-
1
-
-
0037317763
-
Innate immune sensing and its roots: The story of endotoxin
-
Beutler B and Rietschel ET (2003) Innate immune sensing and its roots: the story of endotoxin. Nat Rev Immunol 3: 169-176
-
(2003)
Nat Rev Immunol
, vol.3
, pp. 169-176
-
-
Beutler, B.1
Rietschel, E.T.2
-
2
-
-
0019345977
-
Direct action of bacterial endotoxin on cells, mitochondria, and lysosomes
-
Bradley SG (1981) Direct action of bacterial endotoxin on cells, mitochondria, and lysosomes. Prog Clin Biol Res 62: 3-14
-
(1981)
Prog Clin Biol Res
, vol.62
, pp. 3-14
-
-
Bradley, S.G.1
-
3
-
-
0022371461
-
Identity of tumour necrosis factor and the macrophage-secreted factor cachectin
-
Beutler B et al. (1985) Identity of tumour necrosis factor and the macrophage-secreted factor cachectin. Nature 316: 552-554
-
(1985)
Nature
, vol.316
, pp. 552-554
-
-
Beutler, B.1
-
4
-
-
0023734898
-
Tumor necrosis factor and endotoxin induce similar metabolic responses in human beings
-
Michie HR et al. (1988) Tumor necrosis factor and endotoxin induce similar metabolic responses in human beings. Surgery 104: 280-286
-
(1988)
Surgery
, vol.104
, pp. 280-286
-
-
Michie, H.R.1
-
5
-
-
0023028369
-
Shock and tissue injury induced by recombinant human cachectin
-
Tracey KJ et al. (1986) Shock and tissue injury induced by recombinant human cachectin. Science 234: 470-474
-
(1986)
Science
, vol.234
, pp. 470-474
-
-
Tracey, K.J.1
-
6
-
-
0009535079
-
Synergy between tumor necrosis factor and bacterial products causes hemorrhagic necrosis and lethal shock in normal mice
-
Rothstein JL and Schreiber H (1988) Synergy between tumor necrosis factor and bacterial products causes hemorrhagic necrosis and lethal shock in normal mice. Proc Natl Acad Sci USA 85: 607-611
-
(1988)
Proc Natl Acad Sci USA
, vol.85
, pp. 607-611
-
-
Rothstein, J.L.1
Schreiber, H.2
-
7
-
-
0030831210
-
A human homologue of the Drosophila Toll protein signals activation of adaptive immunity
-
Medzhitov R et al. (1997) A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature 388: 394-397
-
(1997)
Nature
, vol.388
, pp. 394-397
-
-
Medzhitov, R.1
-
8
-
-
0032509295
-
Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: Mutations in Tlr4 gene
-
Poltorak A et al. (1998) Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science 282: 2085-2088
-
(1998)
Science
, vol.282
, pp. 2085-2088
-
-
Poltorak, A.1
-
9
-
-
3142724031
-
Toll-like receptor signalling
-
Akira S and Takeda K (2004) Toll-like receptor signalling. Nat Rev Immunol 4: 499-511
-
(2004)
Nat Rev Immunol
, vol.4
, pp. 499-511
-
-
Akira, S.1
Takeda, K.2
-
10
-
-
32944464648
-
Pathogen recognition and innate immunity
-
Akira S et al. (2006) Pathogen recognition and innate immunity. Cell 124: 783-801
-
(2006)
Cell
, vol.124
, pp. 783-801
-
-
Akira, S.1
-
11
-
-
5444234216
-
The interface between innate and adaptive immunity
-
Hoebe K et al. (2004) The interface between innate and adaptive immunity. Nat Immunol 5: 971-974
-
(2004)
Nat Immunol
, vol.5
, pp. 971-974
-
-
Hoebe, K.1
-
12
-
-
2442592788
-
+ T cell survival
-
+ T cell survival. J Immunol 172: 6065-6073
-
(2004)
J Immunol
, vol.172
, pp. 6065-6073
-
-
Gelman, A.E.1
-
13
-
-
27844541797
-
Control of B-cell responses by Toll-like receptors
-
Pasare C and Medzhitov R (2005) Control of B-cell responses by Toll-like receptors. Nature 438: 364-368
-
(2005)
Nature
, vol.438
, pp. 364-368
-
-
Pasare, C.1
Medzhitov, R.2
-
14
-
-
4344627821
-
Endogenous ligands of Toll-like receptors
-
Tsan MF and Gao B (2004) Endogenous ligands of Toll-like receptors. J Leukoc Biol 76: 514-519
-
(2004)
J Leukoc Biol
, vol.76
, pp. 514-519
-
-
Tsan, M.F.1
Gao, B.2
-
15
-
-
0035877013
-
An essential role of the NF-kappa B/Toll-like receptor pathway in induction of inflammatory and tissue-repair gene expression by necrotic cells
-
Li M et al. (2001) An essential role of the NF-kappa B/Toll-like receptor pathway in induction of inflammatory and tissue-repair gene expression by necrotic cells. J Immunol 166: 7128-7135
-
(2001)
J Immunol
, vol.166
, pp. 7128-7135
-
-
Li, M.1
-
16
-
-
0037177833
-
HSP70 as endogenous stimulus of the Toll/interleukin-1 receptor signal pathway
-
Vabulas RM et al. (2002) HSP70 as endogenous stimulus of the Toll/interleukin-1 receptor signal pathway. J Biol Chem 277: 15107-15112
-
(2002)
J Biol Chem
, vol.277
, pp. 15107-15112
-
-
Vabulas, R.M.1
-
17
-
-
16244376480
-
Toll-like receptors, endogenous ligands, and systemic autoimmune disease
-
Rifkin IR et al. (2005) Toll-like receptors, endogenous ligands, and systemic autoimmune disease. Immunol Rev 204: 27-42
-
(2005)
Immunol Rev
, vol.204
, pp. 27-42
-
-
Rifkin, I.R.1
-
18
-
-
22244483788
-
Imiquimod: In superficial basal cell carcinoma
-
Oldfield V et al. (2005) Imiquimod: in superficial basal cell carcinoma. Am J Clin Dermatol 6: 195-200
-
(2005)
Am J Clin Dermatol
, vol.6
, pp. 195-200
-
-
Oldfield, V.1
-
19
-
-
14044279966
-
Toll-like receptor 4 on nonhematopoietic cells sustains CNS inflammation during endotoxemia, independent of systemic cytokines
-
Chakravarty S and Herkenham M (2005) Toll-like receptor 4 on nonhematopoietic cells sustains CNS inflammation during endotoxemia, independent of systemic cytokines. J Neurosci 25: 1788-1796
-
(2005)
J Neurosci
, vol.25
, pp. 1788-1796
-
-
Chakravarty, S.1
Herkenham, M.2
-
21
-
-
0035371187
-
In vivo expression of proinflammatory mediators in the adult heart after endotoxin administration: The role of toll-like receptor-4
