Fibrinogen γ' chain binds thrombin exosite II

Journal of Thrombosis and Haemostasis

Volumn 1, Issue 1, 2003, Pages 124-131

  Lovely, R S ^a   Moaddel, M ^b   Farrell, D H ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b PENN STATE COLLEGE OF MEDICINE   (United States)

Author keywords

Fibrinogen; Heparin; Hirudin; Sulfation; Thrombin

Indexed keywords

DNA; FIBRINOGEN; FIBRINOPEPTIDES GAMMA; HEPARIN; HIRUDIN DERIVATIVE; ISOPROTEIN; RECOMBINANT PROTEIN; THROMBIN; TYROSINE;

AMINO ACID SEQUENCE; ANIMAL; ARTICLE; BINDING COMPETITION; BINDING SITE; CELL LINE; CHEMISTRY; ENZYME SPECIFICITY; GENETIC TRANSFECTION; GENETICS; HUMAN; KINETICS; METABOLISM; MOLECULAR GENETICS; MOUSE; PROTEIN BINDING;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; BINDING, COMPETITIVE; CELL LINE; DNA; FIBRINOGEN; HEPARIN; HIRUDINS; HUMANS; KINETICS; MICE; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; PROTEIN ISOFORMS; RECOMBINANT PROTEINS; SUBSTRATE SPECIFICITY; THROMBIN; TRANSFECTION; TYROSINE;

EID: 0037923219     PISSN: 15387933     EISSN: 15387836     Source Type: Journal    
DOI: 10.1046/j.1538-7836.2003.00027.x     Document Type: Article

References (51)

