Varied molecular interactions at the active sites of several DNA polymerases: Nonpolar nucleoside isosteres as probes

Journal of the American Chemical Society

Volumn 122, Issue 6, 2000, Pages 1001-1007

  Morales, Juan C ^a,b   Kool, Eric T ^a,b  

^a UNIVERSITY OF ROCHESTER   (United States)

^b STANFORD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DEOXYADENOSINE DERIVATIVE; DNA; DNA POLYMERASE; NUCLEOSIDE; RNA DIRECTED DNA POLYMERASE; THYMIDINE DERIVATIVE;

ARTICLE; AUTORADIOGRAPHY; AVIAN MYELOBLASTOSIS VIRUS; DNA SEQUENCE; DNA STRUCTURE; ENZYME ACTIVITY; ENZYME ANALYSIS; HUMAN; HYDROGEN BOND; MOLECULAR INTERACTION; MOLONEY LEUKEMIA ONCOVIRUS; NONHUMAN; PROTEIN DNA INTERACTION; STEADY STATE; THERMUS AQUATICUS;

EID: 0034673294     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja993464+     Document Type: Article

References (49)

1. (a) Huang, H.; Chopra, R.; Verdine, G. L.; Harrison, S. C. Science 1998, 282, 1669-1675.
2. (b) Li, Y.; Korolev, S.; Waksman, G. EMBO J. 1998, 17, 7514-7525.
3. (c) Doublié, S.; Tabor, S.; Long A. M.; Richardson, C. C.; Ellenberger, T. Nature 1998, 391, 251-258.
4. (d) Pelletier, H.; Sawaya, M. R.; Kumar, A.; Wilson, S. H. Science, 1994, 264, 1891-1903.
5. (e) Sawaya, M. R.; Prasad, R.; Wilson, S. H.; Kraut, J.; Pelletier, H. Biochemistry 1997, 36, 11205-11215.
6. (f) Kiefer, J. R.; Mao, C.; Braman, J. C.; Beese, L. S. Nature 1998, 391, 304-307.
7. (g) Eom, S. H.; Wang, J.; Steitz, T. A. Nature 1996, 382, 278-281.
8. (h) Beese, L. S.; Derbyshire, V.; Steitz, T. A. Science 1993, 260, 352-355.
9. (i) Brautigam, C. A.; Sun, S.; Piccirilli, J. A.; Steitz, T. A. Biochemistry 1999, 38, 696-704.
10. (j) Georgiadis, M. M.; Jessen, S. M.; Ogata, C. M.; Telesnitsky, A.; Goff, S. P.; Hendrickson, W. A. Structure 1995, 3, 879-892.
11. (k) Wang, J.; Sattar, A. K. M. A.; Wang, C. C.; Konigsberg, W. H.; Steitz, T. A. Cell 1997, 89, 1087-1099.
12. (a) Loeb, L. A.; Kunkel, T. A. Annu. Rev. Biochem. 1982, 52, 429-457.
13. (b) Kuchta, R. D.; Mizrahi, V.; Benkovic, P. A.; Johnson, K. A.; Benkovic, S. J. Biochemistry 1987, 26, 8410-8417.
14. (c) Kuchta, R. D.; Benkovic, P. A.; Benkovic, S. J. Biochemistry 1988, 27, 6716-6725.
15. (d) Wong, I.; Patel, S. S.; Johnson, K. A. Biochemistry 1991, 30, 526-537.
16. (e) Kornberg, A.; Baker, T. A. DNA Replication, 2nd ed.; W. H. Freeman: New York, 1992.
17. (f) Carroll, S. S.; Benkovic, S. J. Chem. Rev. 1990, 90, 1291-1307.
18. (g) Echols, H.; Goodman, M. F. Annu. Rev. Biochem. 1991, 60, 477-511.
19. (h) Petruska, J.; Goodman, M. F. J. Biol. Chem. 1995, 270, 746-750.
20. (i) Law, S. M.; Eritja, R.; Goodman, M. F.; Breslauer, K. J. Biochemistry 1996, 35, 12329-12337.
