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1
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0032403697
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Control of immune pathology by regulatory T cells
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An excellent overview on the role of regulatory T cells in autoimmune disease models.
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Mason D, Powrie F Control of immune pathology by regulatory T cells. Curr Opin Immunol. 10:1998;649-655. An excellent overview on the role of regulatory T cells in autoimmune disease models.
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Curr Opin Immunol
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Mason, D.1
Powrie, F.2
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2
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0016588323
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A disquisition on suppressor T cells
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Gershon RK A disquisition on suppressor T cells. Transplant Rev. 26:1975;170-185.
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Recirculating, suppressor T cells in transplantation tolerance
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Dorsch S, Roser R Recirculating, suppressor T cells in transplantation tolerance. J Exp Med. 145:1977;1144-1157.
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Dorsch, S.1
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0029049128
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In vivo studies of the maintenance of peripheral transplant tolerance after cyclosporine. Radiosensitive antigen-specific suppressor cells mediate lasting graft protection against primed effector cells
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Nisco SJ, Hissink RJ, Vriens PW, Hoyt EG, Reitz BA, Clayberger C In vivo studies of the maintenance of peripheral transplant tolerance after cyclosporine. Radiosensitive antigen-specific suppressor cells mediate lasting graft protection against primed effector cells. Transplantation. 59:1995;1444-1452.
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Nisco, S.J.1
Hissink, R.J.2
Vriens, P.W.3
Hoyt, E.G.4
Reitz, B.A.5
Clayberger, C.6
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6
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0026729563
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Heart allografts in murine systems. The differential activation of Th2- like effector cells in peripheral tolerance
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Takeuchi T, Lowry RP, Konieczny B Heart allografts in murine systems. The differential activation of Th2- like effector cells in peripheral tolerance. Transplantation. 53:1992;1281-1294.
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Takeuchi, T.1
Lowry, R.P.2
Konieczny, B.3
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7
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0025614639
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T suppressor cells induced by transfusions and cyclosporine. Studies in the murine cardiac allograft model
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Mottram PL, Mirisklavos A, Dumble LJ, Clunie GJ T suppressor cells induced by transfusions and cyclosporine. Studies in the murine cardiac allograft model. Transplantation. 50:1990;1033-1037.
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Mottram, P.L.1
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Dumble, L.J.3
Clunie, G.J.4
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8
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0032521267
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Bone marrow transplantation induces either clonal deletion or infectious tolerance depending on the dose
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A conclusive demonstration that variables in a tolerizing treatment regimen may influence the mechanism by which tolerance develops in transplant recipients.
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Bemelman F, Honey K, Adams E, Cobbold S, Waldmann H Bone marrow transplantation induces either clonal deletion or infectious tolerance depending on the dose. J Immunol. 160:1998;2645-2648. A conclusive demonstration that variables in a tolerizing treatment regimen may influence the mechanism by which tolerance develops in transplant recipients.
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J Immunol
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, pp. 2645-2648
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Bemelman, F.1
Honey, K.2
Adams, E.3
Cobbold, S.4
Waldmann, H.5
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9
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0028264982
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Anti-CD2 mAbs suppress cytotoxic lymphocyte activity by the generation of Th2 suppressor cells and receptor blockade
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Chavin KD, Qin L, Yon R, Lin J, Yagita H, Bromberg JS Anti-CD2 mAbs suppress cytotoxic lymphocyte activity by the generation of Th2 suppressor cells and receptor blockade. J Immunol. 152:1994;3729-3739.
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Chavin, K.D.1
Qin, L.2
Yon, R.3
Lin, J.4
Yagita, H.5
Bromberg, J.S.6
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10
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0033609531
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Distinct tolerance pathways in sensitized rat recipients after blockade of activation signal 1 and signal 2
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This proposes that the 'infectious' pathway operates in a cell-dose-dependent manner and therefore the induction of regulatory T cells may represent an important common tolerogenic pathway in transplant recipients. Th2-type deviation in the graft itself is not required for tolerance maintenance and it does not necessarily lead to chronic injury.
