Role of p38 mitogen-activated protein kinase in a murine model of pulmonary inflammation

Journal of Immunology

Volumn 164, Issue 4, 2000, Pages 2151-2159

  Nick, Jerry A ^a,b   Young, Scott K ^a   Brown, Kevin K ^a,b   Avdi, Natalie J ^a   Arndt, Patrick G ^a,b   Suratt, Benjamin T ^a,b   Janes, Michael S ^a   Henson, Peter M ^a   Worthen, G Scott ^a,b  

^a NATIONAL JEWISH MEDICAL AND RESEARCH CENTER   (United States)

^b UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; ENZYME ACTIVITY; FEMALE; IMMUNOMODULATION; MONONUCLEAR CELL; MOUSE; NONHUMAN; PNEUMONIA; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

EID: 0034651730     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.164.4.2151     Document Type: Article

References (45)

1. Worthen, G. S., and J. A. Nick. 1998. Leukocyte accumulation in the lung. In Pulmonary Diseases and Disorders. Vol. 1. A. P. Fishman, ed. McGraw-Hill. New York, p. 325.
2. Lien, D. C., W. W. Wagner, R. L. Capen, C. L. Haslett, W. L. Hanson, S. E. Hofmeister, P. M. Henson, and G. S. Worthen. 1987. Physiologic neutrophil sequestration in the canine pulmonary circulation: evidence for localization in capillaries. J. Appl. Physiol. 62:1236.
3. Worthen, G. S., B. Schwab, E. L. Elson, and G. P. Downey. 1989. Mechanics of stimulated neutrophils: cell stiffening induces retention in capillaries. Science 245:183.
4. Downey, G. P., D. E. Doherty, B. Schwab, III, E. L. Elson, P. M. Henson, and G. S. Worthen. 1990. Retention of leukocytes in capillaries: role of cell size and deformability. J. Appl. Physiol. 69:1767.
5. Xing, Z., H. Kirpalani, D. Torry, M. Jordana, and J. Gauldie. 1993. Polymorphonuclear leukocytes as a significant source of TNF-α in endotoxin-challenged lung tissue. Am. J. Pathol. 143:1009.
6. Doherty, D. E., G. P. Downey, B. I. Schwab, E. Elson, and G. S. Worthen. 1994. Lipopolysaccharide-induced monocyte retention in the lung: role of monocyte stiffness, actin assembly, and CD18-dependent adherence, J. Immunol. 153:241.
7. Fantone, J. C. 1997. Cytokines and neutrophils: neutrophil-derived cytokines and the infammatory response. In Cytokines in Health and Disease. D. G. Remick and J. S. Friedland, eds. Marcel Dekker, New York, p. 373.
8. Rollins, B. 1997. Chemokines. Blood 90:909.
9. Harada, A., N. Sekido, T. Akahoshi, T. Wada, N. Mukaida, and K. Matsushima. 1994. Essential involvement of IL-8 in acute inflammation. J. Leukocyte Biol. 56:559.
10. VanZee, K., L. DeForge, E. Fischer, M. Marano, J. Kenney, D. Remick, S. Lowry, and L. Moldawer. 1991. IL-8 in septic shock, endotoxemia, and after IL-1 administration. J. Immunol. 146:3478.
11. Wolpe, S., B. Sherry, D. Juers, G. Davatelis, R. Yurt, and A. Cerami. 1989. Identification and characterization of macrophage inflammatory protein 2. Proc. Natl. Acad. Sci. USA 86:612.
12. Bozic, C., J. L. F. Kolakowski, N. P. Gerard, C. Garcia-Rodrig, C. v. Uexkull-Guldenband, M. J. Conklyn, R. Breslow, H. J. Showell, and C. Gerard. 1995. Expression and biologic characterization of the murine chemokine KC. J. Immunol. 154:6048.
13. Cobb, M. H., and E. J. Goldsmith. 1995. How MAP kinases are regulated. J. Biol. Chem. 270:14843.
14. Han, J., J.-D. Lee, L. Bibbs, and R. J. Ulevitch. 1994. A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells. Science 265:808.
15. Rouse, J. P. Cohen, S. Trigon, M. Morange, A. Alonso-Llamazares, D. Zamanillo, T. Hunt and A. R. Nebreda. 1994. A novel kinase cascade triggered by chemical stress and heat shock which stimulates MAP kinase-activatedprotein kinase-2 and phosphorylation of the small heat shock proteins. Cell 78:1027.
