-
1
-
-
37049242417
-
Waterfall sequence for intrinsic blood clotting
-
Davie EW, Ratnoff OD. Waterfall sequence for intrinsic blood clotting. Science. 1964;145:1310-1312.
-
(1964)
Science
, vol.145
, pp. 1310-1312
-
-
Davie, E.W.1
Ratnoff, O.D.2
-
2
-
-
0026337077
-
The coagulation cascade: Initiation, maintenance, and regulation
-
Davie EW, Fujikawa K, Kisiel W. The coagulation cascade: initiation, maintenance, and regulation. Biochemistry. 1991;30:10363-10370.
-
(1991)
Biochemistry
, vol.30
, pp. 10363-10370
-
-
Davie, E.W.1
Fujikawa, K.2
Kisiel, W.3
-
4
-
-
11944261500
-
Hemophilia as a defect of the tissue factor pathway of blood coagulation: Effect of factors VIII and IX on factor X activation in a continuous-flow reactor
-
Repke D, Gemmell CH, Guha A, Turitto VT, Broze GJ Jr, Nemerson Y. Hemophilia as a defect of the tissue factor pathway of blood coagulation: effect of factors VIII and IX on factor X activation in a continuous-flow reactor. Proc Natl Acad Sci U S A. 1990;87:7623-7627.
-
(1990)
Proc Natl Acad Sci U S A
, vol.87
, pp. 7623-7627
-
-
Repke, D.1
Gemmell, C.H.2
Guha, A.3
Turitto, V.T.4
Broze Jr., G.J.5
Nemerson, Y.6
-
5
-
-
0033559805
-
Protease-activated receptors 1 and 4 mediate activation of human platelets by thrombin
-
Kahn ML, Nakanishi-Matsui M, Shapiro MJ, Ishihara H, Coughlin SR. Protease-activated receptors 1 and 4 mediate activation of human platelets by thrombin. J Clin Invest. 1999;103:879-887.
-
(1999)
J Clin Invest
, vol.103
, pp. 879-887
-
-
Kahn, M.L.1
Nakanishi-Matsui, M.2
Shapiro, M.J.3
Ishihara, H.4
Coughlin, S.R.5
-
6
-
-
0025139882
-
Activation of human factor V by factor Xa and thrombin
-
Monkovic DD, Tracy PB. Activation of human factor V by factor Xa and thrombin. Biochemistry. 1990;29:1118-1128.
-
(1990)
Biochemistry
, vol.29
, pp. 1118-1128
-
-
Monkovic, D.D.1
Tracy, P.B.2
-
7
-
-
1042276751
-
Activation of factor VIII and mechanisms of cofactor action
-
Fay PJ. Activation of factor VIII and mechanisms of cofactor action. Blood Rev. 2004;18:1-15.
-
(2004)
Blood Rev
, vol.18
, pp. 1-15
-
-
Fay, P.J.1
-
8
-
-
0346850827
-
Thrombin activation of factor XI on activated platelets requires the interaction of factor XI and platelet glycoprotein Ib alpha with thrombin anion-binding exosites I and II, respectively
-
Yun TH, Baglia FA, Myles T, Navaneetham D, Lopez JA, Walsh PN, Leung LL. Thrombin activation of factor XI on activated platelets requires the interaction of factor XI and platelet glycoprotein Ib alpha with thrombin anion-binding exosites I and II, respectively. J Biol Chem. 2003;278:48112-48119.
-
(2003)
J Biol Chem
, vol.278
, pp. 48112-48119
-
-
Yun, T.H.1
Baglia, F.A.2
Myles, T.3
Navaneetham, D.4
Lopez, J.A.5
Walsh, P.N.6
Leung, L.L.7
-
9
-
-
0016759666
-
Cross-linking of fibrinogen and fibrin by fibrin-stablizing factor (factor XIIIa)
-
Kanaide H, Shainoff JR. Cross-linking of fibrinogen and fibrin by fibrin-stablizing factor (factor XIIIa). J Lab Clin Med. 1975;85:574-597.
-
(1975)
J Lab Clin Med
, vol.85
, pp. 574-597
-
-
Kanaide, H.1
Shainoff, J.R.2
-
10
-
-
12844270458
-
Proteolytic inactivation of ADAMTS13 by thrombin and plasmin
-
Crawley JT, Lam JK, Rance JB, Mollica LR, O'Donnell JS, Lane DA. Proteolytic inactivation of ADAMTS13 by thrombin and plasmin. Blood. 2005;105:1085-1093.
-
(2005)
Blood
, vol.105
, pp. 1085-1093
-
-
Crawley, J.T.1
Lam, J.K.2
Rance, J.B.3
Mollica, L.R.4
O'Donnell, J.S.5
Lane, D.A.6
-
11
-
-
0027161205
-
Molecular events that control the protein C anticoagulant pathway
-
Esmon CT. Molecular events that control the protein C anticoagulant pathway. Thromb Haemost. 1993;70:29-35.
-
(1993)
Thromb Haemost
, vol.70
, pp. 29-35
-
-
Esmon, C.T.1
-
12
-
-
0019755874
-
Prothrombin
-
Mann KG, Elion J, Butkowski RJ, Downing M, Nesheim ME. Prothrombin. Methods Enzymol. 1981;80(pt C):286-302.
-
(1981)
Methods Enzymol
, vol.80
, Issue.100 PART
, pp. 286-302
-
-
Mann, K.G.1
Elion, J.2
Butkowski, R.J.3
Downing, M.4
Nesheim, M.E.5
-
13
-
-
0023196008
-
Activation of human prothrombin by human prothrombinase. Influence of factor Va on the reaction mechanism
-
Krishnaswamy S, Church WR, Nesheim ME, Mann KG. Activation of human prothrombin by human prothrombinase. Influence of factor Va on the reaction mechanism. J Biol Chem. 1987;262:3291-3299.
-
(1987)
J Biol Chem
, vol.262
, pp. 3291-3299
-
-
Krishnaswamy, S.1
Church, W.R.2
Nesheim, M.E.3
Mann, K.G.4
-
14
-
-
0034623944
-
Exosite binding tethers the macromolecular substrate to the prothrombinase complex and directs cleavage at two spatially distinct sites
-
Boskovic DS, Krishnaswamy S. Exosite binding tethers the macromolecular substrate to the prothrombinase complex and directs cleavage at two spatially distinct sites. J Biol Chem. 2000;275:38561-38570.
-
(2000)
J Biol Chem
, vol.275
, pp. 38561-38570
-
-
Boskovic, D.S.1
Krishnaswamy, S.2
-
16
-
-
0024431034
-
The refined 1.9 A crystal structure of human alpha-thrombin: Interaction with D-Phe-Pro-Arg chloromethylketone and significance of the Tyr-Pro-Pro-Trp insertion segment
-
Bode W, Mayr I, Baumann U, Huber R, Stone SR, Hofsteenge J. The refined 1.9 A crystal structure of human alpha-thrombin: interaction with D-Phe-Pro-Arg chloromethylketone and significance of the Tyr-Pro-Pro-Trp insertion segment. EMBO J. 1989;8:3467-3475.