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Onodera K, Chandraker A, Kato H, Volk HD, Ritter T, Lehmann M, Sayegh MH, Kupiec-Weglinski JW Distinct tolerance pathways in sensitized rat recipients after blockade of activation signal 1 and signal 2. Transplantation. 68:1999;288-293. This proposes that the 'infectious' pathway operates in a cell-dose-dependent manner and therefore the induction of regulatory T cells may represent an important common tolerogenic pathway in transplant recipients. Th2-type deviation in the graft itself is not required for tolerance maintenance and it does not necessarily lead to chronic injury.
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(1999)
Transplantation
, vol.68
, pp. 288-293
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Onodera, K.1
Chandraker, A.2
Kato, H.3
Volk, H.D.4
Ritter, T.5
Lehmann, M.6
Sayegh, M.H.7
Kupiec-Weglinski, J.W.8
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11
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0031230372
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Distinct mechanisms for the induction and maintenance of allograft tolerance with CTLA4-Fc treatment
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Tran HM, Nickerson PW, Restifo AC, Ivis-Woodward MA, Patel A, Allen RD, Strom TB, O'Connell PJ Distinct mechanisms for the induction and maintenance of allograft tolerance with CTLA4-Fc treatment. J Immunol. 159:1997;2232-2239.
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J Immunol
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Tran, H.M.1
Nickerson, P.W.2
Restifo, A.C.3
Ivis-Woodward, M.A.4
Patel, A.5
Allen, R.D.6
Strom, T.B.7
O'Connell, P.J.8
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12
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0030801836
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Regulation by differential development of Th1 and Th2 cells in peripheral tolerance to cardiac allograft induced by blocking ICAM-1/LFA-1 adhesion
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Isobe M, Suzuki J, Yamazaki S, Yazaki Y, Horie S, Okubo Y, Maemura K, Sekiguchi M Regulation by differential development of Th1 and Th2 cells in peripheral tolerance to cardiac allograft induced by blocking ICAM-1/LFA-1 adhesion. Circulation. 96:1997;2247-2253.
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(1997)
Circulation
, vol.96
, pp. 2247-2253
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Isobe, M.1
Suzuki, J.2
Yamazaki, S.3
Yazaki, Y.4
Horie, S.5
Okubo, Y.6
Maemura, K.7
Sekiguchi, M.8
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13
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0028243877
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Evidence of alloreactive T suppressor cells in the maintenance phase of spontaneous tolerance after orthotopic liver transplantation in the rat
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Knoop M, Pratt JR, Hutchinson IV Evidence of alloreactive T suppressor cells in the maintenance phase of spontaneous tolerance after orthotopic liver transplantation in the rat. Transplantation. 57:1994;1512-1515.
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Transplantation
, vol.57
, pp. 1512-1515
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Knoop, M.1
Pratt, J.R.2
Hutchinson, I.V.3
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14
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0028962839
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Induction of peripheral tolerance by intrathymic inoculation of soluble alloantigens: Evidence for the role of host antigen-presenting cells and suppressor cell mechanism
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Oluwole SF, Jin MX, Chowdhury NC, Engelstad K, Ohajekwe OA, James T Induction of peripheral tolerance by intrathymic inoculation of soluble alloantigens: evidence for the role of host antigen-presenting cells and suppressor cell mechanism. Cell Immunol. 162:1995;33-41.
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Cell Immunol
, vol.162
, pp. 33-41
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Oluwole, S.F.1
Jin, M.X.2
Chowdhury, N.C.3
Engelstad, K.4
Ohajekwe, O.A.5
James, T.6
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15
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0030041197
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Successful transfer of immune unresponsiveness to concordant rat islet xenografts
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Goss JA, Flye MW, Lacy PE Successful transfer of immune unresponsiveness to concordant rat islet xenografts. Transplantation. 61:1996;9-13.
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Transplantation
, vol.61
, pp. 9-13
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Goss, J.A.1
Flye, M.W.2
Lacy, P.E.3
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16
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0031755395
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Infectious tolerance
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An elegant review on regulatory T cells in infectious transplant tolerance, proposing a novel model emphasizing the role of APCs in tolerance induction.