21. (a) Kunkel, T. A.; Wilson, S. H. Nat. Struct. Biol. 1998, 5, 95-99.
22. (b) Beard, W. A.; Wilson, S. H. Chem. Biol. 1998, 5, R7-R13.
23. (a) Polesky, A. H.; Steitz, T. A.; Grindley, N. D. F.; Joyce, C. M. J. Biol. Chem. 1990, 265, 14579-14591.
24. (b) Polesky, A. H.; Dahlberg, M. E.; Benkovic, S. J.; Grindley, N. D. F.; Joyce, C. M. J. Biol. Chem. 1992, 267, 8417-8428.
25. (c) Beard, W. A.; Osheroff, W. P.; Prasad, R.; Sawaya, M. R.; Jaju, M.; Wood, T. G.; Kraut, J.; Kunkel, T. A.; Wilson, S. H. J. Biol. Chem. 1996, 271, 12141-12144.
26. (d) Ahn, J.; Werneburg, B.G.; Tsai, M.-D. Biochemistry 1997, 36, 1100-1107.
27. (e) Sarafianos, S. G.; Pandey, V. N.; Kaushik, N.; Modak, M. J. Biochemistry 1995, 34, 7207-7216.
28. (f) Bebenek, K.; Beard, W. A.; Darden, T. A.; Prasad, R.; Luxon, B. A.; Gorenstein, D. G.; Wilson, S. H.; Kunkel, T. A. Nat. Struct. Biol. 1997, 4, 194-197.
29. Spratt, T. E. Biochemistry 1997, 36, 13292-13297.
30. Guo, M.-J.; Hidbrand, S.; Leumann, C. J.; McLaughlin, L. W.; Waring, M. Nucleic Acids Res. 1998, 26, 1863-1869.
31. Cosstick, R.; Li, X.; Tuli, D. K.; Williams, D. M.; Connoly, B. A.; Newman, P. C. Nucleic Acids Res. 1990, 18, 4771-4778.
32. (a) Schweitzer, B. A.; Kool, E. T. J. Org. Chem. 1994, 59, 7238.
33. (b) Moran, S.; Ren, R. X.-F.; Sheils, C. J.; Kool, E. T. Nucleic Acids Res. 1996, 24, 2044.
34. (c) Chaudhuri, N. C.; Ren, R. X.-F.; Kool, E. T. Synlett 1997, 341.
35. (d) Guckian, K. M.; Kool, E. T. Angew. Chem., Int. Ed. 1998, 36, 22825-22828.
36. (e) Guckian, K. M.; Morales, J. C.; Kool, E. T. J. Org. Chem. 1998, 63, 9652-9656.
37. (f) Guckian, K. M.; Krugh, T. R.; Kool, E. T. 2000, manuscript submitted for publication.
38. (a) Moran, S.; Ren, R. X.-F.; Rumney, S.; Kool, E. T. J. Am. Chem. Soc. 1997, 119, 2056-2057.
39. (b) Moran, S.; Ren, R. X.-F.; Kool, E. T. Proc. Natl. Acad. Sci. U.S.A. 1997, 94, 10506-10511.
40. (c) Liu, D.; Moran, S.; Kool, E. T. Chem. Biol. 1997, 4, 919-926.
41. (d) Morales, J. C.; Kool, E. T. Nature Struct. Biol. 1998, 5, 950-954.
42. (a) Kool, E. T. Biopolymers (Nucleic Acid Sci.) 1998, 48, 3-17.
43. (b) Kool, E. T.; Morales, J. C.; Guckian, K. M. Angew. Chem. 1999, in press.
44. Morales, J. C.; Kool, E. T. J. Am. Chem. Soc. 1999, 121, 2323-2324.
45. Gao, J. Biophys. Chem. 1994, 51, 253-261.
46. Horlacher, J.; Hottiger, M.; Podust, V. N.; Hübscher, U.; Benner, S. A. Proc. Natl. Acad. Sci. U.S.A. 1995, 92, 6329-6333.
47. Schweitzer, B. A.; Kool, E. T. J. Am. Chem. Soc. 1995, 117, 1863-1872.
48. (a) Goodman, M. F.; Creighton, S.; Bloom, L. B.; Petruska, J. Crit. Rev. Bioch. Mol. Biol. 1993, 28, 83-126.
49. (b) Fygenson, D. K.; Goodman, M. F. J. Biol. Chem. 1997, 272, 27931-27935.