메뉴 건너뛰기




Volumn 31, Issue 5, 1998, Pages 345-351

Rapamycin: Distribution, pharmacokinetics and therapeutic range investigations: An update

Author keywords

[No Author keywords available]

Indexed keywords

CORTICOSTEROID; CYCLOSPORIN A; CYTOCHROME P450; DRUG METABOLITE; DRUG VEHICLE; FK 506 BINDING PROTEIN; N,N DIMETHYLACETAMIDE; RAPAMYCIN; TACROLIMUS;

EID: 0032128447     PISSN: 00099120     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0009-9120(98)00048-4     Document Type: Conference Paper
Times cited : (119)

References (49)
  • 1
    • 0016713286 scopus 로고
    • Rapamycin (AY-22,989), A new antifungal antibiotic II. Fermentation, isolation and characterization
    • Sehgal S.N., Baker H., Vezina C. Rapamycin (AY-22,989), A new antifungal antibiotic II. Fermentation, isolation and characterization. J Antibiot. 28:1975;727-732.
    • (1975) J Antibiot , vol.28 , pp. 727-732
    • Sehgal, S.N.1    Baker, H.2    Vezina, C.3
  • 2
    • 85025352713 scopus 로고
    • Rapamycin: Antifungal, antitumour, antiproliferative and immunosuppressive macrolide
    • Morris R.E. Rapamycin antifungal, antitumour, antiproliferative and immunosuppressive macrolide . Transplant Rev. 6:1992;39.
    • (1992) Transplant Rev , vol.6 , pp. 39
    • Morris, R.E.1
  • 3
    • 0026102058 scopus 로고
    • Production of synergistic, but non-identical mechanisms of immunosuppression by rapamycin and cyclosporine
    • Kimball P.M., Kerman R.H., Kahan B.D. Production of synergistic, but non-identical mechanisms of immunosuppression by rapamycin and cyclosporine. Transplantation. 51:1991;486-490.
    • (1991) Transplantation , vol.51 , pp. 486-490
    • Kimball, P.M.1    Kerman, R.H.2    Kahan, B.D.3
  • 4
    • 0025228926 scopus 로고
    • Cyclosporine, FK506 and rapamycin: Some effects on early activation events in serum-free, mitogen-stimulated mouse spleen cells
    • Metcalfe S.M., Richards F.M. Cyclosporine, FK506 and rapamycin some effects on early activation events in serum-free, mitogen-stimulated mouse spleen cells . Transplantation. 49:1990;798-802.
    • (1990) Transplantation , vol.49 , pp. 798-802
    • Metcalfe, S.M.1    Richards, F.M.2
  • 5
    • 0025099697 scopus 로고
    • Distinct mechanisms of suppression of murine T-cell activation by the related macrolides FK506 and Rapamycin
    • Dumont F.J., Staruch M.J., Koprak S.L., Melino M.R., Siga N.H. Distinct mechanisms of suppression of murine T-cell activation by the related macrolides FK506 and Rapamycin. J Immunol. 144:1990;251-258.
    • (1990) J Immunol , vol.144 , pp. 251-258
    • Dumont, F.J.1    Staruch, M.J.2    Koprak, S.L.3    Melino, M.R.4    Siga, N.H.5
  • 6
    • 0025902276 scopus 로고
    • Preclinical evaluation of a new immunosuppressive agent, rapamycin
    • Kahan B.D., Chang J., Sehgal S.N. Preclinical evaluation of a new immunosuppressive agent, rapamycin. Transplantation. 52:1991;185-191.
    • (1991) Transplantation , vol.52 , pp. 185-191
    • Kahan, B.D.1    Chang, J.2    Sehgal, S.N.3
  • 7
    • 0026024078 scopus 로고
    • Rapamycin, a potent immunosuppressive drug for vascularized heart, kidney and small bowel transplantation in the rat
    • Stepkowkski S.M., Chen H., Daloze P., Kahan D.B. Rapamycin, a potent immunosuppressive drug for vascularized heart, kidney and small bowel transplantation in the rat. Transplantation. 51:1991;22-26.
    • (1991) Transplantation , vol.51 , pp. 22-26
    • Stepkowkski, S.M.1    Chen, H.2    Daloze, P.3    Kahan, D.B.4
  • 8
    • 0025073524 scopus 로고
    • Rapamycin in experimental renal allografts in dogs and pigs
    • Collier D., Calne R., Thiru S., et al. Rapamycin in experimental renal allografts in dogs and pigs. Transplant Proc. 22:1990;1674-1675.
