Cutting edge: TLR4 activation mediates liver ischemia/reperfusion inflammatory response via IFN regulatory factor 3-dependent MyD88-independent pathway

Journal of Immunology

Volumn 173, Issue 12, 2004, Pages 7115-7119

  Zhai, Yuan ^a   Shen, Xiu Da ^a   O'Connell, Ryan ^b   Gao, Feng ^a   Lassman, Charles ^c   Busuttil, Ronald W ^a   Cheng, Genhong ^b   Kupiec Weglinski, Jerzy W ^a,b,c  

^a UCLA MEDICAL CENTER   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; CYTOKINE; GAMMA INTERFERON INDUCIBLE PROTEIN 10; INTERFERON REGULATORY FACTOR 3; INTERLEUKIN 6; MYELOID DIFFERENTIATION FACTOR 88; RNA; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; INFLAMMATION; LIVER FUNCTION; LIVER ISCHEMIA; LIVER PERFUSION; LIVER TRANSPLANTATION; MALE; MOUSE; NONHUMAN; ORGAN TRANSPLANTATION; PATHOPHYSIOLOGY; PRIORITY JOURNAL; REPERFUSION INJURY;

EID: 10344264453     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.173.12.7115     Document Type: Article

References (30)

1. Laskowski, I., J. Pratschke, M. J. Wilhelm, M. Gasser, and N. L. Tilney. 2000. Molecular and cellular events associated with ischemia/reperfusion injury. Ann. Transplant 5:29.
2. Fondevila, C., R. W. Busuttil, and J. W. Kupiec-Weglinski. 2003. Hepatic ischemia/reperfusion injury-a fresh look. Exp. Mol. Pathol. 74:86.
3. Takeda, K., T. Kaisho, and S. Akira. 2003. Toll-like receptors. Annu. Rev. Immunol. 21:335.
4. Beg, A. A. 2002. Endogenous ligands of Toll-like receptors: implications for regulating inflammatory and immune responses. Trends Immunol. 23:509.
5. + T-lymphocytes mediate ischemia/reperfusion- induced inflammatory responses in mouse liver. J. Clin. Invest. 100:279.
6. Shen, X. D., B. Ke, Y. Zhai, F. Amersi, F. Gao, D. M. Anselmo, R. W. Busuttil, and J. W. Kupiec-Weglinski. 2002. CD154-CD40 T-cell costimulation pathway is required in the mechanism of hepatic ischemia/reperfusion injury, and its blockade facilitates and depends on heme oxygenase-1 mediated cytoprotection. Transplantation 74:315.
7. Doyle, S., S. Vaidya, R. O'Connell, H. Dadgostar, P. Dempsey, T. Wu, G. Rao, R. Sun, M. Haberland, R. Modlin, and G. Cheng. 2002. IRF3 mediates a TLR3/ TLR4-specific antiviral gene program. Immunity 17:251.
8. Vaidya, S. A., and G. Cheng. 2003. Toll-like receptors and innate antiviral responses. Curr. Opin. Immunol. 15:402.
9. b-tsA58 mice. J. Leukocyte Biol. 74:49.
10. Matsumura, T., A. Ito, T. Takii, H. Hayashi, and K. Onozaki. 2000. Endotoxin and cytokine regulation of Toll-like receptor (TLR) 2 and TLR4 gene expression in murine liver and hepatocytes. J. Interferon Cytokine Res. 20:915.
11. Liu, S., D. J. Gallo, A. M. Green, D. L. Williams, X. Gong, R. A. Shapiro, A. A. Gambotto, E. L. Humphris, Y. Vodovotz, and T. R. Billiar. 2002. Role of Toll-like receptors in changes in gene expression and NF-κB activation in mouse hepatocytes stimulated with lipopolysaccharide. Infect. Immun. 70:3433.
12. Su, G. L., R. D. Klein, A. Aminlari, H. Y. Zhang, L. Steinstraesser, W. H. Alarcon, D. G. Remick, and S. C. Wang. 2000. Kupffer cell activation by lipopolysaccharide in rats: role for lipopolysaccharide binding protein and Toll-like receptor 4. Hepatology 31:932.
13. Miyata, T., I. Yokoyama, S. Todo, A. Tzakis, R. Selby, and T. E. Starzl. 1989. Endotoxaemia, pulmonary complications, and thrombocytopenia in liver transplantation. Lancet 2:189.
14. Tsoulfas, G., Y. Takahashi, R. W. Ganster, G. Yagnik, Z. Guo, J. J. Fung, N. Murase, and D. A. Geller. 2002. Activation of the lipopolysaccharide signaling pathway in hepatic transplantation preservarion injury. Transplantation 74:7.
