cell lines. Oncogene, 11: 1319-1326, 1995
22. ctn from E-cadherin disrupts strong adhesion. J. Cell Biol., 148: 189-202, 2000
23. Gottardi, C. J., Wong, E., and Gumbiner, B. M. E-cadherin suppresses cellular transformation by inhibiting β-catenin signaling in an adhesion-independent manner. J. Cell Biol., 153: 1049-1060, 2001
24. Nieman, M. T., Prudoff, R. S., Johnson, K. R., and Wheelock, M. J. N-cadherin promotes motility in human breast cancer cells regardless of their E-cadherin expression. J. Cell Biol., 147: 631-644, 1999
25. Alberts, B. D. Molecular Biology of the Cell. New York: Garland Publishing, Inc., 1994
26. Wyke, J. A. Overview: Burgeoning promise in metastasis research. Eur. J. Cancer, 36: 1589-1594, 2000
27. Perl, A. K., Wilgenbus, P., Dahl, U., Semb, H., and Christofori, G. A causal role for E-cadherin in the transition from adenoma to carcinoma. Nature (Lond.), 392: 190-193, 1998
28. ctn. J. Cell Biol., 141: 779-789, 1998