Accommodation of a 1S-(-)-benzo[c]phenanthrenyl-N6-dA adduct in the Y-family Dpo4 DNA polymerase active site: Structural insights through molecular dynamics simulations

Chemical Research in Toxicology

Volumn 18, Issue 3, 2005, Pages 441-456

  Wang, Lihua ^a   Wu, Min ^a,c   Yan, S Frank ^a,d   Patel, Dinshaw J ^b   Geacintov, Nicholas E ^a   Broyde, Suse ^a,b  

^a NEW YORK UNIVERSITY   (United States)

^b MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^c PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

^d GENOMICS INSTITUTE OF THE NOVARTIS RESEARCH FOUNDATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENINE; BENZO[C]PHENANTHRIDINE DERIVATIVE; DEOXYADENOSINE TRIPHOSPHATE; DEOXYGUANOSINE TRIPHOSPHATE; DEOXYRIBONUCLEOSIDE TRIPHOSPHATE; DNA POLYMERASE; POLYCYCLIC AROMATIC HYDROCARBON;

ARTICLE; CARCINOGENESIS; DNA ADDUCT; ENZYME ACTIVE SITE; MOLECULAR DYNAMICS; MOLECULAR MODEL; MUTATION; PROTEIN FAMILY; SIMULATION; STEREOCHEMISTRY; STRUCTURE ANALYSIS;

CARCINOGENS; COMPUTER SIMULATION; DNA ADDUCTS; DNA POLYMERASE BETA; MODELS, MOLECULAR; PHENANTHRENES;

EID: 15344345083     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx049786v     Document Type: Article

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