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Volumn 2, Issue 10, 2006, Pages 568-581

Renal Toll-like receptors: Recent advances and implications for disease

Author keywords

Glomerulonephritis; Inflammation; Ischemia; Renal failure; Sepsis

Indexed keywords

ANTIINFECTIVE AGENT; CD14 ANTIGEN; CYTOKINE; LIGAND; LIPOPOLYSACCHARIDE; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4;

EID: 33749079461     PISSN: 17458323     EISSN: 17458331     Source Type: Journal    
DOI: 10.1038/ncpneph0300     Document Type: Review
Times cited : (57)

References (150)
  • 1
    • 0037317763 scopus 로고    scopus 로고
    • Innate immune sensing and its roots: The story of endotoxin
    • Beutler B and Rietschel ET (2003) Innate immune sensing and its roots: the story of endotoxin. Nat Rev Immunol 3: 169-176
    • (2003) Nat Rev Immunol , vol.3 , pp. 169-176
    • Beutler, B.1    Rietschel, E.T.2
  • 2
    • 0019345977 scopus 로고
    • Direct action of bacterial endotoxin on cells, mitochondria, and lysosomes
    • Bradley SG (1981) Direct action of bacterial endotoxin on cells, mitochondria, and lysosomes. Prog Clin Biol Res 62: 3-14
    • (1981) Prog Clin Biol Res , vol.62 , pp. 3-14
    • Bradley, S.G.1
  • 3
    • 0022371461 scopus 로고
    • Identity of tumour necrosis factor and the macrophage-secreted factor cachectin
    • Beutler B et al. (1985) Identity of tumour necrosis factor and the macrophage-secreted factor cachectin. Nature 316: 552-554
    • (1985) Nature , vol.316 , pp. 552-554
    • Beutler, B.1
  • 4
    • 0023734898 scopus 로고
    • Tumor necrosis factor and endotoxin induce similar metabolic responses in human beings
    • Michie HR et al. (1988) Tumor necrosis factor and endotoxin induce similar metabolic responses in human beings. Surgery 104: 280-286
    • (1988) Surgery , vol.104 , pp. 280-286
    • Michie, H.R.1
  • 5
    • 0023028369 scopus 로고
    • Shock and tissue injury induced by recombinant human cachectin
    • Tracey KJ et al. (1986) Shock and tissue injury induced by recombinant human cachectin. Science 234: 470-474
    • (1986) Science , vol.234 , pp. 470-474
    • Tracey, K.J.1
  • 6
    • 0009535079 scopus 로고
    • Synergy between tumor necrosis factor and bacterial products causes hemorrhagic necrosis and lethal shock in normal mice
    • Rothstein JL and Schreiber H (1988) Synergy between tumor necrosis factor and bacterial products causes hemorrhagic necrosis and lethal shock in normal mice. Proc Natl Acad Sci USA 85: 607-611
    • (1988) Proc Natl Acad Sci USA , vol.85 , pp. 607-611
    • Rothstein, J.L.1    Schreiber, H.2
  • 7
    • 0030831210 scopus 로고    scopus 로고
    • A human homologue of the Drosophila Toll protein signals activation of adaptive immunity
    • Medzhitov R et al. (1997) A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature 388: 394-397
    • (1997) Nature , vol.388 , pp. 394-397
    • Medzhitov, R.1
  • 8
    • 0032509295 scopus 로고    scopus 로고
    • Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: Mutations in Tlr4 gene
    • Poltorak A et al. (1998) Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science 282: 2085-2088
    • (1998) Science , vol.282 , pp. 2085-2088
    • Poltorak, A.1
  • 9
    • 3142724031 scopus 로고    scopus 로고
    • Toll-like receptor signalling
    • Akira S and Takeda K (2004) Toll-like receptor signalling. Nat Rev Immunol 4: 499-511
    • (2004) Nat Rev Immunol , vol.4 , pp. 499-511
    • Akira, S.1    Takeda, K.2
  • 10
    • 32944464648 scopus 로고    scopus 로고
    • Pathogen recognition and innate immunity
    • Akira S et al. (2006) Pathogen recognition and innate immunity. Cell 124: 783-801
    • (2006) Cell , vol.124 , pp. 783-801
    • Akira, S.1
  • 11
    • 5444234216 scopus 로고    scopus 로고
    • The interface between innate and adaptive immunity
    • Hoebe K et al. (2004) The interface between innate and adaptive immunity. Nat Immunol 5: 971-974
    • (2004) Nat Immunol , vol.5 , pp. 971-974
    • Hoebe, K.1
  • 12
    • 2442592788 scopus 로고    scopus 로고
    • + T cell survival
    • + T cell survival. J Immunol 172: 6065-6073
    • (2004) J Immunol , vol.172 , pp. 6065-6073
    • Gelman, A.E.1
  • 13
    • 27844541797 scopus 로고    scopus 로고
    • Control of B-cell responses by Toll-like receptors
    • Pasare C and Medzhitov R (2005) Control of B-cell responses by Toll-like receptors. Nature 438: 364-368
    • (2005) Nature , vol.438 , pp. 364-368
    • Pasare, C.1    Medzhitov, R.2
  • 14
    • 4344627821 scopus 로고    scopus 로고
    • Endogenous ligands of Toll-like receptors
    • Tsan MF and Gao B (2004) Endogenous ligands of Toll-like receptors. J Leukoc Biol 76: 514-519
    • (2004) J Leukoc Biol , vol.76 , pp. 514-519
    • Tsan, M.F.1    Gao, B.2
  • 15
    • 0035877013 scopus 로고    scopus 로고
    • An essential role of the NF-kappa B/Toll-like receptor pathway in induction of inflammatory and tissue-repair gene expression by necrotic cells
    • Li M et al. (2001) An essential role of the NF-kappa B/Toll-like receptor pathway in induction of inflammatory and tissue-repair gene expression by necrotic cells. J Immunol 166: 7128-7135
    • (2001) J Immunol , vol.166 , pp. 7128-7135
    • Li, M.1
  • 16
    • 0037177833 scopus 로고    scopus 로고
    • HSP70 as endogenous stimulus of the Toll/interleukin-1 receptor signal pathway
    • Vabulas RM et al. (2002) HSP70 as endogenous stimulus of the Toll/interleukin-1 receptor signal pathway. J Biol Chem 277: 15107-15112
    • (2002) J Biol Chem , vol.277 , pp. 15107-15112
    • Vabulas, R.M.1
  • 17
    • 16244376480 scopus 로고    scopus 로고
    • Toll-like receptors, endogenous ligands, and systemic autoimmune disease
    • Rifkin IR et al. (2005) Toll-like receptors, endogenous ligands, and systemic autoimmune disease. Immunol Rev 204: 27-42
    • (2005) Immunol Rev , vol.204 , pp. 27-42
    • Rifkin, I.R.1
  • 18
    • 22244483788 scopus 로고    scopus 로고
    • Imiquimod: In superficial basal cell carcinoma
    • Oldfield V et al. (2005) Imiquimod: in superficial basal cell carcinoma. Am J Clin Dermatol 6: 195-200
    • (2005) Am J Clin Dermatol , vol.6 , pp. 195-200
    • Oldfield, V.1
  • 19
    • 14044279966 scopus 로고    scopus 로고
    • Toll-like receptor 4 on nonhematopoietic cells sustains CNS inflammation during endotoxemia, independent of systemic cytokines
    • Chakravarty S and Herkenham M (2005) Toll-like receptor 4 on nonhematopoietic cells sustains CNS inflammation during endotoxemia, independent of systemic cytokines. J Neurosci 25: 1788-1796
    • (2005) J Neurosci , vol.25 , pp. 1788-1796
    • Chakravarty, S.1    Herkenham, M.2
  • 20
    • 1942485347 scopus 로고    scopus 로고
