-
1
-
-
0033538448
-
Expression of factor VIII by murine liver sinusoidal endothelial cells
-
Do H, Healey JF, Waller EK, Lollar P. Expression of factor VIII by murine liver sinusoidal endothelial cells. J Biol Chem 1999;274:19587-92.
-
(1999)
J Biol Chem
, vol.274
, pp. 19587-19592
-
-
Do, H.1
Healey, J.F.2
Waller, E.K.3
Lollar, P.4
-
2
-
-
0021715169
-
Molecular cloning of a cDNA encoding human antihaemophilic factor
-
Toole JJ, Knopf JL, Wozney JM, Sultzman LA, Buecker JL, Pittman DD, Kaufman RJ, Brown E, Shoemaker C, Orr EC, Amphlett GW, Foster WB, Coe ML, Knutson GJ, Fass DN, Hewick RM. Molecular cloning of a cDNA encoding human antihaemophilic factor. Nature 1984;312:342-7.
-
(1984)
Nature
, vol.312
, pp. 342-347
-
-
Toole, J.J.1
Knopf, J.L.2
Wozney, J.M.3
Sultzman, L.A.4
Buecker, J.L.5
Pittman, D.D.6
Kaufman, R.J.7
Brown, E.8
Shoemaker, C.9
Orr, E.C.10
Amphlett, G.W.11
Foster, W.B.12
Coe, M.L.13
Knutson, G.J.14
Fass, D.N.15
Hewick, R.M.16
-
3
-
-
0021715168
-
Expression of active human factor VIII from recombinant DNA clones
-
Wood WI, Capon DJ, Simonsen CC, Eaton DL, Gitschier J, Keyt B, Seeburg PH, Smith DH, Hollingshead P, Wion KL, Delwart E, Tuddenham EDG, Vehar GA, Lawn RM. Expression of active human factor VIII from recombinant DNA clones. Nature 1984;312:330-7.
-
(1984)
Nature
, vol.312
, pp. 330-337
-
-
Wood, W.I.1
Capon, D.J.2
Simonsen, C.C.3
Eaton, D.L.4
Gitschier, J.5
Keyt, B.6
Seeburg, P.H.7
Smith, D.H.8
Hollingshead, P.9
Wion, K.L.10
Delwart, E.11
Tuddenham, E.D.G.12
Vehar, G.A.13
Lawn, R.M.14
-
4
-
-
0021677942
-
Structure of human factor VIII
-
Vehar GA, Keyt B, Eaton D, Rodriguez H, O'Brien DP, Rotblat F, Oppermann H, Keck R, Wood WI, Harkins RN, Tuddenham EGD, Lawn RM, Capon DJ. Structure of human factor VIII. Nature 1984;312:337-42.
-
(1984)
Nature
, vol.312
, pp. 337-342
-
-
Vehar, G.A.1
Keyt, B.2
Eaton, D.3
Rodriguez, H.4
O'Brien, D.P.5
Rotblat, F.6
Oppermann, H.7
Keck, R.8
Wood, W.I.9
Harkins, R.N.10
Tuddenham, E.G.D.11
Lawn, R.M.12
Capon, D.J.13
-
5
-
-
0028939696
-
Locations of disulfide bonds and free cysteines in the heavy and light chains of recombinant human factor VIII (antihemophilic factor A)
-
McMullen BA, Fujikawa K, Davie EW, Hedner U, Ezban M. Locations of disulfide bonds and free cysteines in the heavy and light chains of recombinant human factor VIII (antihemophilic factor A). Protein Sci 1995;4:740-6.
-
(1995)
Protein Sci
, vol.4
, pp. 740-746
-
-
McMullen, B.A.1
Fujikawa, K.2
Davie, E.W.3
Hedner, U.4
Ezban, M.5
-
6
-
-
0017744154
-
Relationship of sialic acid to function and in vivo survival of human factor VIII/von Willebrand factor protein
-
Sodetz JM, Pizzo SV, McKee PA. Relationship of sialic acid to function and in vivo survival of human factor VIII/von Willebrand factor protein. J Biol Chem 1977;252:5538-46.
-
(1977)
J Biol Chem
, vol.252
, pp. 5538-5546
-
-
Sodetz, J.M.1
Pizzo, S.V.2
McKee, P.A.3
-
7
-
-
0021151729
-
The effect of carbohydrate depletion on procoagulant activity and in vivo survival of highly purified human factor VIII
-
Fay PJ, Chavin SI, Malone JE, Schroeder D, Young FE, Marder VJ. The effect of carbohydrate depletion on procoagulant activity and in vivo survival of highly purified human factor VIII. Biochim Biophys Acta 1984;800:152-8.
-
(1984)
Biochim Biophys Acta
, vol.800
, pp. 152-158
-
-
Fay, P.J.1
Chavin, S.I.2
Malone, J.E.3
Schroeder, D.4
Young, F.E.5
Marder, V.J.6
-
8
-
-
0028058606
-
Identification of individual tyrosine sulfation sites within factor VIII required for optimal activity and efficient thrombin cleavage
-
Michnick DA, Pittman DD, Wise RJ, Kaufman RJ. Identification of individual tyrosine sulfation sites within factor VIII required for optimal activity and efficient thrombin cleavage. J Biol Chem 1994;269:20095-102.
-
(1994)
J Biol Chem
, vol.269
, pp. 20095-20102
-
-
Michnick, D.A.1
Pittman, D.D.2
Wise, R.J.3
Kaufman, R.J.4
-
9
-
-
0029377507
-
Proposed structure of the A domains of factor VIII by homology modelling
-
Pan Y, DeFay T, Gitschier J, Cohen FE. Proposed structure of the A domains of factor VIII by homology modelling [letter]. Nat Struct Biol 1995;2:740-4.
-
(1995)
Nat Struct Biol
, vol.2
, pp. 740-744
-
-
Pan, Y.1
DeFay, T.2
Gitschier, J.3
Cohen, F.E.4
-
10
-
-
0030903424
-
A molecular model for the triplicated A domains of human factor VIII based on the crystal structure of human ceruloplasmin
-
Pemberton S, Lindley P, Zaitsev V, Card G, Tuddenham EGD, Kemball-Cook G. A molecular model for the triplicated A domains of human factor VIII based on the crystal structure of human ceruloplasmin. Blood 1997;89:2413-21.
-
(1997)
Blood
, vol.89
, pp. 2413-2421
-
-
Pemberton, S.1
Lindley, P.2
Zaitsev, V.3
Card, G.4
Tuddenham, E.G.D.5
Kemball-Cook, G.6
-
11
-
-
0033604501
-
Structure of the C2 domain of human factor VIII at 1.5 Å resolution
-
Pratt KP, Shen BW, Takeshima K, Davie EW, Fujikawa K, Stoddard BL. Structure of the C2 domain of human factor VIII at 1.5 Å resolution. Nature 1999;402:439-42.
-
(1999)
Nature
, vol.402
, pp. 439-442
-
-
Pratt, K.P.1
Shen, B.W.2
Takeshima, K.3
Davie, E.W.4
Fujikawa, K.5
Stoddard, B.L.6
-
12
-
-
0033579442
-
Electron crystallography of human blood coagulation factor VIII bound to phospholipid monolayers
-
Stoylova SS, Lenting PJ, Kemball-Cook G, Holzenburg A. Electron crystallography of human blood coagulation factor VIII bound to phospholipid monolayers. J Biol Chem 1999;274:36573-8.
-
(1999)
J Biol Chem
, vol.274
, pp. 36573-36578
-
-
Stoylova, S.S.1
Lenting, P.J.2
Kemball-Cook, G.3
Holzenburg, A.4
-
13
-
-
0020043657
-
Monoclonal antibodies to porcine factor VIII coagulant and their use in the isolation of active coagulant protein
-
Fass DN, Knutson GJ, Katzmann JA. Monoclonal antibodies to porcine factor VIII coagulant and their use in the isolation of active coagulant protein. Blood 1982;59:594-600.
