Translocation of cortactin to the cell periphery is mediated by the small GTPase Rac1

Journal of Cell Science

Volumn 111, Issue 16, 1998, Pages 2433-2443

  Weed, Scott A ^a   Du, Yunrui ^a   Thomas Parsons, J ^a  

^a UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

Author keywords

Actin; Cortactin; Membrane ruffling; PAK; Rac

Indexed keywords

ACTIN; ACTIN BINDING PROTEIN; CORTACTIN; GUANOSINE TRIPHOSPHATASE; PROTEIN SERINE THREONINE KINASE; UNCLASSIFIED DRUG;

ACTIN POLYMERIZATION; ANIMAL CELL; ARTICLE; CELL MEMBRANE; CELL STRAIN 3T3; CELLULAR DISTRIBUTION; MOUSE; NONHUMAN; PRIORITY JOURNAL;

3T3 CELLS; ACTINS; ANIMALS; BASE SEQUENCE; BIOLOGICAL TRANSPORT, ACTIVE; CELL MEMBRANE; CORTACTIN; DNA PRIMERS; ENZYME ACTIVATION; GTP PHOSPHOHYDROLASES; GTP-BINDING PROTEINS; MICE; MICROFILAMENT PROTEINS; MUTATION; PLATELET-DERIVED GROWTH FACTOR; PROTEIN-SERINE-THREONINE KINASES; RAC GTP-BINDING PROTEINS; SIGNAL TRANSDUCTION; TETRADECANOYLPHORBOL ACETATE;

ANIMALIA;

EID: 0031696485     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (69)

