Regulatory T: Cells

Measuring Immunity: Basic Biology and Clinical Assessment

Volumn , Issue , 2005, Pages 322-335

  Fehérvari, Zoltán ^a   Sakaguchi, Shimon ^a  

^a KYOTO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 33745688318     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-012455900-4/50289-0     Document Type: Chapter

References (96)

1. Almeida A.R., Legrand N., Papiernik M., Freitas A.A. Homeostasis of peripheral CD4+ T cells: IL-2R alpha and IL-2 shape a population of regulatory cells that controls CD4+ T cell numbers. J Immunol 2002, 169:4850-4860.
2. Arnold B. Levels of peripheral T cell tolerance. Transpl Immunol 2002, 10:109-114.
3. Asano M., Toda M., Sakaguchi N., Sakaguchi S. Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation. J Exp Med 1996, 184:387-396.
4. Asseman C., Mauze S., Leach M.W., Coffman R.L., Powrie F. An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation. J Exp Med 1999, 190:995-1004.
5. Barrat F.J., Cua D.J., Boonstra A., et al. In vitro generation of interleukin 10-producing regulatory CD4(+) T cells is induced by immunosuppressive drugs and inhibited by T helper type 1 (Th1)- and Th2-inducing cytokines. J Exp Med 2002, 195:603-616.
6. Barrett S.P., Toh B.H., Alderuccio F., van Driel I.R., Gleeson P.A. Organ-specific autoimmunity induced by adult thymectomy and cyclophosphamide-induced lymphopenia. Eur J Immunol 1995, 25:238-244.
7. Belkaid Y., Piccirillo C.A., Mendez S., Shevach E.M., Sacks D.L. CD4+ CD25+ regulatory T cells control Leishmania major persistence and immunity. Nature 2002, 420:502-507.
8. Benacerraf B., Greene M.I., Sy M.S., Dorf M.E. Suppressor T cell circuits. Ann NY Acad Sci 1982, 392:300-308.
9. Bennett C.L., Christie J., Ramsdell F., et al. The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3. Nat Genet 2001, 27:20-21.
10. Berg D.J., Davidson N., Kuhn R., et al. Enterocolitis and colon cancer in interleukin-10-deficient mice are associated with aberrant cytokine production and CD4(+) TH1-like responses. J Clin Invest 1996, 98:1010-1020.
11. Blair P.J., Bultman S.J., Haas J.C., Rouse B.T., Wilkinson J.E., Godfrey V.L. CD4+ CD8- T cells are the effector cells in disease pathogenesis in the scurfy (sf) mouse. J Immunol 1994, 153:3764-3774.
12. Bluestone J.A., Abbas A.K. Natural versus adaptive regulatory T cells. Nat Rev Immunol 2003, 3:253-257.
13. Brunkow M.E., Jeffery E.W., Hjerrild K.A., et al. Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse. Nat Genet 2001, 27:68-73.
14. Caramalho I., Lopes-Carvalho T., Ostler D., Zelenay S., Haury M., Demengeot J. Regulatory T cells selectively express toll-like receptors and are activated by lipopolysaccharide. J Exp Med 2003, 197:403-411.
15. Cederbom L., Hall H., Ivars F. CD4+ CD25+ regulatory T cells down-regulate co-stimulatory molecules on antigen-presenting cells. Eur J Immunol 2000, 30:1538-1543.
16. Chen Y., Kuchroo V.K., Inobe J., Hafler D.A., Weiner H.L. Regulatory T cell clones induced by oral tolerance: suppression of autoimmune encephalomyelitis. Science 1994, 265:1237-1240.
17. Cobbold S., Waldmann H. Infectious tolerance. Curr Opin Immunol 1998, 10:518-524.
18. Dorf M.E., Benacerraf B. Suppressor cells and immunoregulation. Annu Rev Immunol 1984, 2:127-157.
19. Edinger M., Hoffmann P., Ermann J., et al. CD4+ CD25+ regulatory T cells preserve graft-versus-tumor activity while inhibiting graft-versus-host disease after bone marrow transplantation. Nat Med 2003, 9:1144-1150.