-
(1982)
Blood
, vol.59
, pp. 594-600
-
-
Fass, D.N.1
Knutson, G.J.2
Katzmann, J.A.3
-
14
-
-
0000640811
-
Isolation and characterization of human factor VIII: Molecular forms in commercial factor VIII concentrate, cryoprecipitate, and plasma
-
Andersson LO, Forsman N, Huang K, Larsen K, Lundin A, Pavlu B, Sandberg H, Sewerin K, Smart J. Isolation and characterization of human factor VIII: molecular forms in commercial factor VIII concentrate, cryoprecipitate, and plasma. Proc Natl Acad Sci USA 1986;83:2979-83.
-
(1986)
Proc Natl Acad Sci USA
, vol.83
, pp. 2979-2983
-
-
Andersson, L.O.1
Forsman, N.2
Huang, K.3
Larsen, K.4
Lundin, A.5
Pavlu, B.6
Sandberg, H.7
Sewerin, K.8
Smart, J.9
-
15
-
-
0022445266
-
The size of human factor VIII heterodimers and the effects produced by thrombin
-
Fay PJ, Anderson MT, Chavin SI, Marder VJ. The size of human factor VIII heterodimers and the effects produced by thrombin. Biochim Biophys Acta 1986;871:268-78.
-
(1986)
Biochim Biophys Acta
, vol.871
, pp. 268-278
-
-
Fay, P.J.1
Anderson, M.T.2
Chavin, S.I.3
Marder, V.J.4
-
16
-
-
0022760260
-
A large region (approximately equal to 95 kDa) of human factor VIII is dispensible for in vitro procoagulant activity
-
Toole JJ, Pittman DD, Orr EC, Murtha P, Wasley LC, Kaufman RJ. A large region (approximately equal to 95 kDa) of human factor VIII is dispensible for in vitro procoagulant activity. Proc Natl Acad Sci USA 1986;83:5939.
-
(1986)
Proc Natl Acad Sci USA
, vol.83
, pp. 5939
-
-
Toole, J.J.1
Pittman, D.D.2
Orr, E.C.3
Murtha, P.4
Wasley, L.C.5
Kaufman, R.J.6
-
17
-
-
0026708655
-
Characterization of the interaction between the A2 subunit and A1/A3-C1-C2 dimer in human factor VIIIa
-
Fay PJ, Smudzin TM. Characterization of the interaction between the A2 subunit and A1/A3-C1-C2 dimer in human factor VIIIa. J Biol Chem 1992;267:13246-50.
-
(1992)
J Biol Chem
, vol.267
, pp. 13246-13250
-
-
Fay, P.J.1
Smudzin, T.M.2
-
18
-
-
0028358217
-
Copper-atom identification in the active and inactive forms of plasma-derived FVIII and recombinant FVIII-ΔII
-
Bihoreau N, Pin S, Kersabiec AMD, Vodot F, Fontaine-Aupart MP. Copper-atom identification in the active and inactive forms of plasma-derived FVIII and recombinant FVIII-ΔII. Eur J Biochem 1994;220:41-8.
-
(1994)
Eur J Biochem
, vol.220
, pp. 41-48
-
-
Bihoreau, N.1
Pin, S.2
Kersabiec, A.M.D.3
Vodot, F.4
Fontaine-Aupart, M.P.5
-
19
-
-
0030783138
-
Identification and functional requirement of Cu(I) and its ligands within coagulation factor VIII
-
Tagliavacca L, Moon N, Dunham WR, Kaufman RJ. Identification and functional requirement of Cu(I) and its ligands within coagulation factor VIII. J Biol Chem 1997;272:27428-34.
-
(1997)
J Biol Chem
, vol.272
, pp. 27428-27434
-
-
Tagliavacca, L.1
Moon, N.2
Dunham, W.R.3
Kaufman, R.J.4
-
20
-
-
0032510718
-
Effects of copper on the structure and function of factor VIII subunits: Evidence for an auxiliary role for copper ions in cofactor activity
-
Sudhakar K, Fay PJ. Effects of copper on the structure and function of factor VIII subunits: evidence for an auxiliary role for copper ions in cofactor activity. Biochemistry 1998;37:6874-82.
-
(1998)
Biochemistry
, vol.37
, pp. 6874-6882
-
-
Sudhakar, K.1
Fay, P.J.2
-
21
-
-
0035964179
-
Metal ion-independent association of factor VIII subunits and the roles of calcium and copper ions for cofactor activity and inter-subunit affinity
-
Wakabayashi H, Koszelak ME, Mastri M, Fay PJ. Metal ion-independent association of factor VIII subunits and the roles of calcium and copper ions for cofactor activity and inter-subunit affinity. Biochemistry 2001;40:10293-300.
-
(2001)
Biochemistry
, vol.40
, pp. 10293-10300
-
-
Wakabayashi, H.1
Koszelak, M.E.2
Mastri, M.3
Fay, P.J.4
-
22
-
-
0023918416
-
Reconstitution of human factor VIII from isolated subunits
-
Fay PJ. Reconstitution of human factor VIII from isolated subunits. Arch Biochem Biophys 1988;262:525-31.
-
(1988)
Arch Biochem Biophys
, vol.262
, pp. 525-531
-
-
Fay, P.J.1
-
23
-
-
0037007964
-
Ca(2+) binding to both the heavy and light chains of factor VIII is required for cofactor activity
-
Wakabayashi H, Schmidt KM, Fay PJ. Ca(2+) binding to both the heavy and light chains of factor VIII is required for cofactor activity. Biochemistry 2002;41:8485-92.
-
(2002)
Biochemistry
, vol.41
, pp. 8485-8492
-
-
Wakabayashi, H.1
Schmidt, K.M.2
Fay, P.J.3
-
25
-
-
0035827682
-
2+-dependent complex of fragments bound to phospholipid
-
2+-dependent complex of fragments bound to phospholipid. J Biol Chem 2001;276:19929-36.
-
(2001)
J Biol Chem
, vol.276
, pp. 19929-19936
-
-
Zeibdawi, A.R.1
Pryzdial, E.L.2
-
26
-
-
0031686041
-
Biochemistry and genetics of von Willebrand factor
-
Sadler JE. Biochemistry and genetics of von Willebrand factor. Annu Rev Biochem 1998;67:395-424.
-
(1998)
Annu Rev Biochem
, vol.67
, pp. 395-424
-
-
Sadler, J.E.1
-
27
-
-
0023229458
-
r-80,000 light chain
-
r-80,000 light chain. Eur J Biochem 1987;166:37-43.
-
(1987)
Eur J Biochem
, vol.166
, pp. 37-43
-
-
Hamer, R.J.1
Koedam, J.A.2
Beeser-Visser, N.H.3
Bertina, R.M.4
Van Mourik, J.A.5
Sixma, J.J.6
-
28
-
-
0023677854
-
Association of the factor VIII light chain with von Willebrand factor
-
Lollar P, Hill-Eubanks DC, Parker CG. Association of the factor VIII light chain with von Willebrand factor. J Biol Chem 1988;263:10451-5.
-
(1988)
J Biol Chem
, vol.263
, pp. 10451-10455
-
-
Lollar, P.1
Hill-Eubanks, D.C.2
Parker, C.G.3
-
29
-
-
0024497345
-
The interaction between human blood-coagulation factor VIII and von Willebrand factor. Characterization of a high-affinity binding site on factor VIII
-
Leyte A, Verbeet MP, Brodniewicz-Proba T, Van Mourik JA, Mertens K. The interaction between human blood-coagulation factor VIII and von Willebrand factor. Characterization of a high-affinity binding site on factor VIII. Biochem J 1989;257:679-83.
-
(1989)
Biochem J
, vol.257
, pp. 679-683
-
-
Leyte, A.1
Verbeet, M.P.2
Brodniewicz-Proba, T.3
Van Mourik, J.A.4
Mertens, K.5
-
30
-
-
0025174175
-
Binding of human factor VIII to phospholipid vesicles
-
Gilbert GE, Furie BC, Furie B. Binding of human factor VIII to phospholipid vesicles. J Biol Chem 1990;265:815-22.