    • Toll-like receptors: Function and roles in lung disease
    • Basu S and Fenton MJ (2004) Toll-like receptors: function and roles in lung disease. Am J Physiol Lung Cell Mol Physiol 286: L887-L892
    • (2004) Am J Physiol Lung Cell Mol Physiol , vol.286
    • Basu, S.1    Fenton, M.J.2
  • 21
    • 0035371187 scopus 로고    scopus 로고
    • In vivo expression of proinflammatory mediators in the adult heart after endotoxin administration: The role of toll-like receptor-4
    • Baumgarten G et al. (2001) In vivo expression of proinflammatory mediators in the adult heart after endotoxin administration: the role of toll-like receptor-4. J Infect Dis 183: 1617-1624
    • (2001) J Infect Dis , vol.183 , pp. 1617-1624
    • Baumgarten, G.1
  • 22
    • 0033779915 scopus 로고    scopus 로고
    • Endotoxin and cytokine regulation of toll-like receptor (TLR) 2 and TLR4 gene expression in murine liver and hepatocytes
    • Matsumura T et al. (2000) Endotoxin and cytokine regulation of toll-like receptor (TLR) 2 and TLR4 gene expression in murine liver and hepatocytes. J Interferon Cytokine Res 20: 915-921
    • (2000) J Interferon Cytokine Res , vol.20 , pp. 915-921
    • Matsumura, T.1
  • 23
    • 26444571820 scopus 로고    scopus 로고
    • Renal-associated TLR2 mediates ischemia/reperfusion injury in the kidney
    • Leemans JC et al. (2005) Renal-associated TLR2 mediates ischemia/reperfusion injury in the kidney. J Clin Invest 115: 2894-2903
    • (2005) J Clin Invest , vol.115 , pp. 2894-2903
    • Leemans, J.C.1
  • 24
    • 0036467357 scopus 로고    scopus 로고
    • In vivo expression of Toll-like receptor 2 and 4 by renal epithelial cells: IFN-γ and TNF-α mediated up-regulation during inflammation
    • Wolfs TG et al. (2002) In vivo expression of Toll-like receptor 2 and 4 by renal epithelial cells: IFN-γ and TNF-α mediated up-regulation during inflammation. J Immunol 168: 1286-1293
    • (2002) J Immunol , vol.168 , pp. 1286-1293
    • Wolfs, T.G.1
  • 25
    • 0842321773 scopus 로고    scopus 로고
    • Role of Toll-like receptor 4 in endotoxin-induced acute renal failure
    • Cunningham PN et al. (2004) Role of Toll-like receptor 4 in endotoxin-induced acute renal failure. J Immunol 172: 2629-2635
    • (2004) J Immunol , vol.172 , pp. 2629-2635
    • Cunningham, P.N.1
  • 26
    • 33644814101 scopus 로고    scopus 로고
    • Donor polymorphisms in Toll-like receptor-4 influence the development of rejection after renal transplantation
    • Palmer SM et al. (2006) Donor polymorphisms in Toll-like receptor-4 influence the development of rejection after renal transplantation. Clin Transplant 20: 30-36
    • (2006) Clin Transplant , vol.20 , pp. 30-36
    • Palmer, S.M.1
  • 27
    • 4644298916 scopus 로고    scopus 로고
    • Minireview: Functions of the renal tract epithelium in coordinating the innate immune response to infection
    • Chowdhury P et al. (2004) Minireview: functions of the renal tract epithelium in coordinating the innate immune response to infection. Kidney Int 66: 1334-1344
    • (2004) Kidney Int , vol.66 , pp. 1334-1344
    • Chowdhury, P.1
  • 28
    • 1642275654 scopus 로고    scopus 로고
    • Signaling danger: Toll-like receptors and their potential roles in kidney disease
    • Anders HJ et al. (2004) Signaling danger: toll-like receptors and their potential roles in kidney disease. J Am Soc Nephrol 15: 854-867
    • (2004) J Am Soc Nephrol , vol.15 , pp. 854-867
    • Anders, H.J.1
  • 29
    • 0141559415 scopus 로고    scopus 로고
    • Leucine-rich repeats and pathogen recognition in Toll-like receptors
    • Bell JK et al. (2003) Leucine-rich repeats and pathogen recognition in Toll-like receptors. Trends Immunol 24: 528-533
    • (2003) Trends Immunol , vol.24 , pp. 528-533
    • Bell, J.K.1
  • 30
    • 0032524335 scopus 로고    scopus 로고
    • MyD88, an adapter protein involved in interleukin-1 signaling
    • Burns K et al. (1998) MyD88, an adapter protein involved in interleukin-1 signaling. J Biol Chem 273: 12203-12209
    • (1998) J Biol Chem , vol.273 , pp. 12203-12209
    • Burns, K.1
  • 31
    • 0030694108 scopus 로고    scopus 로고
    • IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling
    • Muzio M et al. (1997) IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling. Science 278: 1612-1615
    • (1997) Science , vol.278 , pp. 1612-1615
    • Muzio, M.1
  • 32
    • 0034084163 scopus 로고    scopus 로고
    • Phosphorylation meets ubiquitination: The control of NF-κB activity
    • Karin M and Ben-Neriah Y (2000) Phosphorylation meets ubiquitination: the control of NF-κB activity. Annu Rev Immunol 18: 621-663
    • (2000) Annu Rev Immunol , vol.18 , pp. 621-663
    • Karin, M.1    Ben-Neriah, Y.2
  • 33
    • 0038792224 scopus 로고    scopus 로고
    • Map kinase signaling pathways and hematologic malignancies
    • Platanias LC (2003) Map kinase signaling pathways and hematologic malignancies. Blood 101: 4667-4679
    • (2003) Blood , vol.101 , pp. 4667-4679
    • Platanias, L.C.1
  • 34
    • 27744496768 scopus 로고    scopus 로고
    • The biology of p38 kinase: A central role in inflammation
    • Schieven GL (2005) The biology of p38 kinase: a central role in inflammation. Curr Top Med Chem 5: 921-928
    • (2005) Curr Top Med Chem , vol.5 , pp. 921-928
    • Schieven, G.L.1
  • 35
    • 0347997608 scopus 로고    scopus 로고
    • MAPK signal pathways in the regulation of cell proliferation in mammalian cells
    • Zhang W and Liu HT (2002) MAPK signal pathways in the regulation of cell proliferation in mammalian cells. Cell Res 12: 9-18
    • (2002) Cell Res , vol.12 , pp. 9-18
    • Zhang, W.1    Liu, H.T.2
  • 36
    • 0033580466 scopus 로고    scopus 로고
    • The kinase TAK1 can activate the NIK-IκB as well as the MAP kinase cascade in the IL-1 signalling pathway
    • Ninomiya-Tsuji J et al. (1999) The kinase TAK1 can activate the NIK-IκB as well as the MAP kinase cascade in the IL-1 signalling pathway. Nature 398: 252-256
    • (1999) Nature , vol.398 , pp. 252-256
    • Ninomiya-Tsuji, J.1
  • 37
    • 0141532262 scopus 로고    scopus 로고
    • Toll-like receptor signaling
    • Akira S (2003) Toll-like receptor signaling. J Biol Chem 278: 38105-38108
    • (2003) J Biol Chem , vol.278 , pp. 38105-38108
    • Akira, S.1
  • 38
    • 0037672694 scopus 로고    scopus 로고
    • Myeloid differentiation factor 88-dependent and -independent pathways in toll-like receptor signaling
    • Akira S and Hoshino K (2003) Myeloid differentiation factor 88-dependent and -independent pathways in toll-like receptor signaling. J Infect Dis 187 (Suppl 2): S356-S363
    • (2003) J Infect Dis , vol.187 , Issue.2 SUPPL.