1. Amano, M., Chihara, K., Kimura, K., Fukata, Y., Nakamura, N., Matsuura, Y. and Kaibuchi, K. (1997). Formation of actin stress fibers and focal adhesions enhanced by Rho-kinase. Science 275, 1308-1311.
2. Bagrodia, S., Derijard, B., Davis, R. J. and Cerione, R. A. (1995). Cdc42 and PAK-mediated signaling leads to Jun kinase and p38 mitogen-activated protein kinase activation. J. Biol. Chem. 270, 27995-27998.
3. Bokoch, G. M., Wang, Y., Bohl, B. P., Sells, M. A., Quilliam, L. A. and Knaus, U. G. (1996). Interaction of the Nck adapter protein with p21-activated kinase (PAK1). J. Biol. Chem. 271, 25746-25749.
4. Bretscher, A. (1991). Microfilament structure and function in the cortical cytoskeleton. Annu. Rev. Cell. Biol. 7, 337-374.
5. Bretscher, M. S. (1996a). Moving membrane up to the front of migrating cells. Cell 85, 465-467.
6. Bretscher, M. S. (1996b). Getting membrane flow and the cytoskeleton to cooperate in moving cells. Cell 87, 601-606.
7. Brill, S., Li, S., Layman, C. W., Church, D. M., Wasmuth, J. J., Weissbach, L., Bernards, A. and Snijders, A. J. (1996). The ras GTPase-activating-protein-related human protein IQGAP2 harbors a potential actin binding domain and interacts with calmodulin and rho family GTPases. Mol. Cell Biol. 16, 4869-4878.
8. Burbelo, P. D., Drechsel, D. and Hall, A. (1995). A conserved binding motif defines numerous candidate target proteins for both cdc42 and rac GTPases. J. Biol. Chem. 270, 29071-29074.
9. Chou, M. M. and Blenis, J. (1996). The 70 kDa S6 kinase complexes with and is activated by the Rho family G proteins cdc42 and Rac 1. Cell 85, 573-583.
10. Condeelis, J. (1993). Life at the leading edge: the formation of cell protrusions. Annu. Rev. Cell. Biol. 9, 411-444.
11. Coso, O. A., Chiariello, M., Yu, J. C., Teramoto, H., Crespo, P., Xu, N., Miki, T. and Gutkind, J. S. (1995). The small GTP-binding proteins Rac1 and cdc42 regulate the activity of the JNK/SAPK signaling pathway. Cell 81, 1137-1146.
12. D'Souza-Schorey, C., Boshans, R. L., McDonough, M., Sthal, P. D. and Van Aelst, L. (1997). A role for POR1, a Rac1-interacting protein, in ARF6-mediated cytoskeletal rearrangements. EMBO J. 16, 5445-5454.
13. Dharmawardhane, S., Sanders, L. C., Martin, S. S., Daniels, R. H. and Bokoch, G. M. (1997). Localization of p21-activated kinase 1 (PAK1) to pinocytic vesicles and cortical actin structures in stimulated cells. J. Cell Biol. 138, 1265-1278.
14. phox and regulation of phagocyticNADPH oxidase activity. Science 265, 531-533.
15. Fincham, V. J., Unlu, M., Brunton, V. G., Pitts, J. D., Wyke, J. A. and Frame, M. C. (1996). Translocation of Src kinase to the cell periphery is mediated by the actin cytoskeleton under the control of the Rho family of small G proteins. J. Cell Biol. 135, 1551-1564.
16. Galisteo, M. L., Chernoff, J., Su, Y.-C., Skolnik, E. Y. and Schlessinger, J. (1996). The adaptor protein Nck links receptor tyrosine kinases with the serine-threonine kinase Pak1. J. Biol. Chem. 271, 20997-21000.
17. Gips, S. J., Kandzari, D. E. and Goldschmidt-Clermont, P. J. (1994). Growth factor receptors, phospholipases, phospholipid kinases and actin reorganization. Sem. Cell Biol. 5, 201-208.
18. Hall, A. (1998). Rho GTPases and the actin cytoskeleton. Science 279, 509-514.
19. Hart, M. J., Callow, M. G., Souza, B. and Polakis, P. (1996). IQGAP1, a calmodulin-binding protein with a rasGAP-related domain, is a potential effector for cdc42Hs. EMBO J. 15, 2997-3005.
20. Huang, C., Ni, Y., Wang, T., Gao, Y., Haudenschild, C. C. and Zhan, X. (1997). Down-regulation of the filamentous actin cross-linking activity of cortactin by Src-mediated tyrosine phosphorylation. J. Biol. Chem. 272, 13911-13915.
21. Ishizaki, T., Maekawa, M., Fujisawa, K., Okawa, K., Iwamatsu, A., Fujita, A., Watanabe, N., Sato, Y., Kakizuka, A., Morii, N., and Narumiya, S. (1996). The small GTP-binding protein Rho binds to and activates a 160 kDa Ser/Thr protein kinase homologous to myotonic dystrophy kinase. EMBO J. 15, 1885-1893.
22. Joneson, T., McDonough, M., Bar-Sagi, D. and Van Aelst, L. (1996). RAC regulation of actin polymerization and proliferation by a pathway distinct from jun kinase. Science 274, 1374-1376.