16. Lee, J. C., J. T. Laydon, P. C. McDonnell, T. F. Gallagher, S. Kumar, D. Green, D. McNulty, M. J. Blumenthal, J. R. Heys, S. W. Landvatter, et al. 1994. A protein kinase involved in the regulation of inflammatory cytokine biosynthesis. Nature 372:739.
17. Nick, J. A., N. J. Avdi, P. Gerwins, G. L. Johnson, and G. S. Worthen. 1996. Activation of a p38 mitogen-activated protein kinase in human neutrophils by lipopolysaccharide. J. Immunol. 156:4867.
18. Nahas, N., T. F. P. Molski, G. A. Fernandez, and R. I. Sha'afi. 1996. Tyrosine phosphorylation and activation of a new mitogen-activated protein (MAP)-kinase cascade in human neutrophil stimulated with various agonists. Biochem. J. 318: 247.
19. Nick, J. A., N. J. Avdi, S. K. Young, C. Knall, G. L. Johnson, and G. S. Worthen. 1997. Common and distinct intracellular signalling pathways in human neutrophil utilized by platelet activating factor and EMLP. J. Clin. Invest. 99:975.
20. Zu, Y.-L., J. Qi, A. Gilchrist, G. A. Fernandez, D. Vazquez-Abad, D. L. Kreutzer, C.-K. Huang, and R. I. Sha'afi. 1998. p.38 Mitogen-activated protein kinase activation is required for human neutrophil function triggered by TNF-α or FMLP stimulation. J. Immunol. 160:1982.
21. 2-integrin-dependent neutrophil adhesion and the adhesion-dependent oxidative burst. J Immunol. 161:1921.
22. Manthey, C. L., S.-W. Wang, S. D. Kinney, and Z. Yao. 1998. SB202190, a selective inhibitor of p38 mitogen-activated protein kinase, is a powerful regulator of LPS-induced mRNA-s in monocytes. J. Leukocyte Biol. 64:409.
23. Matsumato, K., S. Hashimoto, Y. Gon, T. Nakayama, and T. Horie. 1998. Proin-flammatory cytokine-induced and chemical mediator-induced IL-8 expression in human bronchial epithelial cells through p38 mitogen-activated protein kinase-dependent pathway. J. Allergy Clin. Immunol. 101:825.
24. Schumann, R. R., D. Pfeil, N. Lamping, C. Kirschning, G. Scherzinger, P. Schlag, L. Karawajew, and F. Herrmann. 1996. LPS induces the rapid tyrosine phosphorylation of the MAP kinases ERK-1 and p38 in cultered human vascular endothelial cells requiring the presence of soluable CD14. Blood 87:2805.
25. Liverton, N. J., J. W. Butcher, C. F. Claiborne, D. A. Claremon, B. E. Libby, K. T. Nguyen, S. M. Pitzenberger, H. G. Sclnick, G. R. Smith, A. Tebben, et al. 1999. The design and synthesis of potent, selective and orally bioavailable tetrasubstituted imidazole inhibitors of p38 MAP kinase. J. Med. Chem. 42:2180.
26. Haslett, C., L. A. Guthrie, M. Kopaniak, R. B. Johnston, Jr., and P. M. Henson. 1985. Modulation of multiple neutrophil functions by trace amounts of bacterial LPS and by preparative methods. Am. J. Pathol 119:101.
27. Haslett, C., G. S. Worthen, P. C. Giclas, D. C. Morrison, J. E. Henson, and P. M. Henson. 1987. The pulmonary vascular sequestration of neutrophils in endotoxemia is initiated by an effect of endotoxin on the neutrophil in the rabbit. Am. Rev. Respir. Dis. 136:9.
28. Rosengren, S., P. M. Henson, and G. S. Worthen. 1994. Migration-associated volume changes in neutrophils facilitate the migratory process. Am. J. Physiol. Cell. Physiol. 267:C1623.
29. Goldblum, S. E., K.-M. Wu, and M. Jay. 1985. Lung myeloperoxidase as a measure of pulmonary leukostasis in rabbits. J. Appl. Physiol. 59:1978.