    • Akira, S.1    Hoshino, K.2
  • 39
    • 0036781941 scopus 로고    scopus 로고
    • Urinary soluble CD14 mediates human proximal tubular epithelial cell injury induced by LPS
    • Bussolati B et al. (2002) Urinary soluble CD14 mediates human proximal tubular epithelial cell injury induced by LPS. Int J Mol Med 10: 441-449
    • (2002) Int J Mol Med , vol.10 , pp. 441-449
    • Bussolati, B.1
  • 40
    • 0030460595 scopus 로고    scopus 로고
    • Regulation of Fas and Fas ligand expression in cultured murine renal cells and in the kidney during endotoxemia
    • Ortiz-Arduan A et al. (1996) Regulation of Fas and Fas ligand expression in cultured murine renal cells and in the kidney during endotoxemia. Am J Physiol 271: F1193-F1201
    • (1996) Am J Physiol , vol.271
    • Ortiz-Arduan, A.1
  • 41
    • 0036082273 scopus 로고    scopus 로고
    • Effects of microinjection of synthetic Bcl-2 domain peptides on apoptosis of renal tubular epithelial cells
    • Peherstorfer E et al. (2002) Effects of microinjection of synthetic Bcl-2 domain peptides on apoptosis of renal tubular epithelial cells. Am J Physiol Renal Physiol 283: F190-F196
    • (2002) Am J Physiol Renal Physiol , vol.283
    • Peherstorfer, E.1
  • 42
    • 0035071005 scopus 로고    scopus 로고
    • Apoptosis in sepsis: A new target for therapeutic exploration
    • Oberholzer C et al. (2001) Apoptosis in sepsis: a new target for therapeutic exploration. FASEB J 15: 879-892
    • (2001) FASEB J , vol.15 , pp. 879-892
    • Oberholzer, C.1
  • 43
    • 9644283015 scopus 로고    scopus 로고
    • Acute renal failure in endotoxemia is dependent on caspase activation
    • Guo R et al. (2004) Acute renal failure in endotoxemia is dependent on caspase activation. J Am Soc Nephrol 15: 3093-3102
    • (2004) J Am Soc Nephrol , vol.15 , pp. 3093-3102
    • Guo, R.1
  • 44
    • 0036172129 scopus 로고    scopus 로고
    • The Fas-associated death domain protein suppresses activation of NF-κB by LPS and IL-1β
    • Bannerman DD et al. (2002) The Fas-associated death domain protein suppresses activation of NF-κB by LPS and IL-1β. J Clin Invest 109: 419-425
    • (2002) J Clin Invest , vol.109 , pp. 419-425
    • Bannerman, D.D.1
  • 45
    • 0036199932 scopus 로고    scopus 로고
    • Apoptosis and NF-κB: The FADD connection
    • Duckett CS (2002) Apoptosis and NF-κB: the FADD connection. J Clin Invest 109: 579-580
    • (2002) J Clin Invest , vol.109 , pp. 579-580
    • Duckett, C.S.1
  • 46
    • 0033618630 scopus 로고    scopus 로고
    • Cell activation and apoptosis by bacterial lipoproteins through toll-like receptor-2
    • Aliprantis AO et al. (1999) Cell activation and apoptosis by bacterial lipoproteins through toll-like receptor-2. Science 285: 736-739
    • (1999) Science , vol.285 , pp. 736-739
    • Aliprantis, A.O.1
  • 47
    • 0034601057 scopus 로고    scopus 로고
    • The apoptotic signaling pathway activated by Toll-like receptor-2
    • Aliprantis AO et al. (2000) The apoptotic signaling pathway activated by Toll-like receptor-2. EMBO J 19: 3325-3336
    • (2000) EMBO J , vol.19 , pp. 3325-3336
    • Aliprantis, A.O.1
  • 48
    • 17144413785 scopus 로고    scopus 로고
    • Apoptosis induced by the toll-like receptor adaptor TRIF is dependent on its receptor interacting protein homotypic interaction motif
    • Kaiser WJ and Offermann MK (2005) Apoptosis induced by the toll-like receptor adaptor TRIF is dependent on its receptor interacting protein homotypic interaction motif. J Immunol 174: 4942-4952
    • (2005) J Immunol , vol.174 , pp. 4942-4952
    • Kaiser, W.J.1    Offermann, M.K.2
  • 49
    • 0036604216 scopus 로고    scopus 로고
    • Acute renal failure in endotoxemia is caused by TNF acting directly on TNF receptor-1 in kidney
    • Cunningham PN et al. (2002) Acute renal failure in endotoxemia is caused by TNF acting directly on TNF receptor-1 in kidney. J Immunol 168: 5817-5823
    • (2002) J Immunol , vol.168 , pp. 5817-5823
    • Cunningham, P.N.1
  • 50
    • 0029890385 scopus 로고    scopus 로고
    • Tissue remodeling during tumor necrosis factor-induced apoptosis in LLC-PK1 renal epithelial cells
    • Peralta Soler A et al. (1996) Tissue remodeling during tumor necrosis factor-induced apoptosis in LLC-PK1 renal epithelial cells. Am J Physiol 270: F869-F879
    • (1996) Am J Physiol , vol.270
    • Peralta Soler, A.1
  • 51
    • 0037080024 scopus 로고    scopus 로고
    • Tissue expression of human Toll-like receptors and differential regulation of Toll-like receptor mRNAs in leukocytes in response to microbes, their products, and cytokines
    • Zarember KA and Godowski PJ (2002) Tissue expression of human Toll-like receptors and differential regulation of Toll-like receptor mRNAs in leukocytes in response to microbes, their products, and cytokines. J Immunol 168: 554-561
    • (2002) J Immunol , vol.168 , pp. 554-561
    • Zarember, K.A.1    Godowski, P.J.2
  • 52
    • 19644362276 scopus 로고    scopus 로고
    • Tissue-specific mRNA expression profiles of human toll-like receptors and related genes
    • Nishimura M and Naito S (2005) Tissue-specific mRNA expression profiles of human toll-like receptors and related genes. Biol Pharm Bull 28: 886-892
    • (2005) Biol Pharm Bull , vol.28 , pp. 886-892
    • Nishimura, M.1    Naito, S.2
  • 53
    • 0035076194 scopus 로고    scopus 로고
    • Induction of innate immune responses by Escherichia coli and purified lipopolysaccharide correlate with organ- And cell-specific expression of Toll-like receptors within the human urinary tract
    • Backhed F et al. (2001) Induction of innate immune responses by Escherichia coli and purified lipopolysaccharide correlate with organ- and cell-specific expression of Toll-like receptors within the human urinary tract. Cell Microbiol 3: 153-158
    • (2001) Cell Microbiol , vol.3 , pp. 153-158
    • Backhed, F.1
  • 54
    • 0037103247 scopus 로고    scopus 로고
    • Roles of toll-like receptors in C-C chemokine production by renal tubular epithelial cells
    • Tsuboi N et al. (2002) Roles of toll-like receptors in C-C chemokine production by renal tubular epithelial cells. J Immunol 169: 2026-2033
    • (2002) J Immunol , vol.169 , pp. 2026-2033
    • Tsuboi, N.1
  • 55
    • 23944497673 scopus 로고    scopus 로고
    • Viral double-stranded RNA aggravates lupus nephritis through Toll-like receptor 3 on glomerular mesangial cells and antigen-presenting cells
    • Patole PS et al. (2005) Viral double-stranded RNA aggravates lupus nephritis through Toll-like receptor 3 on glomerular mesangial cells and antigen-presenting cells. J Am Soc Nephrol 16: 1326-1338
    • (2005) J Am Soc Nephrol , vol.16 , pp. 1326-1338
    • Patole, P.S.1
  • 56
    • 33144487115 scopus 로고    scopus 로고
    • Novel role of toll-like receptor 3 in hepatitis C-associated glomerulonephritis