-
(1990)
J Biol Chem
, vol.265
, pp. 815-822
-
-
Gilbert, G.E.1
Furie, B.C.2
Furie, B.3
-
31
-
-
0025991461
-
The effect of plasma von Willebrand factor on the binding of human factor VIII to thrombin-activated human platelets
-
Nesheim M, Pittman DD, Giles AR, Fass DN, Wang JH, Slonosky D, Kaufman RJ. The effect of plasma von Willebrand factor on the binding of human factor VIII to thrombin-activated human platelets. J Biol Chem 1991;266:17815-20.
-
(1991)
J Biol Chem
, vol.266
, pp. 17815-17820
-
-
Nesheim, M.1
Pittman, D.D.2
Giles, A.R.3
Fass, D.N.4
Wang, J.H.5
Slonosky, D.6
Kaufman, R.J.7
-
32
-
-
0037082464
-
3-Dimensional structure of membrane-bound coagulation factor VIII: Modeling of the factor VIII heterodimer within a 3-dimensional density map derived by electron crystallography
-
Stoilova-McPhie S, Villoutreix BO, Mertens K, Kemball-Cook G, Holzenburg A. 3-Dimensional structure of membrane-bound coagulation factor VIII: modeling of the factor VIII heterodimer within a 3-dimensional density map derived by electron crystallography. Blood 2002;99:1215-23.
-
(2002)
Blood
, vol.99
, pp. 1215-1223
-
-
Stoilova-McPhie, S.1
Villoutreix, B.O.2
Mertens, K.3
Kemball-Cook, G.4
Holzenburg, A.5
-
33
-
-
0343962699
-
Role of activation of the coagulation factor VIII in interaction with vWf, phospholipid, and functioning within the factor Xase complex
-
Saenko EL, Shima M, Sarafanov AG. Role of activation of the coagulation factor VIII in interaction with vWf, phospholipid, and functioning within the factor Xase complex. Trends Cardiovasc Med 1999;9:185-92.
-
(1999)
Trends Cardiovasc Med
, vol.9
, pp. 185-192
-
-
Saenko, E.L.1
Shima, M.2
Sarafanov, A.G.3
-
34
-
-
0036625005
-
A novel mechanism of factor VIII protection by von Willebrand factor from activated protein C-catalyzed inactivation
-
Nogami K, Shima M, Nishiya K, Hosokawa K, Saenko EL, Sakurai Y, Shibata M, Suzuki H, Tanaka I, Yoshioka A. A novel mechanism of factor VIII protection by von Willebrand factor from activated protein C-catalyzed inactivation. Blood 2002;99:3993-8.
-
(2002)
Blood
, vol.99
, pp. 3993-3998
-
-
Nogami, K.1
Shima, M.2
Nishiya, K.3
Hosokawa, K.4
Saenko, E.L.5
Sakurai, Y.6
Shibata, M.7
Suzuki, H.8
Tanaka, I.9
Yoshioka, A.10
-
35
-
-
1842408993
-
Proteolytic requirements for thrombin activation of anti-hemophilic factor (factor VIII)
-
Pittman DD, Kaufman RJ. Proteolytic requirements for thrombin activation of anti-hemophilic factor (factor VIII). Proc Natl Acad Sci USA 1988;85:2429-33.
-
(1988)
Proc Natl Acad Sci USA
, vol.85
, pp. 2429-2433
-
-
Pittman, D.D.1
Kaufman, R.J.2
-
36
-
-
0030800963
-
The acidic region of the factor VIII light chain and the C2 domain together form the high affinity binding site for von willebrand factor
-
Saenko EL, Scandella D. The acidic region of the factor VIII light chain and the C2 domain together form the high affinity binding site for von willebrand factor. J Biol Chem 1997;272:18007-14.
-
(1997)
J Biol Chem
, vol.272
, pp. 18007-18014
-
-
Saenko, E.L.1
Scandella, D.2
-
37
-
-
0022454539
-
Proteolytic processing of human factor VIII. Correlation of specific cleavages by thrombin, factor Xa, and activated protein C with activation and inactivation of factor VIII coagulant activity
-
Eaton D, Rodriguez H, Vehar GA. Proteolytic processing of human factor VIII. Correlation of specific cleavages by thrombin, factor Xa, and activated protein C with activation and inactivation of factor VIII coagulant activity. Biochemistry 1986;25:505-12.
-
(1986)
Biochemistry
, vol.25
, pp. 505-512
-
-
Eaton, D.1
Rodriguez, H.2
Vehar, G.A.3
-
38
-
-
0028052967
-
Inhibition by heparin of thrombin-catalyzed activation of the factor VIII-von Willebrand factor complex
-
Barrow RT, Healey JF, Lollar P. Inhibition by heparin of thrombin-catalyzed activation of the factor VIII-von Willebrand factor complex. J Biol Chem 1994;269:593-8.
-
(1994)
J Biol Chem
, vol.269
, pp. 593-598
-
-
Barrow, R.T.1
Healey, J.F.2
Lollar, P.3
-
39
-
-
0028338559
-
Glycosaminoglycan contributions to both protein C activation and thrombin inhibition involve a common arginine-rich site in thrombin that includes residues arginine 93, 97, and 101
-
Ye J, Rezaie AR, Esmon CT. Glycosaminoglycan contributions to both protein C activation and thrombin inhibition involve a common arginine-rich site in thrombin that includes residues arginine 93, 97, and 101. J Biol Chem 1994;269:17965-70.
-
(1994)
J Biol Chem
, vol.269
, pp. 17965-17970
-
-
Ye, J.1
Rezaie, A.R.2
Esmon, C.T.3
-
40
-
-
0029935853
-
Involvement of thrombin anion-binding exosites 1 and 2 in the activation of factor V and factor VIII
-
Esmon CT, Lollar P. Involvement of thrombin anion-binding exosites 1 and 2 in the activation of factor V and factor VIII. J Biol Chem 1996;271:13882-7.
-
(1996)
J Biol Chem
, vol.271
, pp. 13882-13887
-
-
Esmon, C.T.1
Lollar, P.2
-
41
-
-
0035816595
-
An extensive interaction interface between thrombin and factor V is required for factor V activation
-
Myles T, Yun TH, Hall SW, Leung LL. An extensive interaction interface between thrombin and factor V is required for factor V activation. J Biol Chem 2001;276:25143-9.
-
(2001)
J Biol Chem
, vol.276
, pp. 25143-25149
-
-
Myles, T.1
Yun, T.H.2
Hall, S.W.3
Leung, L.L.4
-
42
-
-
0024996181
-
The COOH-terminal domain of hirudin. An exosite-directed competitive inhibitor of the action of alpha-thrombin on fibrinogen
-
Naski MC, Fenton II JW, Maraganore JM, Olson ST, Shafer JA. The COOH-terminal domain of hirudin. An exosite-directed competitive inhibitor of the action of alpha-thrombin on fibrinogen. J Biol Chem 1990;265:13484-9.
-
(1990)
J Biol Chem
, vol.265
, pp. 13484-13489
-
-
Naski, M.C.1
Fenton II, J.W.2
Maraganore, J.M.3
Olson, S.T.4
Shafer, J.A.5
-
43
-
-
0034682752
-
Factor VIII C2 domain contains the thrombin-binding site responsible for thrombin-catalyzed cleavage at Arg1689
-
Nogami K, Shima M, Hosokawa K, Nagata M, Koide T, Saenko EL, Tanaka I, Shibata M, Yoshioka A. Factor VIII C2 domain contains the thrombin-binding site responsible for thrombin-catalyzed cleavage at Arg1689. J Biol Chem 2000;275:25774-80.