    • (1990) Transplant Proc , vol.22 , pp. 1674-1675
    • Collier, D.1    Calne, R.2    Thiru, S.3
  • 9
    • 0025117941 scopus 로고
    • A study of the contrasting effects of cyclosporine, FK506 and rapamycin on the suppression of allograft rejection
    • Morris R.E., Wu J., Shorthouse R. A study of the contrasting effects of cyclosporine, FK506 and rapamycin on the suppression of allograft rejection. Transplant Proc. 22:1990;1638-1641.
    • (1990) Transplant Proc , vol.22 , pp. 1638-1641
    • Morris, R.E.1    Wu, J.2    Shorthouse, R.3
  • 10
    • 0027446611 scopus 로고
    • The relationship of blood concentrations of rapamycin and cyclosporine to suppression of allograft rejection in a rabbit heterotopic heart transplant model
    • Fryer J., Yatscoff R.W., Pascoe E.A., Thliveris J. The relationship of blood concentrations of rapamycin and cyclosporine to suppression of allograft rejection in a rabbit heterotopic heart transplant model. Transplantation. 55:1993;340-345.
    • (1993) Transplantation , vol.55 , pp. 340-345
    • Fryer, J.1    Yatscoff, R.W.2    Pascoe, E.A.3    Thliveris, J.4
  • 11
    • 0027328261 scopus 로고
    • Rapamycin, immunosuppressive and tolerogenic effects in a porcine renal allograft model
    • Almond P.S., Moss A., Nakhleh R.F., et al. Rapamycin, immunosuppressive and tolerogenic effects in a porcine renal allograft model. Transplantation. 56:1993;275-281.
    • (1993) Transplantation , vol.56 , pp. 275-281
    • Almond, P.S.1    Moss, A.2    Nakhleh, R.F.3
  • 12
    • 0027717739 scopus 로고
    • Combination low dose rapamycin and cyclosporine prolong canine pancreatic islet allograft survival: Rapamycin efficacy is blood-level related
    • Yakimets W.J., Lakey J.R., Yatscoff R.W., et al. Combination low dose rapamycin and cyclosporine prolong canine pancreatic islet allograft survival rapamycin efficacy is blood-level related . Transplantation. 56:1993;1293-1298.
    • (1993) Transplantation , vol.56 , pp. 1293-1298
    • Yakimets, W.J.1    Lakey, J.R.2    Yatscoff, R.W.3
  • 13
    • 0026081972 scopus 로고
    • Synergistic interaction of cyclosporine and rapamycin to inhibit immune performances for normal peripheral blood lymphocytes in vitro
    • Kahan B.D., Gibbons S., Tejpal N., Stepkowski S.M., Chou T.C. Synergistic interaction of cyclosporine and rapamycin to inhibit immune performances for normal peripheral blood lymphocytes in vitro. Transplantation. 51:1991;232-239.
    • (1991) Transplantation , vol.51 , pp. 232-239
    • Kahan, B.D.1    Gibbons, S.2    Tejpal, N.3    Stepkowski, S.M.4    Chou, T.C.5
  • 14
    • 0028878220 scopus 로고
    • The synergistic effects of cyclosporine, sirolimus and brequinar on heart allograft survival in mice
    • Tu Y., Stepkowski S.M., Chou T.C., Kahan B.D. The synergistic effects of cyclosporine, sirolimus and brequinar on heart allograft survival in mice. Transplantation. 59:1995;177-183.
    • (1995) Transplantation , vol.59 , pp. 177-183
    • Tu, Y.1    Stepkowski, S.M.2    Chou, T.C.3    Kahan, B.D.4
  • 15
    • 0027530260 scopus 로고
    • Low-dose rapamycin potentiates the effect of subtherapeutic doses of cyclosporine to prolong renal allograft survival in the mongrel canine model
    • Knight R., Ferraresso M., Serino F., Katz S., Lewis R., Kahan B.D. Low-dose rapamycin potentiates the effect of subtherapeutic doses of cyclosporine to prolong renal allograft survival in the mongrel canine model. Transplantation. 55:1993;947-949.
