Fyn tyrosine kinase is a downstream mediator of Rho/PRK2 function in keratinocyte cell-cell adhesion

Journal of Cell Biology

Volumn 156, Issue 1, 2002, Pages 137-148

  Calautti, Enzo ^a   Grossi, Maddalena ^a   Mammucari, Cristina ^a   Aoyama, Yumi ^a   Pirro, Maria ^a   Ono, Yoshitaka ^a   Li, Jie ^a   Dotto, G Paolo ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

and catenin; Adherens junctions; E cadherin; p120Ctn; PKN PRK2

Indexed keywords

ACTIN; BETA CATENIN; CALCIUM; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; PLAKOGLOBIN; PROTEIN TYROSINE KINASE; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; UVOMORULIN;

ANIMAL CELL; ARTICLE; CELL ADHESION; CELL DIFFERENTIATION; CONTROLLED STUDY; CYTOSKELETON; EXPRESSION VECTOR; EXTRACELLULAR CALCIUM; IMMUNOPRECIPITATION; KERATINOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

ACTINS; ANIMALS; BETA CATENIN; CADHERINS; CALCIUM; CELL ADHESION; CELL DIFFERENTIATION; CELLS, CULTURED; CYTOSKELETAL PROTEINS; CYTOSKELETON; DESMOPLAKINS; ENZYME ACTIVATION; GAMMA CATENIN; HUMANS; KERATINOCYTES; MICE; MICE, INBRED SENCAR; MUTATION; PHOSPHORYLATION; PHOSPHOTYROSINE; PROTEIN BINDING; PROTEIN KINASE C; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-FYN; PROTO-ONCOGENE PROTEINS PP60(C-SRC); RHO GTP-BINDING PROTEINS; SIGNAL TRANSDUCTION; TRANS-ACTIVATORS;

ANIMALIA;

EID: 0037033804     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.200105140     Document Type: Article

References (44)

1. Inhibition of RhoA by p120 catenin
2. The p120 catenin family: Complex roles in adhesion, signaling and cancer
3. Loss of epithelial differentiation and gain of invasiveness correlates with tyrosine phosphorylation of the E-cadherin/beta-catenin complex in cells transformed with a temperature-sensitive v-SRC gene
4. Role of c-Src tyrosine kinase in EGF-induced mitogenesis
5. Rho GTPases and their effector proteins
6. Bacterial toxins inhibiting or activating small GTP-binding proteins
7. The small GTPases Rho and Rac are required for the establishment of cadherin-dependent cell-cell contacts
8. A PKC-eta/Fyn-dependent pathway leading to keratinocyte growth arrest and differentiation
9. Tyrosine phosphorylation and src family kinases control keratinocyte cell-cell adhesion
10. Tyrosine kinase is involved in keratinocyte differentiation control
11. Purification and assay of recombinant C3 transferase
12. Signal transduction pathways controlling the switch between keratinocyte growth and differentiation
13. Translocation of Src kinase to the cell periphery is mediated by the actin cytoskeleton under the control of the Rho family of small G proteins
14. Rho stimulates tyrosine phosphorylation of focal adhesion kinase, p130 and paxillin
15. Rho GTPase control of protein kinase C-related protein kinase activation by 3-phosphoinositide-dependent protein kinase
16. Regulation of cadherin adhesive activity
17. Rho GTPases and the actin cytoskeleton
18. p60v-src causes tyrosine phosphorylation and inactivation of the N-cadherin-catenin cell adhesion system
19. Discovery of a novel, potent, and Src family-selective tyrosine kinase inhibitor. Study of Lck- and FynT-dependent T cell activation
20. A simplified system for generating recombinant adenoviruses
21. The Rho family GTPases RhoA, Racl, and CDC42Hs regulate transcriptional activation by SRF
22. Tyrosine phosphorylation of a 120-kilodalton pp60src substrate upon epidermal growth factor and platelet-derived growth factor receptor stimulation and in polyomavirus middle-T-antigen-transformed cells
23. Cadherin function is required for human keratinocytes to assemble desmosomes and stratify in response to calcium
24. Tec/Bmx non-receptor tyrosine kinases are involved in regulation of Rho and serum response factor by Galpha12/13
25. Rho-dependent and -independent tyrosine phosphorylation of focal adhesion kinase, paxillin and p130Cas mediated by Ret kinase
26. Calcium-induced assembly of adherens junctions in keratinocytes
27. Introduction of macromolecules into cultured mammalian cells by osmotic lysis of pinocytic vesicles
28. Controversies at the cytoplasmic face of the cadherin-based adhesion complex
29. Regulation of the small GTP-binding protein Rho by cell adhesion and the cytoskeleton
30. Determination of GTP loading on Rho
31. Identification of a new catenin: The tyrosine kinase substrate p 120cas associates with E-cadherin complexes
32. RhoA effector mutants reveal distinct effector pathways for cycoskeletal reorganization, rfsti SRF activation and transformation
33. Association of p 120, a tyrosine kinase substrate, with E-cadherin/catenin complexes
34. Tyrosine phosphorylation of beta-catenin and plakoglobin enhanced by hepatocyte growth factor and epidermal growth factor in human carcinoma cells
35. pp59fyn mutant mice display differential signaling in thymocytes and peripheral T cells
36. Regulation of cell-cell adhesion by rac and rho small G proteins in MDCK cells
37. V-src kinase shifts the cadherin-based cell adhesion from the strong to the weak state and beta catenin is not required for the shift
38. Beta-catenin associates with the actin-bundling protein fascin in a noncadherin complex
39. Selective uncoupling of p120(ctn) from E-cadherin disrupts strong adhesion
40. Diaphanous-related formins bridge Rho GTPase and Src tyrosine kinase signaling
41. Rho GTPases and signaling networks
42. Directed actin polymerization is the driving force for epithelial cell-cell adhesion
43. The PRK2 kinase is a potential effector target of both Rho and Rac GTPases and regulates actin cytosketetal organization
44. Mutational analysis of the regulatory mechanism of PKN: The regulatory region of PKN contains an arachidonic acid-sensitive autoinhibitory domain