-
(2000)
J Biol Chem
, vol.275
, pp. 25774-25780
-
-
Nogami, K.1
Shima, M.2
Hosokawa, K.3
Nagata, M.4
Koide, T.5
Saenko, E.L.6
Tanaka, I.7
Shibata, M.8
Yoshioka, A.9
-
44
-
-
0035982216
-
A Tyr346→Cys substitution in the interdomain acidic region a1 of factor VIII in an individual with factor VIII:C assay discrepancy
-
Mumford AD, Laffan M, O'Donnell J, McVey JH, Johnson DJ, Manning RA, Kemball-Cook G. A Tyr346→Cys substitution in the interdomain acidic region a1 of factor VIII in an individual with factor VIII:C assay discrepancy. Br J Haematol 2002;118:589-94.
-
(2002)
Br J Haematol
, vol.118
, pp. 589-594
-
-
Mumford, A.D.1
Laffan, M.2
O'Donnell, J.3
McVey, J.H.4
Johnson, D.J.5
Manning, R.A.6
Kemball-Cook, G.7
-
45
-
-
0022318904
-
Activation of porcine factor VIII:C by thrombin and factor Xa
-
Lollar P, Knutson GJ, Fass DN. Activation of porcine factor VIII:C by thrombin and factor Xa. Biochemistry 1985;24:8056-64.
-
(1985)
Biochemistry
, vol.24
, pp. 8056-8064
-
-
Lollar, P.1
Knutson, G.J.2
Fass, D.N.3
-
46
-
-
0025123702
-
Von Willebrand factor is a cofactor for thrombin-catalyzed cleavage of the factor VIII light chain
-
Hill-Eubanks DC, Lollar P. von Willebrand factor is a cofactor for thrombin-catalyzed cleavage of the factor VIII light chain. J Biol Chem 1990;265:17854-8.
-
(1990)
J Biol Chem
, vol.265
, pp. 17854-17858
-
-
Hill-Eubanks, D.C.1
Lollar, P.2
-
47
-
-
0029919613
-
Model for the factor VIIIa-dependent decay of the intrinsic factor Xase. Role of subunit dissociation and factor IXa-catalyzed proteolysis
-
Fay PJ, Beattie TL, Regan LM, O'Brien LM, Kaufman RJ. Model for the factor VIIIa-dependent decay of the intrinsic factor Xase. Role of subunit dissociation and factor IXa-catalyzed proteolysis. J Biol Chem 1996;271:6027-32.
-
(1996)
J Biol Chem
, vol.271
, pp. 6027-6032
-
-
Fay, P.J.1
Beattie, T.L.2
Regan, L.M.3
O'Brien, L.M.4
Kaufman, R.J.5
-
48
-
-
0030849972
-
Subunit structure and function of porcine factor Xa-activated factor VIII
-
Parker ET, Pohl J, Blackburn MN, Lollar P. Subunit structure and function of porcine factor Xa-activated factor VIII. Biochemistry 1997;36:9365-73.
-
(1997)
Biochemistry
, vol.36
, pp. 9365-9373
-
-
Parker, E.T.1
Pohl, J.2
Blackburn, M.N.3
Lollar, P.4
-
49
-
-
0037449806
-
Mechanisms of factor VIIIa A1 subunit cleavage by factor Xa during cofactor Inactivation
-
Nogami K, Wakabayashi H, Fay PJ. Mechanisms of factor VIIIa A1 subunit cleavage by factor Xa during cofactor Inactivation. J Biol Chem 2003;278:1634-41.
-
(2003)
J Biol Chem
, vol.278
, pp. 1634-1641
-
-
Nogami, K.1
Wakabayashi, H.2
Fay, P.J.3
-
50
-
-
0034602993
-
Identification of basic residues in the heparin-binding exosite of factor Xa critical for heparin and factor Va binding
-
Rezaie AR. Identification of basic residues in the heparin-binding exosite of factor Xa critical for heparin and factor Va binding. J Biol Chem 2000;275:3320-7.
-
(2000)
J Biol Chem
, vol.275
, pp. 3320-3327
-
-
Rezaie, A.R.1
-
51
-
-
0032724656
-
Role of factor VIII C2 domain in factor VIII binding to factor Xa
-
Nogami K, Shima M, Hosokawa K, Suzuki T, Koide T, Saenko EL, Scandella D, Shibata M, Kamisue S, Tanaka I, Yoshioka A. Role of factor VIII C2 domain in factor VIII binding to factor Xa. J Biol Chem 1999;274:31000-7.
-
(1999)
J Biol Chem
, vol.274
, pp. 31000-31007
-
-
Nogami, K.1
Shima, M.2
Hosokawa, K.3
Suzuki, T.4
Koide, T.5
Saenko, E.L.6
Scandella, D.7
Shibata, M.8
Kamisue, S.9
Tanaka, I.10
Yoshioka, A.11
-
52
-
-
0031754930
-
Interaction of the A1 subunit of factor VIIIa and the serine protease domain of factor X identified by zero-length cross-linking
-
Lapan KA, Fay PJ. Interaction of the A1 subunit of factor VIIIa and the serine protease domain of factor X identified by zero-length cross-linking. Thromb Haemost 1998;80:418-22.
-
(1998)
Thromb Haemost
, vol.80
, pp. 418-422
-
-
Lapan, K.A.1
Fay, P.J.2
-
53
-
-
0029032377
-
A mechanism for inhibition of factor VIII binding to phospholipid by von Willebrand factor
-
Saenko EL, Scandella D. A mechanism for inhibition of factor VIII binding to phospholipid by von Willebrand factor. J Biol Chem 1995;270:13826-33.
-
(1995)
J Biol Chem
, vol.270
, pp. 13826-13833
-
-
Saenko, E.L.1
Scandella, D.2
-
54
-
-
0024361839
-
In situ-generated thrombin is the only enzyme that effectively activates factor VIII and factor V in thromboplastin-activated plasma
-
Pieters J, Lindhout T, Hemker HC. In situ-generated thrombin is the only enzyme that effectively activates factor VIII and factor V in thromboplastin-activated plasma. Blood 1989;74:1021-4.
-
(1989)
Blood
, vol.74
, pp. 1021-1024
-
-
Pieters, J.1
Lindhout, T.2
Hemker, H.C.3
-
55
-
-
0024367339
-
Differential proteolytic activation of factor VIII-von Willebrand factor complex by thrombin
-
Hill-Eubanks DC, Parker CG, Lollar P. Differential proteolytic activation of factor VIII-von Willebrand factor complex by thrombin. Proc Natl Acad Sci USA 1989;86:6508-12.
-
(1989)
Proc Natl Acad Sci USA
, vol.86
, pp. 6508-6512
-
-
Hill-Eubanks, D.C.1
Parker, C.G.2
Lollar, P.3
-
56
-
-
0032561326
-
Activation of factor VIII by thrombin increases its affinity for binding to synthetic phospholipid membranes and activated platelets
-
Saenko EL, Scandella D, Yakhyaev AV, Greco NJ. Activation of factor VIII by thrombin increases its affinity for binding to synthetic phospholipid membranes and activated platelets. J Biol Chem 1998;273:27918-26.
-
(1998)
J Biol Chem
, vol.273
, pp. 27918-27926
-
-
Saenko, E.L.1
Scandella, D.2
Yakhyaev, A.V.3
Greco, N.J.4
-
57
-
-
0028933042
-
Cleavage of factor VIII light chain is required for maximal generation of factor VIIIa activity
-
Regan LM, Fay PJ. Cleavage of factor VIII light chain is required for maximal generation of factor VIIIa activity. J Biol Chem 1995;270:8546-52.
-
(1995)
J Biol Chem
, vol.270
, pp. 8546-8552
-
-
Regan, L.M.1
Fay, P.J.2
-
58
-
-
0028919216
-
The role of cleavage of the light chain at positions Arg1689 or Arg1721 in subunit interaction and activation of human blood coagulation factor VIII
-
Donath MS, Lenting PJ, van Mourik JA, Mertens K. The role of cleavage of the light chain at positions Arg1689 or Arg1721 in subunit interaction and activation of human blood coagulation factor VIII. J Biol Chem 1995;270:3648-55.