    • (1993) Transplantation , vol.55 , pp. 947-949
    • Knight, R.1    Ferraresso, M.2    Serino, F.3    Katz, S.4    Lewis, R.5    Kahan, B.D.6
  • 16
    • 0026504422 scopus 로고
    • Opportunities for integration of pharmacokinetics, pharmacodynamics and toxicokinetics in rational drug development
    • Peck C.C., Barr W.H., Benet L.Z., et al. Opportunities for integration of pharmacokinetics, pharmacodynamics and toxicokinetics in rational drug development. J Clin Pharm Ther. 51:1992;465-473.
    • (1992) J Clin Pharm Ther , vol.51 , pp. 465-473
    • Peck, C.C.1    Barr, W.H.2    Benet, L.Z.3
  • 17
    • 0028886999 scopus 로고
    • Rapamycin: Distribution, pharmacokinetics, and therapeutic range investigations
    • Yatscoff R.W., Wang P., Chan K., Hicks D., Zimmerman J. Rapamycin distribution, pharmacokinetics, and therapeutic range investigations . Ther Drug Monit. 17:1995;666-671.
    • (1995) Ther Drug Monit , vol.17 , pp. 666-671
    • Yatscoff, R.W.1    Wang, P.2    Chan, K.3    Hicks, D.4    Zimmerman, J.5
  • 18
    • 0031008434 scopus 로고    scopus 로고
    • Pharmacokinetics of sirolimus in stable renal transplant patients after multiple oral dose administration
    • Zimmerman J.J., Kahan B.D. Pharmacokinetics of sirolimus in stable renal transplant patients after multiple oral dose administration. J Clin Pharmacol. 37:1997;405-415.
    • (1997) J Clin Pharmacol , vol.37 , pp. 405-415
    • Zimmerman, J.J.1    Kahan, B.D.2
  • 19
    • 0029922065 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled study to determine safety, tolerance, and preliminary pharmacokinetics of ascending single doses of orally administered sirolimus (rapamycin) in stable renal transplant recipients
    • Brattström C., Tydén G., Säwe J., Herlenius G., Claesson K., Groth C.G. A randomized, double-blind, placebo-controlled study to determine safety, tolerance, and preliminary pharmacokinetics of ascending single doses of orally administered sirolimus (rapamycin) in stable renal transplant recipients. Transplant Proc. 28:1996;985-986.
    • (1996) Transplant Proc , vol.28 , pp. 985-986
    • Brattström, C.1    Tydén, G.2    Säwe, J.3    Herlenius, G.4    Claesson, K.5    Groth, C.G.6
  • 20
    • 9244240732 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled study to determine safety, tolerance, and preliminary pharmacokinetics of ascending single doses of orally administered sirolimus (rapamycin) in stable renal transplant recipients
    • Johnson E.M., Zimmerman J.J., Duderstadt K., et al. A randomized, double-blind, placebo-controlled study to determine safety, tolerance, and preliminary pharmacokinetics of ascending single doses of orally administered sirolimus (rapamycin) in stable renal transplant recipients. Transplant Proc. 28:1996;987.
    • (1996) Transplant Proc , vol.28 , pp. 987
    • Johnson, E.M.1    Zimmerman, J.J.2    Duderstadt, K.3
  • 21
  • 23
    • 0026438717 scopus 로고
    • The pharmacokinetics of rapamycin: Single-dose studies in the rabbit
    • Honcharik N., Fryer J., Yatscoff R. The pharmacokinetics of rapamycin single-dose studies in the rabbit . Ther Drug Monit. 14:1992;475-478.
    • (1992) Ther Drug Monit , vol.14 , pp. 475-478
    • Honcharik, N.1    Fryer, J.2    Yatscoff, R.3
  • 24
    • 0026710725 scopus 로고
    • Measurement of rapamycin in whole blood using reverse-phase high performance liquid chromatography
    • Yatscoff R.W., Faraci C., Bolingbroke P. Measurement of rapamycin in whole blood using reverse-phase high performance liquid chromatography. Ther Drug Monit. 14:1992;138-141.
    • (1992) Ther Drug Monit , vol.14 , pp. 138-141
    • Yatscoff, R.W.1    Faraci, C.2    Bolingbroke, P.3
  • 25
    • 0028219564 scopus 로고
    • Sample clean-up and high performance liquid chromatography techniques for measurement of whole blood rapamycin concentrations
    • Napoli K.L., Kahan B.D. Sample clean-up and high performance liquid chromatography techniques for measurement of whole blood rapamycin concentrations. J Chromatogr B. 654:1994;111-120.