23. Kanner, S. B., Reynolds, A. B., Vines, R. R. and Parsons, J. T. (1990). Monoclonal antibodies to individual tyrosine-phosphorylated protein substates of oncogene-encoded tyrosine kinases. Proc. Nat. Acad. Sci. USA 87, 3328-3332.
24. Keely, P. J., Westwick, J. K., Whitehead, I. P., Der, C. J. and Parise, L. V. (1997). Cdc42 and Rac1 induce integrin-mediated cell motility and invasiveness through PI(3)K. Nature 390, 632-636.
25. Kitamura, D., Kaneko, H., Miyagoe, Y., Ariyasu, T. and Watanabe, T. (1989). Isolation and characterization of a novel human gene expressed specifically in the cells of hematopoietic lineage. Nucleic Acid Res. 17, 9367-9379.
26. Kowluru, A., Li, G., Rabagila, M. E., Segu, V. B., Huffman, F., Aktories, K. and Metz, S. M. (1997). Evidence for differential roles of the Rho subfamily of GTP-binding proteins in glucose and calcium-induced secretion from pancreatic β cells. Biochem. Pharm. 54, 1097-1108.
27. Kozma, R., Ahmed, S., Best, A. and Lim, L. (1995). The ras-related protein cdc42hs and bradykinin promote formation of peripheral actin microspikes and filopodia in Swiss 3T3 fibroblasts. Mol. Cell. Biol. 15, 1942-1952.
28. PAK and the JNK/SAPK MAP kinase cascade. Cell 87, 519-529.
29. Lamaze, C., Chuang, T.-H., Terlecky, L. J., Bokoch, G. M. and Schmid, S. L. (1996). Regulation of receptor-mediated endocytosis by Rho and Rac. Nature 392, 177-179.
30. Leusen, J. H. W., de Kline, A., Hilarius, P. M., Ahlin, A., Palmbald, J., Smith, C. I. E., Diekmann, D., Hall, A., Verhoeven, A. J. and Roos, D. (1996). Disturbed interaction of p21-rac with mutated p67-phox causes chronic granulomatous disease. J. Exp. Med. 184, 1243-1249.
31. Lombardo, C. R., Willardson, B. M. and Low, P. S. (1992). Localization of the protein 4. 1-binding site on the cytoplasmic domain of erythrocyte membrane band 3. J. Biol. Chem. 267, 9540-9546.
32. Lu, W., Katz, S., Gupta, R. and Mayer, B. J. (1997). Activation of Pak by membrane localization mediated by an SH3 domain from the adaptor protein Nck. Curr. Biol. 7, 85-94.
33. c-src substrate. Oncogene 7, 2429-2438.
34. Mackay, D. J. G., Esch, F., Furthmayer, H. and Hall, A. (1997). Rho- and Rac-dependent assembly of focal adhesion complexes and actin filaments in permeabilized fibroblasts: an essential role for ezrin/radixin/moesin proteins. J. Cell Biol. 138, 927-938.
35. Manser, E., Leung, T., Salihuddin, H., Zhao, Z.-S. and Lim, L. (1994). A brain serine/threonine protein kinase activated by cdc42 and Rac1. Nature 367, 40-46.
36. Manser, E., Huang, H.-Y., Loo, T.-H., Chen, X.-Q., Dong, J.-M., Leung, T. and Lim, L. (1997). Expression of constitutively active α-PAK reveals effects of the kinase on actin and focal complexes. Mol. Cell. Biol. 17, 1129-1143.
37. Manser, E., Loo, T.-H., Koh, C.-G., Zhao, Z.-S., Chen, X.-Q., Tan, L., Tan, I., Leung, T. and Lim, L. (1998). PAK kinases are directly coupled to the PIX family of nucleotide exchange factors. Mol. Cell 1, 183-192.
38. Miglarese, M. R., Hannion-Henderson, J., Wu, H., Parsons, J. T. and Bender, T. P. (1994). The protein tyrosine kinase substrate cortactin is differentially expressed in murine B lymphoid tumors. Oncogene 9, 1989-1997.
39. Minden, A., Lin, A., Claret, F. X., Abo, A. and Karin, M. (1995). Selective activation of the JNK signaling cascade and c-Jun transcriptional activity by the small GTPases Rac and cdc42Hs. Cell 81, 1147-1157.
40. Mitchison, T. J. and Cramer, L. P. (1996). Actin-based cell motility and cell locomotion. Cell 85, 371-379.
41. Myat, M. M., Anderson, S., Alien, L. H. and Aderem, A. (1997). MARKS regulates membrane ruffling and cell spreading. Curr. Biol. 7, 611-614.
42. Nobes, C. D., Hawkins, P., Stephens, L. and Hall, A. (1995). Activation of the small GTP-binding proteins Rho and Rac by growth factor receptors. J. Cell Sci. 108, 225-233.
43. Nobes, C. D. and Hall, A. (1995). Rho, Rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia. Cell 81, 53-62.
44. Norman, J. C., Price, L. S., Ridley, A. J. and Koffer, A. (1996). The small GTP-binding proteins, Rac and Rho, regulate cytoskeletal organization and exocytosis in mast cells by parallel pathways. Mol. Biol. Cell 7, 1429-1442.