15. Kato, H., F. Amersi, R. Buelow, J. Melinek, A. J. Coito, B. Ke, R. W. Busuttil, and J. W. Kupiec-Weglinski. 2001. Heme oxygenase-1 overexpression protects rat livers from ischemia/reperfusion injury with extended cold preservation. Am. J. Transplant. 1:121.
16. Ohashi, K., V. Burkart, S. Flohe, and H. Kolb. 2000. Cutting edge: heat shock protein 60 is a putative endogenous ligand of the Toll-like receptor-4 complex. J. Immunol. 164:558.
17. Vabulas, R. M., S. Braedel, N. Hilf, H. Singh-Jasuja, S. Herter, P. Ahmad-Nejad, C. J. Kirschning, C. Da Costa, H. G. Rammensee, H. Wagner, and H. Schild. 2002. The endoplasmic reticulum-resident heat shock protein Gp96 activates dendritic cells via the Toll-like receptor 2/4 pathway. J. Biol. Chem. 277:20847.
18. Shi, Y., J. E. Evans, and K. L. Rock. 2003. Molecular identification of a danger signal that alerts the immune system to dying cells. Nature 425:516.
19. Sampson, P. M., C. L. Rochester, B. Freundlich, and J. A. Elias. 1992. Cytokine regulation of human lung fibroblast hyaluronan (hyaluronic acid) production: evidence for cytokine-regulated hyaluronan (hyaluronic acid) degradation and human lung fibroblast-derived hyaluronidase. J. Clin. Invest. 90:1492.
20. Termeer, C., F. Benedix, J. Sleeman, C. Fieber, U. Voith, T. Ahrens, K. Miyake, M. Freudenberg, C. Galanos, and J. C. Simon. 2002. Oligosaccharides of Hyaluronan activate dendritic cells via Toll-like receptor 4. J. Exp. Med. 195:99.
21. Smiley, S. T., J. A. King, and W. W. Hancock. 2001. Fibrinogen stimulates macrophage chemokine secretion through Toll-like receptor 4. J. Immunol. 167:2887.
22. Okamura, Y., M. Watari, E. S. Jerud, D. W. Young, S. T. Ishizaka, J. Rose, J. C. Chow, and J. F. Strauss III. 2001. The extra domain A of fibronectin activates Toll-like receptor 4. J. Biol. Chem. 276:10229.
23. Vabulas, R. M., P. Ahmad-Nejad, C. da Costa, T. Miethke, C. J. Kirschning, H. Hacker, and H. Wagner. 2001. Endocytosed HSP60s use Toll-like receptor 2 (TLR2) and TLR4 to activate the Toll/interleukin-1 receptor signaling pathway in innate immune cells. J. Biol. Chem. 276:31332.
24. Johnson, G. B., G. J. Brunn, Y. Kodaira, and J. L. Platt. 2002. Receptor-mediated monitoring of tissue well-being via detection of soluble heparan sulfate by Toll-like receptor 4. J. Immunol. 168:5233.
25. Kodaira, Y., S. K. Nair, L. E. Wrenshall, E. Gilboa, and J. L. Platt. 2000. Phenotypic and functional maturation of dendritic cells mediated by heparan sulfate. J. Immunol. 165:1599.
26. Vink, A., A. H. Schoneveld, J. J. van der Meer, B. J. van Middelaar, J. P. Sluijter, M. B. Smeets, P. H. Quax, S. K. Lim, C. Borst, G. Pasterkamp, and D. P. de Kleijn. 2002. In vivo evidence for a role of toll-like receptor 4 in the development of intimal lesions. Circulation 106:1985.
27. Oyama, J., C. Blais, Jr., X. Liu, M. Pu, L. Kobzik, R. A. Kelly, and T. Bourcier. 2004. Reduced myocardial ischemia-reperfusion injury in Toll-like receptor 4-deficient mice. Circulation 109:784.
28. Shishido, T., N. Nozaki, S. Yamaguchi, Y. Shibata, J. Nitobe, T. Miyamoto, H. Takahashi, T. Arimoto, K. Maeda, M. Yamakawa, et al. 2003. Toll-like receptor-2 modulates ventricular remodeling after myocardial infarction. Circulation 108:2905.
29. Goldstein, D. R., B. M. Tesar, S. Akira, and F. G. Lakkis. 2003. Critical role of the Toll-like receptor signal adaptor protein MyD88 in acute allograft rejection. J. Clin. Invest. 111:1571.
30. Samstein, B., G. B. Johnson, and J. L. Platt. 2004. Toll-like receptor-4 and allograft responses. Transplantation 77:475.