-
Baumgarten G et al. (2001) In vivo expression of proinflammatory mediators in the adult heart after endotoxin administration: the role of toll-like receptor-4. J Infect Dis 183: 1617-1624
-
(2001)
J Infect Dis
, vol.183
, pp. 1617-1624
-
-
Baumgarten, G.1
-
22
-
-
0033779915
-
Endotoxin and cytokine regulation of toll-like receptor (TLR) 2 and TLR4 gene expression in murine liver and hepatocytes
-
Matsumura T et al. (2000) Endotoxin and cytokine regulation of toll-like receptor (TLR) 2 and TLR4 gene expression in murine liver and hepatocytes. J Interferon Cytokine Res 20: 915-921
-
(2000)
J Interferon Cytokine Res
, vol.20
, pp. 915-921
-
-
Matsumura, T.1
-
23
-
-
26444571820
-
Renal-associated TLR2 mediates ischemia/reperfusion injury in the kidney
-
Leemans JC et al. (2005) Renal-associated TLR2 mediates ischemia/reperfusion injury in the kidney. J Clin Invest 115: 2894-2903
-
(2005)
J Clin Invest
, vol.115
, pp. 2894-2903
-
-
Leemans, J.C.1
-
24
-
-
0036467357
-
In vivo expression of Toll-like receptor 2 and 4 by renal epithelial cells: IFN-γ and TNF-α mediated up-regulation during inflammation
-
Wolfs TG et al. (2002) In vivo expression of Toll-like receptor 2 and 4 by renal epithelial cells: IFN-γ and TNF-α mediated up-regulation during inflammation. J Immunol 168: 1286-1293
-
(2002)
J Immunol
, vol.168
, pp. 1286-1293
-
-
Wolfs, T.G.1
-
25
-
-
0842321773
-
Role of Toll-like receptor 4 in endotoxin-induced acute renal failure
-
Cunningham PN et al. (2004) Role of Toll-like receptor 4 in endotoxin-induced acute renal failure. J Immunol 172: 2629-2635
-
(2004)
J Immunol
, vol.172
, pp. 2629-2635
-
-
Cunningham, P.N.1
-
26
-
-
33644814101
-
Donor polymorphisms in Toll-like receptor-4 influence the development of rejection after renal transplantation
-
Palmer SM et al. (2006) Donor polymorphisms in Toll-like receptor-4 influence the development of rejection after renal transplantation. Clin Transplant 20: 30-36
-
(2006)
Clin Transplant
, vol.20
, pp. 30-36
-
-
Palmer, S.M.1
-
27
-
-
4644298916
-
Minireview: Functions of the renal tract epithelium in coordinating the innate immune response to infection
-
Chowdhury P et al. (2004) Minireview: functions of the renal tract epithelium in coordinating the innate immune response to infection. Kidney Int 66: 1334-1344
-
(2004)
Kidney Int
, vol.66
, pp. 1334-1344
-
-
Chowdhury, P.1
-
28
-
-
1642275654
-
Signaling danger: Toll-like receptors and their potential roles in kidney disease
-
Anders HJ et al. (2004) Signaling danger: toll-like receptors and their potential roles in kidney disease. J Am Soc Nephrol 15: 854-867
-
(2004)
J Am Soc Nephrol
, vol.15
, pp. 854-867
-
-
Anders, H.J.1
-
29
-
-
0141559415
-
Leucine-rich repeats and pathogen recognition in Toll-like receptors
-
Bell JK et al. (2003) Leucine-rich repeats and pathogen recognition in Toll-like receptors. Trends Immunol 24: 528-533
-
(2003)
Trends Immunol
, vol.24
, pp. 528-533
-
-
Bell, J.K.1
-
30
-
-
0032524335
-
MyD88, an adapter protein involved in interleukin-1 signaling
-
Burns K et al. (1998) MyD88, an adapter protein involved in interleukin-1 signaling. J Biol Chem 273: 12203-12209
-
(1998)
J Biol Chem
, vol.273
, pp. 12203-12209
-
-
Burns, K.1
-
31
-
-
0030694108
-
IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling
-
Muzio M et al. (1997) IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling. Science 278: 1612-1615
-
(1997)
Science
, vol.278
, pp. 1612-1615
-
-
Muzio, M.1
-
32
-
-
0034084163
-
Phosphorylation meets ubiquitination: The control of NF-κB activity
-
Karin M and Ben-Neriah Y (2000) Phosphorylation meets ubiquitination: the control of NF-κB activity. Annu Rev Immunol 18: 621-663
-
(2000)
Annu Rev Immunol
, vol.18
, pp. 621-663
-
-
Karin, M.1
Ben-Neriah, Y.2
-
33
-
-
0038792224
-
Map kinase signaling pathways and hematologic malignancies
-
Platanias LC (2003) Map kinase signaling pathways and hematologic malignancies. Blood 101: 4667-4679
-
(2003)
Blood
, vol.101
, pp. 4667-4679
-
-
Platanias, L.C.1
-
34
-
-
27744496768
-
The biology of p38 kinase: A central role in inflammation
-
Schieven GL (2005) The biology of p38 kinase: a central role in inflammation. Curr Top Med Chem 5: 921-928
-
(2005)
Curr Top Med Chem
, vol.5
, pp. 921-928
-
-
Schieven, G.L.1
-
35
-
-
0347997608
-
MAPK signal pathways in the regulation of cell proliferation in mammalian cells
-
Zhang W and Liu HT (2002) MAPK signal pathways in the regulation of cell proliferation in mammalian cells. Cell Res 12: 9-18
-
(2002)
Cell Res
, vol.12
, pp. 9-18
-
-
Zhang, W.1
Liu, H.T.2
-
36
-
-
0033580466
-
The kinase TAK1 can activate the NIK-IκB as well as the MAP kinase cascade in the IL-1 signalling pathway
-
Ninomiya-Tsuji J et al. (1999) The kinase TAK1 can activate the NIK-IκB as well as the MAP kinase cascade in the IL-1 signalling pathway. Nature 398: 252-256
-
(1999)
Nature
, vol.398
, pp. 252-256
-
-
Ninomiya-Tsuji, J.1
-
37
-
-
0141532262
-
Toll-like receptor signaling
-
Akira S (2003) Toll-like receptor signaling. J Biol Chem 278: 38105-38108
-
(2003)
J Biol Chem
, vol.278
, pp. 38105-38108
-
-
Akira, S.1
-
38
-
-
0037672694
-
Myeloid differentiation factor 88-dependent and -independent pathways in toll-like receptor signaling
-
Akira S and Hoshino K (2003) Myeloid differentiation factor 88-dependent and -independent pathways in toll-like receptor signaling. J Infect Dis 187 (Suppl 2): S356-S363
-
(2003)
J Infect Dis
, vol.187
, Issue.2 SUPPL.