-
(1995)
J Biol Chem
, vol.270
, pp. 3648-3655
-
-
Donath, M.S.1
Lenting, P.J.2
Van Mourik, J.A.3
Mertens, K.4
-
59
-
-
0035853784
-
Cleavage of factor VIII heavy chain is required for the functional interaction of a2 subunit with factor IXA
-
Fay PJ, Mastri M, Koszelak ME, Wakabayashi H. Cleavage of factor VIII heavy chain is required for the functional interaction of a2 subunit with factor IXA. J Biol Chem 2001;276:12434-9.
-
(2001)
J Biol Chem
, vol.276
, pp. 12434-12439
-
-
Fay, P.J.1
Mastri, M.2
Koszelak, M.E.3
Wakabayashi, H.4
-
60
-
-
0024576076
-
Subunit structure of thrombin-activated porcine factor VIII
-
Lollar P, Parker CG. Subunit structure of thrombin-activated porcine factor VIII. Biochemistry 1989;28:666-74.
-
(1989)
Biochemistry
, vol.28
, pp. 666-674
-
-
Lollar, P.1
Parker, C.G.2
-
61
-
-
0025923490
-
Human factor VIIIa subunit structure. Reconstitution of factor VIIIa from the isolated A1/A3-C1-C2 dimer and A2 subunit
-
Fay PJ, Haidaris PJ, Smudzin TM. Human factor VIIIa subunit structure. Reconstitution of factor VIIIa from the isolated A1/A3-C1-C2 dimer and A2 subunit. J Biol Chem 1991;266:8957-62.
-
(1991)
J Biol Chem
, vol.266
, pp. 8957-8962
-
-
Fay, P.J.1
Haidaris, P.J.2
Smudzin, T.M.3
-
62
-
-
0025101070
-
pH-dependent denaturation of thrombin-activated porcine factor VIII
-
Lollar P, Parker CG. pH-dependent denaturation of thrombin-activated porcine factor VIII. J Biol Chem 1990;265:1688-92.
-
(1990)
J Biol Chem
, vol.265
, pp. 1688-1692
-
-
Lollar, P.1
Parker, C.G.2
-
63
-
-
0027105147
-
Coagulant properties of hybrid human/porcine factor VIII molecules
-
Lollar P, Parker ET, Fay PJ. Coagulant properties of hybrid human/ porcine factor VIII molecules. J Biol Chem 1992;267:23652-7.
-
(1992)
J Biol Chem
, vol.267
, pp. 23652-23657
-
-
Lollar, P.1
Parker, E.T.2
Fay, P.J.3
-
64
-
-
0027295497
-
Role of the COOH-terminal acidic region of A1 subunit in A2 subunit retention in human factor VIIIa
-
Fay PJ, Haidaris PJ, Huggins CF. Role of the COOH-terminal acidic region of A1 subunit in A2 subunit retention in human factor VIIIa. J Biol Chem 1993;268:17861-6.
-
(1993)
J Biol Chem
, vol.268
, pp. 17861-17866
-
-
Fay, P.J.1
Haidaris, P.J.2
Huggins, C.F.3
-
65
-
-
0037023727
-
Cofactor activities of factor VIIIa and A2 subunit following cleavage of A1 subunit at Arg336
-
Koszelak Rosenblum ME, Schmidt K, Freas J, Mastri M, Fay PJ. Cofactor activities of factor VIIIa and A2 subunit following cleavage of A1 subunit at Arg336. J Biol Chem 2002;277:11664-9.
-
(2002)
J Biol Chem
, vol.277
, pp. 11664-11669
-
-
Koszelak Rosenblum, M.E.1
Schmidt, K.2
Freas, J.3
Mastri, M.4
Fay, P.J.5
-
66
-
-
0034282886
-
Sites in A2 subunit involved in the interfactor VIIIa interaction
-
Koszelak ME, Huggins CF, Fay PJ. Sites in A2 subunit involved in the interfactor VIIIa interaction. J Biol Chem 2000;275:27137-44.
-
(2000)
J Biol Chem
, vol.275
, pp. 27137-27144
-
-
Koszelak, M.E.1
Huggins, C.F.2
Fay, P.J.3
-
67
-
-
0030832791
-
Interacting regions in the A1 and A2 subunits of factor VIIIa identified by zero-length cross-linking
-
O'Brien LM, Huggins CF, Fay PJ. Interacting regions in the A1 and A2 subunits of factor VIIIa identified by zero-length cross-linking. Blood 1997;90:3943-50.
-
(1997)
Blood
, vol.90
, pp. 3943-3950
-
-
O'Brien, L.M.1
Huggins, C.F.2
Fay, P.J.3
-
68
-
-
0029841943
-
Exposed hydrophobic sites in factor VIII and isolated subunits
-
Sudhakar K, Fay PJ. Exposed hydrophobic sites in factor VIII and isolated subunits. J Biol Chem 1996;271:23015-21.
-
(1996)
J Biol Chem
, vol.271
, pp. 23015-23021
-
-
Sudhakar, K.1
Fay, P.J.2
-
69
-
-
0028122250
-
Isolation and characterization of thrombin-activated human factor VIII
-
Curtis JE, Helgerson SL, Parker ET, Lollar P. Isolation and characterization of thrombin-activated human factor VIII. J Biol Chem 1994;269:6246-51.
-
(1994)
J Biol Chem
, vol.269
, pp. 6246-6251
-
-
Curtis, J.E.1
Helgerson, S.L.2
Parker, E.T.3
Lollar, P.4
-
70
-
-
0032402122
-
The life cycle of coagulation factor VIII in view of its structure and function
-
Lenting PJ, van Mourik JA, Mertens K. The life cycle of coagulation factor VIII in view of its structure and function. Blood 1998;92:3983-96.
-
(1998)
Blood
, vol.92
, pp. 3983-3996
-
-
Lenting, P.J.1
Van Mourik, J.A.2
Mertens, K.3
-
71
-
-
0021646754
-
2+ and phospholipids to the activation of human blood-coagulation factor X by activated factor IX
-
2+ and phospholipids to the activation of human blood-coagulation factor X by activated factor IX. Biochem J 1984;223:607-15.
-
(1984)
Biochem J
, vol.223
, pp. 607-615
-
-
Mertens, K.1
Bertina, R.M.2
-
72
-
-
0034724872
-
Structural and functional characterization of platelet receptor-mediated factor VIII binding
-
Ahmad SS, Scandura JM, Walsh PN. Structural and functional characterization of platelet receptor-mediated factor VIII binding. J Biol Chem 2000;275:13071-81.
-
(2000)
J Biol Chem
, vol.275
, pp. 13071-13081
-
-
Ahmad, S.S.1
Scandura, J.M.2
Walsh, P.N.3
-
73
-
-
0028239173
-
Identification of a binding site for blood coagulation factor IXa on the light chain of human factor VIII
-
Lenting PJ, Donath MJ, van Mourik JA, Mertens K. Identification of a binding site for blood coagulation factor IXa on the light chain of human factor VIII. J Biol Chem 1994;269:7150-5.
-
(1994)
J Biol Chem
, vol.269
, pp. 7150-7155
-
-
Lenting, P.J.1
Donath, M.J.2
Van Mourik, J.A.3
Mertens, K.4
-
74
-
-
0026785721
-
Binding of factor VIIIa and factor VIII to factor IXa on phospholipid vesicles
-
Duffy EJ, Parker ET, Mutucumarana VP, Johnson AE, Lollar P. Binding of factor VIIIa and factor VIII to factor IXa on phospholipid vesicles. J Biol Chem 1992;267:17006-11.
-
(1992)
J Biol Chem
, vol.267
, pp. 17006-17011
-
-
Duffy, E.J.1
Parker, E.T.2
Mutucumarana, V.P.3
Johnson, A.E.4
Lollar, P.5
-
75
-
-
0029670912
-
The sequence Glu1811-Lys1818 of human blood coagulation factor VIII comprises a binding site for activated factor IX
-
Lenting PJ, van de Loo JW, Donath MJ, van Mourik JA, Mertens K. The sequence Glu1811-Lys1818 of human blood coagulation factor VIII comprises a binding site for activated factor IX. J Biol Chem 1996;271:1935-40.