    • Wornle M et al. (2006) Novel role of toll-like receptor 3 in hepatitis C-associated glomerulonephritis. Am J Pathol 168: 370-385
    • (2006) Am J Pathol , vol.168 , pp. 370-385
    • Wornle, M.1
  • 57
    • 0037307507 scopus 로고    scopus 로고
    • Bacterial CpG-DNA aggravates immune complex glomerulonephritis: Role of TLR9-mediated expression of chemokines and chemokine receptors
    • Anders HJ et al. (2003) Bacterial CpG-DNA aggravates immune complex glomerulonephritis: role of TLR9-mediated expression of chemokines and chemokine receptors. J Am Soc Nephrol 14: 317-326
    • (2003) J Am Soc Nephrol , vol.14 , pp. 317-326
    • Anders, H.J.1
  • 58
    • 1642396952 scopus 로고    scopus 로고
    • Activation of toll-like receptor-9 induces progression of renal disease in MRL-Fas(lpr) mice
    • Anders HJ et al. (2004) Activation of toll-like receptor-9 induces progression of renal disease in MRL-Fas(lpr) mice. FASEB J 18: 534-536
    • (2004) FASEB J , vol.18 , pp. 534-536
    • Anders, H.J.1
  • 59
    • 33644515263 scopus 로고    scopus 로고
    • Toll-like receptor-7 modulates immune complex glomerulonephritis
    • Pawar RD et al. (2006) Toll-like receptor-7 modulates immune complex glomerulonephritis. J Am Soc Nephrol 17: 141-149
    • (2006) J Am Soc Nephrol , vol.17 , pp. 141-149
    • Pawar, R.D.1
  • 60
    • 1542377424 scopus 로고    scopus 로고
    • A toll-like receptor that prevents infection by uropathogenic bacteria
    • Zhang D et al. (2004) A toll-like receptor that prevents infection by uropathogenic bacteria. Science 303: 1522-1526
    • (2004) Science , vol.303 , pp. 1522-1526
    • Zhang, D.1
  • 61
    • 19644364807 scopus 로고    scopus 로고
    • Ischemia-reperfusion injury activates innate immunity in rat kidneys
    • Kim BS et al. (2005) Ischemia-reperfusion injury activates innate immunity in rat kidneys. Transplantation 79: 1370-1377
    • (2005) Transplantation , vol.79 , pp. 1370-1377
    • Kim, B.S.1
  • 62
    • 25644433465 scopus 로고    scopus 로고
    • Cyclosporine-induced renal injury induces toll-like receptor and maturation of dendritic cells
    • Lim SW et al. (2005) Cyclosporine-induced renal injury induces toll-like receptor and maturation of dendritic cells. Transplantation 80: 691-699
    • (2005) Transplantation , vol.80 , pp. 691-699
    • Lim, S.W.1
  • 63
    • 2542530840 scopus 로고    scopus 로고
    • Toll-like receptor 4 expression and cytokine responses in the human urinary tract mucosa
    • Samuelsson P et al. (2004) Toll-like receptor 4 expression and cytokine responses in the human urinary tract mucosa. Infect Immun 72: 3179-3186
    • (2004) Infect Immun , vol.72 , pp. 3179-3186
    • Samuelsson, P.1
  • 64
    • 0141453904 scopus 로고    scopus 로고
    • Developmental aspects of Escherichia coli-induced innate responses in rat renal epithelial cells
    • Laestadius A et al. (2003) Developmental aspects of Escherichia coli-induced innate responses in rat renal epithelial cells. Pediatr Res 54: 536-541
    • (2003) Pediatr Res , vol.54 , pp. 536-541
    • Laestadius, A.1
  • 65
    • 33646578794 scopus 로고    scopus 로고
    • Sepsis induces changes in the expression and distribution of Toll-like receptor 4 in the rat kidney
    • El-Achkar TM et al. (2006) Sepsis induces changes in the expression and distribution of Toll-like receptor 4 in the rat kidney. Am J Physiol Renal Physiol 290: F1034-F1043
    • (2006) Am J Physiol Renal Physiol , vol.290
    • El-Achkar, T.M.1
  • 66
    • 0141608641 scopus 로고    scopus 로고
    • The enigma of sepsis
    • Riedemann NC et al. (2003) The enigma of sepsis. J Clin Invest 112: 460-467
    • (2003) J Clin Invest , vol.112 , pp. 460-467
    • Riedemann, N.C.1
  • 67
    • 0037426726 scopus 로고    scopus 로고
    • The pathophysiology and treatment of sepsis
    • Hotchkiss RS and Karl IE (2003) The pathophysiology and treatment of sepsis. N Engl J Med 348: 138-150
    • (2003) N Engl J Med , vol.348 , pp. 138-150
    • Hotchkiss, R.S.1    Karl, I.E.2
  • 68
    • 0037180768 scopus 로고    scopus 로고
    • The immunopathogenesis of sepsis
    • Cohen J (2002) The immunopathogenesis of sepsis. Nature 420: 885-891
    • (2002) Nature , vol.420 , pp. 885-891
    • Cohen, J.1
  • 69
    • 0016294676 scopus 로고
    • Genetic control of responses to bacterial lipopolysaccharides in mice. I. Evidence for a single gene that influences mitogenic and immunogenic responses to lipopolysaccharides
    • Watson J and Riblet R (1974) Genetic control of responses to bacterial lipopolysaccharides in mice. I. Evidence for a single gene that influences mitogenic and immunogenic responses to lipopolysaccharides. J Exp Med 140: 1147-1161
    • (1974) J Exp Med , vol.140 , pp. 1147-1161
    • Watson, J.1    Riblet, R.2
  • 70
    • 0014425756 scopus 로고
    • Genetic control of leucocyte responses to endotoxin
    • Sultzer BM (1968) Genetic control of leucocyte responses to endotoxin. Nature 219: 1253-1254
    • (1968) Nature , vol.219 , pp. 1253-1254
    • Sultzer, B.M.1
  • 71
    • 0017752368 scopus 로고
    • Genetic analysis of generation of serum interferon by bacterial lipopolysaccharide
    • Apte RN et al. (1977) Genetic analysis of generation of serum interferon by bacterial lipopolysaccharide. J Immunol 119: 1898-1902
    • (1977) J Immunol , vol.119 , pp. 1898-1902
    • Apte, R.N.1
  • 72
    • 0023690962 scopus 로고
    • Mouse genetic locus Lps influences susceptibility to Neisseria meningitidis infection
    • Woods JP et al. (1988) Mouse genetic locus Lps influences susceptibility to Neisseria meningitidis infection. Infect Immun 56: 1950-1955
    • (1988) Infect Immun , vol.56 , pp. 1950-1955
    • Woods, J.P.1
  • 73
    • 0018841829 scopus 로고
    • Genetic control of susceptibility to Salmonella typhimurium in mice: Role of the LPS gene
    • O'Brien AD et al. (1980) Genetic control of susceptibility to Salmonella typhimurium in mice: role of the LPS gene. J Immunol 124: 20-24
    • (1980) J Immunol , vol.124 , pp. 20-24
    • O'Brien, A.D.1
  • 74
    • 3142634845 scopus 로고    scopus 로고
    • Acute renal failure and sepsis
    • Schrier RW and Wang W (2004) Acute renal failure and sepsis. N Engl J Med 351: 159-169
    • (2004) N Engl J Med , vol.351 , pp. 159-169
    • Schrier, R.W.1    Wang, W.2
  • 75
    • 0344686275 scopus 로고    scopus 로고
    • The pathogenesis of septic acute renal failure
    • Wan L et al. (2003) The pathogenesis of septic acute renal failure. Curr Opin Crit Care 9: 496-502
    • (2003) Curr Opin Crit Care , vol.9 , pp. 496-502
    • Wan, L.1
  • 76
    • 0034999831 scopus 로고    scopus 로고
    • Endotoxemic renal failure in mice: Role of tumor necrosis factor independent of inducible nitric oxide synthase
    • Knotek M et al. (2001) Endotoxemic renal failure in mice: role of tumor necrosis factor independent of inducible nitric oxide synthase. Kidney Int 59: 2243-2249