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Cobbold S, Waldmann H Infectious tolerance. Curr Opin Immunol. 10:1998;518-524. An elegant review on regulatory T cells in infectious transplant tolerance, proposing a novel model emphasizing the role of APCs in tolerance induction.
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(1998)
Curr Opin Immunol
, vol.10
, pp. 518-524
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Cobbold, S.1
Waldmann, H.2
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17
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0027479685
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'Infectious' transplantation tolerance
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Qin S, Cobbold SP, Pope H, Elliott J, Kioussis D, Davies J, Waldmann H 'Infectious' transplantation tolerance. Science. 259:1993;974-977.
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Science
, vol.259
, pp. 974-977
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Qin, S.1
Cobbold, S.P.2
Pope, H.3
Elliott, J.4
Kioussis, D.5
Davies, J.6
Waldmann, H.7
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18
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0030461536
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Amplification of natural regulatory immune mechanisms for transplantation tolerance
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Chen ZK, Cobbold SP, Waldmann H, Metcalfe S Amplification of natural regulatory immune mechanisms for transplantation tolerance. Transplantation. 62:1996;1200-1206.
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Transplantation
, vol.62
, pp. 1200-1206
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Chen, Z.K.1
Cobbold, S.P.2
Waldmann, H.3
Metcalfe, S.4
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19
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0028027043
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Mechanisms in CD4 antibody-mediated transplantation tolerance: Kinetics of induction, antigen dependency and role of regulatory T cells
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Scully R, Qin S, Cobbold S, Waldmann H Mechanisms in CD4 antibody-mediated transplantation tolerance: kinetics of induction, antigen dependency and role of regulatory T cells. Eur J Immunol. 24:1994;2383-2392.
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Eur J Immunol
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, pp. 2383-2392
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Scully, R.1
Qin, S.2
Cobbold, S.3
Waldmann, H.4
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20
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0032526605
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Thymus requirement and antigen dependency in the 'infectious' tolerance pathway in transplant recipients
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This paper deals with the role of the thymus in the induction and maintenance of tolerance and documents that both central and peripheral immune mechanisms, orchestrated by the tolerizing antigen, contribute to the infectious tolerance pathway in transplant recipients under the cover of CD4-targeted therapy.
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Onodera K, Volk HD, Ritter T, Kupiec-Weglinski JW Thymus requirement and antigen dependency in the 'infectious' tolerance pathway in transplant recipients. J Immunol. 160:1998;5765-5772. This paper deals with the role of the thymus in the induction and maintenance of tolerance and documents that both central and peripheral immune mechanisms, orchestrated by the tolerizing antigen, contribute to the infectious tolerance pathway in transplant recipients under the cover of CD4-targeted therapy.
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(1998)
J Immunol
, vol.160
, pp. 5765-5772
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Onodera, K.1
Volk, H.D.2
Ritter, T.3
Kupiec-Weglinski, J.W.4
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21
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0030240965
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Induction of 'infectious' tolerance to MHC-incompatible cardiac allografts in CD4 monoclonal antibody-treated sensitized rat recipients
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Onodera K, Lehmann M, Akalin E, Volk HD, Sayegh MH, Kupiec-Weglinski JW Induction of 'infectious' tolerance to MHC-incompatible cardiac allografts in CD4 monoclonal antibody-treated sensitized rat recipients. J Immunol. 157:1996;1944-1950.
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(1996)
J Immunol
, vol.157
, pp. 1944-1950
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Onodera, K.1
Lehmann, M.2
Akalin, E.3
Volk, H.D.4
Sayegh, M.H.5
Kupiec-Weglinski, J.W.6
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22
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17144450671
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Anti-CD4 monoclonal antibody-induced allograft tolerance in rats despite persistence of donor-reactive T cells
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Lehmann M, Graser E, Risch K, Hancock WW, Muller A, Kuttler B, Hahn HJ, Kupiec-Weglinski JW, Brock J, Volk HD Anti-CD4 monoclonal antibody-induced allograft tolerance in rats despite persistence of donor-reactive T cells. Transplantation. 64:1997;1181-1187.