-
-
Akira, S.1
Hoshino, K.2
-
39
-
-
0036781941
-
Urinary soluble CD14 mediates human proximal tubular epithelial cell injury induced by LPS
-
Bussolati B et al. (2002) Urinary soluble CD14 mediates human proximal tubular epithelial cell injury induced by LPS. Int J Mol Med 10: 441-449
-
(2002)
Int J Mol Med
, vol.10
, pp. 441-449
-
-
Bussolati, B.1
-
40
-
-
0030460595
-
Regulation of Fas and Fas ligand expression in cultured murine renal cells and in the kidney during endotoxemia
-
Ortiz-Arduan A et al. (1996) Regulation of Fas and Fas ligand expression in cultured murine renal cells and in the kidney during endotoxemia. Am J Physiol 271: F1193-F1201
-
(1996)
Am J Physiol
, vol.271
-
-
Ortiz-Arduan, A.1
-
41
-
-
0036082273
-
Effects of microinjection of synthetic Bcl-2 domain peptides on apoptosis of renal tubular epithelial cells
-
Peherstorfer E et al. (2002) Effects of microinjection of synthetic Bcl-2 domain peptides on apoptosis of renal tubular epithelial cells. Am J Physiol Renal Physiol 283: F190-F196
-
(2002)
Am J Physiol Renal Physiol
, vol.283
-
-
Peherstorfer, E.1
-
42
-
-
0035071005
-
Apoptosis in sepsis: A new target for therapeutic exploration
-
Oberholzer C et al. (2001) Apoptosis in sepsis: a new target for therapeutic exploration. FASEB J 15: 879-892
-
(2001)
FASEB J
, vol.15
, pp. 879-892
-
-
Oberholzer, C.1
-
43
-
-
9644283015
-
Acute renal failure in endotoxemia is dependent on caspase activation
-
Guo R et al. (2004) Acute renal failure in endotoxemia is dependent on caspase activation. J Am Soc Nephrol 15: 3093-3102
-
(2004)
J Am Soc Nephrol
, vol.15
, pp. 3093-3102
-
-
Guo, R.1
-
44
-
-
0036172129
-
The Fas-associated death domain protein suppresses activation of NF-κB by LPS and IL-1β
-
Bannerman DD et al. (2002) The Fas-associated death domain protein suppresses activation of NF-κB by LPS and IL-1β. J Clin Invest 109: 419-425
-
(2002)
J Clin Invest
, vol.109
, pp. 419-425
-
-
Bannerman, D.D.1
-
45
-
-
0036199932
-
Apoptosis and NF-κB: The FADD connection
-
Duckett CS (2002) Apoptosis and NF-κB: the FADD connection. J Clin Invest 109: 579-580
-
(2002)
J Clin Invest
, vol.109
, pp. 579-580
-
-
Duckett, C.S.1
-
46
-
-
0033618630
-
Cell activation and apoptosis by bacterial lipoproteins through toll-like receptor-2
-
Aliprantis AO et al. (1999) Cell activation and apoptosis by bacterial lipoproteins through toll-like receptor-2. Science 285: 736-739
-
(1999)
Science
, vol.285
, pp. 736-739
-
-
Aliprantis, A.O.1
-
47
-
-
0034601057
-
The apoptotic signaling pathway activated by Toll-like receptor-2
-
Aliprantis AO et al. (2000) The apoptotic signaling pathway activated by Toll-like receptor-2. EMBO J 19: 3325-3336
-
(2000)
EMBO J
, vol.19
, pp. 3325-3336
-
-
Aliprantis, A.O.1
-
48
-
-
17144413785
-
Apoptosis induced by the toll-like receptor adaptor TRIF is dependent on its receptor interacting protein homotypic interaction motif
-
Kaiser WJ and Offermann MK (2005) Apoptosis induced by the toll-like receptor adaptor TRIF is dependent on its receptor interacting protein homotypic interaction motif. J Immunol 174: 4942-4952
-
(2005)
J Immunol
, vol.174
, pp. 4942-4952
-
-
Kaiser, W.J.1
Offermann, M.K.2
-
49
-
-
0036604216
-
Acute renal failure in endotoxemia is caused by TNF acting directly on TNF receptor-1 in kidney
-
Cunningham PN et al. (2002) Acute renal failure in endotoxemia is caused by TNF acting directly on TNF receptor-1 in kidney. J Immunol 168: 5817-5823
-
(2002)
J Immunol
, vol.168
, pp. 5817-5823
-
-
Cunningham, P.N.1
-
50
-
-
0029890385
-
Tissue remodeling during tumor necrosis factor-induced apoptosis in LLC-PK1 renal epithelial cells
-
Peralta Soler A et al. (1996) Tissue remodeling during tumor necrosis factor-induced apoptosis in LLC-PK1 renal epithelial cells. Am J Physiol 270: F869-F879
-
(1996)
Am J Physiol
, vol.270
-
-
Peralta Soler, A.1
-
51
-
-
0037080024
-
Tissue expression of human Toll-like receptors and differential regulation of Toll-like receptor mRNAs in leukocytes in response to microbes, their products, and cytokines
-
Zarember KA and Godowski PJ (2002) Tissue expression of human Toll-like receptors and differential regulation of Toll-like receptor mRNAs in leukocytes in response to microbes, their products, and cytokines. J Immunol 168: 554-561
-
(2002)
J Immunol
, vol.168
, pp. 554-561
-
-
Zarember, K.A.1
Godowski, P.J.2
-
52
-
-
19644362276
-
Tissue-specific mRNA expression profiles of human toll-like receptors and related genes
-
Nishimura M and Naito S (2005) Tissue-specific mRNA expression profiles of human toll-like receptors and related genes. Biol Pharm Bull 28: 886-892
-
(2005)
Biol Pharm Bull
, vol.28
, pp. 886-892
-
-
Nishimura, M.1
Naito, S.2
-
53
-
-
0035076194
-
Induction of innate immune responses by Escherichia coli and purified lipopolysaccharide correlate with organ- And cell-specific expression of Toll-like receptors within the human urinary tract
-
Backhed F et al. (2001) Induction of innate immune responses by Escherichia coli and purified lipopolysaccharide correlate with organ- and cell-specific expression of Toll-like receptors within the human urinary tract. Cell Microbiol 3: 153-158
-
(2001)
Cell Microbiol
, vol.3
, pp. 153-158
-
-
Backhed, F.1
-
54
-
-
0037103247
-
Roles of toll-like receptors in C-C chemokine production by renal tubular epithelial cells
-
Tsuboi N et al. (2002) Roles of toll-like receptors in C-C chemokine production by renal tubular epithelial cells. J Immunol 169: 2026-2033
-
(2002)
J Immunol
, vol.169
, pp. 2026-2033
-
-
Tsuboi, N.1
-
55
-
-
23944497673
-
Viral double-stranded RNA aggravates lupus nephritis through Toll-like receptor 3 on glomerular mesangial cells and antigen-presenting cells
-
Patole PS et al. (2005) Viral double-stranded RNA aggravates lupus nephritis through Toll-like receptor 3 on glomerular mesangial cells and antigen-presenting cells. J Am Soc Nephrol 16: 1326-1338
-
(2005)
J Am Soc Nephrol
, vol.16
, pp. 1326-1338
-
-
Patole, P.S.1
-
56
-
-
33144487115
-
Novel role of toll-like receptor 3 in hepatitis C-associated glomerulonephritis
-
