Notch signalling in the regulation of peripheral immunity

Immunological Reviews

Volumn 182, Issue , 2001, Pages 215-227

  Hoyne, Gerard F ^a,d   Dallman, Margaret J ^b   Champion, Brian R ^c   Lamb, Jonathan R ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b IMPERIAL COLLEGE LONDON   (United Kingdom)

^c Celldex Therapeutics Inc   (United Kingdom)

^d UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

T LYMPHOCYTE RECEPTOR;

B LYMPHOCYTE; CAENORHABDITIS ELEGANS; CELL SURVIVAL; DROSOPHILA; EMBRYO DEVELOPMENT; HEMATOPOIETIC STEM CELL; IMMUNOLOGICAL TOLERANCE; IMMUNOREGULATION; NONHUMAN; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION; T LYMPHOCYTE;

ANIMALS; CELL DIFFERENTIATION; CYTOKINES; HEMATOPOIETIC STEM CELLS; HOMEOSTASIS; IMMUNE TOLERANCE; IMMUNITY; MEMBRANE PROTEINS; RECEPTORS, NOTCH; SIGNAL TRANSDUCTION; T-LYMPHOCYTES;

EID: 0035176364     PISSN: 01052896     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1600-065X.2001.1820118.x     Document Type: Review

References (81)

1. Notch signalling
2. Structural conservation of Notch receptors and ligands
3. Notch signalling and the control of cell fate choices in vertebrates
4. Physical interaction between a novel domain of the receptor Notch and the transcription factor RBP-J κ/Su(H)
5. Notch signalling: Cell fate control and signal integration in development
6. The role of Notch in lateral inhibition and cell fate specification
7. Mouse notch: Expression in hair follicles correlates with cell fate determination
8. The intracellular domain of mouse Notch: A constitutively activated repressor of myogenesis directed at the basic helix-loop-helix region of MyoD
9. Notch signalling inhibits muscle cell differentiation through a CBF1-independent pathway
10. Inhibition of granulocytic differentiation by mNotch1
11. Correlating notch signalling with thymocyte maturation
12. Protective effects of notch-1 on TCR-induced apoptosis
13. Notch-1 prevents apoptosis in murine erythroleukemia cells and is necessary for differentiation induced by hybrid polar drugs
14. Transient notch activation initiates an irreversible switch from neurogenesis to gliogenesis by neural crest stem cells
15. Contact dependent inhibition of cortical neurite growth mediated by Notch signalling
16. Nuclear Notch1 signalling and the regulation of dendritic development
17. LIN-12/Notch signalling: Lessons from worms and flies
18. Multiple positive and negative regulators of signalling by the EGF-receptor
19. Notch inhibition of RAS signalling through MAP kinase phosphatase LIP-1 during C. elegans vulval development
20. Dorsal-ventral signalling in limb development
21. Fringe, Notch, and making developmental boundaries
22. Expression of Radical fringe in limb-bud ectoderm regulates apical ectodermal ridge formation
23. Radical fringe positions the apical ectodermal ridge at the dorsoventral boundary of the vertebrate limb
24. Serrate2 is disrupted in the mouse limb-development mutant syndactylism
25. A chick homologue of Serrate and its relationship with Notch and Delta homologues during central neurogenesis
26. The notch signalling regulator fringe acts in the Golgi apparatus and requires the glycosyltransferase signature motif DXD
27. Fringe forms a complex with Notch
28. Fringe is a glycosyltransferase that modifies Notch
29. Glycosyltransferase activity of Fringe modulates Notch-Delta interactions
30. Fringe modulates Notch-ligand interactions
31. Fringe differentially modulates Jagged1 and Delta1 signalling through Notch1 and Notch2
32. Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain
33. Nuclear access and action of notch in vivo
34. Notch signal transduction: A real Rip and more
35. Notch and the immune system
36. Human deltex is a conserved regulator of Notch signalling
37. An activated form of Notch influences the choice between CD4 and CD8 T cell lineages
38. Notch activity influences the αβ versus γδ T cell lineage decision
39. Notch1 signalling promotes the maturation of CD4 and CD8 SP thymocytes
40. + T-cell lineage fate
41. + thymocytes by modulating TCR signal strength
42. Deficient T cell fate specification in mice with an induced inactivation of Notch1
43. Inactivation of Notch in immature thymocytes does not perturb CD4 or CD8 development
44. Notch1 expression in early lymphopoiesis influences B versus T lineage determination
45. Lineage commitment in the immune system: The T helper lymphocyte grows up
46. + T-cell subset inhibits antigen-specific T-cell responses and prevents colitis
47. + T cells
48. An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation
49. Regulatory T cell clones induced by oral tolerance: Suppression of autoimmune encephalomyelitis
50. Interleukin-2 programs mouse αβ T lymphocytes for apoptosis
51. Chemokines as regulators of T cell differentiation
52. The role of CD40 ligand in costimulation and T-cell activation
53. CD28/B7 system of T cell costimulation
54. Cell cycle arrest and apoptosis induced by Notch1 in B cells
55. Rel/NF-κB can trigger the Notch signalling pathway by inducing the expression of Jagged1, a ligand for Notch receptors
56. + T cells
57. Control of immune pathology by regulatory T cells
58. Regulatory T cells: Key controllers of immunologic self-tolerance
59. + immunoregulatory T cells that control autoimmune diabetes
60. + T cells
61. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor α-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases
62. + regulatory cells that control intestinal inflammation
63. + regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4
64. CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation
65. Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4
66. + naturally anergic and suppressive T cells: Induction of autoimmune disease by breaking their anergic/suppressive state
67. + T cells: A population of T cells with immune regulatory activities in vitro
68. + immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production
69. Notch1 and Notch2 inhibit myeloid differentiation in response to different cytokines
70. Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor
71. LKLF: A transcriptional regulator of single-positive T cell quiescence
72. The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3
73. Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse
74. X-linked neonatal diabetes mellitus, enteropathy, and endocrinopathy syndrome is the human equivalent of mouse scurfy
75. The murine mutation scurfy (sf) results in an antigen-dependent lymphoproliferative disease with altered T cell sensitivity
76. A human homologue of the Drosophila Toll protein signals activation of adaptive immunity
77. Innate immune recognition and control of adaptive immune responses
78. The Mirror transcription factor links signalling pathways in Drosophila oogenesis
79. Redundant regulation of T cell differentiation and TCRα gene expression by the transcription factors LEF-1 and TCF-1
80. Hedgehog signalling regulates differentiation from double-negative to double-positive thymocyte
81. Sonic hedgehog induces the proliferation of primitive human hematopoietic cells via BMP regulation