30. Raingeaud, J., S. Gupta, J. S. Rogers, M. Dickens, J. Han, R. J. Ulevitch, and R. J. Davis. 1995. Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine. J. Biol. Chem. 270:7420.
31. Cassatella, M. 1995. The production of cytokines by polymorphonuclear neutrophils. Immunol. Today 16:21.
32. Weinstein, S. L., J. S. Sanghera, K. Lemke, A. L. DeFranco, and S. L. Pelech. 1992. Bacterial lipopolysaccharide induces tyrosine phosphorylation and activation of mitogen-activated protein kinases in macrophages. J. Biol. Chem. 267: 14955.
33. Swantek, J. L., M. H. Cobb, and T. D. Geppert. 1997. Jun N-terminal kinase/ stress-activated protein kinase (JNK/SAPK) is required for lipopolysaccharide stimulation of tumor necrosis factor α (TNF-α) translation: glucocorticoids inhibit TNF-α translation by blocking JNK/SAPK. Mol. Cell. Biol. 17:6274.
34. Hambleton, J., S. L. Weinstein, L. Lem, and A. L. DeFranco. 1996. Activation of c-Jun N-terminal kinase in bacterial LPS-stimulated macrophages. Proc. Natl. Acad. Sci. USA 93:2774.
35. 2 production in LPS-stimulated monocytes. J. Immunol. 161:5681.
36. Lu, H.-T., D. D. Young, M. Wysk, E. Gatti, I. Mellman, R. J. Davis, and R. A. Flavell. 1999. Defective IL-12 production in mitogen-activated protein (MAP) kinase kinase 3 (Mkk3)-deficient mice. EMBO J. 1845.
37. Schafer, P. H., L. Wang, S. A. Wadsworth, J. E. Davis, and J. J. Siekierka. 1999. T cell activation signals up-regulate p38 mitogen-activated protein kinase activity and induce TNF-α production in a manner distinct from LPS activation of monocytes. J. Immunol. 162:659.
38. Fouda, B. L. T. F. P. Molski, M. S. Ashour, and R. I. Sha'afi. 1995. Effect of lipopolysaccharide on mitogen-activated protein kinases and cytosolic phospholipase A2. Biochem. J. 308:815.
39. Griswold, D. E., S. Hoffstein, P. J. Marshall, E. F. Webb, L. Hillegass, P. E. Bender, and N. Hanna. 1989. Inhibition of inflammatory cell infiltration by bicyclic imidazoles, SK&F 86002 and SK&F 104493. Inflammation 13:727.
40. Griswold, D. E., L. M. Hillegass, P. C. Meunier, M. J. DiMartino, and N. Hanna. 1988. Effect of inhibitors of eicosanoid metabolism in murine collagen-induced arthritis. Arthritis Rheum. 31:1406.
41. Badger, A. M., J. N. Bradbeer, B. Votta, J. C. Lee, J. L. Adams, and D. E. Griswold. 1996. Pharmacologic profile of SB 203580, a selective inhibitor of cytokine suppressive binding protein/p38 kinase, in animal models of arthritis, bone resorption, endotoxin shock and immune function. J. Pharmacol. Exp. Ther. 279:1453.
42. Lee, J. C., A. M. Badger, D. E. Griswold, D. Dunnington, A. Truneh, B. Votta, J. R. White, P. R. Young, and P. E. Bender. 1993. Bicyclic imidazoles as a novel class of cytokine biosynthesis inhibitors. Ann. NY Acad. Sci. 696:149.
43. Badger, A. M., D. L. Olivera, J. E. Talmadge, and N. Hanna. 1989. Protective effects of SK&F 86002, a novel dual inhibitor of arachidonic acid metabolism, in murine models of endotoxic shock: inhibition of TNF as a possible mechanism of action. Circ. Shock 27:51.
44. Olivera, D. L., K. K. Esser, J. C. Lee, R. G. Greig, and A. M. Badger. 1992. Beneficial effects of SK&F 105809, a novel cytokine-suppressive agent, in murine models of endotoxin shock. Circ. Shock 37:301.
45. Reddy, M. P., E. F. Webb, D. Cassatt, D. Maley, J. C. Lee, D. E. Griswold, and A. Truneh. 1994. Pyridinyl imidazoles inhibit the inflammatory phase of delayed type hypersensitivity reactions without affecting T-dependent immune responses. Int. J. Immunopharmacol. 16:795.