    • (2001) Kidney Int , vol.59 , pp. 2243-2249
    • Knotek, M.1
  • 77
    • 0026585007 scopus 로고
    • Anti-tumor necrosis factor antibody therapy fails to prevent lethality after cecal ligation and puncture or endotoxemia
    • Eskandari MK et al. (1992) Anti-tumor necrosis factor antibody therapy fails to prevent lethality after cecal ligation and puncture or endotoxemia. J Immunol 148: 2724-2730
    • (1992) J Immunol , vol.148 , pp. 2724-2730
    • Eskandari, M.K.1
  • 78
    • 0024513550 scopus 로고
    • Tumor necrosis factor induces glomerular damage in the rabbit
    • Bertani T et al. (1989) Tumor necrosis factor induces glomerular damage in the rabbit. Am J Pathol 134: 419-430
    • (1989) Am J Pathol , vol.134 , pp. 419-430
    • Bertani, T.1
  • 79
    • 22344453543 scopus 로고    scopus 로고
    • Ischemic proximal tubular injury primes mice to endotoxin-induced TNF-α generation and systemic release
    • Zager RA et al. (2005) Ischemic proximal tubular injury primes mice to endotoxin-induced TNF-α generation and systemic release. Am J Physiol Renal Physiol 289: F289-F297
    • (2005) Am J Physiol Renal Physiol , vol.289
    • Zager, R.A.1
  • 80
    • 0037477629 scopus 로고    scopus 로고
    • Activation of innate immunity in the CNS triggers neurodegeneration through a Toll-like receptor 4-dependent pathway
    • Lehnardt S et al. (2003) Activation of innate immunity in the CNS triggers neurodegeneration through a Toll-like receptor 4-dependent pathway. Proc Natl Acad Sci USA 100: 8514-8519
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 8514-8519
    • Lehnardt, S.1
  • 81
    • 0028929534 scopus 로고
    • Murine CD14 gene expression in vivo: Extramyeloid synthesis and regulation by lipopolysaccharide
    • Fearns C et al. (1995) Murine CD14 gene expression in vivo: extramyeloid synthesis and regulation by lipopolysaccharide. J Exp Med 181: 857-866
    • (1995) J Exp Med , vol.181 , pp. 857-866
    • Fearns, C.1
  • 82
    • 0033840086 scopus 로고    scopus 로고
    • Induction of CD14 in tubular epithelial cells during kidney disease
    • Morrissey J et al. (2000) Induction of CD14 in tubular epithelial cells during kidney disease. J Am Soc Nephrol 11: 1681-1690
    • (2000) J Am Soc Nephrol , vol.11 , pp. 1681-1690
    • Morrissey, J.1
  • 83
    • 0027446922 scopus 로고
    • Lipopolysaccharide activation of human endothelial and epithelial cells is mediated by lipopolysaccharide-binding protein and soluble CD14
    • Pugin J et al. (1993) Lipopolysaccharide activation of human endothelial and epithelial cells is mediated by lipopolysaccharide-binding protein and soluble CD14. Proc Natl Acad Sci USA 90: 2744-2748
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 2744-2748
    • Pugin, J.1
  • 84
    • 0030829208 scopus 로고    scopus 로고
    • Role of tumor necrosis factor alpha in induction of murine CD14 gene expression by lipopolysaccharide
    • Fearns C and Loskutoff DJ (1997) Role of tumor necrosis factor alpha in induction of murine CD14 gene expression by lipopolysaccharide. Infect Immun 65: 4822-4831
    • (1997) Infect Immun , vol.65 , pp. 4822-4831
    • Fearns, C.1    Loskutoff, D.J.2
  • 85
    • 3142690482 scopus 로고    scopus 로고
    • TLR4 is the signaling but not the lipopolysaccharide uptake receptor
    • Dunzendorfer S et al. (2004) TLR4 is the signaling but not the lipopolysaccharide uptake receptor. J Immunol 173: 1166-1170
    • (2004) J Immunol , vol.173 , pp. 1166-1170
    • Dunzendorfer, S.1
  • 86
    • 10344264453 scopus 로고    scopus 로고
    • Cutting edge: TLR4 activation mediates liver ischemia/reperfusion inflammatory response via IFN regulatory factor 3-dependent MyD88-independent pathway
    • Zhai Y et al. (2004) Cutting edge: TLR4 activation mediates liver ischemia/reperfusion inflammatory response via IFN regulatory factor 3-dependent MyD88-independent pathway. J Immunol 173: 7115-7119
    • (2004) J Immunol , vol.173 , pp. 7115-7119
    • Zhai, Y.1
  • 87
    • 22844436646 scopus 로고    scopus 로고
    • Toll-like receptor and heme oxygenase-1 signaling in hepatic ischemia/reperfusion injury
    • Shen XD et al. (2005) Toll-like receptor and heme oxygenase-1 signaling in hepatic ischemia/reperfusion injury. Am J Transplant 5: 1793-1800
    • (2005) Am J Transplant , vol.5 , pp. 1793-1800
    • Shen, X.D.1
  • 88
    • 3242769906 scopus 로고    scopus 로고
    • Toll-like receptor 4 mediates ischemia/reperfusion injury of the heart
    • Chong AJ et al. (2004) Toll-like receptor 4 mediates ischemia/reperfusion injury of the heart. J Thorac Cardiovasc Surg 128: 170-179
    • (2004) J Thorac Cardiovasc Surg , vol.128 , pp. 170-179
    • Chong, A.J.1
  • 89
    • 0345599171 scopus 로고    scopus 로고
    • Toll-like receptor-2 modulates ventricular remodeling after myocardial infarction
    • Shishido T et al. (2003) Toll-like receptor-2 modulates ventricular remodeling after myocardial infarction. Circulation 108: 2905-2910
    • (2003) Circulation , vol.108 , pp. 2905-2910
    • Shishido, T.1
  • 90
    • 0034650427 scopus 로고    scopus 로고
    • Cutting edge: Heat shock protein 60 is a putative endogenous ligand of the tolllike receptor-4 complex
    • Ohashi K et al. (2000) Cutting edge: heat shock protein 60 is a putative endogenous ligand of the tolllike receptor-4 complex. J Immunol 164: 558-561
    • (2000) J Immunol , vol.164 , pp. 558-561
    • Ohashi, K.1
  • 91
    • 0035909372 scopus 로고    scopus 로고
    • Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3
    • Alexopoulou L et al. (2001) Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3. Nature 413: 732-738
    • (2001) Nature , vol.413 , pp. 732-738
    • Alexopoulou, L.1
  • 92
    • 0023176617 scopus 로고
    • Neutrophil recruitment and bacterial clearance correlated with LPS responsiveness in local gram-negative infection
    • Shahin RD et al. (1987) Neutrophil recruitment and bacterial clearance correlated with LPS responsiveness in local gram-negative infection. J Immunol 138: 3475-3480
    • (1987) J Immunol , vol.138 , pp. 3475-3480
    • Shahin, R.D.1
  • 93
    • 0033389454 scopus 로고    scopus 로고
    • Neutrophil recruitment and resistance to urinary tract infection
    • Haraoka M et al. (1999) Neutrophil recruitment and resistance to urinary tract infection. J Infect Dis 180: 1220-1229
    • (1999) J Infect Dis , vol.180 , pp. 1220-1229
    • Haraoka, M.1
  • 94
    • 0035282686 scopus 로고    scopus 로고
    • Toll-like receptor signaling and chemokine receptor expression influence the severity of urinary tract infection
    • Svanborg C et al. (2001) Toll-like receptor signaling and chemokine receptor expression influence the severity of urinary tract infection. J Infect Dis 183 (Suppl 1): S61-S65
    • (2001) J Infect Dis , vol.183 , Issue.1 SUPPL.