Wornle M et al. (2006) Novel role of toll-like receptor 3 in hepatitis C-associated glomerulonephritis. Am J Pathol 168: 370-385
-
(2006)
Am J Pathol
, vol.168
, pp. 370-385
-
-
Wornle, M.1
-
57
-
-
0037307507
-
Bacterial CpG-DNA aggravates immune complex glomerulonephritis: Role of TLR9-mediated expression of chemokines and chemokine receptors
-
Anders HJ et al. (2003) Bacterial CpG-DNA aggravates immune complex glomerulonephritis: role of TLR9-mediated expression of chemokines and chemokine receptors. J Am Soc Nephrol 14: 317-326
-
(2003)
J Am Soc Nephrol
, vol.14
, pp. 317-326
-
-
Anders, H.J.1
-
58
-
-
1642396952
-
Activation of toll-like receptor-9 induces progression of renal disease in MRL-Fas(lpr) mice
-
Anders HJ et al. (2004) Activation of toll-like receptor-9 induces progression of renal disease in MRL-Fas(lpr) mice. FASEB J 18: 534-536
-
(2004)
FASEB J
, vol.18
, pp. 534-536
-
-
Anders, H.J.1
-
59
-
-
33644515263
-
Toll-like receptor-7 modulates immune complex glomerulonephritis
-
Pawar RD et al. (2006) Toll-like receptor-7 modulates immune complex glomerulonephritis. J Am Soc Nephrol 17: 141-149
-
(2006)
J Am Soc Nephrol
, vol.17
, pp. 141-149
-
-
Pawar, R.D.1
-
60
-
-
1542377424
-
A toll-like receptor that prevents infection by uropathogenic bacteria
-
Zhang D et al. (2004) A toll-like receptor that prevents infection by uropathogenic bacteria. Science 303: 1522-1526
-
(2004)
Science
, vol.303
, pp. 1522-1526
-
-
Zhang, D.1
-
61
-
-
19644364807
-
Ischemia-reperfusion injury activates innate immunity in rat kidneys
-
Kim BS et al. (2005) Ischemia-reperfusion injury activates innate immunity in rat kidneys. Transplantation 79: 1370-1377
-
(2005)
Transplantation
, vol.79
, pp. 1370-1377
-
-
Kim, B.S.1
-
62
-
-
25644433465
-
Cyclosporine-induced renal injury induces toll-like receptor and maturation of dendritic cells
-
Lim SW et al. (2005) Cyclosporine-induced renal injury induces toll-like receptor and maturation of dendritic cells. Transplantation 80: 691-699
-
(2005)
Transplantation
, vol.80
, pp. 691-699
-
-
Lim, S.W.1
-
63
-
-
2542530840
-
Toll-like receptor 4 expression and cytokine responses in the human urinary tract mucosa
-
Samuelsson P et al. (2004) Toll-like receptor 4 expression and cytokine responses in the human urinary tract mucosa. Infect Immun 72: 3179-3186
-
(2004)
Infect Immun
, vol.72
, pp. 3179-3186
-
-
Samuelsson, P.1
-
64
-
-
0141453904
-
Developmental aspects of Escherichia coli-induced innate responses in rat renal epithelial cells
-
Laestadius A et al. (2003) Developmental aspects of Escherichia coli-induced innate responses in rat renal epithelial cells. Pediatr Res 54: 536-541
-
(2003)
Pediatr Res
, vol.54
, pp. 536-541
-
-
Laestadius, A.1
-
65
-
-
33646578794
-
Sepsis induces changes in the expression and distribution of Toll-like receptor 4 in the rat kidney
-
El-Achkar TM et al. (2006) Sepsis induces changes in the expression and distribution of Toll-like receptor 4 in the rat kidney. Am J Physiol Renal Physiol 290: F1034-F1043
-
(2006)
Am J Physiol Renal Physiol
, vol.290
-
-
El-Achkar, T.M.1
-
66
-
-
0141608641
-
The enigma of sepsis
-
Riedemann NC et al. (2003) The enigma of sepsis. J Clin Invest 112: 460-467
-
(2003)
J Clin Invest
, vol.112
, pp. 460-467
-
-
Riedemann, N.C.1
-
67
-
-
0037426726
-
The pathophysiology and treatment of sepsis
-
Hotchkiss RS and Karl IE (2003) The pathophysiology and treatment of sepsis. N Engl J Med 348: 138-150
-
(2003)
N Engl J Med
, vol.348
, pp. 138-150
-
-
Hotchkiss, R.S.1
Karl, I.E.2
-
68
-
-
0037180768
-
The immunopathogenesis of sepsis
-
Cohen J (2002) The immunopathogenesis of sepsis. Nature 420: 885-891
-
(2002)
Nature
, vol.420
, pp. 885-891
-
-
Cohen, J.1
-
69
-
-
0016294676
-
Genetic control of responses to bacterial lipopolysaccharides in mice. I. Evidence for a single gene that influences mitogenic and immunogenic responses to lipopolysaccharides
-
Watson J and Riblet R (1974) Genetic control of responses to bacterial lipopolysaccharides in mice. I. Evidence for a single gene that influences mitogenic and immunogenic responses to lipopolysaccharides. J Exp Med 140: 1147-1161
-
(1974)
J Exp Med
, vol.140
, pp. 1147-1161
-
-
Watson, J.1
Riblet, R.2
-
70
-
-
0014425756
-
Genetic control of leucocyte responses to endotoxin
-
Sultzer BM (1968) Genetic control of leucocyte responses to endotoxin. Nature 219: 1253-1254
-
(1968)
Nature
, vol.219
, pp. 1253-1254
-
-
Sultzer, B.M.1
-
71
-
-
0017752368
-
Genetic analysis of generation of serum interferon by bacterial lipopolysaccharide
-
Apte RN et al. (1977) Genetic analysis of generation of serum interferon by bacterial lipopolysaccharide. J Immunol 119: 1898-1902
-
(1977)
J Immunol
, vol.119
, pp. 1898-1902
-
-
Apte, R.N.1
-
72
-
-
0023690962
-
Mouse genetic locus Lps influences susceptibility to Neisseria meningitidis infection
-
Woods JP et al. (1988) Mouse genetic locus Lps influences susceptibility to Neisseria meningitidis infection. Infect Immun 56: 1950-1955
-
(1988)
Infect Immun
, vol.56
, pp. 1950-1955
-
-
Woods, J.P.1
-
73
-
-
0018841829
-
Genetic control of susceptibility to Salmonella typhimurium in mice: Role of the LPS gene
-
O'Brien AD et al. (1980) Genetic control of susceptibility to Salmonella typhimurium in mice: role of the LPS gene. J Immunol 124: 20-24
-
(1980)
J Immunol
, vol.124
, pp. 20-24
-
-
O'Brien, A.D.1
-
74
-
-
3142634845
-
Acute renal failure and sepsis
-
Schrier RW and Wang W (2004) Acute renal failure and sepsis. N Engl J Med 351: 159-169
-
(2004)
N Engl J Med
, vol.351
, pp. 159-169
-
-
Schrier, R.W.1
Wang, W.2
-
75
-
-
0344686275
-
The pathogenesis of septic acute renal failure
-
Wan L et al. (2003) The pathogenesis of septic acute renal failure. Curr Opin Crit Care 9: 496-502
-
(2003)
Curr Opin Crit Care
, vol.9
, pp. 496-502
-
-
Wan, L.1
-
76
-
-
0034999831
-
Endotoxemic renal failure in mice: Role of tumor necrosis factor independent of inducible nitric oxide synthase
-
Knotek M et al. (2001) Endotoxemic renal failure in mice: role of tumor necrosis factor independent of inducible nitric oxide synthase. Kidney Int 59: 2243-2249
-
(2001)
