Drosophila p120 catenin plays a supporting role in cell adhesion but is not an essential adherens junction component

Journal of Cell Biology

Volumn 160, Issue 3, 2003, Pages 433-449

  Myster, Steven H ^a   Cavallo, Robert ^a   Anderson, Charles T ^a   Fox, Donald T ^a   Peifer, Mark ^a  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

Cadherin; Catenin; Cell cell adhesion; p120; Rho

Indexed keywords

GUANOSINE TRIPHOSPHATASE; PROTEIN P120; ARMADILLO DOMAIN PROTEIN; ARMADILLO PROTEIN, DROSOPHILA; CADHERIN; CADHERIN ASSOCIATED SRC SUBSTRATE P120; CADHERIN-ASSOCIATED SRC SUBSTRATE P120; CELL ADHESION MOLECULE; COMPLEMENTARY DNA; DROSOPHILA PROTEIN; PHOSPHOPROTEIN; TRANSACTIVATOR PROTEIN; TRANSCRIPTION FACTOR;

ARTICLE; CELL ADHESION; CELL FUNCTION; CELL JUNCTION; CELL STRUCTURE; CELL VIABILITY; COMPLEX FORMATION; CONTROLLED STUDY; CYTOPLASM; DROSOPHILA; EMBRYO DEVELOPMENT; ENZYME REGULATION; FEMALE; FERTILITY; GENE MUTATION; GENETIC CODE; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; NULL ALLELE; PRIORITY JOURNAL; PROTEIN FAMILY; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; SEQUENCE HOMOLOGY; TRANSCRIPTION REGULATION; ANIMAL; ANIMAL EMBRYO; CELL MEMBRANE; CONGENITAL MALFORMATION; CYTOLOGY; DROSOPHILA MELANOGASTER; GENETICS; METABOLISM; MOLECULAR EVOLUTION; MOLECULAR GENETICS; MUTATION; PHYLOGENY; PRENATAL DEVELOPMENT;

ARMADILLO;

ADHERENS JUNCTIONS; ANIMALS; ARMADILLO DOMAIN PROTEINS; CADHERINS; CELL ADHESION; CELL ADHESION MOLECULES; CELL MEMBRANE; DNA, COMPLEMENTARY; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; EMBRYO, NONMAMMALIAN; EVOLUTION, MOLECULAR; FEMALE; MALE; MOLECULAR SEQUENCE DATA; MUTATION; PHOSPHOPROTEINS; PHYLOGENY; SEQUENCE HOMOLOGY, AMINO ACID; SEQUENCE HOMOLOGY, NUCLEIC ACID; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS;

EID: 0037415610     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.200211083     Document Type: Article

References (29)