-
(1996)
J Biol Chem
, vol.271
, pp. 1935-1940
-
-
Lenting, P.J.1
Van De Loo, J.W.2
Donath, M.J.3
Van Mourik, J.A.4
Mertens, K.5
-
76
-
-
0028263884
-
Inhibition of human factor VIIIa by anti-A2 subunit antibodies
-
Lollar P, Parker ET, Curtis JE, Helgerson SL, Hoyer LW, Scott ME, Scandella D. Inhibition of human factor VIIIa by anti-A2 subunit antibodies. J Clin Invest 1994;93:2497-504.
-
(1994)
J Clin Invest
, vol.93
, pp. 2497-2504
-
-
Lollar, P.1
Parker, E.T.2
Curtis, J.E.3
Helgerson, S.L.4
Hoyer, L.W.5
Scott, M.E.6
Scandella, D.7
-
77
-
-
0033570089
-
Human inhibitor antibodies specific for the factor VIII A2 domain disrupt the interaction between the subunit and factor IXa
-
Fay PJ, Scandella D. Human inhibitor antibodies specific for the factor VIII A2 domain disrupt the interaction between the subunit and factor IXa. J Biol Chem 1999;274:29826-30.
-
(1999)
J Biol Chem
, vol.274
, pp. 29826-29830
-
-
Fay, P.J.1
Scandella, D.2
-
78
-
-
0027938728
-
Factor VIIIa A2 subunit residues 558-565 represent a factor IXa interactive site
-
Fay PJ, Beattie T, Huggins CF, Regan LM. Factor VIIIa A2 subunit residues 558-565 represent a factor IXa interactive site. J Biol Chem 1994;269:20522-7.
-
(1994)
J Biol Chem
, vol.269
, pp. 20522-20527
-
-
Fay, P.J.1
Beattie, T.2
Huggins, C.F.3
Regan, L.M.4
-
79
-
-
0037100409
-
Mutations associated with hemophilia A in the 558-565 loop of the factor VIIIa A2 subunit alter the catalytic activity of the factor Xase complex
-
Jenkins PV, Freas J, Schmidt KM, Zhou Q, Fay PJ. Mutations associated with hemophilia A in the 558-565 loop of the factor VIIIa A2 subunit alter the catalytic activity of the factor Xase complex. Blood 2002;100:501-8.
-
(2002)
Blood
, vol.100
, pp. 501-508
-
-
Jenkins, P.V.1
Freas, J.2
Schmidt, K.M.3
Zhou, Q.4
Fay, P.J.5
-
80
-
-
0022358562
-
The functional defect of factor VIII Leiden, a genetic variant of coagulation factor VIII
-
Mertens K, van Wijngaarden A, Bertina RM, Veltkamp JJ. The functional defect of factor VIII Leiden, a genetic variant of coagulation factor VIII. Thromb Haemost 1985;54:650-3.
-
(1985)
Thromb Haemost
, vol.54
, pp. 650-653
-
-
Mertens, K.1
Van Wijngaarden, A.2
Bertina, R.M.3
Veltkamp, J.J.4
-
81
-
-
0011708659
-
Synthetic peptides derived from residues 698-710 of factor VIII inhibit factor IXa activity
-
abstract
-
Jorquera JI, McClntock RA, Roberts JR, McDonald RA, Houghten RA, Fulcher CA. Synthetic peptides derived from residues 698-710 of factor VIII inhibit factor IXa activity. Circulation 1992;86:685 (abstract).
-
(1992)
Circulation
, vol.86
, pp. 685
-
-
Jorquera, J.I.1
McClntock, R.A.2
Roberts, J.R.3
McDonald, R.A.4
Houghten, R.A.5
Fulcher, C.A.6
-
82
-
-
0003291369
-
The factor VIII peptide consisting of amino acids 698-712 enhances factor IXa cleavage of factor X
-
Liles DK, Monroe DM, Roberts HR. The factor VIII peptide consisting of amino acids 698-712 enhances factor IXa cleavage of factor X. Blood 1997;90:463a.
-
(1997)
Blood
, vol.90
-
-
Liles, D.K.1
Monroe, D.M.2
Roberts, H.R.3
-
83
-
-
0032563086
-
The A2 subunit of factor VIIIa modulates the active site of factor IXa
-
Fay PJ, Koshibu K. The A2 subunit of factor VIIIa modulates the active site of factor IXa. J Biol Chem 1998;273:19049-54.
-
(1998)
J Biol Chem
, vol.273
, pp. 19049-19054
-
-
Fay, P.J.1
Koshibu, K.2
-
84
-
-
0026799442
-
The active site of factor IXa is located far above the membrane surface and its conformation is altered upon association with factor VIIIa. A fluorescence study
-
Mutucumarana VP, Duffy EJ, Lollar P, Johnson AE. The active site of factor IXa is located far above the membrane surface and its conformation is altered upon association with factor VIIIa. A fluorescence study. J Biol Chem 1992;267:17012-21.
-
(1992)
J Biol Chem
, vol.267
, pp. 17012-17021
-
-
Mutucumarana, V.P.1
Duffy, E.J.2
Lollar, P.3
Johnson, A.E.4
-
85
-
-
0028802711
-
Localization of factor IXa and factor VIIIa interactive sites
-
O'Brien LM, Medved LV, Fay PJ. Localization of factor IXa and factor VIIIa interactive sites. J Biol Chem 1995;270:27087-92.
-
(1995)
J Biol Chem
, vol.270
, pp. 27087-27092
-
-
O'Brien, L.M.1
Medved, L.V.2
Fay, P.J.3
-
86
-
-
0033603299
-
Protease and EGF1 domains of factor IXa play distinct roles in binding to factor VIIIa. Importance of helix 330 (helix 162 in chymotrypsin) of protease domain of factor IXa in its interaction with factor VIIIa
-
Mathur A, Bajaj SP. Protease and EGF1 domains of factor IXa play distinct roles in binding to factor VIIIa. Importance of helix 330 (helix 162 in chymotrypsin) of protease domain of factor IXa in its interaction with factor VIIIa. J Biol Chem 1999;274:18477-86.
-
(1999)
J Biol Chem
, vol.274
, pp. 18477-18486
-
-
Mathur, A.1
Bajaj, S.P.2
-
87
-
-
0035844226
-
Factor IXa: Factor VIIIa interaction, helix 330-338 of factor IXa interacts with residues 558-565 and spatially adjacent regions of the A2 subunit of factor VIIIa
-
Bajaj SP, Schmidt AE, Mathur A, Padmanabhan K, Zhong D, Mastri M, Fay PJ. Factor IXa: factor VIIIa interaction, helix 330-338 of factor IXa interacts with residues 558-565 and spatially adjacent regions of the A2 subunit of factor VIIIa. J Biol Chem 2001;276:16302-9.
-
(2001)
J Biol Chem
, vol.276
, pp. 16302-16309
-
-
Bajaj, S.P.1
Schmidt, A.E.2
Mathur, A.3
Padmanabhan, K.4
Zhong, D.5
Mastri, M.6
Fay, P.J.7
-
88
-
-
0028981058
-
Cleavage at arginine 145 in human blood coagulation factor IX converts the zymogen into a factor VIII binding enzyme
-
Lenting PJ, ter Maat H, Clijsters PP, Donath MJ, van Mourik JA, Mertens K. Cleavage at arginine 145 in human blood coagulation factor IX converts the zymogen into a factor VIII binding enzyme. J Biol Chem 1995;270:14884-90.