Kidney Int
, vol.59
, pp. 2243-2249
-
-
Knotek, M.1
-
77
-
-
0026585007
-
Anti-tumor necrosis factor antibody therapy fails to prevent lethality after cecal ligation and puncture or endotoxemia
-
Eskandari MK et al. (1992) Anti-tumor necrosis factor antibody therapy fails to prevent lethality after cecal ligation and puncture or endotoxemia. J Immunol 148: 2724-2730
-
(1992)
J Immunol
, vol.148
, pp. 2724-2730
-
-
Eskandari, M.K.1
-
78
-
-
0024513550
-
Tumor necrosis factor induces glomerular damage in the rabbit
-
Bertani T et al. (1989) Tumor necrosis factor induces glomerular damage in the rabbit. Am J Pathol 134: 419-430
-
(1989)
Am J Pathol
, vol.134
, pp. 419-430
-
-
Bertani, T.1
-
79
-
-
22344453543
-
Ischemic proximal tubular injury primes mice to endotoxin-induced TNF-α generation and systemic release
-
Zager RA et al. (2005) Ischemic proximal tubular injury primes mice to endotoxin-induced TNF-α generation and systemic release. Am J Physiol Renal Physiol 289: F289-F297
-
(2005)
Am J Physiol Renal Physiol
, vol.289
-
-
Zager, R.A.1
-
80
-
-
0037477629
-
Activation of innate immunity in the CNS triggers neurodegeneration through a Toll-like receptor 4-dependent pathway
-
Lehnardt S et al. (2003) Activation of innate immunity in the CNS triggers neurodegeneration through a Toll-like receptor 4-dependent pathway. Proc Natl Acad Sci USA 100: 8514-8519
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 8514-8519
-
-
Lehnardt, S.1
-
81
-
-
0028929534
-
Murine CD14 gene expression in vivo: Extramyeloid synthesis and regulation by lipopolysaccharide
-
Fearns C et al. (1995) Murine CD14 gene expression in vivo: extramyeloid synthesis and regulation by lipopolysaccharide. J Exp Med 181: 857-866
-
(1995)
J Exp Med
, vol.181
, pp. 857-866
-
-
Fearns, C.1
-
82
-
-
0033840086
-
Induction of CD14 in tubular epithelial cells during kidney disease
-
Morrissey J et al. (2000) Induction of CD14 in tubular epithelial cells during kidney disease. J Am Soc Nephrol 11: 1681-1690
-
(2000)
J Am Soc Nephrol
, vol.11
, pp. 1681-1690
-
-
Morrissey, J.1
-
83
-
-
0027446922
-
Lipopolysaccharide activation of human endothelial and epithelial cells is mediated by lipopolysaccharide-binding protein and soluble CD14
-
Pugin J et al. (1993) Lipopolysaccharide activation of human endothelial and epithelial cells is mediated by lipopolysaccharide-binding protein and soluble CD14. Proc Natl Acad Sci USA 90: 2744-2748
-
(1993)
Proc Natl Acad Sci USA
, vol.90
, pp. 2744-2748
-
-
Pugin, J.1
-
84
-
-
0030829208
-
Role of tumor necrosis factor alpha in induction of murine CD14 gene expression by lipopolysaccharide
-
Fearns C and Loskutoff DJ (1997) Role of tumor necrosis factor alpha in induction of murine CD14 gene expression by lipopolysaccharide. Infect Immun 65: 4822-4831
-
(1997)
Infect Immun
, vol.65
, pp. 4822-4831
-
-
Fearns, C.1
Loskutoff, D.J.2
-
85
-
-
3142690482
-
TLR4 is the signaling but not the lipopolysaccharide uptake receptor
-
Dunzendorfer S et al. (2004) TLR4 is the signaling but not the lipopolysaccharide uptake receptor. J Immunol 173: 1166-1170
-
(2004)
J Immunol
, vol.173
, pp. 1166-1170
-
-
Dunzendorfer, S.1
-
86
-
-
10344264453
-
Cutting edge: TLR4 activation mediates liver ischemia/reperfusion inflammatory response via IFN regulatory factor 3-dependent MyD88-independent pathway
-
Zhai Y et al. (2004) Cutting edge: TLR4 activation mediates liver ischemia/reperfusion inflammatory response via IFN regulatory factor 3-dependent MyD88-independent pathway. J Immunol 173: 7115-7119
-
(2004)
J Immunol
, vol.173
, pp. 7115-7119
-
-
Zhai, Y.1
-
87
-
-
22844436646
-
Toll-like receptor and heme oxygenase-1 signaling in hepatic ischemia/reperfusion injury
-
Shen XD et al. (2005) Toll-like receptor and heme oxygenase-1 signaling in hepatic ischemia/reperfusion injury. Am J Transplant 5: 1793-1800
-
(2005)
Am J Transplant
, vol.5
, pp. 1793-1800
-
-
Shen, X.D.1
-
88
-
-
3242769906
-
Toll-like receptor 4 mediates ischemia/reperfusion injury of the heart
-
Chong AJ et al. (2004) Toll-like receptor 4 mediates ischemia/reperfusion injury of the heart. J Thorac Cardiovasc Surg 128: 170-179
-
(2004)
J Thorac Cardiovasc Surg
, vol.128
, pp. 170-179
-
-
Chong, A.J.1
-
89
-
-
0345599171
-
Toll-like receptor-2 modulates ventricular remodeling after myocardial infarction
-
Shishido T et al. (2003) Toll-like receptor-2 modulates ventricular remodeling after myocardial infarction. Circulation 108: 2905-2910
-
(2003)
Circulation
, vol.108
, pp. 2905-2910
-
-
Shishido, T.1
-
90
-
-
0034650427
-
Cutting edge: Heat shock protein 60 is a putative endogenous ligand of the tolllike receptor-4 complex
-
Ohashi K et al. (2000) Cutting edge: heat shock protein 60 is a putative endogenous ligand of the tolllike receptor-4 complex. J Immunol 164: 558-561
-
(2000)
J Immunol
, vol.164
, pp. 558-561
-
-
Ohashi, K.1
-
91
-
-
0035909372
-
Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3
-
Alexopoulou L et al. (2001) Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3. Nature 413: 732-738
-
(2001)
Nature
, vol.413
, pp. 732-738
-
-
Alexopoulou, L.1
-
92
-
-
0023176617
-
Neutrophil recruitment and bacterial clearance correlated with LPS responsiveness in local gram-negative infection
-
Shahin RD et al. (1987) Neutrophil recruitment and bacterial clearance correlated with LPS responsiveness in local gram-negative infection. J Immunol 138: 3475-3480
-
(1987)
J Immunol
, vol.138
, pp. 3475-3480
-
-
Shahin, R.D.1
-
93
-
-
0033389454
-
Neutrophil recruitment and resistance to urinary tract infection
-
Haraoka M et al. (1999) Neutrophil recruitment and resistance to urinary tract infection. J Infect Dis 180: 1220-1229
-
(1999)
J Infect Dis
, vol.180
, pp. 1220-1229
-
-
Haraoka, M.1
-
94
-
-
0035282686
-
Toll-like receptor signaling and chemokine receptor expression influence the severity of urinary tract infection
-
Svanborg C et al. (2001) Toll-like receptor signaling and chemokine receptor expression influence the severity of urinary tract infection. J Infect Dis 183 (Suppl 1): S61-S65
-
(2001)
J Infect Dis
, vol.183
, Issue.1 SUPPL.