    • Svanborg, C.1
  • 95
    • 0037388307 scopus 로고    scopus 로고
    • Toll-like receptor 4 on stromal and hematopoietic cells mediates innate resistance to uropathogenic Escherichia coli
    • Schilling JD et al. (2003) Toll-like receptor 4 on stromal and hematopoietic cells mediates innate resistance to uropathogenic Escherichia coli. Proc Natl Acad Sci USA 100: 4203-4208
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 4203-4208
    • Schilling, J.D.1
  • 96
    • 32844466826 scopus 로고    scopus 로고
    • Toll-like receptor-4: Renal cells and bone marrow cells signal for neutrophil recruitment during pyelonephritis
    • Patole PS et al. (2005) Toll-like receptor-4: renal cells and bone marrow cells signal for neutrophil recruitment during pyelonephritis. Kidney Int 68: 2582-2587
    • (2005) Kidney Int , vol.68 , pp. 2582-2587
    • Patole, P.S.1
  • 97
    • 0035135138 scopus 로고    scopus 로고
    • Type 1 fimbriae deliver an LPS- And TLR4-dependent activation signal to CD14-negative cells
    • Hedlund M et al. (2001) Type 1 fimbriae deliver an LPS- and TLR4-dependent activation signal to CD14-negative cells. Mol Microbiol 39: 542-552
    • (2001) Mol Microbiol , vol.39 , pp. 542-552
    • Hedlund, M.1
  • 98
    • 0035044165 scopus 로고    scopus 로고
    • Escherichia coli P fimbriae utilize the Toll-like receptor 4 pathway for cell activation
    • Frendeus B et al. (2001) Escherichia coli P fimbriae utilize the Toll-like receptor 4 pathway for cell activation. Mol Microbiol 40: 37-51
    • (2001) Mol Microbiol , vol.40 , pp. 37-51
    • Frendeus, B.1
  • 99
    • 0037369767 scopus 로고    scopus 로고
    • CD14- And Toll-like receptor-dependent activation of bladder epithelial cells by lipopolysaccharide and type 1 piliated Escherichia coli
    • Schilling JD et al. (2003) CD14- and Toll-like receptor-dependent activation of bladder epithelial cells by lipopolysaccharide and type 1 piliated Escherichia coli. Infect Immun 71: 1470-1480
    • (2003) Infect Immun , vol.71 , pp. 1470-1480
    • Schilling, J.D.1
  • 100
    • 0036672050 scopus 로고    scopus 로고
    • TLR4-dependent recognition of lipopolysaccharide by epithelial cells requires sCD14
    • Backhed F et al. (2002) TLR4-dependent recognition of lipopolysaccharide by epithelial cells requires sCD14. Cell Microbiol 4: 493-501
    • (2002) Cell Microbiol , vol.4 , pp. 493-501
    • Backhed, F.1
  • 101
    • 0141620216 scopus 로고    scopus 로고
    • Tamm-Horsfall glycoprotein: Biology and clinical relevance
    • Serafini-Cessi F et al. (2003) Tamm-Horsfall glycoprotein: biology and clinical relevance. Am J Kidney Dis 42: 658-676
    • (2003) Am J Kidney Dis , vol.42 , pp. 658-676
    • Serafini-Cessi, F.1
  • 102
    • 0019328660 scopus 로고
    • Tamm-Horsfall protein or uromucoid is the normal urinary slime that traps type 1 fimbriated Escherichia coli
    • Orskov I et al. (1980) Tamm-Horsfall protein or uromucoid is the normal urinary slime that traps type 1 fimbriated Escherichia coli. Lancet 1: 887
    • (1980) Lancet , vol.1 , pp. 887
    • Orskov, I.1
  • 103
    • 0023695035 scopus 로고
    • Identification of factors in human urine that inhibit the binding of Escherichia coli adhesins
    • Parkkinen J et al. (1988) Identification of factors in human urine that inhibit the binding of Escherichia coli adhesins. Infect Immun 56: 2623-2630
    • (1988) Infect Immun , vol.56 , pp. 2623-2630
    • Parkkinen, J.1
  • 104
    • 0035971077 scopus 로고    scopus 로고
    • Tamm-Horsfall protein binds to type 1 fimbriated Escherichia coli and prevents E. coli from binding to uroplakin Ia and Ib receptors
    • Pak J et al. (2001) Tamm-Horsfall protein binds to type 1 fimbriated Escherichia coli and prevents E. coli from binding to uroplakin Ia and Ib receptors. J Biol Chem 276: 9924-9930
    • (2001) J Biol Chem , vol.276 , pp. 9924-9930
    • Pak, J.1
  • 105
    • 1342322652 scopus 로고    scopus 로고
    • Tamm-Horsfall protein knockout mice are more prone to urinary tract infection: Rapid communication
    • Bates JM et al. (2004) Tamm-Horsfall protein knockout mice are more prone to urinary tract infection: rapid communication. Kidney Int 65: 791-797
    • (2004) Kidney Int , vol.65 , pp. 791-797
    • Bates, J.M.1
  • 106
    • 20144373629 scopus 로고    scopus 로고
    • Tamm-Horsfall glycoprotein links innate immune cell activation with adaptive immunity via a Toll-like receptor-4-dependent mechanism
    • Saemann MD et al. (2005) Tamm-Horsfall glycoprotein links innate immune cell activation with adaptive immunity via a Toll-like receptor-4-dependent mechanism. J Clin Invest 115: 468-475
    • (2005) J Clin Invest , vol.115 , pp. 468-475
    • Saemann, M.D.1
  • 107
    • 0035875835 scopus 로고    scopus 로고
    • Heat shock proteins, anti-heat shock protein reactivity and allograft rejection
    • Pockley AG (2001) Heat shock proteins, anti-heat shock protein reactivity and allograft rejection. Transplantation 71: 1503-1507
    • (2001) Transplantation , vol.71 , pp. 1503-1507
    • Pockley, A.G.1
  • 108
    • 0037974914 scopus 로고    scopus 로고
    • Critical role of the Toll-like receptor signal adaptor protein MyD88 in acute allograft rejection
    • Goldstein DR et al. (2003) Critical role of the Toll-like receptor signal adaptor protein MyD88 in acute allograft rejection. J Clin Invest 111: 1571-1578
    • (2003) J Clin Invest , vol.111 , pp. 1571-1578
    • Goldstein, D.R.1
  • 109
    • 0037183894 scopus 로고    scopus 로고
    • Cytomegalovirus seromismatching increases the risk of acute renal allograft rejection
    • McLaughlin K et al. (2002) Cytomegalovirus seromismatching increases the risk of acute renal allograft rejection. Transplantation 74: 813-816
    • (2002) Transplantation , vol.74 , pp. 813-816
    • McLaughlin, K.1
  • 110
    • 4344703413 scopus 로고    scopus 로고
    • TH1 immune responses to fully MHC mismatched allografts are diminished in the absence of MyD88, a toll-like receptor signal adaptor protein
    • Tesar BM et al. (2004) TH1 immune responses to fully MHC mismatched allografts are diminished in the absence of MyD88, a toll-like receptor signal adaptor protein. Am J Transplant 4: 1429-1439
    • (2004) Am J Transplant , vol.4 , pp. 1429-1439
    • Tesar, B.M.1
  • 111
    • 0034084438 scopus 로고    scopus 로고
    • TLR4 mutations are associated with endotoxin hyporesponsiveness in humans
    • Arbour NC et al. (2000) TLR4 mutations are associated with endotoxin hyporesponsiveness in humans. Nat Genet 25: 187-191
    • (2000) Nat Genet , vol.25 , pp. 187-191
    • Arbour, N.C.1
  • 112
    • 23044480567 scopus 로고    scopus 로고
    • Relevance of Toll-like receptor-4 polymorphisms in renal transplantation