    • (1994) J Chromatogr B , vol.654 , pp. 111-120
    • Napoli, K.L.1    Kahan, B.D.2
  • 26
    • 0031410316 scopus 로고    scopus 로고
    • Determination of rapamycin in whole blood by HPLC
    • Svensson J.O., Brattström C., Säwe J. Determination of rapamycin in whole blood by HPLC. Ther Drug Monit. 19:1997;112-116.
    • (1997) Ther Drug Monit , vol.19 , pp. 112-116
    • Svensson, J.O.1    Brattström, C.2    Säwe, J.3
  • 27
    • 0010602521 scopus 로고
    • Characterization of biliary rapamycin metabolites by ionspray liquid chromatography/mass spectrometry [abstract]
    • San Francisco, May 31-June 4
    • Chan K, Wang P, Scantina J, et al. Characterization of biliary rapamycin metabolites by ionspray liquid chromatography/mass spectrometry [abstract]. Proceedings of the 41st ASMS Conference on Mass Spectrometry and Allied Topics, San Francisco, May 31-June 4, 1993; 545.
    • (1993) Proceedings of the 41st ASMS Conference on Mass Spectrometry and Allied Topics , pp. 545
    • Chan, K.1    Wang, P.2    Scantina, J.3
  • 28
    • 0029738491 scopus 로고    scopus 로고
    • Sensitive and specific quantitation of sirolimus (rapamycin) and its metabolites in blood of kidney graft recipients by HPLC/electrospray-mass spectrometry
    • Streit F., Christians U., Schiebel H.M., et al. Sensitive and specific quantitation of sirolimus (rapamycin) and its metabolites in blood of kidney graft recipients by HPLC/electrospray-mass spectrometry. Clin Chem. 42:1996;1417-1425.
    • (1996) Clin Chem , vol.42 , pp. 1417-1425
    • Streit, F.1    Christians, U.2    Schiebel, H.M.3
  • 29
    • 0030477754 scopus 로고    scopus 로고
    • Pharmacokinetics of prenisolone during administration of sirolimus in patients with renal transplants
    • Jusko W.J., Ferron G.M., Mis S.M., et al. Pharmacokinetics of prenisolone during administration of sirolimus in patients with renal transplants. J Clin Pharmacol. 36:1996;1100-1106.
    • (1996) J Clin Pharmacol , vol.36 , pp. 1100-1106
    • Jusko, W.J.1    Ferron, G.M.2    Mis, S.M.3
  • 30
    • 0026662551 scopus 로고
    • Cytochrome P450 3A enzymes are responsible for biotransformation of FK506 and rapamycin in man and rat
    • Satter M., Guengerich F.P., Yun C.H., Christians U., Sewing K.F. Cytochrome P450 3A enzymes are responsible for biotransformation of FK506 and rapamycin in man and rat. Drug Metab Dispos. 20:1992;753-761.
    • (1992) Drug Metab Dispos , vol.20 , pp. 753-761
    • Satter, M.1    Guengerich, F.P.2    Yun, C.H.3    Christians, U.4    Sewing, K.F.5
  • 32
    • 0029826653 scopus 로고    scopus 로고
    • P70 S6 kinase assay: A pharmacodynamic strategy for rapamycin, assay development
    • Gallant H.L., Yatscoff R.W. p70 S6 kinase assay a pharmacodynamic strategy for rapamycin, assay development . Transplant Proc. 28:1996;3058-3061.
    • (1996) Transplant Proc , vol.28 , pp. 3058-3061
    • Gallant, H.L.1    Yatscoff, R.W.2
  • 33
    • 0026519765 scopus 로고
    • Isolation of two immunosuppressive metabolites after in vitro metabolism of rapamycin
    • Christians U., Sattler M., Schiebel H.M., et al. Isolation of two immunosuppressive metabolites after in vitro metabolism of rapamycin. Drug Metab Dispos. 20:1992;186-191.