-
-
Svanborg, C.1
-
95
-
-
0037388307
-
Toll-like receptor 4 on stromal and hematopoietic cells mediates innate resistance to uropathogenic Escherichia coli
-
Schilling JD et al. (2003) Toll-like receptor 4 on stromal and hematopoietic cells mediates innate resistance to uropathogenic Escherichia coli. Proc Natl Acad Sci USA 100: 4203-4208
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 4203-4208
-
-
Schilling, J.D.1
-
96
-
-
32844466826
-
Toll-like receptor-4: Renal cells and bone marrow cells signal for neutrophil recruitment during pyelonephritis
-
Patole PS et al. (2005) Toll-like receptor-4: renal cells and bone marrow cells signal for neutrophil recruitment during pyelonephritis. Kidney Int 68: 2582-2587
-
(2005)
Kidney Int
, vol.68
, pp. 2582-2587
-
-
Patole, P.S.1
-
97
-
-
0035135138
-
Type 1 fimbriae deliver an LPS- And TLR4-dependent activation signal to CD14-negative cells
-
Hedlund M et al. (2001) Type 1 fimbriae deliver an LPS- and TLR4-dependent activation signal to CD14-negative cells. Mol Microbiol 39: 542-552
-
(2001)
Mol Microbiol
, vol.39
, pp. 542-552
-
-
Hedlund, M.1
-
98
-
-
0035044165
-
Escherichia coli P fimbriae utilize the Toll-like receptor 4 pathway for cell activation
-
Frendeus B et al. (2001) Escherichia coli P fimbriae utilize the Toll-like receptor 4 pathway for cell activation. Mol Microbiol 40: 37-51
-
(2001)
Mol Microbiol
, vol.40
, pp. 37-51
-
-
Frendeus, B.1
-
99
-
-
0037369767
-
CD14- And Toll-like receptor-dependent activation of bladder epithelial cells by lipopolysaccharide and type 1 piliated Escherichia coli
-
Schilling JD et al. (2003) CD14- and Toll-like receptor-dependent activation of bladder epithelial cells by lipopolysaccharide and type 1 piliated Escherichia coli. Infect Immun 71: 1470-1480
-
(2003)
Infect Immun
, vol.71
, pp. 1470-1480
-
-
Schilling, J.D.1
-
100
-
-
0036672050
-
TLR4-dependent recognition of lipopolysaccharide by epithelial cells requires sCD14
-
Backhed F et al. (2002) TLR4-dependent recognition of lipopolysaccharide by epithelial cells requires sCD14. Cell Microbiol 4: 493-501
-
(2002)
Cell Microbiol
, vol.4
, pp. 493-501
-
-
Backhed, F.1
-
101
-
-
0141620216
-
Tamm-Horsfall glycoprotein: Biology and clinical relevance
-
Serafini-Cessi F et al. (2003) Tamm-Horsfall glycoprotein: biology and clinical relevance. Am J Kidney Dis 42: 658-676
-
(2003)
Am J Kidney Dis
, vol.42
, pp. 658-676
-
-
Serafini-Cessi, F.1
-
102
-
-
0019328660
-
Tamm-Horsfall protein or uromucoid is the normal urinary slime that traps type 1 fimbriated Escherichia coli
-
Orskov I et al. (1980) Tamm-Horsfall protein or uromucoid is the normal urinary slime that traps type 1 fimbriated Escherichia coli. Lancet 1: 887
-
(1980)
Lancet
, vol.1
, pp. 887
-
-
Orskov, I.1
-
103
-
-
0023695035
-
Identification of factors in human urine that inhibit the binding of Escherichia coli adhesins
-
Parkkinen J et al. (1988) Identification of factors in human urine that inhibit the binding of Escherichia coli adhesins. Infect Immun 56: 2623-2630
-
(1988)
Infect Immun
, vol.56
, pp. 2623-2630
-
-
Parkkinen, J.1
-
104
-
-
0035971077
-
Tamm-Horsfall protein binds to type 1 fimbriated Escherichia coli and prevents E. coli from binding to uroplakin Ia and Ib receptors
-
Pak J et al. (2001) Tamm-Horsfall protein binds to type 1 fimbriated Escherichia coli and prevents E. coli from binding to uroplakin Ia and Ib receptors. J Biol Chem 276: 9924-9930
-
(2001)
J Biol Chem
, vol.276
, pp. 9924-9930
-
-
Pak, J.1
-
105
-
-
1342322652
-
Tamm-Horsfall protein knockout mice are more prone to urinary tract infection: Rapid communication
-
Bates JM et al. (2004) Tamm-Horsfall protein knockout mice are more prone to urinary tract infection: rapid communication. Kidney Int 65: 791-797
-
(2004)
Kidney Int
, vol.65
, pp. 791-797
-
-
Bates, J.M.1
-
106
-
-
20144373629
-
Tamm-Horsfall glycoprotein links innate immune cell activation with adaptive immunity via a Toll-like receptor-4-dependent mechanism
-
Saemann MD et al. (2005) Tamm-Horsfall glycoprotein links innate immune cell activation with adaptive immunity via a Toll-like receptor-4-dependent mechanism. J Clin Invest 115: 468-475
-
(2005)
J Clin Invest
, vol.115
, pp. 468-475
-
-
Saemann, M.D.1
-
107
-
-
0035875835
-
Heat shock proteins, anti-heat shock protein reactivity and allograft rejection
-
Pockley AG (2001) Heat shock proteins, anti-heat shock protein reactivity and allograft rejection. Transplantation 71: 1503-1507
-
(2001)
Transplantation
, vol.71
, pp. 1503-1507
-
-
Pockley, A.G.1
-
108
-
-
0037974914
-
Critical role of the Toll-like receptor signal adaptor protein MyD88 in acute allograft rejection
-
Goldstein DR et al. (2003) Critical role of the Toll-like receptor signal adaptor protein MyD88 in acute allograft rejection. J Clin Invest 111: 1571-1578
-
(2003)
J Clin Invest
, vol.111
, pp. 1571-1578
-
-
Goldstein, D.R.1
-
109
-
-
0037183894
-
Cytomegalovirus seromismatching increases the risk of acute renal allograft rejection
-
McLaughlin K et al. (2002) Cytomegalovirus seromismatching increases the risk of acute renal allograft rejection. Transplantation 74: 813-816
-
(2002)
Transplantation
, vol.74
, pp. 813-816
-
-
McLaughlin, K.1
-
110
-
-
4344703413
-
TH1 immune responses to fully MHC mismatched allografts are diminished in the absence of MyD88, a toll-like receptor signal adaptor protein
-
Tesar BM et al. (2004) TH1 immune responses to fully MHC mismatched allografts are diminished in the absence of MyD88, a toll-like receptor signal adaptor protein. Am J Transplant 4: 1429-1439
-
(2004)
Am J Transplant
, vol.4
, pp. 1429-1439
-
-
Tesar, B.M.1
-
111
-
-
0034084438
-
TLR4 mutations are associated with endotoxin hyporesponsiveness in humans
-
Arbour NC et al. (2000) TLR4 mutations are associated with endotoxin hyporesponsiveness in humans. Nat Genet 25: 187-191
-
(2000)
Nat Genet
, vol.25
, pp. 187-191
-
-
Arbour, N.C.1