-
(1995)
J Biol Chem
, vol.270
, pp. 14884-14890
-
-
Lenting, P.J.1
Ter Maat, H.2
Clijsters, P.P.3
Donath, M.J.4
Van Mourik, J.A.5
Mertens, K.6
-
89
-
-
0029661981
-
2+ binding to the first epidermal growth factor-like domain of human blood coagulation factor IX promotes enzyme activity and factor VIII light chain binding
-
2+ binding to the first epidermal growth factor-like domain of human blood coagulation factor IX promotes enzyme activity and factor VIII light chain binding. J Biol Chem 1996;271:25332-7.
-
(1996)
J Biol Chem
, vol.271
, pp. 25332-25337
-
-
Lenting, P.J.1
Christophe, O.D.2
Maat, H.3
Rees, D.J.G.4
Mertens, K.5
-
90
-
-
0031972636
-
Blood coagulation factor IX residues Glu78 and Arg94 provide a link between both epidermal growth factor-like domains that is crucial in the interaction with factor VIII light chain
-
Christophe OD, Lenting PJ, Kolkman JA, Brownlee GG, Mertens K. Blood coagulation factor IX residues Glu78 and Arg94 provide a link between both epidermal growth factor-like domains that is crucial in the interaction with factor VIII light chain. J Biol Chem 1998;273:222-7.
-
(1998)
J Biol Chem
, vol.273
, pp. 222-227
-
-
Christophe, O.D.1
Lenting, P.J.2
Kolkman, J.A.3
Brownlee, G.G.4
Mertens, K.5
-
91
-
-
0019831499
-
The role of phospholipid and factor VIIIa in the activation of bovine factor X
-
van Dieijen G, Tans G, Rosing J, Hemker HC. The role of phospholipid and factor VIIIa in the activation of bovine factor X. J Biol Chem 1981;256:3433-42.
-
(1981)
J Biol Chem
, vol.256
, pp. 3433-3442
-
-
Van Dieijen, G.1
Tans, G.2
Rosing, J.3
Hemker, H.C.4
-
92
-
-
0025317472
-
Kinetics of coagulation factor X activation by platelet-bound factor IXa
-
Rawala-Sheikh R, Ahmad SS, Ashby B, Walsh PN. Kinetics of coagulation factor X activation by platelet-bound factor IXa. Biochemistry 1990;29:2606-11.
-
(1990)
Biochemistry
, vol.29
, pp. 2606-2611
-
-
Rawala-Sheikh, R.1
Ahmad, S.S.2
Ashby, B.3
Walsh, P.N.4
-
93
-
-
0028801352
-
X-ray structure of clotting factor IXa: Active site and module structure related to Xase activity and hemophilia B
-
Brandstetter H, Bauer M, Huber R, Lollar P, Bode W. X-ray structure of clotting factor IXa: active site and module structure related to Xase activity and hemophilia B. Proc Natl Acad Sci USA 1995;92:9796-800.
-
(1995)
Proc Natl Acad Sci USA
, vol.92
, pp. 9796-9800
-
-
Brandstetter, H.1
Bauer, M.2
Huber, R.3
Lollar, P.4
Bode, W.5
-
94
-
-
0010333946
-
Coagulation factor IXa: The relaxed conformation of Tyr99 blocks substrate binding
-
Hopfner KP, Lang A, Karcher A, Sichler K, Kopetzki E, Brandstetter H, Huber R, Bode W, Engh RA. Coagulation factor IXa: the relaxed conformation of Tyr99 blocks substrate binding. Structure Fold Des 1999;7:989-96.
-
(1999)
Structure Fold Des
, vol.7
, pp. 989-996
-
-
Hopfner, K.P.1
Lang, A.2
Karcher, A.3
Sichler, K.4
Kopetzki, E.5
Brandstetter, H.6
Huber, R.7
Bode, W.8
Engh, R.A.9
-
95
-
-
0034720774
-
Insertion loop 256-268 in coagulation factor IX restricts enzymatic activity in the absence but not in the presence of factor VIII
-
Kolkman JA, Mertens K. Insertion loop 256-268 in coagulation factor IX restricts enzymatic activity in the absence but not in the presence of factor VIII. Biochemistry 2000;39:7398-405.
-
(2000)
Biochemistry
, vol.39
, pp. 7398-7405
-
-
Kolkman, J.A.1
Mertens, K.2
-
96
-
-
0030768937
-
2+ binding site, proteolysis in the autolysis loop, phospholipid, and factor X
-
2+ binding site, proteolysis in the autolysis loop, phospholipid, and factor X. J Biol Chem 1997;272:23418-26.
-
(1997)
J Biol Chem
, vol.272
, pp. 23418-23426
-
-
Mathur, A.1
Zhong, D.2
Sabharwal, A.K.3
Smith, K.J.4
Bajaj, S.P.5
-
97
-
-
0029926396
-
The crystal structure of the complex of blood coagulation factor VIIa with soluble tissue factor
-
Banner DW, D'Arcy A, Chene C, Winkler FK, Guha A, Konigsberg WH, Nemerson Y, Kirchhofer D. The crystal structure of the complex of blood coagulation factor VIIa with soluble tissue factor [comment]. Nature 1996;380:41-6.
-
(1996)
Nature
, vol.380
, pp. 41-46
-
-
Banner, D.W.1
D'Arcy, A.2
Chene, C.3
Winkler, F.K.4
Guha, A.5
Konigsberg, W.H.6
Nemerson, Y.7
Kirchhofer, D.8
-
98
-
-
0037423301
-
Physiological factor IXa activation involves a cooperative conformational rearrangement of the 99-loop
-
Sichler K, Kopetzki E, Huber R, Bode W, Hopfner KP, Brandstetter H. Physiological factor IXa activation involves a cooperative conformational rearrangement of the 99-loop. J Biol Chem 2003;278:4121-6.
-
(2003)
J Biol Chem
, vol.278
, pp. 4121-4126
-
-
Sichler, K.1
Kopetzki, E.2
Huber, R.3
Bode, W.4
Hopfner, K.P.5
Brandstetter, H.6
-
99
-
-
0032983331
-
The A1 and A2 subunits of factor VIIIa synergistically stimulate factor IXa catalytic activity
-
Fay PJ, Koshibu K, Mastri M. The A1 and A2 subunits of factor VIIIa synergistically stimulate factor IXa catalytic activity. J Biol Chem 1999;274:15401-6.
-
(1999)
J Biol Chem
, vol.274
, pp. 15401-15406
-
-
Fay, P.J.1
Koshibu, K.2
Mastri, M.3
-
100
-
-
0030768937
-
2+ binding site, proteolysis in the autolysis loop, phospholipid, and factor X
-
2+ binding site, proteolysis in the autolysis loop, phospholipid, and factor X. J Biol Chem 1997;272:23418-26.
-
(1997)
J Biol Chem
, vol.272
, pp. 23418-23426
-
-
Mathur, A.1
Zhong, D.G.2
Sabharwal, A.K.3
Smith, K.J.4
Bajaj, S.P.5
-
101
-
-
15844386398
-
Activation of the factor VIIIa-factor IXa enzyme complex of blood coagulation by membranes containing phosphatidyl-L-serine
-
Gilbert GE, Arena AA. Activation of the factor VIIIa-factor IXa enzyme complex of blood coagulation by membranes containing phosphatidyl-L-serine. J Biol Chem 1996;271:11120-5.
-
(1996)
J Biol Chem
, vol.271
, pp. 11120-11125
-
-
Gilbert, G.E.1
Arena, A.A.2
-
102
-
-
0035832859
-
Factor VIIIa cofactor activity shows enhanced ionic strength sensitivity in the absence of phospholipid
-
Fay PJ, Mastri M, Koszelak ME. Factor VIIIa cofactor activity shows enhanced ionic strength sensitivity in the absence of phospholipid. Biochim Biophys Acta 2001;1548:159-68.
-
(2001)
Biochim Biophys Acta
, vol.1548
, pp. 159-168
-
-
Fay, P.J.1
Mastri, M.2
Koszelak, M.E.3
-
103
-
-
0031027575
-
Localization of a factor X interactive site in the A1 subunit of factor VIIIa
-
Lapan KA, Fay PJ. Localization of a factor X interactive site in the A1 subunit of factor VIIIa. J Biol Chem 1997;272:2082-8.
