Thrombomodulin enhances the reactivity of thrombin with protein C inhibitor by providing both a binding site for the serpin and allosterically modulating the activity of thrombin

Journal of Biological Chemistry

Volumn 278, Issue 39, 2003, Pages 37465-37470

  Yang, Likui ^a   Manithody, Chandrashekhara ^a   Walston, Timothy D ^b   Cooper, Scott T ^b   Rezaie, Alireza R ^a  

^a SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF WISCONSIN LA CROSSE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYSIS; CONFORMATIONS; ENZYME INHIBITION; MUTAGENESIS;

BINDING SITES;

PROTEINS;

ACID; ALANINE; ANTITHROMBIN; ARGININE; BASE; EPIDERMAL GROWTH FACTOR LIKE DOMAIN 456 PROTEIN; HEPARIN; PLASMINOGEN ACTIVATOR INHIBITOR 3; PROTEIN; PROTEIN C; PROTEINASE; SERINE PROTEINASE INHIBITOR; THROMBIN; THROMBOMODULIN; UNCLASSIFIED DRUG;

ALLOSTERISM; AMINO ACID SUBSTITUTION; ARTICLE; BINDING SITE; CATALYSIS; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVITY; ENZYME INHIBITOR INTERACTION; ENZYME SPECIFICITY; ENZYME SUBSTRATE COMPLEX; HUMAN; HUMAN CELL; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; STRUCTURE ANALYSIS; SURFACE CHARGE;

ALLOSTERIC REGULATION; BINDING SITES; HUMANS; PROTEIN C INHIBITOR; PROTEIN CONFORMATION; RECOMBINANT PROTEINS; SERPINS; THROMBIN; THROMBOMODULIN;

EID: 0141509969     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M307243200     Document Type: Article

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