20. Fallarino F., Grohmann U., Hwang K.W., et al. Modulation of tryptophan catabolism by regulatory T cells. Nat Immunol 2003, 4:1206-1212.
21. Fontenot J.D., Gavin M.A., Rudensky A.Y. Foxp3 programs the development and function of CD4+ CD25+ regulatory T cells. Nat Immunol 2003, 4:330-336.
22. Fowell D., Mason D. Evidence that the T cell repertoire of normal rats contains cells with the potential to cause diabetes. Characterization of the CD4+ T cell subset that inhibits this autoimmune potential. J Exp Med 1993, 177:627-636.
23. Gavin M.A., Clarke S.R., Negrou E., Gallegos A., Rudensky A. Homeostasis and anergy of CD4(+)CD25(+) suppressor T cells in vivo. Nat Immunol 2002, 3:33-41.
24. Gershon R.K., Kondo K. Cell interactions in the induction of tolerance: the role of thymic lymphocytes. Immunology 1970, 18:723-737.
25. Godfrey V.L., Wilkinson J.E., Rinchik E.M., Russell L.B. Fatal lymphoreticular disease in the scurfy (sf) mouse requires T cells that mature in a sf thymic environment: potential model for thymic education. Proc Natl Acad Sci USA 1991, 88:5528-5532.
26. Graca L., Cobbold S.P., Waldmann H. Identification of regulatory T cells in tolerated allografts. J Exp Med 2002, 195:1641-1646.
27. Green D.R., Webb D.R. Saying the 'S' word in public. Immunol Today 1993, 14:523-525.
28. Groux H. IL-10 is required for regulatory T cells to mediate tolerance to alloantigens in vivo. Transplantation 2003, 75:8S-12S.
29. Groux H., O'Garra A., Bigler M., et al. A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitis. Nature 1997, 389:737-742.
30. Hara M., Kingsley C.I., Niimi M., et al. IL-10 is required for regulatory T cells to mediate tolerance to alloantigens in vivo. J Immunol 2001, 166:3789-3796.
31. Hoffmann P., Ermann J., Edinger M., Fathman C.G., Strober S. Donor-type CD4(+)CD25(+) regulatory T cells suppress lethal acute graft-versus-host disease after allogeneic bone marrow transplantation. J Exp Med 2002, 196:389-399.
32. Holmdahl R. Genetics of susceptibility to chronic experimental encephalomyelitis and arthritis. Curr Opin Immunol 1998, 10:710-717.
33. Hori S., Carvalho T.L., Demengeot J. CD25+ CD4+ regulatory T cells suppress CD4+ T cell-mediated pulmonary hyperinflammation driven by Pneumocystis carinii in immunodeficient mice. Eur J Immunol 2002, 32:1282-1291.
34. Hori S., Nomura T., Sakaguchi S. Control of regulatory T cell development by the transcription factor Foxp3. Science 2003, 299:1057-1061.
35. Hoyne G.F., Dallman M.J., Champion B.R., Lamb J.R. Notch signalling in the regulation of peripheral immunity. Immunol Rev 2001, 182:215-227.
36. Itoh M., Takahashi T., Sakaguchi N., et al. Thymus and autoimmunity: production of CD25+ CD4+ naturally anergic and suppressive T cells as a key function of the thymus in maintaining immunologic self-tolerance. J Immunol 1999, 162:5317-5326.
37. Jonuleit H., Schmitt E., Schuler G., Knop J., Enk A.H. Induction of interleukin 10-producing, nonproliferating CD4(+) T cells with regulatory properties by repetitive stimulation with allogeneic immature human dendritic cells. J Exp Med 2000, 192:1213-1222.
38. Kemper C., Chan A.C., Green J.M., Brett K.A., Murphy K.M., Atkinson J.P. Activation of human CD4+ cells with CD3 and CD46 induces a T-regulatory cell 1 phenotype. Nature 2003, 421:388-392.
39. Khattri R., Cox T., Yasayko S.A., Ramsdell F. An essential role for Scurfin in CD4+ CD25+ T regulatory cells. Nat Immunol 2003, 4:337-342.