-
(1989)
EMBO J
, vol.8
, pp. 3467-3475
-
-
Bode, W.1
Mayr, I.2
Baumann, U.3
Huber, R.4
Stone, S.R.5
Hofsteenge, J.6
-
17
-
-
0020964886
-
Steady state kinetic parameters for the thrombin-catalyzed conversion of human fibrinogen to fibrin
-
Higgins DL, Lewis SD, Shafer JA. Steady state kinetic parameters for the thrombin-catalyzed conversion of human fibrinogen to fibrin. J Biol Chem. 1983;258:9276-9282.
-
(1983)
J Biol Chem
, vol.258
, pp. 9276-9282
-
-
Higgins, D.L.1
Lewis, S.D.2
Shafer, J.A.3
-
18
-
-
0035165038
-
The dual role of thrombin's anion-binding exosite-I in the recognition and cleavage of the protease-activated receptor 1
-
Myles T, Le Bonniec BF, Stone SR. The dual role of thrombin's anion-binding exosite-I in the recognition and cleavage of the protease-activated receptor 1. Eur J Biochem. 2001;268:70-77.
-
(2001)
Eur J Biochem
, vol.268
, pp. 70-77
-
-
Myles, T.1
Le Bonniec, B.F.2
Stone, S.R.3
-
19
-
-
0141484541
-
Thrombin interactions
-
Di Cera E. Thrombin interactions. Chest. 2003;124:11S-17S.
-
(2003)
Chest
, vol.124
-
-
Di Cera, E.1
-
20
-
-
0029935853
-
Involvement of thrombin anion-binding exosites 1 and 2 in the activation of factor V and factor VIII
-
Esmon CT, Lollar P. Involvement of thrombin anion-binding exosites 1 and 2 in the activation of factor V and factor VIII. J Biol Chem. 1996;271:13882-13887.
-
(1996)
J Biol Chem
, vol.271
, pp. 13882-13887
-
-
Esmon, C.T.1
Lollar, P.2
-
21
-
-
0035816595
-
An extensive interaction interface between thrombin and factor V is required for factor V activation
-
Myles T, Yun TH, Hall SW, Leung LL. An extensive interaction interface between thrombin and factor V is required for factor V activation. J Biol Chem. 2001;276:25143-25149.
-
(2001)
J Biol Chem
, vol.276
, pp. 25143-25149
-
-
Myles, T.1
Yun, T.H.2
Hall, S.W.3
Leung, L.L.4
-
22
-
-
0037108447
-
Structural requirements for the activation of human factor VIII by thrombin
-
Myles T, Yun TH, Leung LL. Structural requirements for the activation of human factor VIII by thrombin. Blood. 2002;100:2820-2826.
-
(2002)
Blood
, vol.100
, pp. 2820-2826
-
-
Myles, T.1
Yun, T.H.2
Leung, L.L.3
-
23
-
-
27144505651
-
Molecular recognition mechanisms of thrombin
-
Huntington JA. Molecular recognition mechanisms of thrombin. J Thromb Haemost. 2005;3:1861-1872.
-
(2005)
J Thromb Haemost
, vol.3
, pp. 1861-1872
-
-
Huntington, J.A.1
-
24
-
-
0019876461
-
Purification and preliminary physicochemical characterization of human platelet membrane glycoprotein V
-
Berndt MC, Phillips DR. Purification and preliminary physicochemical characterization of human platelet membrane glycoprotein V. J Biol Chem. 1981;256:59-65.
-
(1981)
J Biol Chem
, vol.256
, pp. 59-65
-
-
Berndt, M.C.1
Phillips, D.R.2
-
25
-
-
0029963871
-
Mocarhagin, a novel cobra venom metalloproteinase, cleaves the platelet von Willebrand factor receptor glycoprotein Ibalpha. Identification of the sulfated tyrosine/anionic sequence Tyr-276-Glu-282 of glycoprotein Ibalpha as a binding site for von Willebrand factor and alpha-thrombin
-
Ward CM, Andrews RK, Smith AI, Berndt MC. Mocarhagin, a novel cobra venom metalloproteinase, cleaves the platelet von Willebrand factor receptor glycoprotein Ibalpha. Identification of the sulfated tyrosine/anionic sequence Tyr-276-Glu-282 of glycoprotein Ibalpha as a binding site for von Willebrand factor and alpha-thrombin. Biochemistry. 1996;35:4929-4938.
-
(1996)
Biochemistry
, vol.35
, pp. 4929-4938
-
-
Ward, C.M.1
Andrews, R.K.2
Smith, A.I.3
Berndt, M.C.4
-
26
-
-
0035895962
-
Binding of thrombin to glycoprotein Ib accelerates the hydrolysis of Par-1 on intact platelets
-
De Candia E, Hall SW, Rutella S, Landolfi R, Andrews RK, De Cristofaro R. Binding of thrombin to glycoprotein Ib accelerates the hydrolysis of Par-1 on intact platelets. J Biol Chem. 2001;276:4692-4698.
-
(2001)
J Biol Chem
, vol.276
, pp. 4692-4698
-
-
De Candia, E.1
Hall, S.W.2
Rutella, S.3
Landolfi, R.4
Andrews, R.K.5
De Cristofaro, R.6
-
27
-
-
0034648757
-
Thrombin signalling and protease-activated receptors
-
Coughlin SR. Thrombin signalling and protease-activated receptors. Nature. 2000;407:258-264.
-
(2000)
Nature
, vol.407
, pp. 258-264
-
-
Coughlin, S.R.1
-
28
-
-
0037127251
-
Factor XI binding to the platelet glycoprotein Ib-IX-V complex promotes factor XI activation by thrombin
-
Baglia FA, Badellino KO, Li CQ, Lopez JA, Walsh PN. Factor XI binding to the platelet glycoprotein Ib-IX-V complex promotes factor XI activation by thrombin. J Biol Chem. 2002;277:1662-1668.
-
(2002)
J Biol Chem
, vol.277
, pp. 1662-1668
-
-
Baglia, F.A.1
Badellino, K.O.2
Li, C.Q.3
Lopez, J.A.4
Walsh, P.N.5
-
29
-
-
0020516779
-
Correlation of thrombin-induced glycoprotein V hydrolysis and platelet activation
-
McGowan EB, Ding A, Detwiler TC. Correlation of thrombin-induced glycoprotein V hydrolysis and platelet activation. J Biol Chem. 1983;258:11243-11248.
-
(1983)
J Biol Chem
, vol.258
, pp. 11243-11248
-
-
McGowan, E.B.1
Ding, A.2
Detwiler, T.C.3
-
30
-
-
0035852682
-
A thrombin receptor function for platelet glycoprotein Ib-IX unmasked by cleavage of glycoprotein V
-
Ramakrishnan V, DeGuzman F, Bao M, Hall SW, Leung LL, Phillips DR. A thrombin receptor function for platelet glycoprotein Ib-IX unmasked by cleavage of glycoprotein V. Proc Natl Acad Sci U S A. 2001;98:1823-1828.
-
(2001)
Proc Natl Acad Sci U S A
, vol.98
, pp. 1823-1828
-
-
Ramakrishnan, V.1
DeGuzman, F.2
Bao, M.3
Hall, S.W.4
Leung, L.L.5
Phillips, D.R.6
-
31
-
-
0028940892
-
Identification of three tyrosine residues of glycoprotein Ib alpha with distinct roles in von Willebrand factor and alpha-thrombin binding
-
Marchese P, Murata M, Mazzucato M, Pradella P, De Marco L, Ware J, Ruggeri ZM. Identification of three tyrosine residues of glycoprotein Ib alpha with distinct roles in von Willebrand factor and alpha-thrombin binding. J Biol Chem. 1995;270:9571-9578.
