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Volumn 99, Issue 17, 2002, Pages 11079-11084
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Crystal structures of native and thrombin-complexed heparin cofactor II reveal a multistep allosteric mechanism
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Author keywords
[No Author keywords available]
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Indexed keywords
ANTITHROMBIN;
HEPARIN COFACTOR II;
SERINE PROTEINASE;
SERINE PROTEINASE INHIBITOR;
THROMBIN;
ALLOSTERISM;
AMINO TERMINAL SEQUENCE;
ARTICLE;
BETA SHEET;
BLOOD CLOTTING;
COMPLEX FORMATION;
CRYSTAL STRUCTURE;
ENZYME INHIBITION;
MOLECULAR INTERACTION;
NONHUMAN;
PRIORITY JOURNAL;
PROTEIN CONFORMATION;
STRUCTURE ANALYSIS;
ALLOSTERIC REGULATION;
AMINO ACID SUBSTITUTION;
ANTITHROMBINS;
BINDING SITES;
CRYSTALLOGRAPHY, X-RAY;
HEPARIN COFACTOR II;
KINETICS;
MODELS, MOLECULAR;
MUTAGENESIS, SITE-DIRECTED;
PROTEIN CONFORMATION;
RECOMBINANT PROTEINS;
SERPINS;
THROMBIN;
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EID: 0037143655
PISSN: 00278424
EISSN: None
Source Type: Journal
DOI: 10.1073/pnas.162232399 Document Type: Article |
Times cited : (191)
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References (51)
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