-
(1997)
J Biol Chem
, vol.272
, pp. 2082-2088
-
-
Lapan, K.A.1
Fay, P.J.2
-
104
-
-
0025866980
-
Structural basis for the decreased procoagulant activity of human factor VIII compared to the porcine homolog
-
Lollar P, Parker ET. Structural basis for the decreased procoagulant activity of human factor VIII compared to the porcine homolog. J Biol Chem 1991;266:12481-6.
-
(1991)
J Biol Chem
, vol.266
, pp. 12481-12486
-
-
Lollar, P.1
Parker, E.T.2
-
105
-
-
0021252593
-
Stabilization of thrombin-activated porcine factor VIII:C by factor IXa phospholipid
-
Lollar P, Knutson GJ, Fass DN. Stabilization of thrombin-activated porcine factor VIII:C by factor IXa phospholipid. Blood 1984;63:1303-8.
-
(1984)
Blood
, vol.63
, pp. 1303-1308
-
-
Lollar, P.1
Knutson, G.J.2
Fass, D.N.3
-
106
-
-
0037166290
-
A model for the stoichiometric regulation of blood coagulation
-
Hockin MF, Jones KC, Everse SJ, Mann KG. A model for the stoichiometric regulation of blood coagulation. J Biol Chem 2002;277:18322-33.
-
(2002)
J Biol Chem
, vol.277
, pp. 18322-18333
-
-
Hockin, M.F.1
Jones, K.C.2
Everse, S.J.3
Mann, K.G.4
-
107
-
-
0029886287
-
Mutations in a subgroup of patients with mild haemophilia A and a familial discrepancy between the one-stage and two-stage factor VIII:C methods
-
Rudzki Z, Duncan EM, Casey GJ, Neumann M, Favaloro EJ, Lloyd JV. Mutations in a subgroup of patients with mild haemophilia A and a familial discrepancy between the one-stage and two-stage factor VIII:C methods. Br J Haematol 1996;94:400-6.
-
(1996)
Br J Haematol
, vol.94
, pp. 400-406
-
-
Rudzki, Z.1
Duncan, E.M.2
Casey, G.J.3
Neumann, M.4
Favaloro, E.J.5
Lloyd, J.V.6
-
108
-
-
0033192464
-
Substitution of Arg527 and Arg531 in factor VIII associated with mild haemophilia A: Characterization in terms of subunit interaction and cofactor function
-
Celie PH, Van Stempvoort G, Jorieux S, Mazurier C, Van Mourik JA, Mertens K. Substitution of Arg527 and Arg531 in factor VIII associated with mild haemophilia A: characterization in terms of subunit interaction and cofactor function. Br J Haematol 1999;106:792-800.
-
(1999)
Br J Haematol
, vol.106
, pp. 792-800
-
-
Celie, P.H.1
Van Stempvoort, G.2
Jorieux, S.3
Mazurier, C.4
Van Mourik, J.A.5
Mertens, K.6
-
109
-
-
0032932325
-
Mild hemophilia A caused by increased rate of factor VIII A2 subunit dissociation: Evidence for nonproteolytic inactivation of factor VIIIa in vivo
-
Pipe SW, Eickhorst AN, McKinley SH, Saenko EL, Kaufman RJ. Mild hemophilia A caused by increased rate of factor VIII A2 subunit dissociation: evidence for nonproteolytic inactivation of factor VIIIa in vivo. Blood 1999;93:176-83.
-
(1999)
Blood
, vol.93
, pp. 176-183
-
-
Pipe, S.W.1
Eickhorst, A.N.2
McKinley, S.H.3
Saenko, E.L.4
Kaufman, R.J.5
-
110
-
-
0035254221
-
Hemophilia A mutations associated with 1-stage/2-stage activity discrepancy disrupt protein-protein interactions within the triplicated A domains of thrombin-activated factor VIIIa
-
Pipe SW, Saenko EL, Eickhorst AN, Kemball-Cook G, Kaufman RJ. Hemophilia A mutations associated with 1-stage/2-stage activity discrepancy disrupt protein-protein interactions within the triplicated A domains of thrombin-activated factor VIIIa. Blood 2001;97:685-91.
-
(2001)
Blood
, vol.97
, pp. 685-691
-
-
Pipe, S.W.1
Saenko, E.L.2
Eickhorst, A.N.3
Kemball-Cook, G.4
Kaufman, R.J.5
-
111
-
-
0025888388
-
Activated protein C-catalyzed inactivation of human factor VIII and factor VIIIa. Identification of cleavage sites and correlation of proteolysis with cofactor activity
-
Fay PJ, Smudzin TM, Walker FJ. Activated protein C-catalyzed inactivation of human factor VIII and factor VIIIa. Identification of cleavage sites and correlation of proteolysis with cofactor activity. J Biol Chem 1991;266:20139-45.
-
(1991)
J Biol Chem
, vol.266
, pp. 20139-20145
-
-
Fay, P.J.1
Smudzin, T.M.2
Walker, F.J.3
-
112
-
-
0030053236
-
Activated protein C-catalyzed proteolysis of factor VIIIa alters its interactions within factor Xase
-
Regan LM, O'Brien LM, Beattie TL, Sudhakar K, Walker FJ, Fay PJ. Activated protein C-catalyzed proteolysis of factor VIIIa alters its interactions within factor Xase. J Biol Chem 1996;271:3982-7.
-
(1996)
J Biol Chem
, vol.271
, pp. 3982-3987
-
-
Regan, L.M.1
O'Brien, L.M.2
Beattie, T.L.3
Sudhakar, K.4
Walker, F.J.5
Fay, P.J.6
-
113
-
-
0028235757
-
Factor IXa protects factor VIIIa from activated protein C. Factor IXa inhibits activated protein C-catalyzed cleavage of factor VIIIa at Arg562
-
Regan LM, Lamphear BJ, Huggins CF, Walker FJ, Fay PJ. Factor IXa protects factor VIIIa from activated protein C. Factor IXa inhibits activated protein C-catalyzed cleavage of factor VIIIa at Arg562. J Biol Chem 1994;269:9445-52.
-
(1994)
J Biol Chem
, vol.269
, pp. 9445-9452
-
-
Regan, L.M.1
Lamphear, B.J.2
Huggins, C.F.3
Walker, F.J.4
Fay, P.J.5
-
114
-
-
0029941850
-
Comparison of activated protein C/protein S-mediated inactivation of human factor VIII and factor V
-
Lu D, Kalafatis M, Mann KG, Long GL. Comparison of activated protein C/protein S-mediated inactivation of human factor VIII and factor V. Blood 1996;87:4708-17.
-
(1996)
Blood
, vol.87
, pp. 4708-4717
-
-
Lu, D.1
Kalafatis, M.2
Mann, K.G.3
Long, G.L.4
-
115
-
-
0345195222
-
Inhibitory mechanism of the protein C pathway on tissue factor-induced thrombin generation. Synergistic effect in combination with tissue factor pathway inhibitor
-
van 't Veer C, Golden NJ, Kalafatis M, Mann KG. Inhibitory mechanism of the protein C pathway on tissue factor-induced thrombin generation. Synergistic effect in combination with tissue factor pathway inhibitor. J Biol Chem 1997;272:7983-94.
-
(1997)
J Biol Chem
, vol.272
, pp. 7983-7994
-
-
Van 't Veer, C.1
Golden, N.J.2
Kalafatis, M.3
Mann, K.G.4
-
117
-
-
0027091631
-
Proteolytic interactions of factor IXa with human factor VIII and factor VIIIa
-
Lamphear BJ, Fay PJ. Proteolytic interactions of factor IXa with human factor VIII and factor VIIIa. Blood 1992;80:3120-6.
-
(1992)
Blood
, vol.80
, pp. 3120-3126
-
-
Lamphear, B.J.1
Fay, P.J.2
|