-
(1995)
J Biol Chem
, vol.270
, pp. 9571-9578
-
-
Marchese, P.1
Murata, M.2
Mazzucato, M.3
Pradella, P.4
De Marco, L.5
Ware, J.6
Ruggeri, Z.M.7
-
32
-
-
0028181314
-
High-affinity alpha-thrombin binding to platelet glycoprotein Ib alpha: Identification of two binding domains
-
Gralnick HR, Williams S, McKeown LP, Hansmann K, Fenton JW, Krutzsch H. High-affinity alpha-thrombin binding to platelet glycoprotein Ib alpha: identification of two binding domains. Proc Natl Acad Sci U S A. 1994;91:6334-6338.
-
(1994)
Proc Natl Acad Sci U S A
, vol.91
, pp. 6334-6338
-
-
Gralnick, H.R.1
Williams, S.2
McKeown, L.P.3
Hansmann, K.4
Fenton, J.W.5
Krutzsch, H.6
-
33
-
-
0028029520
-
Tyrosine sulfation of the glycoprotein Ib-IX complex: Identification of sulfated residues and effect on ligand binding
-
Dong JF, Li CQ, Lopez JA. Tyrosine sulfation of the glycoprotein Ib-IX complex: identification of sulfated residues and effect on ligand binding. Biochemistry. 1994;33:13946-13953.
-
(1994)
Biochemistry
, vol.33
, pp. 13946-13953
-
-
Dong, J.F.1
Li, C.Q.2
Lopez, J.A.3
-
34
-
-
0035818425
-
Structural and functional mapping of the thrombin domain involved in the binding to the platelet glycoprotein Ib
-
De Cristofaro R, De Candia E, Landolfi R, Rutella S, Hall SW. Structural and functional mapping of the thrombin domain involved in the binding to the platelet glycoprotein Ib. Biochemistry. 2001;40:13268-13273.
-
(2001)
Biochemistry
, vol.40
, pp. 13268-13273
-
-
De Cristofaro, R.1
De Candia, E.2
Landolfi, R.3
Rutella, S.4
Hall, S.W.5
-
35
-
-
0035794133
-
Platelet glycoprotein Ib alpha binds to thrombin anion-binding exosite II inducing allosteric changes in the activity of thrombin
-
Li CQ, Vindigni A, Sadler JE, Wardell MR. Platelet glycoprotein Ib alpha binds to thrombin anion-binding exosite II inducing allosteric changes in the activity of thrombin. J Biol Chem. 2001;276:6161-6168.
-
(2001)
J Biol Chem
, vol.276
, pp. 6161-6168
-
-
Li, C.Q.1
Vindigni, A.2
Sadler, J.E.3
Wardell, M.R.4
-
36
-
-
0026035523
-
Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation
-
Vu TK, Hung DT, Wheaton VI, Coughlin SR. Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation. Cell. 1991;64:1057-1068.
-
(1991)
Cell
, vol.64
, pp. 1057-1068
-
-
Vu, T.K.1
Hung, D.T.2
Wheaton, V.I.3
Coughlin, S.R.4
-
37
-
-
0026072517
-
Domains specifying thrombin-receptor interaction
-
Vu TK, Wheaton VI, Hung DT, Charo I, Coughlin SR. Domains specifying thrombin-receptor interaction. Nature. 1991;353:674-677.
-
(1991)
Nature
, vol.353
, pp. 674-677
-
-
Vu, T.K.1
Wheaton, V.I.2
Hung, D.T.3
Charo, I.4
Coughlin, S.R.5
-
38
-
-
0038157329
-
Crystal structure of the GpIbalpha-thrombin complex essential for platelet aggregation
-
Dumas JJ, Kumar R, Seehra J, Somers WS, Mosyak L. Crystal structure of the GpIbalpha-thrombin complex essential for platelet aggregation. Science. 2003;301:222-226.
-
(2003)
Science
, vol.301
, pp. 222-226
-
-
Dumas, J.J.1
Kumar, R.2
Seehra, J.3
Somers, W.S.4
Mosyak, L.5
-
39
-
-
0037815126
-
Modulation of alpha-thrombin function by distinct interactions with platelet glycoprotein Ibalpha
-
Celikel R, McClintock RA, Roberts JR, Mendolicchio GL, Ware J, Varughese KI, Ruggeri ZM. Modulation of alpha-thrombin function by distinct interactions with platelet glycoprotein Ibalpha. Science. 2003;301:218-221.
-
(2003)
Science
, vol.301
, pp. 218-221
-
-
Celikel, R.1
McClintock, R.A.2
Roberts, J.R.3
Mendolicchio, G.L.4
Ware, J.5
Varughese, K.I.6
Ruggeri, Z.M.7
-
40
-
-
0034964447
-
The structure and biological features of fibrinogen and fibrin
-
Mosesson MW, Siebenlist KR, Meh DA. The structure and biological features of fibrinogen and fibrin. Ann N Y Acad Sci. 2001;936:11-30.
-
(2001)
Ann N Y Acad Sci
, vol.936
, pp. 11-30
-
-
Mosesson, M.W.1
Siebenlist, K.R.2
Meh, D.A.3
-
41
-
-
0023932353
-
Thrombin-induced fibrinopeptide B release from normal and variant fibrinogens: Influence of inhibitors of fibrin polymerization
-
Ruf W, Bender A, Lane DA, Preissner KT, Selmayr E, Muller-Berghaus G. Thrombin-induced fibrinopeptide B release from normal and variant fibrinogens: influence of inhibitors of fibrin polymerization. Biochim Biophys Acta. 1988;965:169-175.
-
(1988)
Biochim Biophys Acta
, vol.965
, pp. 169-175
-
-
Ruf, W.1
Bender, A.2
Lane, D.A.3
Preissner, K.T.4
Selmayr, E.5
Muller-Berghaus, G.6
-
42
-
-
0027194661
-
The sequence of cleavage of fibrinopeptides from fibrinogen is important for protofibril formation and enhancement of lateral aggregation in fibrin clots
-
Weisel JW, Veklich Y, Gorkun O. The sequence of cleavage of fibrinopeptides from fibrinogen is important for protofibril formation and enhancement of lateral aggregation in fibrin clots. J Mol Biol. 1993;232:285-297.
-
(1993)
J Mol Biol
, vol.232
, pp. 285-297
-
-
Weisel, J.W.1
Veklich, Y.2
Gorkun, O.3
-
43
-
-
0029950081
-
Transient intermediates in the thrombin activation of fibrinogen. Evidence for only the desAA species
-
Li X, Galanakis D, Gabriel DA. Transient intermediates in the thrombin activation of fibrinogen. Evidence for only the desAA species. J Biol Chem. 1996;271:11767-11771.
-
(1996)
J Biol Chem
, vol.271
, pp. 11767-11771
-
-
Li, X.1
Galanakis, D.2
Gabriel, D.A.3
-
44
-
-
0030803827
-
Fibrinogen and fibrin polymerization: Appraisal of the binding events that accompany fibrin generation and fibrin clot assembly
-
Mosesson MW. Fibrinogen and fibrin polymerization: appraisal of the binding events that accompany fibrin generation and fibrin clot assembly. Blood Coagul Fibrinolysis. 1997;8:257-267.