1. Akong, K., B. McCartney, and M. Peifer. 2002. Drosophila APC2 and APC1 have overlapping roles in the larval brain despite their distinct intracellular localizations. Dev. Biol. 250:71-90.
2. Anastasiadis, P.Z., and P.B. Reynolds. 2000. The p120 catenin family: complex roles in adhesion, signaling and cancer. J. Cell Sci. 113:1319-1334.
3. Anastasiadis, P.Z., S.Y. Moon, M.A. Thoreson, D.J. Mariner, H.C. Crawford, Y. Zheng, and A.B. Reynolds. 2000. Inhibition of RhoA by p120 catenin. Nat. Cell Biol. 2:637-644.
4. Aono, S., S. Nakagawa, A.B. Reynolds, and M. Takeichi. 1999. p120(ctn) acts as an inhibitory regulator of cadherin function in colon carcinoma cells. J. Cell Biol. 145:551-562.
5. Baki, L., P. Marambaud, S. Efthimiopoulos, A. Georgakopoulos, P. Wen, W. Cui, J. Shioi, E. Koo, M, Ozawa, V.L. Friedrich, Jr., and N.K. Robakis. 2001. Presenilin-1 binds cytoplasmic epithelial cadherin, inhibits cadherin/p120 association, and regulates stability and function of the cadherin/catenin adhesion complex. Proc. Natl. Acad. Sci. USA. 98:2381-2386.
6. Cox, R.T., C. Kirkpatrick, and M. Peifer. 1996. Armadillo is required for adherens junction assembly, cell polarity, and morphogenesis during Drosophila embryogenesis. J. Cell Biol. 134:133-148.
7. Duronio, R.J., and P.H. O'Farrell. 1994. Developmental control of a G1-S transcriptional program in Drosophila. Development. 120:1503-1515.
8. Green, K.J., and C.A. Gaudry. 2000. Are desmosomes more than tethers for intermediate filaments? Nat. Rev. Mol. Cell Biol. 1:208-216.
9. Ireton, R.C., M.A. Davis, J. van Hengel, D.J. Mariner, K. Barnes, M.A. Thoreson, P.Z. Anastasiadis, L. Matrisian, L.M. Bundy, L. Sealy, et al. 2002. A novel role for p120 catenin in E-cadherin function. J. Cell Biol. 159:465-476.
10. Kiehart, D.P., C.G. Galbraith, K.A. Edwards, W.L. Rickoll, and R.A. Montague. 2000. Multiple forces contribute to cell sheet morphogenesis for dorsal closure in Drosophila. J. Cell Biol. 149:471-490.
11. Kopan, R., and A. Goate. 2000. A common enzyme connects notch signaling and Alzheimer's disease. Genes Dev. 14:2799-2806.
12. Lu, Q., M. Paredes, M. Medina, J. Zhou, R. Cavallo, M. Peifer, L. Orecchio, and K. Kosik. 1999. δ-catenin, an adhesive junction associated protein which promotes cell scattering. J. CellBiol. 144:519-532.
13. Magie, C.R., D. Pinto-Santini, and S.M. Parkhurst. 2002. Rho1 interacts with p120(ctn) and alpha-catenin, and regulates cadherin-based adherens junction components in Drosophila. Development. 129:3771-3782.
14. McCartney, B.M., D.G. McEwen, E. Grevengoed, P. Maddox, A. Bejsovec, and M. Peifer. 2001. Drosophila APC2 and Armadillo participate in tethering mitotic spindles to cortical actin. Nat. Cell Biol. 3:933-938.
15. Noren, N.K., B.P. Liu, K. Burridge, and B. Kreft. 2000. p120 catenin regulates the actin cytoskeleton via Rho family GTPases. J. Cell Biol. 150:567-580.
16. Ohkubo, T., and M. Ozawa. 1999. p120(ctn) binds to the membrane-proximal region of the E-cadherin cytoplasmic domain and is involved in modulation of adhesion activity. J. Biol. Chem. 274:21409-21415.
17. Ozawa, M., and R. Kemler. 1998. The membrane-proximal region of the E-cadherin cytoplasmic domain prevents dimerization and negatively regulates adhesion activity. J. Cell Biol. 142:1605-1613.
18. Pacquelet, A., L. Lin, and P. Rørth. 2003. Binding site for p120/δ-catenin is not required for Drosophila E-cadherin function in vivo. J. Cell Biol. 160:313-319.
19. Pai, L.-M., C. Kirkpatrick, J. Blanton, H. Oda, M. Takeichi, and M. Peifer. 1996. Drosophila α-catenin and E-cadherin bind to distinct regions of Drosophila Armadillo. J. Biol. Chem. 271:32411-32420.
20. Peifer, M. 1993. The product of the Drosophila segment polarity gene armadillo is part of a multi-protein complex resembling the vertebrate adherens junction. J. Cell Sci. 105:993-1000.
21. Reynolds, A.B., J. Daniel, P. McCrea, M.J. Wheelock, J. Wu, and Z. Zhang. 1994. Identification of a new catenin: the tyrosine kinase substrate p120cas associates with E-cadherin complexes. Mol. Cell. Biol. 14:8333-8342.
22. Settleman, J. 2001. Rac 'n Rho: the music that shapes a developing embryo. Dev. Cell. 1:321-331.
23. Tepass, U., E. Gruszyṅski-DeFeo, T.A. Haag, L. Omatyar, T. Török, and V. Hartenstein. 1996. shotgun encodes Drosophila E-cadherin and is preferentially required during cell rearrangement in the neurectoderm and other morphogenetically active epithelia. Genes Dev. 10:672-685.
24. Tepass, U., G. Tanentzapf, R. Ward, and R. Fehon. 2001. Epithelial cell polarity and cell junctions in Drosophila. Annu. Rev. Genet. 35:747-784.
25. Thoreson, M.A., P.Z. Anastasiadis, J.M. Daniel, R.C. Ireton, M.J. Wheelock, K.R. Johnson, D.K. Hummingbird, and A.B. Reynolds. 2000. Selective uncoupling of p120(ctn) from E-cadherin disrupts strong adhesion. J. Cell Biol. 148:189-202.
26. Uemura, T., H. Oda, R. Kraut, S. Hayashi, Y. Kotaoka, and M. Takeichi. 1996. Zygotic Drosophila E-cadherin expression is required for processes of dynamic epithelial cell rearrangement in the Drosophila embryo. Genes Dev. 10:659-671.
27. Wieschaus, E., and C. Nüsslein-Volhard. 1986. Looking at embryos. In Drosophila, A Practical Approach. D.B. Roberts, editor. IRL Press, Oxford, UK. 199-228.
28. Yap, A.S., W.M. Brieher, and B.M. Gumbiner. 1997. Molecular and functional analysis of cadherin-based adherens junctions. Annu. Rev. Cell Dev. Biol. 13:119-146.
29. Yap, A.S., C.M. Niessen, and B.M. Gumbiner. 1998. The juxtamembrane region of the cadherin cytoplasmic tail supports lateral clustering, adhesive strengthening, and interaction with p120ctn. J. Cell Biol. 141:779-789.