    • Ducloux D et al. (2005) Relevance of Toll-like receptor-4 polymorphisms in renal transplantation. Kidney Int 67: 2454-2461
    • (2005) Kidney Int , vol.67 , pp. 2454-2461
    • Ducloux, D.1
  • 113
    • 0037207471 scopus 로고    scopus 로고
    • Cell biology of the glomerular podocyte
    • Pavenstadt H et al. (2003) Cell biology of the glomerular podocyte. Physiol Rev 83: 253-307
    • (2003) Physiol Rev , vol.83 , pp. 253-307
    • Pavenstadt, H.1
  • 114
    • 85047691168 scopus 로고    scopus 로고
    • Induction of B7-1 in podocytes is associated with nephrotic syndrome
    • Reiser J et al. (2004) Induction of B7-1 in podocytes is associated with nephrotic syndrome. J Clin Invest 113: 1390-1397
    • (2004) J Clin Invest , vol.113 , pp. 1390-1397
    • Reiser, J.1
  • 115
    • 0347146027 scopus 로고    scopus 로고
    • Upregulation of costimulatory molecules induced by lipopolysaccharide and double-stranded RNA occurs by Trif-dependent and Trif-independent pathways
    • Hoebe K et al. (2003) Upregulation of costimulatory molecules induced by lipopolysaccharide and double-stranded RNA occurs by Trif-dependent and Trif-independent pathways. Nat Immunol 4: 1223-1229
    • (2003) Nat Immunol , vol.4 , pp. 1223-1229
    • Hoebe, K.1
  • 116
    • 0015058519 scopus 로고
    • Regulation of the immune system by synthetic polynucleotides. I. Characteristics of adjuvant action on antibody synthesis
    • Schmidtke JR and Johnson AG (1971) Regulation of the immune system by synthetic polynucleotides. I. Characteristics of adjuvant action on antibody synthesis. J Immunol 106: 1191-1200
    • (1971) J Immunol , vol.106 , pp. 1191-1200
    • Schmidtke, J.R.1    Johnson, A.G.2
  • 117
    • 0345883301 scopus 로고
    • Effect of meningococcal endotoxin on the immune response
    • Condie RM et al. (1955) Effect of meningococcal endotoxin on the immune response. Proc Soc Exp Biol Med 90: 355-360
    • (1955) Proc Soc Exp Biol Med , vol.90 , pp. 355-360
    • Condie, R.M.1
  • 118
    • 0037061453 scopus 로고    scopus 로고
    • Chromatin-IgG complexes activate B cells by dual engagement of IgM and Tolllike receptors
    • Leadbetter EA et al. (2002) Chromatin-IgG complexes activate B cells by dual engagement of IgM and Tolllike receptors. Nature 416: 603-607
    • (2002) Nature , vol.416 , pp. 603-607
    • Leadbetter, E.A.1
  • 119
    • 22944490869 scopus 로고    scopus 로고
    • Toll-like receptor 9 controls anti-DNA autoantibody production in murine lupus
    • Christensen SR et al. (2005) Toll-like receptor 9 controls anti-DNA autoantibody production in murine lupus. J Exp Med 202: 321-331
    • (2005) J Exp Med , vol.202 , pp. 321-331
    • Christensen, S.R.1
  • 120
    • 0034619794 scopus 로고    scopus 로고
    • A Toll-like receptor recognizes bacterial DNA
    • Hemmi H et al. (2000) A Toll-like receptor recognizes bacterial DNA. Nature 408: 740-745
    • (2000) Nature , vol.408 , pp. 740-745
    • Hemmi, H.1
  • 121
    • 85047693371 scopus 로고    scopus 로고
    • Human lupus autoantibody-DNA complexes activate DCs through cooperation of CD32 and TLR9
    • Means TK et al. (2005) Human lupus autoantibody-DNA complexes activate DCs through cooperation of CD32 and TLR9. J Clin Invest 115: 407-417
    • (2005) J Clin Invest , vol.115 , pp. 407-417
    • Means, T.K.1
  • 122
    • 0035905409 scopus 로고    scopus 로고
    • A pivotal role for the natural interferon alpha-producing cells (plasmacytoid dendritic cells) in the pathogenesis of lupus
    • Ronnblom L and Alm GV (2001) A pivotal role for the natural interferon alpha-producing cells (plasmacytoid dendritic cells) in the pathogenesis of lupus. J Exp Med 194: F59-F63
    • (2001) J Exp Med , vol.194
    • Ronnblom, L.1    Alm, G.V.2
  • 123
    • 31044440025 scopus 로고    scopus 로고
    • Toll-like receptor 9 signaling protects against murine lupus
    • Wu X and Peng SL (2006) Toll-like receptor 9 signaling protects against murine lupus. Arthritis Rheum 54: 336-342
    • (2006) Arthritis Rheum , vol.54 , pp. 336-342
    • Wu, X.1    Peng, S.L.2
  • 124
    • 3042548183 scopus 로고    scopus 로고
    • Toll-like receptor 9-dependent and -independent dendritic cell activation by chromatin-immunoglobulin G complexes
    • Boule MW et al. (2004) Toll-like receptor 9-dependent and -independent dendritic cell activation by chromatin-immunoglobulin G complexes. J Exp Med 199: 1631-1640
    • (2004) J Exp Med , vol.199 , pp. 1631-1640
    • Boule, M.W.1
  • 125
    • 14844291442 scopus 로고    scopus 로고
    • Association study of Toll-like receptor 9 gene polymorphism in Korean patients with systemic lupus erythematosus
    • Hur JW et al. (2005) Association study of Toll-like receptor 9 gene polymorphism in Korean patients with systemic lupus erythematosus. Tissue Antigens 65: 266-270
    • (2005) Tissue Antigens , vol.65 , pp. 266-270
    • Hur, J.W.1
  • 126
    • 1642521633 scopus 로고    scopus 로고
    • Polymorphisms of toll-like receptor 2 and 4 genes in rheumatoid arthritis and systemic lupus erythematosus
    • Sanchez E et al. (2004) Polymorphisms of toll-like receptor 2 and 4 genes in rheumatoid arthritis and systemic lupus erythematosus. Tissue Antigens 63: 54-57
    • (2004) Tissue Antigens , vol.63 , pp. 54-57
    • Sanchez, E.1
  • 127
    • 33144458473 scopus 로고    scopus 로고
    • G-rich DNA suppresses systemic lupus
    • Patole PS et al. (2005) G-rich DNA suppresses systemic lupus. J Am Soc Nephrol 16: 3273-3280
    • (2005) J Am Soc Nephrol , vol.16 , pp. 3273-3280
    • Patole, P.S.1
  • 128
    • 1542317578 scopus 로고    scopus 로고
    • Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8
    • Heil F et al. (2004) Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8. Science 303: 1526-1529
    • (2004) Science , vol.303 , pp. 1526-1529
    • Heil, F.1
  • 129
    • 0035370526 scopus 로고    scopus 로고
    • Spliceosomal UsnRNP biogenesis, structure and function
    • Will CL and Luhrmann R (2001) Spliceosomal UsnRNP biogenesis, structure and function. Curr Opin Cell Biol 13: 290-301
    • (2001) Curr Opin Cell Biol , vol.13 , pp. 290-301
    • Will, C.L.1    Luhrmann, R.2
  • 130
    • 23044475966 scopus 로고    scopus 로고
    • A stop codon polymorphism of Toll-like receptor 5 is associated with resistance to systemic lupus erythematosus
    • Hawn TR et al. (2005) A stop codon polymorphism of Toll-like receptor 5 is associated with resistance to systemic lupus erythematosus. Proc Natl Acad Sci USA 102: 10593-10597
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 10593-10597
    • Hawn, T.R.1
  • 131
    • 1842631153 scopus 로고    scopus 로고