1. Blombäck B. Fibrinogen: evolution of the structure-function concept: Keynote address at the Fibrinogen 2000 Congress. Ann NY Acad Sci 2001; 936: 1-10.
2. Seegers WH, Nieft M, Loomis EC. Note on the adsorption of thrombin on fibrin. Science 1945; 101: 520-1.
3. Meh DA, Siebenlist KR, Mosesson MW. Identification and characterization of the thrombin binding sites on fibrin. J Biol Chem 1996; 271: 23121-5.
4. Vali Z, Scheraga HA. Localization of the binding site on fibrin for the secondary binding site of thrombin. Biochemistry 1988; 27: 1956-63.
5. van Nispen JW, Hageman TC, Scheraga HA. Mechanism of action of thrombin on fibrinogen. The reaction of thrombin with fibrinogen-like peptides containing 11, 14, and 16 residues. Arch Biochem Biophys 1977; 182: 227-43.
6. Meh DA, Siebenlist KR, Brennan SO, Holyst T, Mosesson MW. The amino acid sequence in fibrin responsible for high affinity thrombin binding. Thromb Haemost 2001; 85: 470-4.
7. Chung DW, Davie EW. γ and γ' chains of human fibrinogen are produced by alternative mRNA processing. Biochemistry 1984; 23: 4232-6.
8. Fornace AJII, Cummings D, Comeau CM, Kant JA, Crabtree GR. Structure of the human γ-fibrinogen gene. Alternate mRNA splicing near the 3′ end of the gene produces γA and γB forms of γ-fibrinogen. J Biol Chem 1984; 259: 12826-30.
9. MosessonMW, Finlayson JS. Biochemical and chromatographic studies of certain activities associated with human fibrinogen preparations. J Clin Invest 1963; 42: 747-55.
10. Farrell DH, Mulvihill ER, Huang S, Chung DW, Davie EW. Recombinant human fibrinogen and sulfation of the g0 chain. Biochemistry 1991; 30: 9414-20.
11. Haidaris PJ, Peerschke EIB, Marder VJ, Francis CW. The C-terminal sequences of the g 57.5 chain of human fibrinogen constitute a plasmin sensitive epitope that is exposed in crosslinked fibrin. Blood 1989; 74: 2437-44.
12. Francis CW, Marder VJ, Martin SE. Demonstration of a large molecular weight variant of the γ chain of normal human plasma fibrinogen. J Biol Chem 1980; 255: 5599-604.
13. Wolfenstein-Todel C, Mosesson MW. Human plasma fibrinogen heterogeneity: Evidence for an extended carboxyl-terminal sequence in a normal γ chain variant (γ'). Proc Natl Acad Sci USA 1980; 77: 5069-73.
14. Hogg PJ, Jackson CM. Fibrin monomer protects thrombin from inactivation by heparin-antithrombin III. Implications for heparin therapy. Proc Natl Acad Sci USA 1989; 86: 3619-23.
15. Weitz JI, Hudoba M, Massel D, Maraganore J, Hirsh J. Clot-bound thrombin is protected from inhibition by heparin-antithrombin III but is susceptible to inactivation by antithrombin III-independent inhibitors. J Clin Invest 1990; 86: 385-91.
16. Rosenberg RD, Damus PS. The purification and mechanism of action of human antithrombin-heparin cofactor. J Biol Chem 1973; 248: 6490-505.
17. Wilner GD, Danitz MP, Mudd MS, Hsieh KH, Fenton JWII. Selective immobilization of α-thrombin by surface-bound fibrin. J Lab Clin Med 1981; 97: 403-11.
18. Kumar R, Beguin S, Hemker HC. The influence of fibrinogen and fibrin on thrombin generation - evidence for feedback activation of the clotting system by clot bound thrombin. Thromb Haemost 1994; 72: 713-21.
19. Falls LA, Farrell DH. Resistance of γA/γ' fibrin clots to fibrinolysis. J Biol Chem 1997; 272: 14251-6.
20. Moaddel M, Falls LA, Farrell DH. The role of γA/γ' fibrinogen in plasma factor XIII activation. J Biol Chem 2000; 275: 32135-40.
21. Lovely RS, Falls LA, Al-Mondhiry HA, et al. Association of γA/γ' fibrinogen levels and coronary artery disease. Thromb Haemost 2002; 88: 26-31.
22. BodeW, Turk D, Karshikov A. The refined 1.9-Å X-ray crystal structure of D-Phe-Pro-Arg chloromethylketone-inhibited human α-thrombin: structure analysis, overall structure, electrostatic properties, detailed active-site geometry, and structure-function relationships. Protein Sci 1992; 1: 426-71.
23. Fenton JWII, Olson TA, Zabinski MP, Wilner GD. Anion-binding exosite of human α-thrombin and fibrin (ogen) recognition. Biochemistry 1988; 27: 7106-12.
24. Myles T, Church FC, Whinna HC, Monard D, Stone SR. Role of thrombin anion-binding exosite-I in the formation of thrombin-serpin complexes. J Biol Chem 1998; 273: 31203-8.
25. Mathews II, Padmanabhan KP, Ganesh V, Tulinsky A, Ishii M, Chen J, Turck CW, Coughlin SR, Fenton JW II. Crystallographic structures of thrombin complexed with thrombin receptor peptides: existence of expected and novel binding modes. Biochemistry 1994; 33: 3266-79.