-
(1997)
Blood Coagul Fibrinolysis
, vol.8
, pp. 257-267
-
-
Mosesson, M.W.1
-
45
-
-
0002162129
-
Activation of the fibrin stabilizing factor of plasma by thrombin
-
Lorand L, Konishi K. Activation of the fibrin stabilizing factor of plasma by thrombin. Arch Biochem Biophys. 1964;105:58-67.
-
(1964)
Arch Biochem Biophys
, vol.105
, pp. 58-67
-
-
Lorand, L.1
Konishi, K.2
-
46
-
-
0033525536
-
Exosites 1 and 2 are essential for protection of fibrin-bound thrombin from heparin-catalyzed inhibition by antithrombin and heparin cofactor II
-
Becker DL, Fredenburgh JC, Stafford AR, Weitz JI. Exosites 1 and 2 are essential for protection of fibrin-bound thrombin from heparin-catalyzed inhibition by antithrombin and heparin cofactor II. J Biol Chem. 1999;274:6226-6233.
-
(1999)
J Biol Chem
, vol.274
, pp. 6226-6233
-
-
Becker, D.L.1
Fredenburgh, J.C.2
Stafford, A.R.3
Weitz, J.I.4
-
47
-
-
0021080275
-
Promotion of thrombin-catalyzed activation of factor XIII by fibrinogen
-
Janus TJ, Lewis SD, Lorand L, Shafer JA. Promotion of thrombin-catalyzed activation of factor XIII by fibrinogen. Biochemistry. 1983;22:6269-6272.
-
(1983)
Biochemistry
, vol.22
, pp. 6269-6272
-
-
Janus, T.J.1
Lewis, S.D.2
Lorand, L.3
Shafer, J.A.4
-
49
-
-
3042662496
-
The impact of factor XIII on coagulation kinetics and clot strength determined by thrombelastography
-
Nielsen VG, Gurley WQ Jr, Burch TM. The impact of factor XIII on coagulation kinetics and clot strength determined by thrombelastography. Anesth Analg. 2004;99:120-123.
-
(2004)
Anesth Analg
, vol.99
, pp. 120-123
-
-
Nielsen, V.G.1
Gurley Jr., W.Q.2
Burch, T.M.3
-
50
-
-
0029830698
-
Identification and characterization of the thrombin binding sites on fibrin
-
Meh DA, Siebenlist KR, Mosesson MW. Identification and characterization of the thrombin binding sites on fibrin. J Biol Chem. 1996;271:23121-23125.
-
(1996)
J Biol Chem
, vol.271
, pp. 23121-23125
-
-
Meh, D.A.1
Siebenlist, K.R.2
Mosesson, M.W.3
-
51
-
-
0027258750
-
The fibrinogen sequences that interact with thrombin
-
Binnie CG, Lord ST. The fibrinogen sequences that interact with thrombin. Blood. 1993;81:3186-3192.
-
(1993)
Blood
, vol.81
, pp. 3186-3192
-
-
Binnie, C.G.1
Lord, S.T.2
-
52
-
-
0030941564
-
Modulation of thrombin and heparin activities by fibrin
-
Hogg PJ, Bock PE. Modulation of thrombin and heparin activities by fibrin. Thromb Haemost. 1997;77:424-433.
-
(1997)
Thromb Haemost
, vol.77
, pp. 424-433
-
-
Hogg, P.J.1
Bock, P.E.2
-
53
-
-
0037166273
-
Three-dimensional modeling of thrombin-fibrinogen interaction
-
Rose T, Di Cera E. Three-dimensional modeling of thrombin-fibrinogen interaction. J Biol Chem. 2002;277:18875-18880.
-
(2002)
J Biol Chem
, vol.277
, pp. 18875-18880
-
-
Rose, T.1
Di Cera, E.2
-
54
-
-
0035940439
-
Crystal structure of native chicken fibrinogen at 2.7 A resolution
-
Yang Z, Kollman JM, Pandi L, Doolittle RF. Crystal structure of native chicken fibrinogen at 2.7 A resolution. Biochemistry. 2001;40:12515-12523.
-
(2001)
Biochemistry
, vol.40
, pp. 12515-12523
-
-
Yang, Z.1
Kollman, J.M.2
Pandi, L.3
Doolittle, R.F.4
-
55
-
-
0029017360
-
Functional mapping of the surface residues of human thrombin
-
Tsiang M, Jain AK, Dunn KE, Rojas ME, Leung LL, Gibbs CS. Functional mapping of the surface residues of human thrombin. J Biol Chem. 1995;270:16854-16863.
-
(1995)
J Biol Chem
, vol.270
, pp. 16854-16863
-
-
Tsiang, M.1
Jain, A.K.2
Dunn, K.E.3
Rojas, M.E.4
Leung, L.L.5
Gibbs, C.S.6
-
56
-
-
0035655901
-
Identification of critical residues on thrombin mediating its interaction with fibrin
-
Hall SW, Gibbs CS, Leung LL. Identification of critical residues on thrombin mediating its interaction with fibrin. Thromb Haemost. 2001;86:1466-1474.
-
(2001)
Thromb Haemost
, vol.86
, pp. 1466-1474
-
-
Hall, S.W.1
Gibbs, C.S.2
Leung, L.L.3
-
57
-
-
1542297770
-
Crystal structure of the complex between thrombin and the central "E" region of fibrin
-
Pechik I, Madrazo J, Mosesson MW, Hernandez I, Gilliland GL, Medved L. Crystal structure of the complex between thrombin and the central "E" region of fibrin. Proc Natl Acad Sci U S A. 2004;101:2718-2723.
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, pp. 2718-2723
-
-
Pechik, I.1
Madrazo, J.2
Mosesson, M.W.3
Hernandez, I.4
Gilliland, G.L.5
Medved, L.6
-
58
-
-
0141450410
-
Fibrinogen gamma chain functions
-
Mosesson MW. Fibrinogen gamma chain functions. J Thromb Haemost. 2003;1:231-238.
-
(2003)
J Thromb Haemost
, vol.1
, pp. 231-238
-
-
Mosesson, M.W.1
-
60
-
-
0037821812
-
Evidence that both exosites on thrombin participate in its high affinity interaction with fibrin
-
Pospisil CH, Stafford AR, Fredenburgh JC, Weitz JI. Evidence that both exosites on thrombin participate in its high affinity interaction with fibrin. J Biol Chem. 2003;278:21584-21591.
-
(2003)
J Biol Chem
, vol.278
, pp. 21584-21591
-
-
Pospisil, C.H.1
Stafford, A.R.2
Fredenburgh, J.C.3
Weitz, J.I.4
-
61
-
-
0035077402
-
The amino acid sequence in fibrin responsible for high affinity thrombin binding
-
Meh DA, Siebenlist KR, Brennan SO, Holyst T, Mosesson MW. The amino acid sequence in fibrin responsible for high affinity thrombin binding. Thromb Haemost. 2001;85:470-474.
-
(2001)
Thromb Haemost
, vol.85
, pp. 470-474
-
-
Meh, D.A.1
Siebenlist, K.R.2
Brennan, S.O.3
Holyst, T.4
Mosesson, M.W.5
-
62
-
-
0029798238
-
Plasma factor XIII binds specifically to fibrinogen molecules containing gamma chains
-
Siebenlist KR, Meh DA, Mosesson MW. Plasma factor XIII binds specifically to fibrinogen molecules containing gamma chains. Biochemistry. 1996;35:10448-10453.