-
112
-
-
23044480567
-
Relevance of Toll-like receptor-4 polymorphisms in renal transplantation
-
Ducloux D et al. (2005) Relevance of Toll-like receptor-4 polymorphisms in renal transplantation. Kidney Int 67: 2454-2461
-
(2005)
Kidney Int
, vol.67
, pp. 2454-2461
-
-
Ducloux, D.1
-
113
-
-
0037207471
-
Cell biology of the glomerular podocyte
-
Pavenstadt H et al. (2003) Cell biology of the glomerular podocyte. Physiol Rev 83: 253-307
-
(2003)
Physiol Rev
, vol.83
, pp. 253-307
-
-
Pavenstadt, H.1
-
114
-
-
85047691168
-
Induction of B7-1 in podocytes is associated with nephrotic syndrome
-
Reiser J et al. (2004) Induction of B7-1 in podocytes is associated with nephrotic syndrome. J Clin Invest 113: 1390-1397
-
(2004)
J Clin Invest
, vol.113
, pp. 1390-1397
-
-
Reiser, J.1
-
115
-
-
0347146027
-
Upregulation of costimulatory molecules induced by lipopolysaccharide and double-stranded RNA occurs by Trif-dependent and Trif-independent pathways
-
Hoebe K et al. (2003) Upregulation of costimulatory molecules induced by lipopolysaccharide and double-stranded RNA occurs by Trif-dependent and Trif-independent pathways. Nat Immunol 4: 1223-1229
-
(2003)
Nat Immunol
, vol.4
, pp. 1223-1229
-
-
Hoebe, K.1
-
116
-
-
0015058519
-
Regulation of the immune system by synthetic polynucleotides. I. Characteristics of adjuvant action on antibody synthesis
-
Schmidtke JR and Johnson AG (1971) Regulation of the immune system by synthetic polynucleotides. I. Characteristics of adjuvant action on antibody synthesis. J Immunol 106: 1191-1200
-
(1971)
J Immunol
, vol.106
, pp. 1191-1200
-
-
Schmidtke, J.R.1
Johnson, A.G.2
-
117
-
-
0345883301
-
Effect of meningococcal endotoxin on the immune response
-
Condie RM et al. (1955) Effect of meningococcal endotoxin on the immune response. Proc Soc Exp Biol Med 90: 355-360
-
(1955)
Proc Soc Exp Biol Med
, vol.90
, pp. 355-360
-
-
Condie, R.M.1
-
118
-
-
0037061453
-
Chromatin-IgG complexes activate B cells by dual engagement of IgM and Tolllike receptors
-
Leadbetter EA et al. (2002) Chromatin-IgG complexes activate B cells by dual engagement of IgM and Tolllike receptors. Nature 416: 603-607
-
(2002)
Nature
, vol.416
, pp. 603-607
-
-
Leadbetter, E.A.1
-
119
-
-
22944490869
-
Toll-like receptor 9 controls anti-DNA autoantibody production in murine lupus
-
Christensen SR et al. (2005) Toll-like receptor 9 controls anti-DNA autoantibody production in murine lupus. J Exp Med 202: 321-331
-
(2005)
J Exp Med
, vol.202
, pp. 321-331
-
-
Christensen, S.R.1
-
120
-
-
0034619794
-
A Toll-like receptor recognizes bacterial DNA
-
Hemmi H et al. (2000) A Toll-like receptor recognizes bacterial DNA. Nature 408: 740-745
-
(2000)
Nature
, vol.408
, pp. 740-745
-
-
Hemmi, H.1
-
121
-
-
85047693371
-
Human lupus autoantibody-DNA complexes activate DCs through cooperation of CD32 and TLR9
-
Means TK et al. (2005) Human lupus autoantibody-DNA complexes activate DCs through cooperation of CD32 and TLR9. J Clin Invest 115: 407-417
-
(2005)
J Clin Invest
, vol.115
, pp. 407-417
-
-
Means, T.K.1
-
122
-
-
0035905409
-
A pivotal role for the natural interferon alpha-producing cells (plasmacytoid dendritic cells) in the pathogenesis of lupus
-
Ronnblom L and Alm GV (2001) A pivotal role for the natural interferon alpha-producing cells (plasmacytoid dendritic cells) in the pathogenesis of lupus. J Exp Med 194: F59-F63
-
(2001)
J Exp Med
, vol.194
-
-
Ronnblom, L.1
Alm, G.V.2
-
123
-
-
31044440025
-
Toll-like receptor 9 signaling protects against murine lupus
-
Wu X and Peng SL (2006) Toll-like receptor 9 signaling protects against murine lupus. Arthritis Rheum 54: 336-342
-
(2006)
Arthritis Rheum
, vol.54
, pp. 336-342
-
-
Wu, X.1
Peng, S.L.2
-
124
-
-
3042548183
-
Toll-like receptor 9-dependent and -independent dendritic cell activation by chromatin-immunoglobulin G complexes
-
Boule MW et al. (2004) Toll-like receptor 9-dependent and -independent dendritic cell activation by chromatin-immunoglobulin G complexes. J Exp Med 199: 1631-1640
-
(2004)
J Exp Med
, vol.199
, pp. 1631-1640
-
-
Boule, M.W.1
-
125
-
-
14844291442
-
Association study of Toll-like receptor 9 gene polymorphism in Korean patients with systemic lupus erythematosus
-
Hur JW et al. (2005) Association study of Toll-like receptor 9 gene polymorphism in Korean patients with systemic lupus erythematosus. Tissue Antigens 65: 266-270
-
(2005)
Tissue Antigens
, vol.65
, pp. 266-270
-
-
Hur, J.W.1
-
126
-
-
1642521633
-
Polymorphisms of toll-like receptor 2 and 4 genes in rheumatoid arthritis and systemic lupus erythematosus
-
Sanchez E et al. (2004) Polymorphisms of toll-like receptor 2 and 4 genes in rheumatoid arthritis and systemic lupus erythematosus. Tissue Antigens 63: 54-57
-
(2004)
Tissue Antigens
, vol.63
, pp. 54-57
-
-
Sanchez, E.1
-
127
-
-
33144458473
-
G-rich DNA suppresses systemic lupus
-
Patole PS et al. (2005) G-rich DNA suppresses systemic lupus. J Am Soc Nephrol 16: 3273-3280
-
(2005)
J Am Soc Nephrol
, vol.16
, pp. 3273-3280
-
-
Patole, P.S.1
-
128
-
-
1542317578
-
Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8
-
Heil F et al. (2004) Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8. Science 303: 1526-1529
-
(2004)
Science
, vol.303
, pp. 1526-1529
-
-
Heil, F.1
-
129
-
-
0035370526
-
Spliceosomal UsnRNP biogenesis, structure and function
-
Will CL and Luhrmann R (2001) Spliceosomal UsnRNP biogenesis, structure and function. Curr Opin Cell Biol 13: 290-301
-
(2001)
Curr Opin Cell Biol
, vol.13
, pp. 290-301
-
-
Will, C.L.1
Luhrmann, R.2
-
130
-
-
23044475966
-
A stop codon polymorphism of Toll-like receptor 5 is associated with resistance to systemic lupus erythematosus
-
Hawn TR et al. (2005) A stop codon polymorphism of Toll-like receptor 5 is associated with resistance to systemic lupus erythematosus. Proc Natl Acad Sci USA 102: 10593-10597
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 10593-10597