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Transplantation
, vol.64
, pp. 1181-1187
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Lehmann, M.1
Graser, E.2
Risch, K.3
Hancock, W.W.4
Muller, A.5
Kuttler, B.6
Hahn, H.J.7
Kupiec-Weglinski, J.W.8
Brock, J.9
Volk, H.D.10
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23
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0030479490
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Tolerance and suppression in a primed immune system
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Marshall SE, Cobbold SP, Davies JD, Martin GM, Phillips JM, Waldmann H Tolerance and suppression in a primed immune system. Transplantation. 62:1996;1614-1621.
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Transplantation
, vol.62
, pp. 1614-1621
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Marshall, S.E.1
Cobbold, S.P.2
Davies, J.D.3
Martin, G.M.4
Phillips, J.M.5
Waldmann, H.6
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24
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0029893961
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Kinetics of induction of transplantation tolerance with a nondepleting anti-CD4 monoclonal antibody and donor-specific transfusion before transplantation. A critical period of time is required for development of immunological unresponsiveness
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Saitovitch D, Bushell A, Mabbs DW, Morris PJ, Wood KJ Kinetics of induction of transplantation tolerance with a nondepleting anti-CD4 monoclonal antibody and donor-specific transfusion before transplantation. A critical period of time is required for development of immunological unresponsiveness. Transplantation. 61:1996;1642-1647.
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Transplantation
, vol.61
, pp. 1642-1647
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Saitovitch, D.1
Bushell, A.2
Mabbs, D.W.3
Morris, P.J.4
Wood, K.J.5
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25
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0030006103
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T cell regulation in adult transplantation tolerance
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Davies JD, Martin G, Phillips J, Marshall SE, Cobbold SP, Waldmann H T cell regulation in adult transplantation tolerance. J Immunol. 157:1996;529-533.
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(1996)
J Immunol
, vol.157
, pp. 529-533
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Davies, J.D.1
Martin, G.2
Phillips, J.3
Marshall, S.E.4
Cobbold, S.P.5
Waldmann, H.6
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26
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0031568550
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Type 2 helper T cell-type cytokines and the development of 'infectious' tolerance in rat cardiac allograft recipients
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Onodera K, Hancock WW, Graser E, Lehmann M, Sayegh MH, Strom TB, Volk HD, Kupiec-Weglinski JW Type 2 helper T cell-type cytokines and the development of 'infectious' tolerance in rat cardiac allograft recipients. J Immunol. 158:1997;1572-1581.
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J Immunol
, vol.158
, pp. 1572-1581
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Onodera, K.1
Hancock, W.W.2
Graser, E.3
Lehmann, M.4
Sayegh, M.H.5
Strom, T.B.6
Volk, H.D.7
Kupiec-Weglinski, J.W.8
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27
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0032988116
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Depletion of IL-4 does not prevent tolerance induction in an allogeneic rat kidney transplantation model
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Ritter T, Seifert M, Risch K, Fretz A, Tanzmann H, Brock J, Volk HD, Lehmann M Depletion of IL-4 does not prevent tolerance induction in an allogeneic rat kidney transplantation model. Transplant Proc. 31:1999;887-888.
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Transplant Proc
, vol.31
, pp. 887-888
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Ritter, T.1
Seifert, M.2
Risch, K.3
Fretz, A.4
Tanzmann, H.5
Brock, J.6
Volk, H.D.7
Lehmann, M.8
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28
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0032146707
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Tolerance induction by anti-CD2 plus anti-CD3 monoclonal antibodies: Evidence for an IL-4 requirement
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This elegant paper documents the critical role of IL-4 in the induction of transplantation tolerance involving regulatory T cells.
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Punch JD, Tono T, Qin LH, Bishop DK, Bromberg JS Tolerance induction by anti-CD2 plus anti-CD3 monoclonal antibodies: evidence for an IL-4 requirement. J Immunol. 161:1998;1156-1162. This elegant paper documents the critical role of IL-4 in the induction of transplantation tolerance involving regulatory T cells.