    • (1992) Drug Metab Dispos , vol.20 , pp. 186-191
    • Christians, U.1    Sattler, M.2    Schiebel, H.M.3
  • 34
    • 0010566966 scopus 로고
    • Isolation of ten metabolites from the bile of rats receiving rapamycin (sirolimus) intravenously
    • Wang P.C., Lim H.K., Chan K.W., et al. Isolation of ten metabolites from the bile of rats receiving rapamycin (sirolimus) intravenously. ISSX Proc. 8:1995;136.
    • (1995) ISSX Proc , vol.8 , pp. 136
    • Wang, P.C.1    Lim, H.K.2    Chan, K.W.3
  • 35
    • 0030476603 scopus 로고    scopus 로고
    • Structural identification of three metabolites and a degradation product of the macrolide immunosuppressant sirolimus (rapamycin) by electrospray-ms/ms after incubation with human liver microsomes
    • Streit F., Christians U., Schiebel H.M., Meyer A., Sewing K.F. Structural identification of three metabolites and a degradation product of the macrolide immunosuppressant sirolimus (rapamycin) by electrospray-ms/ms after incubation with human liver microsomes. Drug Metab Dispos. 24:1996;1272-1278.
    • (1996) Drug Metab Dispos , vol.24 , pp. 1272-1278
    • Streit, F.1    Christians, U.2    Schiebel, H.M.3    Meyer, A.4    Sewing, K.F.5
  • 36
    • 0029783338 scopus 로고    scopus 로고
    • Tacrolimus (FK506) metabolite patterns in blood from liver and kidney transplant patients
    • Gonschior A.K., Christians Uwe, Winkler M., Linck A., Baumann J., Sewing F.K. Tacrolimus (FK506) metabolite patterns in blood from liver and kidney transplant patients. Clin Chem. 42:1996;1426-1432.
    • (1996) Clin Chem , vol.42 , pp. 1426-1432
    • Gonschior, A.K.1    Christians, U.2    Winkler, M.3    Linck, A.4    Baumann, J.5    Sewing, F.K.6
  • 37
    • 0028500440 scopus 로고
    • High performance liquid chromatographic isolation, spectroscopic characterization, and immunosuppressive activities of two rapamycin degradation products
    • Wang C.P., Chan K.W., Schiksinis R.A., Scantina J.A., Sisenwine S.F. High performance liquid chromatographic isolation, spectroscopic characterization, and immunosuppressive activities of two rapamycin degradation products. J Liq Chromatogr. 17:1994;3383-3392.
    • (1994) J Liq Chromatogr , vol.17 , pp. 3383-3392
    • Wang, C.P.1    Chan, K.W.2    Schiksinis, R.A.3    Scantina, J.A.4    Sisenwine, S.F.5
  • 38
    • 0029126123 scopus 로고
    • High performance liquid chromatographic isolation and spectroscopic characterization, of three major metabolites from the plasma of rats receiving rapamycin (sirolimus) orally
    • Wang C.P., Lim H.K., Chan K.W., Schiksinis R.A., Scantina J.A., Sisenwine S.F. High performance liquid chromatographic isolation and spectroscopic characterization, of three major metabolites from the plasma of rats receiving rapamycin (sirolimus) orally. J Liq Chromatogr. 18:1995;2559-2568.
    • (1995) J Liq Chromatogr , vol.18 , pp. 2559-2568
    • Wang, C.P.1    Lim, H.K.2    Chan, K.W.3    Schiksinis, R.A.4    Scantina, J.A.5    Sisenwine, S.F.6
  • 39
    • 0018101547 scopus 로고
    • Rapamycin (AY-22 989), A new antifungal antibiotic III. In vitro and in vivo
    • Baker H., Sidorowitz A., Sehgal S.N., Vezina C. Rapamycin (AY-22 989), A new antifungal antibiotic III. In vitro and in vivo. J Antibiot (Tokyo). 31:1978;537-545.
    • (1978) J Antibiot (Tokyo) , vol.31 , pp. 537-545
    • Baker, H.1    Sidorowitz, A.2    Sehgal, S.N.3    Vezina, C.4
  • 40
    • 0029827815 scopus 로고    scopus 로고
    • Effects of the pharmacokinetic interaction between orally administered sirolimus and cyclosporine on the synergistic prolongation of heart allograft survival in rats
    • Stepkowski S.M., Napoli K.L., Wang M.E., Qu X., Chou T.C., Kahan B.D. Effects of the pharmacokinetic interaction between orally administered sirolimus and cyclosporine on the synergistic prolongation of heart allograft survival in rats. Transplantation. 62:1996;986-994.
