A thymidine triphosphate shape analog lacking Watson-Crick pairing ability is replicated with high sequence selectivity

Proceedings of the National Academy of Sciences of the United States of America

Volumn 94, Issue 20, 1997, Pages 10506-10511

  Moran, Sean ^a   Ren, Rex X F ^a   Kool, Eric T ^a,b  

^a UNIVERSITY OF ROCHESTER   (United States)

^b UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

Author keywords

Base stacking; Hydrogen bonding; Klenow fragment; Nonpolar isostere; Replication fidelity

Indexed keywords

DIFLUOROTOLUENE DEOXYNUCLEOSIDE 5' TRIPHOSPHATE; DNA DIRECTED DNA POLYMERASE BETA; NUCLEOTIDE DERIVATIVE; THYMIDINE TRIPHOSPHATE; UNCLASSIFIED DRUG;

ARTICLE; BASE PAIRING; CONTROLLED STUDY; DNA REPLICATION; DNA SEQUENCE; HYDROGEN BOND; PRIORITY JOURNAL;

BASE COMPOSITION; DNA POLYMERASE I; HYDROGEN BONDING; KINETICS; NUCLEIC ACID CONFORMATION; NUCLEIC ACID DENATURATION; SUBSTRATE SPECIFICITY; THYMINE NUCLEOTIDES;

ESCHERICHIA COLI;

EID: 0030967829     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.94.20.10506     Document Type: Article

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