Crystal structure of thrombin bound to heparin

Journal of Biological Chemistry

Volumn 280, Issue 4, 2005, Pages 2745-2749

  Carter, Wendy J ^a   Cama, Evis ^a   Huntington, James A ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD VESSELS; CELLS; COAGULATION; CRYSTAL STRUCTURE; DIMERS; FUNCTIONS; MUTAGENESIS; NEGATIVE IONS; SUBSTRATES;

ANION BINDING; BLOOD COAGULATION; CELL SURFACE; MOLECULAR LEVEL;

ENZYMES;

ANION; CELL SURFACE RECEPTOR; GLYCOSAMINOGLYCAN; HEPARIN; MONOSACCHARIDE; PROCOAGULANT; SERINE PROTEINASE INHIBITOR; THROMBIN; THROMBOMODULIN;

ANTICOAGULATION; ARTICLE; BLOOD CLOTTING; CHEMICAL STRUCTURE; CRYSTAL STRUCTURE; HUMAN; HUMAN CELL; MOLECULAR INTERACTION; MUTAGENESIS; PRIORITY JOURNAL; RECEPTOR BINDING;

ANIONS; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; DIMERIZATION; ELECTROSTATICS; GLYCOSAMINOGLYCANS; HEPARIN; HUMANS; MODELS, CHEMICAL; MODELS, MOLECULAR; MONOSACCHARIDES; PROTEIN BINDING; PROTEIN CONFORMATION; THROMBIN;

EID: 13244270050     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M411606200     Document Type: Article

References (29)

1. Bode, W., Mayr, I., Baumann, U., Huber, R., Stone, S. R., and Hofsteenge, J. (1989) EMBO J. 8, 3467-3475
2. Stubbs, M. T., and Bode, W. (1993) Thromb. Res. 69, 1-58
3. Stubbs, M. T., and Bode, W. (1995) Trends Biochem. Sci 20, 23-28
4. Leung, L. L., and Hall, S. W. (2000) Trends Cardiovasc. Med, 10, 89-92
5. Di Cera, E. (2003) Chest 124, 11S-17S
6. Huntington, J. A., and Baglin, T. P. (2003) Trends Pharmacol. Sci. 24, 589-595
7. Huntington, J. A. (2003) J. Thromb. Haemostasis 1, 1535-1549
8. Esmon, C. T. (2003) Chest 124, 26S-32S
9. Rezaie, A. R. (2003) Trends Cardiovasc. Med. 13, 8-15
10. Le Bonniec, B. F., Myles, T., Johnson, T., Knight, C. G., Tapparelli, C., and Stone, S. R. (1996) Biochemistry 35, 7114-7122
11. Rydel, T. J., Tulinsky, A., Bode, W., and Huber, R. (1991) J. Mol. Biol. 221, 583-601
12. Leslie, A. W. G. (1992) Joint CCP4 and ESF-EACMB Newsletter on Protein Crystallography, Vol. 26, Daresbury Laboratory, Warrington, UK
13. Vagin, A., and Teplyakov, A. (2000) Acta Crystallogr. Sect. D Biol. Crystallogr. 56, 1622-1624
14. Brunger, A. T., Adams, P. D., Clore, G. M., Delano, W. L., Gros, P., GrosseKunstleve, R. W., Jiang, J. S., Kuszewski, J., Nilges, M., Pannu, N. S., Read, R. J., Rice, L. M., Simonson, T., and Warren, G. L. (1998) Acta Crystallogr. Sect. D Biol. Crystallogr. 54, 905-921
15. Mulloy, B., and Forster, M. J. (2000) Glycobiology 10, 1147-1156
16. van Aalten, D. M., Bywater, R., Findlay, J.B., Hendlich, M., Hooft, R. W., and Vriend, G. (1996) J. Comput. Aided Mol. Des. 10, 255-262
17. Esnouf, R. M. (1997) J. Mol. Graph. Model. 15, 112-113, 132-134
18. Merritt, E. A., and Murphy, M. E. P. (1994) Acta Crystallogr. Sect. D Biol. Crystallogr. 50, 869-873
19. Boissel, J. P., Le Bonniec, B., Rabiet, M. J., Labie, D., and Elion, J. (1984) J. Biol. Chem. 259, 5691-5697
20. Olson, S. T., Halvorson, H. R., and Bjork, I. (1991) J. Biol. Chem. 266, 6342-6352
21. Gan, Z. R., Li, Y., Chen, Z., Lewis, S. D., and Shafer, J. A. (1994) J. Biol. Chem. 269, 1301-1305
22. Sheehan, J. P., and Sadler, J. E. (1994) Proc. Natl. Acad. Sci. U. S. A. 91, 5518-5522
23. Tsiang, M., Jain, A. K., and Gibbs, C. S. (1997) J. Biol. Chem. 272, 12024-12029
24. Petitou, M., Herault, J. P., Bernat, A., Driguez, P. A., Duchaussoy, P., Lormeau, J. C., and Herbert, J. M. (1999) Nature 398, 417-422
25. Li, W., Johnson, D. J., Esmon, C. T., and Huntington, J. A. (2004) Nat. Struct. Mol. Biol. 11, 857-862
26. Dementiev, A., Petitou, M., Herbert, J. M., and Gettins, P. G. (2004) Nat. Struct. Mol. Biol. 11, 863-867
27. Huntington, J. A., and Esmon, C. T. (2003) Structure (Camb.) 11, 469-479
28. Ye, J., Rezaie, A. R., and Esmon, C. T. (1994) J. Biol. Chem. 269, 17965-17970
29. Vindigni, A., White, C. E., Komives, E. A., and Di Cera, E. (1997) Biochemistry 36, 6674-6681