    • (1996) Transplantation , vol.62 , pp. 986-994
    • Stepkowski, S.M.1    Napoli, K.L.2    Wang, M.E.3    Qu, X.4    Chou, T.C.5    Kahan, B.D.6
  • 41
    • 0028842194 scopus 로고
    • Prolongation of renal allograft survival in a large animal model by oral rapamycin monotherapy
    • Granger D.K., Cromwell J.W., Chen S.C., et al. Prolongation of renal allograft survival in a large animal model by oral rapamycin monotherapy. Transplantation. 27:1995;183-186.
    • (1995) Transplantation , vol.27 , pp. 183-186
    • Granger, D.K.1    Cromwell, J.W.2    Chen, S.C.3
  • 42
    • 0028351290 scopus 로고
    • Chronic cyclosporine-induced nephrotoxicity- a rabbit model
    • Thliveris J.A., Yatscoff R.W., Mihatsch M.J. Chronic cyclosporine-induced nephrotoxicity- a rabbit model. Transplantation. 57:1994;774-776.
    • (1994) Transplantation , vol.57 , pp. 774-776
    • Thliveris, J.A.1    Yatscoff, R.W.2    Mihatsch, M.J.3
  • 43
    • 0028918672 scopus 로고
    • Effect of rapamycin on morphological and functional parameters in the kidney of the rabbit
    • Thliveris J.A., Yatscoff R.W. Effect of rapamycin on morphological and functional parameters in the kidney of the rabbit. Transplantation. 59:1995;427-429.
    • (1995) Transplantation , vol.59 , pp. 427-429
    • Thliveris, J.A.1    Yatscoff, R.W.2
  • 45
    • 0028135344 scopus 로고
    • Efficacy of rapamycin, RS-61443 and cyclophosphomide in the prolongation of survival of discordant pig-to-rabbit cardiac xenografts
    • Yatscoff R.W., Wang S., Chackowsky P., Lowes N., Koshal A. Efficacy of rapamycin, RS-61443 and cyclophosphomide in the prolongation of survival of discordant pig-to-rabbit cardiac xenografts. Can J Cardiol. 10:1994;711-716.
    • (1994) Can J Cardiol , vol.10 , pp. 711-716
    • Yatscoff, R.W.1    Wang, S.2    Chackowsky, P.3    Lowes, N.4    Koshal, A.5
  • 46
    • 0030064388 scopus 로고    scopus 로고
    • The side effect profile of sirolimus: A phase I study in quiescent cyclosporine-prednisone-treated renal transplant patients
    • Murgia M.G., Jordan S., Kahan B.D. The side effect profile of sirolimus a phase I study in quiescent cyclosporine-prednisone-treated renal transplant patients . Kidney International. 49:1996;209-216.
    • (1996) Kidney International , vol.49 , pp. 209-216
    • Murgia, M.G.1    Jordan, S.2    Kahan, B.D.3
  • 47
    • 0030905014 scopus 로고    scopus 로고
    • Sirolimus: A new agent for clinical renal transplantation
    • Kahan B.D. Sirolimus a new agent for clinical renal transplantation . Transplant Proc. 29:1997;48-50.
    • (1997) Transplant Proc , vol.29 , pp. 48-50
    • Kahan, B.D.1
  • 48
    • 0030832514 scopus 로고    scopus 로고
    • SDZ RAD, a new rapamycin derivative. Pharmacolocical properties in vitro and in vivo
    • Schuler W., Sedrani R., Cottens S., et al. SDZ RAD, a new rapamycin derivative. Pharmacolocical properties in vitro and in vivo. Transplantation. 64:1997;34-42.
    • (1997) Transplantation , vol.64 , pp. 34-42
    • Schuler, W.1    Sedrani, R.2    Cottens, S.3
  • 49
    • 0030814696 scopus 로고    scopus 로고
    • SDZ RAD, a new rapamycin derivative. Synergism with cyclosporine
    • Schuurman H.-J., Cottens S., Fuchs, et al. SDZ RAD, a new rapamycin derivative. Synergism with cyclosporine. Transplantation. 64:1997;32-35.
    • (1997) Transplantation , vol.64 , pp. 32-35
    • Schuurman, H.-J.1    Cottens, S.2    Fuchs3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.