CD25+CD4+ regulatory T cells suppress CD4+ T cell-mediated pulmonary hyperinflammation driven by Pneumocystis carinii in immunodeficient mice

European Journal of Immunology

Volumn 32, Issue 5, 2002, Pages 1282-1291

  Hori, Shohei ^a   Carvalho, Thiago L ^a   Demengeot, Jocelyne ^a  

^a INSTITUTO GULBENKIAN DE CIÊNCIA   (Portugal)

Author keywords

Immune regulation; Immunopathology; Pneumocystis carinii pneumonia; T cell subset; Tolerance

Indexed keywords

CD4 ANTIGEN; INTERLEUKIN 2 RECEPTOR;

ADOPTIVE TRANSFER; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOIMMUNITY; CONTROLLED STUDY; DISEASE SEVERITY; ENTERITIS; GENE ACTIVATION; GENETIC RECOMBINATION; IMMUNE DEFICIENCY; IMMUNE RESPONSE; IMMUNOPATHOLOGY; INFLAMMATION; LETHALITY; LYMPHOCYTE FUNCTION; LYMPHOCYTOPENIA; MOUSE; NONHUMAN; PNEUMOCYSTIS CARINII; PNEUMOCYSTIS PNEUMONIA; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECIPIENT; REGULATORY MECHANISM; T LYMPHOCYTE; T LYMPHOCYTE SUBPOPULATION;

EID: 0036107373     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/1521-4141(200205)32:5<1282::aid-immu1282>3.0.co;2-%23     Document Type: Article

References (36)

1. Pneumocystis carinii and the immune response in disease
2. - T cells into severe combined immunodeficiency mice
3. Pneumocystis carinii pneumonia. Differences in lung parasite number and inflammation in patients with and without AIDS
4. Pneumocystis carinii pneumonia in patients without AIDS
5. Pneumocystis carinii pneumonia in cancer patients
6. Immune-mediated inflammation directly impairs pulmonary function, contributing to the pathogenesis of Pneumocystis carinii pneumonia
7. Inflammatory responses to Pneumocystis carinii in mice selectively depleted of helper T lymphocytes
8. The role of T cells in infection-driven interstitial pneumonia after bone marrow transplantation in mice
9. Control of immune pathology by regulatory T cells
10. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor α-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases
11. Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation
12. + T cells inhibit both the induction and effector function of autoreactive T cells and represent a unique lineage of immunoregulatory cells
13. + immunoregulatory T cells that control autoimmune diabetes
14. - subpopulations
15. Endogenous oocyte antigens are required for rapid induction and progression of autoimmune ovarian disease following day-3 thymectomy
16. + T cells
17. + T cells induce or protect from chronic intestinal inflammation in C. B-17 scid mice
18. + T cells in the regulation of inflammatory responses in the intestine
19. + regulatory cells that control intestinal inflammation
20. Regulatory CD4 T cells control the size of the peripheral activated/memory CD4 T cell compartment
21. Hyper immunoglobulin E response in mice with monoclonal populations of B and T lymphocytes
22. Development and resolution of Pneumocystis carinii pneumonia in severe combined immunodeficient mice: A morphological study of host inflammatory responses
23. Spontaneous Pneumocystis carinii pneumonia in immunodeficient mutant scid mice. Natural history and pathobiology
24. Outbreaks of Pneumocystis carinii pneumonia in colonies of immunodeficient mice
25. + immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production
26. + naturally anergic and suppressive T cells: Induction of autoimmune disease by breaking their anergic/suppressive state
27. + T cells regulate the expansion of peripheral CD4 T cells through the production of IL-10
28. Unique chemotactic response profile and specific expression of chemokine receptors CCR4 and CCR8 by CD4(+)CD25(+) regulatory T cells
29. Regulatory T cells: The physiology of autoreactivity in dominant tolerance and "quality control" of immune responses
30. + thymocytes and peripheral T cells have immune suppressive activity in vitro
31. + T cells: A highly differentiated and apoptosis-prone population
32. Cell contact-dependent immunosuppression by CD4(+)CD25(+) regulatory T cells is mediated by cell surface-bound transforming growth factor beta
33. + regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4
34. Amplification of mitochondrial ribosomal RNA sequences from Pneumocystis carinii DNA of rat and human origin
35. Detection of Pneumocystis carinii DNA in blood by PCR is not of value for diagnosis of P. carinii pneumonia