The Fas-associated death domain protein suppresses activation of NF-κB by LPS and IL-1β

Journal of Clinical Investigation

Volumn 109, Issue 3, 2002, Pages 419-425

  Bannerman, Douglas D ^a,c   Tupper, Joan C ^a   Kelly, James D ^b   Winn, Robert K ^a   Harlan, John M ^a  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b ZYMOGENETICS INC   (United States)

^c UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIUM LIPOPOLYSACCHARIDE; CASPASE 8; CYTOKINE; GENE PRODUCT; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1 RECEPTOR; INTERLEUKIN 1BETA; INTERLEUKIN 6;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CORRELATION FUNCTION; EMBRYO; FIBROBLAST; GRAM NEGATIVE SEPSIS; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN INTERACTION; SEPTIC SHOCK;

EID: 0036172129     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI0214774     Document Type: Article

References (35)

1. Trends in infectious diseases mortality in the United States
2. Endotoxemia in human septic shock
3. Receptor-dependent mechanisms of cell stimulation by bacterial endotoxin
4. Toll-like receptor-4 mediates lipopolysaccharide-induced signal transduction
5. Bacterial lipopolysaccharide activates NF-kappaB through Toll-like receptor 4 (TLR-4) in cultured human dermal endothelial cells. Differential expression of tlr-4 and tlr-2 in endothelial cells
6. Interleukin-1/Toll receptor family members: Receptor structure and signal transduction pathways
7. Regulatory roles for CD14 and phosphatidylinositol in the signaling via toll-like receptor 4-MD-2
8. Lipopolysaccharide mediates endothelial apoptosis by a FADD-dependent pathway
9. The apoptotic signaling pathway activated by Toll-like receptor-2
10. Activation of the NF-kappaB pathway by caspase 8 and its homologs
11. Activation of NF-kappaB by FADD, Casper, and caspase-8
12. Fas/FADD-mediated activation of a specific program of inflammatory gene expression in vascular smooth muscle cells
13. Inhibition of death receptor-mediated gene induction by a cycloheximide-sensitive factor occurs at the level of or upstream of Fas-associated death domain protein (FADD)
14. HMEC-1: Establishment of an immortalized human microvascular endothelial cell line
15. FADD: Essential for embryo development and signaling from some, but not all, inducers of apoptosis
16. The T cell activation factor NF-ATc positively regulates HIV-1 replication and gene expression in T cells
17. Functional dichotomy of neutral and acidic sphingomyelinases in tumor necrosis factor signaling
18. c-JUN, JUN B, and JUN D differ in their binding affinities to AP-1 and CRE consensus sequences: Effect of FOS proteins
19. Interleukin 20: Discovery, receptor identification, and role in epidermal function
20. Mapping of the inducible IkappaB phosphorylation sites that signal its ubiquitination and degradation
21. NF-kappaB activation is required for human endothelial survival during exposure to tumor necrosis factor-alpha but not to interleukin-1beta or lipopolysaccharide
22. A constitutive cytoprotective pathway protects endothelial cells from lipopolysaccharide-induced apoptosis
23. FADD/MORT 1 is a common mediator of CD95 (Fas/APO-1) and tumor necrosis factor receptor-induced apoptosis
24. TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways
25. A critical role for the RelA subunit of nuclear factor kappaB in regulation of multiple immune-response genes and in Fas-induced cell death
26. Signal transduction by tumor necrosis factor and gene regulation of the inflammatory cytokine interleukin-6
27. Negative regulation by phosphatidylinositol 3-kinase of inducible nitric oxide synthase expression in macrophages
28. Tumor suppressor MMAC/PTEN inhibits cytokine-induced NFkappaB activation without interfering with the IkappaB degradation pathway
29. Activation of phosphatidylinositol 3-kinase in response to interleukin-1 leads to phosphorylation and activation of the NF-kappaB p65/RelA subunit
30. A phosphatidylinositol 3-kinase/Akt pathway, activated by tumor necrosis factor or interleukin-1, inhibits apopcosis but does not activate NFkappa B in human endothelial cells
31. Inhibition of phosphatidylinositol 3-kinase induces nitric-oxide synthase in lipopolysaccharide- or cytokine-stimulated C6 glial cells
32. I kappa B-beta regulates the persistent response in a biphasic activation of NF-kappa B
33. Lipopolysaccharide-induced NF-kappaB activation in human endothelial cells involves degradation of IkappaBalpha but not IkappaBbeta
34. Drosophila MyD88 is an adapter in the Toll signaling pathway
35. Modulation of the nuclear factor kappa B pathway by Shp-2 tyrosine phosphatase in mediating the induction of interleukin (IL)-6 by IL-1 or tumor necrosis factor