45. 1. Science 269, 1270-1272.
46. Olson, M. F., Pasteris, N. G., Gorski, J. L. and Hall, A. (1996). Faciogenital dysplasia protein (FGD1) and Vav, two related proteins required for normal embryonic development, are upstream regulators of Rho GTPases. Curr. Biol. 6, 1628-1633.
47. Postma, F. R., Jalink, K., Hengeveld, T. and Moolenaar, W. H. (1996). Sphingosine-1-phosphate rapidly induces Rho-dependent neurite retraction: action through a specific cell receptor. EMBO J. 15, 2388-2392.
48. Qui, R.-G., Chen, J., Kirn, D., McCormick, F. and Symons, M. (1995). An essential role for Rac in Ras transformation. Nature 374, 457-459.
49. Radhakrishna, H. and Donaldson, J. G. (1997). ADP-ribosylation factor 6 regulates a novel plasma membrane recycling pathway. J. Cell Biol. 139, 49-61.
50. Radhakrishna, H., Klausner, R. D. and Donaldson, J. G. (1996). Aluminum fluoride stimulates surface protrusions in cells overexpressing the ARF6 GTPase. J. Cell Biol. 134, 935-947.
51. Ridley, A. J. (1994). Membrane ruffling and signal transduction. BioEssays 16, 321-327.
52. Ridley, A. J. and Hall, A. (1992). The small GTP-binding protein Rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors. Cell 70, 389-399.
53. Ridley, A. J., Patterson, H. F., Johnston, C. L., Diekmann, D. and Hall, A. (1992). The small GTP-binding protein Rac regulates growth factor induced membrane ruffling. Cell 70, 401-410.
54. Ruzzene, M., Brunati, A. M., Marin, O., Donella-Deana, A. and Pinna, L. A. (1996). SH2 domains mediate the sequential phosphorylation of HS1 protein by p72syk and src-related protein tyrosine kinases. Biochemistry 35, 5327-5332.
55. Schurring, E., Verhowven, E., Litvinow, S. and Michalides, R. J. A. M. (1993). The product of the EMS1 gene, amplified and overexpressed in human carcinomas, is homologous to a v-src substrate and is located in cell-substratum contact sites. Mol. Cell Biol. 13, 2891-2898.
56. Sells, M. A. and Chernoff, J. (1997). Emerging from the Pak: the p21-activated protein kinase family. Trends Cell Biol. 7, 162-167.
57. Sells, M. A., Knaus, U. G., Bagrodia, S., Ambrose, D. M., Bokoch, G. M. and Chernoff, J. (1997). Human p21-activated kinase (Pak1) regulates actin organization in mammalian cells. Curr. Biol. 7, 202-210.
58. Stossel, T. P. (1993). On the crawling of animal cells. Science 260, 1086-1094.
59. Taniuchi, I., Kitamura, D., Maekawa, Y., Fukuda, T., Kishi, H. and Watanabe, T. (1995). Antigen-receptor induced clonal expansion and deletion of lymphocytes are impaired in mice lacking HS1 protein, a substrate of the antigen-receptor-coupled tyrosine kinases. EMBO J. 14, 3664-3678.
60. Tapon, N., and A. Hall. (1997). Rho, Rac and Cdc42 GTPases regulate organization of the actin cytoskeleton. Curr. Opin. Cell Biol. 9, 86-92.
61. Van Aelst, L. and D'Souza-Schorey, C. (1997). Rho GTPases and signaling networks. Genes Dev. 11, 2295-2322.
62. Van Aelst, L., Joneson, T. and Bar-Sagi, D. (1996). Identification of a novel Rac1-interacting protein involoved in membrane ruffling. EMBO J. 15, 3778-3786.
63. van Damme, H., Brok, H., Schuuring-Scholtes, E. and Schuuring, E. (1997). The redistribution of cortactin into cell-matrix contact sites in human carcinoma cells with 11q13 amplification is associated with both overexpression and post-translational modification. J. Biol. Chem. 272, 7374-7380.
64. Westwick, J. K., Lambert, Q. T., Clark, G. J., Symons, M., Van Aelst, L., Pestell, R. G. and Der, C. J. (1997). Rac regulation of transformation, gene expression, and actin organization by multiple, PAK-independent pathways. Mol. Cell. Biol. 17, 1324-1335.
65. src substrate. Mol. Cell. Biol. 11, 5113-5124.
66. src substrate, is a filamentous actin-binding protein enriched in the cell cortex. J. Cell Biol. 120, 1417-1426.
67. 1 phase of the BALB/c 3T3 cell cycle. J. Biol. Chem. 268, 24427-24431.
68. Zhang, S., Han, J., Sells, M. A., Chernoff, J., Knaus, U. G., Ulevitch, R. J. and Bokoch, G. M. (1995). Rho family GTPases regulate p38 mitogen-activated protein kinase through the downstream mediator Pak1. J. Biol. Chem. 270, 23934-23936.
69. Zigmond, S. H. (1996). Signal transduction and actin filament orgainzation. Curr. Opin. Cell Biol. 8, 66-73.