Downregulation of uPA inhibits migration and PI3k/Akt signaling in glioblastoma cells

Oncogene

Volumn 22, Issue 3, 2003, Pages 392-400

  Chandrasekar, Nirmala ^a   Mohanam, Sanjeeva ^a   Gujrati, Meena ^a   Olivero, William C ^a   Dinh, Dzung H ^a   Rao, Jasti S ^a  

^a UNIVERSITY OF ILLINOIS   (United States)

Author keywords

Antisense uPA; Glioblastoma; Invasion; Migration

Indexed keywords

COMPLEMENTARY DNA; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; SERINE PROTEINASE; STAUROSPORINE; UROKINASE; UROKINASE RECEPTOR;

APOPTOSIS; ARTICLE; CANCER CELL; CANCER CELL CULTURE; CELL CYCLE G2 PHASE; CELL MIGRATION; CELL MOTILITY; CELL SURVIVAL; CLONOGENESIS; CONTROLLED STUDY; CYTOSKELETON; DOWN REGULATION; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; GENETIC TRANSFECTION; GLIOBLASTOMA; HUMAN; HUMAN CELL; MITOSIS; MOLECULAR EVOLUTION; PHENOTYPE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TUMOR RECURRENCE;

1-PHOSPHATIDYLINOSITOL 3-KINASE; APOPTOSIS; BCL-X PROTEIN; CDC42 GTP-BINDING PROTEIN; CELL MOVEMENT; CENTRAL NERVOUS SYSTEM NEOPLASMS; DOWN-REGULATION; ENZYME INHIBITORS; G2 PHASE; GLIOBLASTOMA; HUMANS; MITOSIS; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS C-BCL-2; STAUROSPORINE; TRANSFECTION; TUMOR CELLS, CULTURED; URINARY PLASMINOGEN ACTIVATOR;

EID: 0037461901     PISSN: 09509232     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.onc.1206164     Document Type: Article

References (46)