    • Immunotherapeutic uses of CpG oligodeoxynucleotides
    • Klinman DM (2004) Immunotherapeutic uses of CpG oligodeoxynucleotides. Nat Rev Immunol 4: 249-258
    • (2004) Nat Rev Immunol , vol.4 , pp. 249-258
    • Klinman, D.M.1
  • 132
    • 3142779901 scopus 로고    scopus 로고
    • Therapeutics targeting the innate immune system
    • Ulevitch RJ (2004) Therapeutics targeting the innate immune system. Nat Rev Immunol 4: 512-520
    • (2004) Nat Rev Immunol , vol.4 , pp. 512-520
    • Ulevitch, R.J.1
  • 133
    • 33644872282 scopus 로고    scopus 로고
    • Toll-like receptor therapies compete to reduce side effects
    • Schmidt C (2006) Toll-like receptor therapies compete to reduce side effects. Nat Biotechnol 24: 230-231
    • (2006) Nat Biotechnol , vol.24 , pp. 230-231
    • Schmidt, C.1
  • 134
    • 18144425200 scopus 로고    scopus 로고
    • TLR4 antagonists for endotoxemia and beyond
    • Rossignol DP and Lynn M (2005) TLR4 antagonists for endotoxemia and beyond. Curr Opin Investig Drugs 6: 496-502
    • (2005) Curr Opin Investig Drugs , vol.6 , pp. 496-502
    • Rossignol, D.P.1    Lynn, M.2
  • 135
    • 0036644042 scopus 로고    scopus 로고
    • Cutting edge: Role of Toll-like receptor 1 in mediating immune response to microbial lipoproteins
    • Takeuchi O et al. (2002) Cutting edge: role of Toll-like receptor 1 in mediating immune response to microbial lipoproteins. J Immunol 169: 10-14
    • (2002) J Immunol , vol.169 , pp. 10-14
    • Takeuchi, O.1
  • 136
    • 0033120081 scopus 로고    scopus 로고
    • Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product
    • Hoshino K et al. (1999) Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product. J Immunol 162: 3749-3752
    • (1999) J Immunol , vol.162 , pp. 3749-3752
    • Hoshino, K.1
  • 137
    • 0033580949 scopus 로고    scopus 로고
    • Peptidoglycan- And lipoteichoic acid-induced cell activation is mediated by toll-like receptor 2
    • Schwandner R et al. (1999) Peptidoglycan- and lipoteichoic acid-induced cell activation is mediated by toll-like receptor 2. J Biol Chem 274: 17406-17409
    • (1999) J Biol Chem , vol.274 , pp. 17406-17409
    • Schwandner, R.1
  • 138
    • 0033592748 scopus 로고    scopus 로고
    • The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens
    • Underhill DM et al. (1999) The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens. Nature 401: 811-815
    • (1999) Nature , vol.401 , pp. 811-815
    • Underhill, D.M.1
  • 139
    • 0036467447 scopus 로고    scopus 로고
    • Chlamydial heat shock protein 60 activates macrophages and endothelial cells through Toll-like receptor 4 and MD2 in a MyD88-dependent pathway
    • Bulut Y et al. (2002) Chlamydial heat shock protein 60 activates macrophages and endothelial cells through Toll-like receptor 4 and MD2 in a MyD88-dependent pathway. J Immunol 168: 1435-1440
    • (2002) J Immunol , vol.168 , pp. 1435-1440
    • Bulut, Y.1
  • 140
    • 0034723186 scopus 로고    scopus 로고
    • Mouse toll-like receptor 4.MD-2 complex mediates lipopolysaccharide- mimetic signal transduction by Taxol
    • Kawasaki K et al. (2000) Mouse toll-like receptor 4.MD-2 complex mediates lipopolysaccharide-mimetic signal transduction by Taxol. J Biol Chem 275: 2251-2254
    • (2000) J Biol Chem , vol.275 , pp. 2251-2254
    • Kawasaki, K.1
  • 141
    • 0035971217 scopus 로고    scopus 로고
    • The extra domain A of fibronectin activates Toll-like receptor 4
    • Okamura Y et al. (2001) The extra domain A of fibronectin activates Toll-like receptor 4. J Biol Chem 276: 10229-10233
    • (2001) J Biol Chem , vol.276 , pp. 10229-10233
    • Okamura, Y.1
  • 142
    • 0037033364 scopus 로고    scopus 로고
    • Oligosaccharides of Hyaluronan activate dendritic cells via toll-like receptor 4
    • Termeer C et al. (2002) Oligosaccharides of Hyaluronan activate dendritic cells via toll-like receptor 4. J Exp Med 195: 99-111
    • (2002) J Exp Med , vol.195 , pp. 99-111
    • Termeer, C.1
  • 143
    • 0035451118 scopus 로고    scopus 로고
    • Fibrinogen stimulates macrophage chemokine secretion through toll-like receptor 4
    • Smiley ST et al. (2001) Fibrinogen stimulates macrophage chemokine secretion through toll-like receptor 4. J Immunol 167: 2887-2894
    • (2001) J Immunol , vol.167 , pp. 2887-2894
    • Smiley, S.T.1
  • 144
    • 0037094084 scopus 로고    scopus 로고
    • Receptor-mediated monitoring of tissue well-being via detection of soluble heparan sulfate by Toll-like receptor 4
    • Johnson GB et al. (2002) Receptor-mediated monitoring of tissue well-being via detection of soluble heparan sulfate by Toll-like receptor 4. J Immunol 168: 5233-5239
    • (2002) J Immunol , vol.168 , pp. 5233-5239
    • Johnson, G.B.1
  • 145
    • 0035953543 scopus 로고    scopus 로고
    • The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5
    • Hayashi F et al. (2001) The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5. Nature 410: 1099-1103
    • (2001) Nature , vol.410 , pp. 1099-1103
    • Hayashi, F.1
  • 146
    • 0034610291 scopus 로고    scopus 로고
    • The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between toll-like receptors
    • Ozinsky A et al. (2000) The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between toll-like receptors. Proc Natl Acad Sci USA 97: 13766-13771
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 13766-13771
    • Ozinsky, A.1
  • 147
    • 0034922923 scopus 로고    scopus 로고
    • Discrimination of bacterial lipoproteins by Toll-like receptor 6
    • Takeuchi O et al. (2001) Discrimination of bacterial lipoproteins by Toll-like receptor 6. Int Immunol 13: 933-940
    • (2001) Int Immunol , vol.13 , pp. 933-940
    • Takeuchi, O.1
  • 148
    • 0036008014 scopus 로고    scopus 로고
    • Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway
    • Hemmi H et al. (2002) Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway. Nat Immunol 3: 196-200
    • (2002) Nat Immunol , vol.3 , pp. 196-200
    • Hemmi, H.1
  • 149
    • 0036088492 scopus 로고    scopus 로고
    • Human TLR7 or TLR8 independently confer responsiveness to the antiviral compound R-848
    • Jurk M et al. (2002) Human TLR7 or TLR8 independently confer responsiveness to the antiviral compound R-848. Nat Immunol 3: 499
    • (2002) Nat Immunol , vol.3 , pp. 499
    • Jurk, M.1
  • 150
    • 20644433342 scopus 로고    scopus 로고
    • TLR11 activation of dendritic cells by a protozoan profilin-like protein
    • Yarovinsky F et al. (2005) TLR11 activation of dendritic cells by a protozoan profilin-like protein. Science 308: 1626-1629
    • (2005) Science , vol.308 , pp. 1626-1629
    • Yarovinsky, F.1


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