-
-
Hawn, T.R.1
-
131
-
-
1842631153
-
Immunotherapeutic uses of CpG oligodeoxynucleotides
-
Klinman DM (2004) Immunotherapeutic uses of CpG oligodeoxynucleotides. Nat Rev Immunol 4: 249-258
-
(2004)
Nat Rev Immunol
, vol.4
, pp. 249-258
-
-
Klinman, D.M.1
-
132
-
-
3142779901
-
Therapeutics targeting the innate immune system
-
Ulevitch RJ (2004) Therapeutics targeting the innate immune system. Nat Rev Immunol 4: 512-520
-
(2004)
Nat Rev Immunol
, vol.4
, pp. 512-520
-
-
Ulevitch, R.J.1
-
133
-
-
33644872282
-
Toll-like receptor therapies compete to reduce side effects
-
Schmidt C (2006) Toll-like receptor therapies compete to reduce side effects. Nat Biotechnol 24: 230-231
-
(2006)
Nat Biotechnol
, vol.24
, pp. 230-231
-
-
Schmidt, C.1
-
134
-
-
18144425200
-
TLR4 antagonists for endotoxemia and beyond
-
Rossignol DP and Lynn M (2005) TLR4 antagonists for endotoxemia and beyond. Curr Opin Investig Drugs 6: 496-502
-
(2005)
Curr Opin Investig Drugs
, vol.6
, pp. 496-502
-
-
Rossignol, D.P.1
Lynn, M.2
-
135
-
-
0036644042
-
Cutting edge: Role of Toll-like receptor 1 in mediating immune response to microbial lipoproteins
-
Takeuchi O et al. (2002) Cutting edge: role of Toll-like receptor 1 in mediating immune response to microbial lipoproteins. J Immunol 169: 10-14
-
(2002)
J Immunol
, vol.169
, pp. 10-14
-
-
Takeuchi, O.1
-
136
-
-
0033120081
-
Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product
-
Hoshino K et al. (1999) Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product. J Immunol 162: 3749-3752
-
(1999)
J Immunol
, vol.162
, pp. 3749-3752
-
-
Hoshino, K.1
-
137
-
-
0033580949
-
Peptidoglycan- And lipoteichoic acid-induced cell activation is mediated by toll-like receptor 2
-
Schwandner R et al. (1999) Peptidoglycan- and lipoteichoic acid-induced cell activation is mediated by toll-like receptor 2. J Biol Chem 274: 17406-17409
-
(1999)
J Biol Chem
, vol.274
, pp. 17406-17409
-
-
Schwandner, R.1
-
138
-
-
0033592748
-
The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens
-
Underhill DM et al. (1999) The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens. Nature 401: 811-815
-
(1999)
Nature
, vol.401
, pp. 811-815
-
-
Underhill, D.M.1
-
139
-
-
0036467447
-
Chlamydial heat shock protein 60 activates macrophages and endothelial cells through Toll-like receptor 4 and MD2 in a MyD88-dependent pathway
-
Bulut Y et al. (2002) Chlamydial heat shock protein 60 activates macrophages and endothelial cells through Toll-like receptor 4 and MD2 in a MyD88-dependent pathway. J Immunol 168: 1435-1440
-
(2002)
J Immunol
, vol.168
, pp. 1435-1440
-
-
Bulut, Y.1
-
140
-
-
0034723186
-
Mouse toll-like receptor 4.MD-2 complex mediates lipopolysaccharide- mimetic signal transduction by Taxol
-
Kawasaki K et al. (2000) Mouse toll-like receptor 4.MD-2 complex mediates lipopolysaccharide-mimetic signal transduction by Taxol. J Biol Chem 275: 2251-2254
-
(2000)
J Biol Chem
, vol.275
, pp. 2251-2254
-
-
Kawasaki, K.1
-
141
-
-
0035971217
-
The extra domain A of fibronectin activates Toll-like receptor 4
-
Okamura Y et al. (2001) The extra domain A of fibronectin activates Toll-like receptor 4. J Biol Chem 276: 10229-10233
-
(2001)
J Biol Chem
, vol.276
, pp. 10229-10233
-
-
Okamura, Y.1
-
142
-
-
0037033364
-
Oligosaccharides of Hyaluronan activate dendritic cells via toll-like receptor 4
-
Termeer C et al. (2002) Oligosaccharides of Hyaluronan activate dendritic cells via toll-like receptor 4. J Exp Med 195: 99-111
-
(2002)
J Exp Med
, vol.195
, pp. 99-111
-
-
Termeer, C.1
-
143
-
-
0035451118
-
Fibrinogen stimulates macrophage chemokine secretion through toll-like receptor 4
-
Smiley ST et al. (2001) Fibrinogen stimulates macrophage chemokine secretion through toll-like receptor 4. J Immunol 167: 2887-2894
-
(2001)
J Immunol
, vol.167
, pp. 2887-2894
-
-
Smiley, S.T.1
-
144
-
-
0037094084
-
Receptor-mediated monitoring of tissue well-being via detection of soluble heparan sulfate by Toll-like receptor 4
-
Johnson GB et al. (2002) Receptor-mediated monitoring of tissue well-being via detection of soluble heparan sulfate by Toll-like receptor 4. J Immunol 168: 5233-5239
-
(2002)
J Immunol
, vol.168
, pp. 5233-5239
-
-
Johnson, G.B.1
-
145
-
-
0035953543
-
The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5
-
Hayashi F et al. (2001) The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5. Nature 410: 1099-1103
-
(2001)
Nature
, vol.410
, pp. 1099-1103
-
-
Hayashi, F.1
-
146
-
-
0034610291
-
The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between toll-like receptors
-
Ozinsky A et al. (2000) The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between toll-like receptors. Proc Natl Acad Sci USA 97: 13766-13771
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 13766-13771
-
-
Ozinsky, A.1
-
147
-
-
0034922923
-
Discrimination of bacterial lipoproteins by Toll-like receptor 6
-
Takeuchi O et al. (2001) Discrimination of bacterial lipoproteins by Toll-like receptor 6. Int Immunol 13: 933-940
-
(2001)
Int Immunol
, vol.13
, pp. 933-940
-
-
Takeuchi, O.1
-
148
-
-
0036008014
-
Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway
-
Hemmi H et al. (2002) Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway. Nat Immunol 3: 196-200
-
(2002)
Nat Immunol
, vol.3
, pp. 196-200
-
-
Hemmi, H.1
-
149
-
-
0036088492
-
Human TLR7 or TLR8 independently confer responsiveness to the antiviral compound R-848
-
Jurk M et al. (2002) Human TLR7 or TLR8 independently confer responsiveness to the antiviral compound R-848. Nat Immunol 3: 499
-
(2002)
Nat Immunol
, vol.3
, pp. 499
-
-
Jurk, M.1
-
150
-
-
20644433342
-
TLR11 activation of dendritic cells by a protozoan profilin-like protein
-
Yarovinsky F et al. (2005) TLR11 activation of dendritic cells by a protozoan profilin-like protein. Science 308: 1626-1629
-
(2005)
Science
, vol.308
, pp. 1626-1629
-
-
Yarovinsky, F.1
|