1. Andreasen PA, Kjoller L, Christensen L and Duffy MJ. (1997). Int. J. Cancer, 72, 1-22.
2. Aspenstrom P. (1999). Curr. Opin. Cell Biol., 11, 95-102.
3. Berens ME, Rutka JT and Rosenblum ML. (1990). Neurosurg. Clin. North Am., 1, 1-18.
4. Cardone MH, Roy N, Stennicke HR, Salvesen GS, Franke TF, Stanbridge E, Frisch S and Reed JC. (1998). Science, 282, 1318-1321.
5. Carriero MV, Del Vecchio S, Capozzoli M, Franco P, Fontana L, Zannetti A, Botti G, D'Aiuto G, Salvatore M and Stoppelli MP. (1999). Cancer Res., 59, 5307-5314.
6. Dano K, Behrendt N, Brunner N, Elhis V, Ploug M and Pyke C. (1994). Fibrinolysis, 8, 189-203.
7. Datta SR, Dudek H, Tao X, Masters S, Fu H, Gotoh Y and Greenberg ME. (1997). Cell, 91, 231-241.
8. Dear AE and Medcalf RL. (1998). Eur. J. Biochem., 252, 185-193.
9. Ganju N and Eastman A. (2002). Biochem. Biophys. Res. Commun., 291, 1258-1264.
10. Goodman SL, Vollmers HP and Birchmeier W. (1985). Cell, 41, 1029-1038.
11. Gumbiner BM. (1996). Cell, 84, 345-357.
12. Gunning P, Leavitt J, Muscat G, Ng SY and Kedes L. (1987). Proc. Natl. Acad. Sci. USA, 84, 4831-4835.
13. Haeckel C, Krueger S and Roessner A. (1998). Int. J. Cancer, 77, 153-160.
14. Harsh IV G and Wilson C. (1990). Neurological Surgery. Youman JR (ed). WB Saunders Co.: Philadelphia, PA, pp. 3040-3136.
15. Hengartner MO. (2000). Nature, 407, 770-776.
16. Jimenez C, Portela RA, Mellado M, Rodriguez-Frade JM, Collard J, Serrano A, Martinez A, Avila J and Carrera AC. (2000). J. Cell. Biol., 151, 249-262.
17. Kim EJ, Suliman A, Lam A and Srivastava RK. (2001). Int. J. Oncol., 18, 187-194.
18. Koopman JL, Slomp J, de Bart AC, Quax PH and Verheijen JH. (1998). J. Biol. Chem., 273, 33267-33272.
19. Kusch A, Tkachuk S, Haller H, Dietz R, Gulba DC, Lipp M and Dumler I. (2000). J. Biol. Chem., 275, 39466-39473.
20. Lauffenburger DA and Horwitz AF. (1996). Cell, 84, 359-369.
21. Longstaff C, Merton RE, Fabregas P and Felez J. (1999). Blood, 93, 3839-3846.
22. MacDonald TJ, DeClerck YA and Laug WE. (1998). J. Neuro-oncol., 40, 215-226.
23. Matrisian LM. (1992). Bioessays, 14, 455-463.
24. Meggio F, Donella DA, Ruzzene M, Brunati AM, Cesaro L, Guerra B, Meyer T, Mett H, Fabbro D, Furet P, Dobrowdska G and Pinna LA. (1995). Eur. J. Biochem., 234, 317-322.
25. Metzner B, Barbisch M, Bachmann F, Czech W and Norgauer J. (1996). J. Invest. Dermatol., 107, 597-602.
26. Mignatti P and Rifkin DB. (1993). Physiol. Rev., 73, 161-195.
27. Mohanam S, Chintala SK, Go Y, Bhattacharya A, Venkaiah B, Boyd D, Gokaslan ZL, Sawaya R and Rao JS. (1997). Oncogene, 14, 1351-1359.
28. Mohanam S, Jasti SL, Kondraganti SR, Chandrasekar N, Kin Y, Fuller GN, Lakka SS, Kyritsis AP, Dinh DH, Olivero WC, Gujrati M, Yung WK and Rao JS. (2001). Clin. Cancer Res., 7, 2519-2526.
29. Morales-Ruiz M, Fulton D, Sowa G, Languino LR, Fujio Y, Walsh K and Sessa WC. (2000). Circ. Res., 86, 892-896.
30. Pyke C, Kristensen P, Ralfkiaer E, Grondahl-Hansen J, Eriksen J, Blasi F and Dano K. (1991). Am. J. Pathol., 138, 1059-1067.
31. Renz A, Berdel WE, Kreuter M, Belka C, Schulze-Osthoff K and Los M. (2001). Blood, 98, 1542-1548.
32. Sachdev P, Zeng L and Wang LH. (2002). J. Biol. Chem., 277, 17638-17648.
33. Schmitt M, Harbeck N, Thomssen C, Wilhelm O, Magdolen V, Reuning U, Ulm K, Hofler H, Janicke F and Graeff H. (1997). Thromb. Haemost., 78, 285-296.
34. Sliva D, Rizzo MT and English D. (2002). J. Biol. Chem., 277, 3150-3157.
35. Stahl A and Mueller BM. (1994). Cancer Res., 54, 3066-3071.
36. Stepanova V, Mukhina S, Kohler E, Resink TJ, Erne P and Tkachuk VA. (1999). Mol. Cell. Biol., 195, 199-206.
37. Sturge J, Hamelin J and Jones GE. (2002). J. Cell. Sci., 115, 699-711.
38. Takahashi A, Hirata H, Yonehara S, Imai Y, Lee KK, Moyer RW, Turner PC, Mesner PW, Okazaki T, Sawai H, Kishi S, Yamamoto K, Okuma M and Sasada M. (1997). Oncogene, 14, 2741-2752.
39. Tolias K, Cantley LC and Carpenter CL. (1995). Rho family GTPases bind to phosphoinositide kinases. J. Biol. Chem., 270, 17656-17659.
40. Vanhaesebroeck B and Waterfield MD. (1999). Exp. Cell. Res., 253, 239-254.
41. Vassalli JD, Sappino AP and Belin D. (1991). J. Clin. Invest., 88, 1067-1072.
42. Wei Y, Lukashev M, Simon DI, Bodary SC, Rosenberg S, Doyle MV and Chapman HA. (1996). Science, 273, 1551-1555.
43. Wei Y, Waltz DA, Rao N, Drummond RJ, Rosenberg S and Chapman HA. (1994). J. Biol. Chem., 269, 32380-32388.
44. Wild-Bode C, Weller M and Wick W. (2001). J. Neurosurg., 94, 978-984.
45. Yamamoto M, Sawaya R, Mohanam S, Bindal AK, Bruner JM, Oka K, Rao VH, Tomonaga M, Nicolson GL and Rao JS. (1994). Cancer Res., 54, 3656-3661.
46. Yebra M, Goretzki L, Pfeifer M and Mueller BM. (1999). Exp. Cell Res., 250, 231-240.