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(1998)
J Immunol
, vol.161
, pp. 1156-1162
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Punch, J.D.1
Tono, T.2
Qin, L.H.3
Bishop, D.K.4
Bromberg, J.S.5
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29
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0033083308
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Evidence for immune regulation in the induction of transplantation tolerance: A conditional but limited role for IL-4
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Another paper showing the role of IL-4 in the induction of transplantation tolerance that involves regulatory T cells. It provides evidence that conditions at the time of tolerance induction may obliterate the requirement for IL-4.
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Bushell A, Niimi M, Morris PJ, Wood KJ Evidence for immune regulation in the induction of transplantation tolerance: a conditional but limited role for IL-4. J Immunol. 162:1999;1359-1366. Another paper showing the role of IL-4 in the induction of transplantation tolerance that involves regulatory T cells. It provides evidence that conditions at the time of tolerance induction may obliterate the requirement for IL-4.
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(1999)
J Immunol
, vol.162
, pp. 1359-1366
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Bushell, A.1
Niimi, M.2
Morris, P.J.3
Wood, K.J.4
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30
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0028785917
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Graft-infiltrating T helper cells, CD45RC phenotype, and Th1/Th2- related cytokines in donor-specific transfusion-induced tolerance in adult rats
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Josien R, Pannetier C, Douillard P, Cantarovich D, Menoret S, Bugeon L, Kourilsky P, Soulillou JP, Cuturi MC Graft-infiltrating T helper cells, CD45RC phenotype, and Th1/Th2- related cytokines in donor-specific transfusion-induced tolerance in adult rats. Transplantation. 60:1995;1131-1139.
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(1995)
Transplantation
, vol.60
, pp. 1131-1139
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Josien, R.1
Pannetier, C.2
Douillard, P.3
Cantarovich, D.4
Menoret, S.5
Bugeon, L.6
Kourilsky, P.7
Soulillou, J.P.8
Cuturi, M.C.9
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31
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0032436036
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A critical role for transforming growth factor-beta in donor transfusion-induced allograft tolerance
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This paper provides important insights into the mechanisms by which TGF-β rather than IL-4 contributes to the induction of tolerance in certain animal transplant models.
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Josien R, Douillard P, Guillot C, Muschen M, Anegon I, Chetritt J, Menoret S, Vignes C, Soulillou JP, Cuturi MC A critical role for transforming growth factor-beta in donor transfusion-induced allograft tolerance. J Clin Invest. 102:1998;1920-1926. This paper provides important insights into the mechanisms by which TGF-β rather than IL-4 contributes to the induction of tolerance in certain animal transplant models.
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(1998)
J Clin Invest
, vol.102
, pp. 1920-1926
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Josien, R.1
Douillard, P.2
Guillot, C.3
Muschen, M.4
Anegon, I.5
Chetritt, J.6
Menoret, S.7
Vignes, C.8
Soulillou, J.P.9
Cuturi, M.C.10
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32
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0031470531
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Induction of tolerance with nondepleting anti-CD4 monoclonal antibodies is associated with down-regulation of Th2 cytokines
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Plain KM, Fava L, Spinelli A, He XY, Chen J, Boyd R, Davidson CL, Hall BM Induction of tolerance with nondepleting anti-CD4 monoclonal antibodies is associated with down-regulation of Th2 cytokines. Transplantation. 64:1997;1559-1567.
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(1997)
Transplantation
, vol.64
, pp. 1559-1567
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Plain, K.M.1
Fava, L.2
Spinelli, A.3
He, X.Y.4
Chen, J.5
Boyd, R.6
Davidson, C.L.7
Hall, B.M.8
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33
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0032533460
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Anti-CD4 monoclonal antibody-induced tolerance to MHC-incompatible cardiac allografts maintained by CD4+ suppressor T cells that are not dependent upon IL-4
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An elegant study, which documents that IL-4 is not the only mediator in tolerance induction involving regulatory T cells.
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Hall BM, Fava L, Chen J, Plain KM, Boyd RA, Spicer ST, Berger MF Anti-CD4 monoclonal antibody-induced tolerance to MHC-incompatible cardiac allografts maintained by CD4+ suppressor T cells that are not dependent upon IL-4. J Immunol. 161:1998;5147-5156. An elegant study, which documents that IL-4 is not the only mediator in tolerance induction involving regulatory T cells.