40. Kojima A., Tanaka-Kojima Y., Sakakura T., Nishizuka Y. Prevention of postthymectomy autoimmune thyroiditis in mice. Lab Invest 1976, 34:601-605.
41. Kuniyasu Y., Takahashi T., Itoh M., Shimizu J., Toda G., Sakaguchi S. Naturally anergic and suppressive CD25(+)CD4(+) T cells as a functionally and phenotypically distinct immunoregulatory T cell subpopulation. Int Immunol 2000, 12:1145-1155.
42. Lutz M.B., Schuler G. Immature, semi-mature and fully mature dendritic cells: which signals induce tolerance or immunity?. Trends Immunol 2002, 23:445-449.
43. Lyon M.F., Peters J., Glenister P.H., Ball S., Wright E. The scurfy mouse mutant has previously unrecognized hematological abnormalities and resembles Wiskott-Aldrich syndrome. Proc Natl Acad Sci USA 1990, 87:2433-2437.
44. McHugh R.S., Whitters M.J., Piccirillo C.A., et al. CD4(+)CD25(+) immunoregulatory T cells: gene expression analysis reveals a functional role for the glucocorticoid-induced TNF receptor. Immunity 2002, 16:311-323.
45. Mosmann T.R., Coffman R.L. TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu Rev Immunol 1989, 7:145-173.
46. Nakamura K., Kitani A., Strober W. Cell contact-dependent immunosuppression by CD4(+)CD25(+) regulatory T cells is mediated by cell surface-bound transforming growth factor beta. J Exp Med 2001, 194:629-644.
47. Nishizuka Y., Sakakura T. Thymus and reproduction: sex-linked dysgenesia of the gonad after neonatal thymectomy in mice. Science 1969, 166:753-755.
48. Onizuka S., Tawara I., Shimizu J., Sakaguchi S., Fujita T., Nakayama E. Tumor rejection by in vivo administration of anti-CD25 (interleukin-2 receptor alpha) monoclonal antibody. Cancer Res 1999, 59:3128-3133.
49. Palmer E. Negative selection-clearing out the bad apples from the T-cell repertoire. Nat Rev Immunol 2003, 3:383-391.
50. Pasare C., Medzhitov R. Toll pathway-dependent blockade of CD4+ CD25+ T cell-mediated suppression by dendritic cells. Science 2003, 299:1033-1036.
51. Penhale W.J., Farmer A., McKenna R.P., Irvine W.J. Spontaneous thyroiditis in thymectomized and irradiated Wistar rats. Clin Exp Immunol 1973, 15:225-236.
52. Piccirillo C.A., Letterio J.J., Thornton A.M., et al. CD4(+)CD25(+) regulatory T cells can mediate suppressor function in the absence of transforming growth factor beta 1 production and responsiveness. J Exp Med 2002, 196:237-246.
53. Piccirillo C.A., Shevach E.M. Cutting edge: control of CD8+ T cell activation by CD4+ CD25+ immunoregulatory cells. J Immunol 2001, 167:1137-1140.
54. Powrie F., Carlino J., Leach M.W., Mauze S., Coffman R.L. A critical role for transforming growth factor-beta but not interleukin 4 in the suppression of T helper type 1-mediated colitis by CD45RB(low) CD4+ T cells. J Exp Med 1996, 183:2669-2674.
55. Powrie F., Leach M.W., Mauze S., Caddle L.B., Coffman R.L. Phenotypically distinct subsets of CD4+ T cells induce or protect from chronic intestinal inflammation in C. B-17 scid mice. Int Immunol 1993, 5:1461-1471.
56. Powrie F., Mason D. OX-22high CD4+ T cells induce wasting disease with multiple organ pathology: prevention by the OX-22low subset. J Exp Med 1990, 172:1701-1708.
57. Read S., Malmstrom V., Powrie F. Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25(+)CD4(+) regulatory cells that control intestinal inflammation. J Exp Med 2000, 192:295-302.
58. Sakaguchi N., Miyai K., Sakaguchi S. Ionizing radiation and autoimmunity. Induction of autoimmune disease in mice by high dose fractionated total lymphoid irradiation and its prevention by inoculating normal T cells. J Immunol 1994, 152:2586-2595.