-
(1996)
Biochemistry
, vol.35
, pp. 10448-10453
-
-
Siebenlist, K.R.1
Meh, D.A.2
Mosesson, M.W.3
-
63
-
-
0000650903
-
Identification of an endothelial cell cofactor for thrombin-catalyzed activation of protein C
-
Esmon CT, Owen WG. Identification of an endothelial cell cofactor for thrombin-catalyzed activation of protein C. Proc Natl Acad Sci U S A. 1981;78:2249-2252.
-
(1981)
Proc Natl Acad Sci U S A
, vol.78
, pp. 2249-2252
-
-
Esmon, C.T.1
Owen, W.G.2
-
64
-
-
0022529127
-
Effect of thrombomodulin on the kinetics of the interaction of thrombin with substrates and inhibitors
-
Hofsteenge J, Taguchi H, Stone SR. Effect of thrombomodulin on the kinetics of the interaction of thrombin with substrates and inhibitors. Biochem J. 1986;237:243-251.
-
(1986)
Biochem J
, vol.237
, pp. 243-251
-
-
Hofsteenge, J.1
Taguchi, H.2
Stone, S.R.3
-
65
-
-
0029895009
-
TAFI, or plasma procarboxypeptidase B, couples the coagulation and fibrinolytic cascades through the thrombin-thrombomodulin complex
-
Bajzar L, Morser J, Nesheim M. TAFI, or plasma procarboxypeptidase B, couples the coagulation and fibrinolytic cascades through the thrombin-thrombomodulin complex. J Biol Chem. 1996;271:16603-16608.
-
(1996)
J Biol Chem
, vol.271
, pp. 16603-16608
-
-
Bajzar, L.1
Morser, J.2
Nesheim, M.3
-
66
-
-
0023943394
-
A 10-kDa cyanogen bromide fragment from the epidermal growth factor homology domain of rabbit thrombomodulin contains the primary thrombin binding site
-
Kurosawa S, Stearns DJ, Jackson KW, Esmon CT. A 10-kDa cyanogen bromide fragment from the epidermal growth factor homology domain of rabbit thrombomodulin contains the primary thrombin binding site. J Biol Chem. 1988;263:5993-5996.
-
(1988)
J Biol Chem
, vol.263
, pp. 5993-5996
-
-
Kurosawa, S.1
Stearns, D.J.2
Jackson, K.W.3
Esmon, C.T.4
-
67
-
-
0026781041
-
The fifth and sixth growth factor-like domains of thrombomodulin bind to the anion-binding exosite of thrombin and alter its specificity
-
Ye J, Liu LW, Esmon CT, Johnson AE. The fifth and sixth growth factor-like domains of thrombomodulin bind to the anion-binding exosite of thrombin and alter its specificity. J Biol Chem. 1992;267:11023-11028.
-
(1992)
J Biol Chem
, vol.267
, pp. 11023-11028
-
-
Ye, J.1
Liu, L.W.2
Esmon, C.T.3
Johnson, A.E.4
-
68
-
-
0027411150
-
Alanine-scanning mutagenesis of the epidermal growth factor-like domains of human thrombomodulin identifies critical residues for its cofactor activity
-
Nagashima M, Lundh E, Leonard JC, Morser J, Parkinson JF. Alanine-scanning mutagenesis of the epidermal growth factor-like domains of human thrombomodulin identifies critical residues for its cofactor activity. J Biol Chem. 1993;268:2888-2892.
-
(1993)
J Biol Chem
, vol.268
, pp. 2888-2892
-
-
Nagashima, M.1
Lundh, E.2
Leonard, J.C.3
Morser, J.4
Parkinson, J.F.5
-
69
-
-
0026775230
-
Functional domains of membrane-bound human thrombomodulin. EGF-like domains four to six and the serine/threonine-rich domain are required for cofactor activity
-
Tsiang M, Lentz SR, Sadler JE. Functional domains of membrane-bound human thrombomodulin. EGF-like domains four to six and the serine/threonine-rich domain are required for cofactor activity. J Biol Chem. 1992;267:6164-6170.
-
(1992)
J Biol Chem
, vol.267
, pp. 6164-6170
-
-
Tsiang, M.1
Lentz, S.R.2
Sadler, J.E.3
-
70
-
-
0025719626
-
Aspartic acid 349 in the fourth epidermal growth factor-like structure of human thrombomodulin plays a role in its Ca(2+)-mediated binding to protein C
-
Zushi M, Gomi K, Honda G, Kondo S, Yamamoto S, Hayashi T, Suzuki K. Aspartic acid 349 in the fourth epidermal growth factor-like structure of human thrombomodulin plays a role in its Ca(2+)-mediated binding to protein C. J Biol Chem. 1991;266:19886-19889.
-
(1991)
J Biol Chem
, vol.266
, pp. 19886-19889
-
-
Zushi, M.1
Gomi, K.2
Honda, G.3
Kondo, S.4
Yamamoto, S.5
Hayashi, T.6
Suzuki, K.7
-
71
-
-
0029586382
-
Large-scale expression, purification and characterization of small fragments of thrombomodulin: The roles of the sixth domain and of methionine 388
-
White CE, Hunter MJ, Meininger DP, White LR, Komives EA. Large-scale expression, purification and characterization of small fragments of thrombomodulin: the roles of the sixth domain and of methionine 388. Protein Eng. 1995;8:1177-1187.
-
(1995)
Protein Eng
, vol.8
, pp. 1177-1187
-
-
White, C.E.1
Hunter, M.J.2
Meininger, D.P.3
White, L.R.4
Komives, E.A.5
-
72
-
-
0037518132
-
The fourth epidermal growth factor-like domain of thrombomodulin interacts with the basic exosite of protein C
-
Yang L, Rezaie AR. The fourth epidermal growth factor-like domain of thrombomodulin interacts with the basic exosite of protein C. J Biol Chem. 2003;278:10484-10490.
-
(2003)
J Biol Chem
, vol.278
, pp. 10484-10490
-
-
Yang, L.1
Rezaie, A.R.2
-
73
-
-
0032524918
-
Activation of thrombin-activable fibrinolysis inhibitor requires epidermal growth factor-like domain 3 of thrombomodulin and is inhibited competitively by protein C
-
Kokame K, Zheng X, Sadler JE. Activation of thrombin-activable fibrinolysis inhibitor requires epidermal growth factor-like domain 3 of thrombomodulin and is inhibited competitively by protein C. J Biol Chem. 1998;273:12135-12139.
-
(1998)
J Biol Chem
, vol.273
, pp. 12135-12139
-
-
Kokame, K.1
Zheng, X.2
Sadler, J.E.3
-
74
-
-
0141509969
-
Thrombomodulin enhances the reactivity of thrombin with protein C inhibitor by providing both a binding site for the serpin and allosterically modulating the activity of thrombin
-
Yang L, Manithody C, Walston TD, Cooper ST, Rezaie AR. Thrombomodulin enhances the reactivity of thrombin with protein C inhibitor by providing both a binding site for the serpin and allosterically modulating the activity of thrombin. J Biol Chem. 2003;278:37465-37470.