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(1998)
J Immunol
, vol.161
, pp. 5147-5156
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Hall, B.M.1
Fava, L.2
Chen, J.3
Plain, K.M.4
Boyd, R.A.5
Spicer, S.T.6
Berger, M.F.7
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34
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0026785294
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Induction of specific tolerance to class I-disparate renal allografts in miniature swine with cyclosporine
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Rosengard BR, Ojikutu CA, Guzzetta PC, Smith CV, Sundt TM, Nakajima K, Boorstein SM, Hill GS, Fishbein JM, Sachs DH Induction of specific tolerance to class I-disparate renal allografts in miniature swine with cyclosporine. Transplantation. 54:1992;490-497.
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(1992)
Transplantation
, vol.54
, pp. 490-497
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Rosengard, B.R.1
Ojikutu, C.A.2
Guzzetta, P.C.3
Smith, C.V.4
Sundt, T.M.5
Nakajima, K.6
Boorstein, S.M.7
Hill, G.S.8
Fishbein, J.M.9
Sachs, D.H.10
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35
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0032909116
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Peripheral tolerance to class I mismatched renal allografts in miniature swine: Donor antigen-activated peripheral blood lymphocytes from tolerant swine inhibit antidonor CTL reactivity
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This paper provides important evidence on the existence of regulatory T cells in a large-animal transplant model.
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Ierino FL, Yamada K, Hatch T, Rembert J, Sachs DH Peripheral tolerance to class I mismatched renal allografts in miniature swine: donor antigen-activated peripheral blood lymphocytes from tolerant swine inhibit antidonor CTL reactivity. J Immunol. 162:1999;550-559. This paper provides important evidence on the existence of regulatory T cells in a large-animal transplant model.
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(1999)
J Immunol
, vol.162
, pp. 550-559
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Ierino, F.L.1
Yamada, K.2
Hatch, T.3
Rembert, J.4
Sachs, D.H.5
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36
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0030793682
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Role of the thymus in transplantation tolerance in miniature swine. I. Requirement of the thymus for rapid and stable induction of tolerance to class I-mismatched renal allografts
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Yamada K, Gianello PR, Ierino FL, Lorf T, Shimizu A, Meehan S, Colvin RB, Sachs DH Role of the thymus in transplantation tolerance in miniature swine. I. Requirement of the thymus for rapid and stable induction of tolerance to class I-mismatched renal allografts. J Exp Med. 186:1997;497-506.
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(1997)
J Exp Med
, vol.186
, pp. 497-506
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Yamada, K.1
Gianello, P.R.2
Ierino, F.L.3
Lorf, T.4
Shimizu, A.5
Meehan, S.6
Colvin, R.B.7
Sachs, D.H.8
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37
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0033557297
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Role of the thymus in transplantation tolerance in miniature swine: II. Effect of steroids and age on the induction of tolerance to class I mismatched renal allografts
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Yamada K, Gianello PR, Ierino FL, Fishbein J, Lorf T, Shimizu A, Colvin RB, Sachs DH Role of the thymus in transplantation tolerance in miniature swine: II. Effect of steroids and age on the induction of tolerance to class I mismatched renal allografts. Transplantation. 67:1999;458-467.
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(1999)
Transplantation
, vol.67
, pp. 458-467
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Yamada, K.1
Gianello, P.R.2
Ierino, F.L.3
Fishbein, J.4
Lorf, T.5
Shimizu, A.6
Colvin, R.B.7
Sachs, D.H.8
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38
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0033609091
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Role of the thymus in transplantation tolerance in miniature swine. III. Surgical manipulation of the thymus interferes with stable induction of tolerance to class I-mismatched renal allografts
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Yamada K, Ierino FL, Gianello PR, Shimizu A, Colvin RB, Sachs DH Role of the thymus in transplantation tolerance in miniature swine. III. Surgical manipulation of the thymus interferes with stable induction of tolerance to class I-mismatched renal allografts. Transplantation. 67:1999;1112-1119.