26. Rydel TJ, Ravichandran KG, Tulinsky A, BodeW, Huber R, Roitsch C, Fenton JWII. The structure of a complex of recombinant hirudin and human α-thrombin. Science 1990; 249: 277-80.
27. Stubbs MT, Bode W. A player of many parts: the spotlight falls on thrombin's structure. Thromb Res 1993; 69: 1-58.
28. Tulinsky A, Qiu X. Active site and exosite binding of α-thrombin. Blood Coagul Fibrinolysis 1993; 4: 305-12.
29. 2+ dependence of protein C activation. J Biol Chem 1994; 269: 11807-12.
30. De Cristofaro R, De Candia E, Rutella S, Weitz JI. The Asp(272)-Glu(282) region of platelet glycoprotein Ibα interacts with the heparinbinding site of α-thrombin and protects the enzyme from the heparincatalyzed inhibition by antithrombin III. J Biol Chem 2000; 275: 3887-95.
31. Li CQ, Vindigni A, Sadler JE, Wardell MR. Platelet glycoprotein Ibα binds to thrombin anion-binding exosite II inducing allosteric changes in the activity of thrombin. J Biol Chem 2001; 276: 6161-8.
32. Maraganore JM, Chao B, Joseph ML, Jablonski J, Ramachandran KL. Anticoagulant activity of synthetic hirudin peptides. J Biol Chem 1989; 264: 8692-8.
33. Stone SR, Hofsteenge J. Kinetics of the inhibition of thrombin by hirudin. Biochemistry 1986; 25: 4622-8.
34. Hortin GL, Tollefsen DM, Strauss AW. Identification of two sites of sulfation of human heparin cofactor II. J BiolChem1986; 261: 15827-30.
35. Marchese P, Murata M, Mazzucato M, Pradella P, De Marco L, Ware J, Ruggeri ZM. Identification of three tyrosine residues of glycoprotein Ibα with distinct roles in vonWillebrand factor and α-thrombin binding. J Biol Chem 1995; 270: 9571-8.
36. Pittman DD, Tomkinson KN, Michnick D, Selighsohn U, Kaufman RJ. Posttranslational sulfation of factor V is required for efficient thrombin cleavage and activation and for full procoagulant activity. Biochemistry 1994; 33: 6952-9.
37. Michnick DA, Pittman DD, Wise RJ, Kaufman RJ. Identification of individual tyrosine sulfation sites within factor VIII required for optimal activity and efficient thrombin cleavage. J Biol Chem 1994; 269: 20095-102.
38. Henschen A. On the occurrence and significance of tyrosine sulfation in fibrinogen. Blood Coag Fibrinolysis 1993; 4: 822.
39. Colwell NS, Blinder MA, Tsiang M, Gibbs CS, Bock PE, Tollefsen DM. Allosteric effects of a monoclonal antibody against thrombin exosite II. Biochemistry 1998; 37: 15057-65.
40. Kunkel TA. Rapid and efficient site-specific mutagenesis without phenotypic selection. Proc Natl Acad Sci USA 1985; 82: 488-92.
41. Laemmli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 1970; 227: 680-5.
42. Brown WM, Dziegielewska KM, Foreman RC, Saunders NR. Nucleotide and deduced amino acid sequence of a γ subunit of bovine fibrinogen. Nucleic Acids Res 1989; 17: 6397.
43. Crabtree GR, Kant JA. Organization of the rat γ-fibrinogen gene. Alternative mRNA splice patterns produce the γA and γB(γ') chains of fibrinogen. Cell 1982; 31: 159-66.
44. Hirose S, Oda K, Ikehara Y. Tyrosine O-sulfation of the fibrinogen gB chain in primary cultures of rat hepatocytes. J Biol Chem 1988; 263: 7426-30.
45. Lin WH, Larsen K, Hortin GL, Roth JA. Recognition of substrates by tyrosylprotein sulfotransferase. Determination of affinity by acidic amino acids near the target sites. J Biol Chem 1992; 267: 2876-9.
46. Witting JI, Bourdon P, Brezniak DV, Maraganore JM, Fenton JW II. Thrombin-specific inhibition by and slow cleavage of hirulog-1. Biochem J 1992; 283: 737-43.
47. Fredenburgh JC, Stafford AR, Weitz JI. Evidence for allosteric linkage between exosites 1 and 2 of thrombin. J Biol Chem 1997; 272: 25493-9.
48. Meh DA, MosessonMW, Siebenlist KR, Simpson-Haidaris PJ, Brennan SO, DiOrio JP, Thompson K, Di Minno G. Fibrinogen Naples I (Bb8 A68T) nonsubstrate thrombin-binding capacities. Thromb Res 2001; 103: 63-73.
49. Kaminski M, McDonagh J. Inhibited thrombins: interactions with fibrinogen and fibrin. Biochem J 1987; 242: 881-7.
50. Hogg PJ, Jackson CM, Labanowski JK, Bock PE. Binding of fibrin monomer and heparin to thrombin in a ternary complex alters the environment of the thrombin catalytic site, reduces affinity for hirudin, and inhibits cleavage of fibrinogen. J Biol Chem 1996; 271: 26088-95.
51. Becker DL, Fredenburgh JC, Stafford AR, Weitz JI. Exosites 1 and 2 are essential for protection of fibrin-bound thrombin from heparin-catalyzed inhibition by antithrombin and heparin cofactor II. J Biol Chem 1999; 274: 6226-33.