59. Sakaguchi S. Regulatory T cells: key controllers of immunologic self-tolerance. Cell 2000, 101:455-458.
60. Sakaguchi S., Ermak T.H., Toda M., et al. Induction of autoimmune disease in mice by germline alteration of the T cell receptor gene expression. J Immunol 1994, 152:1471-1484.
61. Sakaguchi S., Fukuma K., Kuribayashi K., Masuda T. Organ-specific autoimmune diseases induced in mice by elimination of T cell subset. I. Evidence for the active participation of T cells in natural self-tolerance; deficit of a T cell subset as a possible cause of autoimmune disease. J Exp Med 1985, 161:72-87.
62. Sakaguchi S., Sakaguchi N. Organ-specific autoimmune disease induced in mice by elimination of T cell subsets. V. Neonatal administration of cyclosporin A causes autoimmune disease. J Immunol 1989, 142:471-480.
63. Sakaguchi S., Sakaguchi N., Asano M., Itoh M., Toda M. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J Immunol 1995, 155:1151-1164.
64. Sakaguchi S., Sakaguchi N., Shimizu J., et al. Immunologic tolerance maintained by CD25+ CD4+ regulatory T cells: their common role in controlling autoimmunity, tumor immunity, and transplantation tolerance. Immunol Rev 2001, 182:18-32.
65. Sakaguchi S., Takahashi T., Nishizuka Y. Study on cellular events in post-thymectomy autoimmune oophoritis in mice. II. Requirement of Lyt-1 cells in normal female mice for the prevention of oophoritis. J Exp Med 1982, 156:1577-1586.
66. Salomon B., Lenschow D.J., Rhee L., et al. B7/CD28 costimulation is essential for the homeostasis of the CD4+ CD25+ immunoregulatory T cells that control autoimmune diabetes. Immunity 2000, 12:431-440.
67. Saoudi A., Seddon B., Fowell D., Mason D. The thymus contains a high frequency of cells that prevent autoimmune diabetes on transfer into prediabetic recipients. J Exp Med 1996, 184:2393-2398.
68. Sato K., Yamashita N., Baba M., Matsuyama T. Modified myeloid dendritic cells act as regulatory dendritic cells to induce anergic and regulatory T cells. Blood 2003, 101:3581-3589.
69. Sato K., Yamashita N., Baba M., Matsuyama T. Regulatory dendritic cells protect mice from murine acute graft-versus-host disease and leukemia relapse. Immunity 2003, 18:367-379.
70. Schubert L.A., Jeffery E., Zhang Y., Ramsdell F., Ziegler S.F. Scurfin (FOXP3) acts as a repressor of transcription and regulates T cell activation. J Biol Chem 2001, 276:37672-37679.
71. Seddon B., Mason D. Regulatory T cells in the control of autoimmunity: the essential role of transforming growth factor beta and interleukin 4 in the prevention of autoimmune thyroiditis in rats by peripheral CD4(+)CD45RC-cells and CD4(+)CD8(-) thymocytes. J Exp Med 1999, 189:279-288.
72. Shimizu J., Yamazaki S., Sakaguchi S. Induction of tumor immunity by removing CD25+ CD4+ T cells: a common basis between tumor immunity and autoimmunity. J Immunol 1999, 163:5211-5218.
73. Shimizu J., Yamazaki S., Takahashi T., Ishida Y., Sakaguchi S. Stimulation of CD25(+)CD4(+) regulatory T cells through GITR breaks immunological self-tolerance. Nat Immunol 2002, 3:135-142.
74. Singh B., Read S., Asseman C., et al. Control of intestinal inflammation by regulatory T cells. Immunol Rev 2001, 182:190-200.
75. Steinman R.M., Hawiger D., Nussenzweig M.C. Tolerogenic dendritic cells. Annu Rev Immunol 2003, 21:685-711.
76. Sutmuller R.P., van Duivenvoorde L.M., van Elsas A., et al. Synergism of cytotoxic T lymphocyte-associated antigen 4 blockade and depletion of CD25(+) regulatory T cells in antitumor therapy reveals alternative pathways for suppression of autoreactive cytotoxic T lymphocyte responses. J Exp Med 2001, 194:823-832.