-
(2003)
J Biol Chem
, vol.278
, pp. 37465-37470
-
-
Yang, L.1
Manithody, C.2
Walston, T.D.3
Cooper, S.T.4
Rezaie, A.R.5
-
75
-
-
0034732094
-
Structural basis for the anticoagulant activity of the thrombin-thrombomodulin complex
-
Fuentes-Prior P, Iwanaga Y, Huber R, Pagila R, Rumennik G, Seto M, Morser J, Light DR, Bode W. Structural basis for the anticoagulant activity of the thrombin-thrombomodulin complex. Nature. 2000;404:518-525.
-
(2000)
Nature
, vol.404
, pp. 518-525
-
-
Fuentes-Prior, P.1
Iwanaga, Y.2
Huber, R.3
Pagila, R.4
Rumennik, G.5
Seto, M.6
Morser, J.7
Light, D.R.8
Bode, W.9
-
76
-
-
0035942306
-
Electrostatic steering and ionic tethering in the formation of thrombin-hirudin complexes: The role of the thrombin anion-binding exosite-I
-
Myles T, Le Bonniec BF, Betz A, Stone SR. Electrostatic steering and ionic tethering in the formation of thrombin-hirudin complexes: the role of the thrombin anion-binding exosite-I. Biochemistry. 2001;40:4972-4979.
-
(2001)
Biochemistry
, vol.40
, pp. 4972-4979
-
-
Myles, T.1
Le Bonniec, B.F.2
Betz, A.3
Stone, S.R.4
-
77
-
-
0026351350
-
The active site of thrombin is altered upon binding to thrombomodulin. Two distinct structural changes are detected by fluorescence, but only one correlates with protein C activation
-
Ye J, Esmon NL, Esmon CT, Johnson AE. The active site of thrombin is altered upon binding to thrombomodulin. Two distinct structural changes are detected by fluorescence, but only one correlates with protein C activation. J Biol Chem. 1991;266:23016-23021.
-
(1991)
J Biol Chem
, vol.266
, pp. 23016-23021
-
-
Ye, J.1
Esmon, N.L.2
Esmon, C.T.3
Johnson, A.E.4
-
78
-
-
0027407874
-
The chondroitin sulfate moiety of thrombomodulin binds a second molecule of thrombin
-
Ye J, Esmon CT, Johnson AE. The chondroitin sulfate moiety of thrombomodulin binds a second molecule of thrombin. J Biol Chem. 1993;268:2373-2379.
-
(1993)
J Biol Chem
, vol.268
, pp. 2373-2379
-
-
Ye, J.1
Esmon, C.T.2
Johnson, A.E.3
-
79
-
-
27744530963
-
Thrombomodulin tightens the thrombin active site loops to promote protein C activation
-
Koeppe JR, Seitova A, Mather T, Komives EA. Thrombomodulin tightens the thrombin active site loops to promote protein C activation. Biochemistry. 2005;44:14784-14791.
-
(2005)
Biochemistry
, vol.44
, pp. 14784-14791
-
-
Koeppe, J.R.1
Seitova, A.2
Mather, T.3
Komives, E.A.4
-
81
-
-
32244444849
-
Activation of protein C by the thrombin-thrombomodulin complex: Cooperative roles of Arg-35 of thrombin and Arg-67 of protein C
-
Yang L, Manithody C, Rezaie AR. Activation of protein C by the thrombin-thrombomodulin complex: cooperative roles of Arg-35 of thrombin and Arg-67 of protein C. Proc Natl Acad Sci U S A. 2006;103:879-884.
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, pp. 879-884
-
-
Yang, L.1
Manithody, C.2
Rezaie, A.R.3
-
82
-
-
0035823595
-
The serpins are an expanding superfamily of structurally similar but functionally diverse proteins. Evolution, mechanism of inhibition, novel functions, and a revised nomenclature
-
Silverman GA, Bird PI, Carrell RW, Church FC, Coughlin PB, Gettins PG, Irving JA, Lomas DA, Luke CJ, Moyer RW, Pemberton PA, Remold-O'Donnell E, Salvesen GS, Travis J, Whisstock JC. The serpins are an expanding superfamily of structurally similar but functionally diverse proteins. Evolution, mechanism of inhibition, novel functions, and a revised nomenclature. J Biol Chem. 2001;276:33293-33296.
-
(2001)
J Biol Chem
, vol.276
, pp. 33293-33296
-
-
Silverman, G.A.1
Bird, P.I.2
Carrell, R.W.3
Church, F.C.4
Coughlin, P.B.5
Gettins, P.G.6
Irving, J.A.7
Lomas, D.A.8
Luke, C.J.9
Moyer, R.W.10
Pemberton, P.A.11
Remold-O'Donnell, E.12
Salvesen, G.S.13
Travis, J.14
Whisstock, J.C.15
-
83
-
-
0028061369
-
Regulation of thrombin activity by antithrombin and heparin
-
Olson ST, Bjork I. Regulation of thrombin activity by antithrombin and heparin. Semin Thromb Hemost. 1994;20:373-409.
-
(1994)
Semin Thromb Hemost
, vol.20
, pp. 373-409
-
-
Olson, S.T.1
Bjork, I.2
-
84
-
-
33646565201
-
Heparin activation of serpins
-
Garg HG, Linhardt RJ, Hales CA, eds. Oxford: Elsevier Ltd
-
Huntington JA. Heparin activation of serpins. In: Garg HG, Linhardt RJ, Hales CA, eds. Chemistry and Biology of Heparin and Heparan Sulfate. Oxford: Elsevier Ltd; 2005:367-398.
-
(2005)
Chemistry and Biology of Heparin and Heparan Sulfate
, pp. 367-398
-
-
Huntington, J.A.1
-
85
-
-
0026690347
-
Role of the antithrombin-binding pentasaccharide in heparin acceleration of antithrombin-proteinase reactions. Resolution of the antithrombin conformational change contribution to heparin rate enhancement
-
Olson ST, Bjork I, Sheffer R, Craig PA, Shore JD, Choay J. Role of the antithrombin-binding pentasaccharide in heparin acceleration of antithrombin-proteinase reactions. Resolution of the antithrombin conformational change contribution to heparin rate enhancement. J Biol Chem. 1992;267:12528-12538.
-
(1992)
J Biol Chem
, vol.267
, pp. 12528-12538
-
-
Olson, S.T.1
Bjork, I.2
Sheffer, R.3
Craig, P.A.4
Shore, J.D.5
Choay, J.6
-
86
-
-
0027498670
-
Kinetic characterization of heparin-catalyzed and uncatalyzed inhibition of blood coagulation proteinases by antithrombin
-
Olson ST, Bjork I, Shore JD. Kinetic characterization of heparin-catalyzed and uncatalyzed inhibition of blood coagulation proteinases by antithrombin. Methods Enzymol. 1993;222:525-559.
-
(1993)
Methods Enzymol
, vol.222
, pp. 525-559
-
-
Olson, S.T.1
Bjork, I.2
Shore, J.D.3
-
87
-
-
0024588039
-
Physicochemical aspects of heparin cofactor II
-
Pratt CW, Whinna HC, Meade JB, Treanor RE, Church FC. Physicochemical aspects of heparin cofactor II. Ann N Y Acad Sci. 1989;556:104-115.
-
(1989)
Ann N Y Acad Sci
, vol.556
, pp. 104-115
-
-
Pratt, C.W.1
Whinna, H.C.2
Meade, J.B.3
Treanor, R.E.4
Church, F.C.5
-
88
-
-
0031453590
-
Heparin cofactor II
-
Tollefsen DM. Heparin cofactor II. Adv Exp Med Biol. 1997;425:35-44.
-
(1997)
Adv Exp Med Biol
, vol.425
, pp. 35-44
-
-
Tollefsen, D.M.1
-
89
-
-
0028332939
-
Molecular mapping of the heparin-binding exosite of thrombin
-
Sheehan JP, Sadler JE. Molecular mapping of the heparin-binding exosite of thrombin. Proc Natl Acad Sci U S A. 1994;91:5518-5522.
-
(1994)
Proc Natl Acad Sci U S A
, vol.91
, pp. 5518-5522
-
-
Sheehan, J.P.1
Sadler, J.E.2
-
90
-
-
0027972583
-
Identification of basic amino acid residues in thrombin essential for heparin-catalyzed inactivation by antithrombin III
-
Gan ZR, Li Y, Chen Z, Lewis SD, Shafer JA. Identification of basic amino acid residues in thrombin essential for heparin-catalyzed inactivation by antithrombin III. J Biol Chem. 1994;269:1301-1305.
-
(1994)
J Biol Chem
, vol.269
, pp. 1301-1305
-
-
Gan, Z.R.1
Li, Y.2
Chen, Z.3
Lewis, S.D.4
Shafer, J.A.5
-
91
-
-
0030991983
-
Functional requirements for inhibition of thrombin by antithrombin III in the presence and absence of heparin
-
Tsiang M, Jain AK, Gibbs CS. Functional requirements for inhibition of thrombin by antithrombin III in the presence and absence of heparin. J Biol Chem. 1997;272:12024-12029.
-
(1997)
J Biol Chem
, vol.272
, pp. 12024-12029
-
-
Tsiang, M.1
Jain, A.K.2
Gibbs, C.S.3
-
92
-
-
0025730441
-
Quantitative characterization of the thrombin-heparin interaction. Discrimination between specific and nonspecific binding models
-
Olson ST, Halvorson HR, Bjork I. Quantitative characterization of the thrombin-heparin interaction. Discrimination between specific and nonspecific binding models. J Biol Chem. 1991;266:6342-6352.
-
(1991)
J Biol Chem
, vol.266
, pp. 6342-6352
-
-
Olson, S.T.1
Halvorson, H.R.2
Bjork, I.3
-
93
-
-
0020395234
-
Demonstration of a two-step reaction mechanism for inhibition of alpha-thrombin by antithrombin III and identification of the step affected by heparin
-
Olson ST, Shore JD. Demonstration of a two-step reaction mechanism for inhibition of alpha-thrombin by antithrombin III and identification of the step affected by heparin. J Biol Chem. 1982;257:14891-14895.
-
(1982)
J Biol Chem
, vol.257
, pp. 14891-14895
-
-
Olson, S.T.1
Shore, J.D.2
-
94
-
-
1642276048
-
The preferred pathway of glycosaminoglycan-accelerated inactivation of thrombin by heparin cofactor II
-
Verhamme IM, Bock PE, Jackson CM. The preferred pathway of glycosaminoglycan-accelerated inactivation of thrombin by heparin cofactor II. J Biol Chem. 2004;279:9785-9795.
-
(2004)
J Biol Chem
, vol.279
, pp. 9785-9795
-
-
Verhamme, I.M.1
Bock, P.E.2
Jackson, C.M.3
-
95
-
-
0037143655
-
Crystal structures of native and thrombin-complexed heparin cofactor II reveal a multistep allosteric mechanism
-
Baglin TP, Carrell RW, Church FC, Esmon CT, Huntington JA. Crystal structures of native and thrombin-complexed heparin cofactor II reveal a multistep allosteric mechanism. Proc Natl Acad Sci U S A. 2002;99:11079-11084.
-
(2002)
Proc Natl Acad Sci U S A
, vol.99
, pp. 11079-11084
-
-
Baglin, T.P.1
Carrell, R.W.2
Church, F.C.3
Esmon, C.T.4
Huntington, J.A.5
-
96
-
-
9644278069
-
The heparin binding properties of heparin cofactor II suggest an antithrombin-like activation mechanism
-
O'Keeffe D, Olson ST, Gasiunas N, Gallagher J, Baglin TP, Huntington JA. The heparin binding properties of heparin cofactor II suggest an antithrombin-like activation mechanism. J Biol Chem. 2004;279:50267-50273.
-
(2004)
J Biol Chem
, vol.279
, pp. 50267-50273
-
-
O'Keeffe, D.1
Olson, S.T.2
Gasiunas, N.3
Gallagher, J.4
Baglin, T.P.5
Huntington, J.A.6
-
97
-
-
13244270050
-
Crystal structure of thrombin bound to heparin
-
Carter WJ, Cama E, Huntington JA. Crystal structure of thrombin bound to heparin. J Biol Chem. 2005;280:2745-2749.
-
(2005)
J Biol Chem
, vol.280
, pp. 2745-2749
-
-
Carter, W.J.1
Cama, E.2
Huntington, J.A.3
-
98
-
-
4344590703
-
Structure of the antithrombin-thrombin-heparin ternary complex reveals the antithrombotic mechanism of heparin
-
Li W, Johnson DJ, Esmon CT, Huntington JA. Structure of the antithrombin-thrombin-heparin ternary complex reveals the antithrombotic mechanism of heparin. Nat Struct Mol Biol. 2004;11:857-862.
-
(2004)
Nat Struct Mol Biol
, vol.11
, pp. 857-862
-
-
Li, W.1
Johnson, D.J.2
Esmon, C.T.3
Huntington, J.A.4
-
99
-
-
4344710558
-
The ternary complex of antithrombin-anhydrothrombin-heparin reveals the basis of inhibitor specificity
-
Dementiev A, Petitou M, Herbert JM, Gettins PG. The ternary complex of antithrombin-anhydrothrombin-heparin reveals the basis of inhibitor specificity. Nat Struct Mol Biol. 2004;11:863-867.
-
(2004)
Nat Struct Mol Biol
, vol.11
, pp. 863-867
-
-
Dementiev, A.1
Petitou, M.2
Herbert, J.M.3
Gettins, P.G.4
-
100
-
-
0028338559
-
Glycosaminoglycan contributions to both protein C activation and thrombin inhibition involve a common arginine-rich site in thrombin that includes residues arginine 93, 97, and 101
-
Ye J, Rezaie AR, Esmon CT. Glycosaminoglycan contributions to both protein C activation and thrombin inhibition involve a common arginine-rich site in thrombin that includes residues arginine 93, 97, and 101. J Biol Chem. 1994;269:17965-17970.
-
(1994)
J Biol Chem
, vol.269
, pp. 17965-17970
-
-
Ye, J.1
Rezaie, A.R.2
Esmon, C.T.3
-
101
-
-
0029090336
-
The Na+ binding site of thrombin
-
Di Cera E, Guinto ER, Vindigni A, Dang QD, Ayala YM, Wuyi M, Tulinsky A. The Na+ binding site of thrombin. J Biol Chem. 1995;270:22089-22092.
-
(1995)
J Biol Chem
, vol.270
, pp. 22089-22092
-
-
Di Cera, E.1
Guinto, E.R.2
Vindigni, A.3
Dang, Q.D.4
Ayala, Y.M.5
Wuyi, M.6
Tulinsky, A.7
-
102
-
-
0029014036
-
An allosteric switch controls the procoagulant and anticoagulant activities of thrombin
-
Dang OD, Vindigni A, Di Cera E. An allosteric switch controls the procoagulant and anticoagulant activities of thrombin. Proc Natl Acad Sci U S A. 1995;92:5977-5981.