77. Takahashi T., Kuniyasu Y., Toda M., et al. Immunologic self-tolerance maintained by CD25+ CD4+ naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state. Int Immunol 1998, 10:1969-1980.
78. Takahashi T., Sakaguchi S. The role of regulatory T cells in controlling immunologic self-tolerance. Int Rev Cytol 2003, 225:1-32.
79. Takahashi T., Tagami T., Yamazaki S., et al. Immunologic self-tolerance maintained by CD25(+)CD4(+) regulatory T cells constitutively expressing cytotoxic T lymphocyteassociated antigen 4. J Exp Med 2000, 192:303-310.
80. Taylor P.A., Noelle R.J., Blazar B.R. CD4(+)CD25(+) immune regulatory cells are required for induction of tolerance to alloantigen via costimulatory blockade. J Exp Med 2001, 193:1311-1318.
81. Thornton A.M., Shevach E.M. CD4+ CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production. J Exp Med 1998, 188:287-296.
82. Thornton A.M., Shevach E.M. Suppressor effector function of CD4+ CD25+ immunoregulatory T cells is antigen nonspecific. J Immunol 2000, 164:183-190.
83. Toh B.H., Sentry J.W., Alderuccio F. The causative H+/K+ ATPase antigen in the pathogenesis of autoimmune gastritis. Immunol Today 2000, 21:348-354.
84. Trenado A., Charlotte F., Fisson S., et al. Recipient-type specific CD4+ CD25+ regulatory T cells favor immune reconstitution and control graft-versus-host disease while maintaining graft-versus-leukemia. J Clin Invest 2003, 112:1688-1696.
85. Tung K., Lou Y., Garza K., Teuscher C. Autoimmune ovarian disease: mechanism of disease induction and prevention. Curr Opin Immunol 1998, 10:839-845.
86. Vigouroux S., Yvon E., Wagner H.J., et al. Induction of antigen-specific regulatory T cells following overexpression of a Notch ligand by human B lymphocytes. J Virol 2003, 77:10872-10880.
87. Wakkach A., Fournier N., Brun V., Breittmayer J.P., Cottrez F., Groux H. Characterization of dendritic cells that induce tolerance and T regulatory 1 cell differentiation in vivo. Immunity 2003, 18:605-617.
88. Waldmann H., Cobbold S. How do monoclonal antibodies induce tolerance? A role for infectious tolerance?. Annu Rev Immunol 1998, 16:619-644.
89. Walker L.S., Chodos A., Eggena M., Dooms H., Abbas A.K. Antigen-dependent proliferation of CD4+ CD25+ regulatory T cells in vivo. J Exp Med 2003, 198:249-258.
90. Wather M.R., Kasprowicz D.J., Gersuk V.H., et al. Induction of FoxP3 and acquisition of T regulatory activity by stimulated human CD4+ CD25-T cells. J Clin Invest 2003, 112:1437-1443.
91. Weigle W.O. Analysis of autoimmunity through experimental models of thyroiditis and allergic encephalomyelitis. Adv Immunol 1980, 30:159-273.
92. Wildin R.S., Smyk-Pearson S., Filipovich A.H. Clinical and molecular features of the immunodysregulation, polyendocrinopathy, enteropathy, X linked (IPEX) syndrome. J Med Genet 2002, 39:537-545.
93. Wood K.J., Sakaguchi S. Regulatory T cells in transplantation tolerance. Nat Rev Immunol 2003, 3:199-210.
94. Yamazaki S., Iyoda T., Tarbell K., et al. Direct expansion of functional CD25+ CD4+ regulatory T cells by antigenprocessing dendritic cells. J Exp Med 2003, 198:235-247.
95. Zhai Y., Kupiec-Weglinski J.W. What is the role of regulatory T cells in transplantation tolerance?. Curr Opin Immunol 1999, 11:497-503.
96. Zhang X., Izikson L., Liu L., Weiner H.L. Activation of CD25(+)CD4(+) regulatory T cells by oral antigen administration. J Immunol 2001, 167:4245-4253.