-
(1995)
Proc Natl Acad Sci U S A
, vol.92
, pp. 5977-5981
-
-
Dang, O.D.1
Vindigni, A.2
Di Cera, E.3
-
104
-
-
0029785840
-
Residue 225 determines the Na(+)-induced allosteric regulation of catalytic activity in serine proteases
-
Dang QD, Di Cera E. Residue 225 determines the Na(+)-induced allosteric regulation of catalytic activity in serine proteases. Proc Natl Acad Sci U S A. 1996;93:10653-10656.
-
(1996)
Proc Natl Acad Sci U S A
, vol.93
, pp. 10653-10656
-
-
Dang, Q.D.1
Di Cera, E.2
-
105
-
-
0034636749
-
Mutation of W215 compromises thrombin cleavage of fibrinogen, but not of PAR-1 or protein C
-
Arosio D, Ayala YM, Di Cera E. Mutation of W215 compromises thrombin cleavage of fibrinogen, but not of PAR-1 or protein C. Biochemistry. 2000;39:8095-8101.
-
(2000)
Biochemistry
, vol.39
, pp. 8095-8101
-
-
Arosio, D.1
Ayala, Y.M.2
Di Cera, E.3
-
106
-
-
0037174836
-
Crystal structure of the anticoagulant slow form of thrombin
-
Pineda AO, Savvides SN, Waksman G, Di Cera E. Crystal structure of the anticoagulant slow form of thrombin. J Biol Chem. 2002;277:40177-40180.
-
(2002)
J Biol Chem
, vol.277
, pp. 40177-40180
-
-
Pineda, A.O.1
Savvides, S.N.2
Waksman, G.3
Di Cera, E.4
-
107
-
-
0037387204
-
The molecular basis of thrombin allostery revealed by a 1.8 A structure of the "slow" form
-
Huntington JA, Esmon CT. The molecular basis of thrombin allostery revealed by a 1.8 A structure of the "slow" form. Structure (Camb). 2003;11:469-479.
-
(2003)
Structure (Camb)
, vol.11
, pp. 469-479
-
-
Huntington, J.A.1
Esmon, C.T.2
-
108
-
-
2942703945
-
Crystal structure of anticoagulant thrombin variant E217K provides insights into thrombin allostery
-
Carter WJ, Myles T, Gibbs CS, Leung LL, Huntington JA. Crystal structure of anticoagulant thrombin variant E217K provides insights into thrombin allostery. J Biol Chem. 2004;279:26387-26394.
-
(2004)
J Biol Chem
, vol.279
, pp. 26387-26394
-
-
Carter, W.J.1
Myles, T.2
Gibbs, C.S.3
Leung, L.L.4
Huntington, J.A.5
-
109
-
-
4544312894
-
The anticoagulant thrombin mutant W215A/E217A has a collapsed primary specificity pocket
-
Pineda AO, Chen ZW, Caccia S, Cantwell AM, Savvides SN, Waksman G, Mathews FS, Di Cera E. The anticoagulant thrombin mutant W215A/E217A has a collapsed primary specificity pocket. J Biol Chem. 2004;279:39824-39828.
-
(2004)
J Biol Chem
, vol.279
, pp. 39824-39828
-
-
Pineda, A.O.1
Chen, Z.W.2
Caccia, S.3
Cantwell, A.M.4
Savvides, S.N.5
Waksman, G.6
Mathews, F.S.7
Di Cera, E.8
-
110
-
-
9644257386
-
Crystal structure of the thrombin mutant D221A/D222K: The Asp222: Arg187 ion-pair stabilizes the fast form
-
Pineda AO, Zhang E, Guinto ER, Savvides SN, Tulinsky A, Di Cera E. Crystal structure of the thrombin mutant D221A/D222K: the Asp222: Arg187 ion-pair stabilizes the fast form. Biophys Chem. 2004;112:253-256.
-
(2004)
Biophys Chem
, vol.112
, pp. 253-256
-
-
Pineda, A.O.1
Zhang, E.2
Guinto, E.R.3
Savvides, S.N.4
Tulinsky, A.5
Di Cera, E.6
-
111
-
-
1642269650
-
Residue Asp-189 controls both substrate binding and the monovalent cation specificity of thrombin
-
Prasad S, Cantwell AM, Bush LA, Shih P, Xu H, Di Cera E. Residue Asp-189 controls both substrate binding and the monovalent cation specificity of thrombin. J Biol Chem. 2004;279:10103-10108.
-
(2004)
J Biol Chem
, vol.279
, pp. 10103-10108
-
-
Prasad, S.1
Cantwell, A.M.2
Bush, L.A.3
Shih, P.4
Xu, H.5
Di Cera, E.6
-
112
-
-
28044461043
-
Crystal structure of wild-type human thrombin in the Na+-free state
-
Johnson DJ, Adams TE, Li W, Huntington JA. Crystal structure of wild-type human thrombin in the Na+-free state. Biochem J. 2005;392:21-28.
-
(2005)
Biochem J
, vol.392
, pp. 21-28
-
-
Johnson, D.J.1
Adams, T.E.2
Li, W.3
Huntington, J.A.4
-
113
-
-
25144446242
-
Effect of Na+ binding on the conformation, stability and molecular recognition properties of thrombin
-
De Filippis V, De Dea E, Lucatello F, Frasson R. Effect of Na+ binding on the conformation, stability and molecular recognition properties of thrombin. Biochem J. 2005;390:485-492.
-
(2005)
Biochem J
, vol.390
, pp. 485-492
-
-
De Filippis, V.1
De Dea, E.2
Lucatello, F.3
Frasson, R.4
-
114
-
-
3843133006
-
Molecular dissection of Na+ binding to thrombin
-
Pineda AO, Carrell CJ, Bush LA, Prasad S, Caccia S, Chen ZW, Mathews FS, Di Cera E. Molecular dissection of Na+ binding to thrombin. J Biol Chem. 2004;279:31842-31853.
-
(2004)
J Biol Chem
, vol.279
, pp. 31842-31853
-
-
Pineda, A.O.1
Carrell, C.J.2
Bush, L.A.3
Prasad, S.4
Caccia, S.5
Chen, Z.W.6
Mathews, F.S.7
Di Cera, E.8
-
115
-
-
33646869004
-
High resolution crystal structures of free thrombin in the presence of K(+) reveal the molecular basis of monovalent cation selectivity and an inactive slow form
-
In press
-
Carrell CJ, Bush LA, Mathews FS, Di Cera E. High resolution crystal structures of free thrombin in the presence of K(+) reveal the molecular basis of monovalent cation selectivity and an inactive slow form. Biophys Chem. In press.
-
Biophys Chem
-
-
Carrell, C.J.1
Bush, L.A.2
Mathews, F.S.3
Di Cera, E.4
-
116
-
-
0026476381
-
Thrombin is a Na(+)-activated enzyme
-
Wells CM, Di Cera E. Thrombin is a Na(+)-activated enzyme. Biochemistry. 1992;31:11721-11730.
-
(1992)
Biochemistry
, vol.31
, pp. 11721-11730
-
-
Wells, C.M.1
Di Cera, E.2
|