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(1999)
Transplantation
, vol.67
, pp. 1112-1119
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Yamada, K.1
Ierino, F.L.2
Gianello, P.R.3
Shimizu, A.4
Colvin, R.B.5
Sachs, D.H.6
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39
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0029086753
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Lymphocytes selected in allogeneic thymic epithelium mediate dominant tolerance toward tissue grafts of the thymic epithelium haplotype
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Regulatory T cells in thymic epithelium-induced tolerance. I. Suppression of mature peripheral non-tolerant T cells
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Modigliani Y, Pereira P, Thomas-Vaslin V, Salaun J, Burlen-Defranoux O, Coutinho A, Le Douarin N, Bandeira A Regulatory T cells in thymic epithelium-induced tolerance. I. Suppression of mature peripheral non-tolerant T cells. Eur J Immunol. 25:1995;2563-2571.
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A model for developmentally acquired thymus-dependent tolerance to central and peripheral antigens
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The effects of nondepleting CD4 targeted therapy in presensitized rat recipients of cardiac allografts
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CD4 mAb therapy modulates alloantibody production and intracardiac graft deposition in association with selective inhibition of Th1 lymphokines
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Kupiec-Weglinski JW, Wasowska B, Papp I, Schmidbauer G, Sayegh MH, Baldwin WM, Wieder KJ, Hancock WW CD4 mAb therapy modulates alloantibody production and intracardiac graft deposition in association with selective inhibition of Th1 lymphokines. J Immunol. 151:1993;5053-5061.
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A role for Th2 cytokines in the suppression of CD8+ T cell-mediated graft rejection
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Th1 development of naive CD4+ T cells is inhibited by co-activation with anti-CD4 monoclonal antibodies
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46
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Activation of CD4+ T cells in the presence of a nondepleting monoclonal antibody to CD4 induces a Th2-type response in vitro
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Stumbles P, Mason D Activation of CD4+ T cells in the presence of a nondepleting monoclonal antibody to CD4 induces a Th2-type response in vitro. J Exp Med. 182:1995;5-13.
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Vanbuskirk AM, Wakely ME, Orosz CG Transfusion of polarized Th2-like cell populations into SCID mouse cardiac allograft recipients results in acute allograft rejection. Transplantation. 62:1996;229-238.
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48
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0032529407
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Rejection of H-Y disparate skin grafts by monospecific CD4+ Th1 and Th2 cells: No requirement for CD8+ T cells or B cells
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This paper presents evidence that Th2-like cells are fully capable of mediating acute allograft rejection.
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Zelenika D, Adams E, Mellor A, Simpson E, Chandler P, Stockinger B, Waldmann H, Cobbold SP Rejection of H-Y disparate skin grafts by monospecific CD4+ Th1 and Th2 cells: no requirement for CD8+ T cells or B cells. J Immunol. 161:1998;1868-1874. This paper presents evidence that Th2-like cells are fully capable of mediating acute allograft rejection.
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49
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0000770628
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On histocompatibility barriers, Th1 to Th2 immune deviation, and the nature of the allograft responses
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The authors highlight the possibility that a Th1-to-Th2 immune deviation does not universally blunt cytopathic, T cell dependent immune responses and it may be insufficient for the acquisition of tolerance. Unique features of MHC-mismatched allografts render the alloimmune response resistant to Th2 cell mediated tolerizing effects.
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Li XC, Zand MS, Li Y, Zheng XX, Strom TB On histocompatibility barriers, Th1 to Th2 immune deviation, and the nature of the allograft responses. J Immunol. 161:1998;2241-2247. The authors highlight the possibility that a Th1-to-Th2 immune deviation does not universally blunt cytopathic, T cell dependent immune responses and it may be insufficient for the acquisition of tolerance. Unique features of MHC-mismatched allografts render the alloimmune response resistant to Th2 cell mediated tolerizing effects.
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51
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0031669999
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Anergic T cells actively suppress T cell responses via the antigen-presenting cell
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This paper demonstrates the role of APCs in mediating the suppression of anergic T cells.
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Taams LS, Van Rensen AJ, Poelen MC, Van Els CA, Besseling AC, Wagenaar JP, Van Eden W, Wauben MH Anergic T cells actively suppress T cell responses via the antigen-presenting cell. Eur J Immunol. 28:1998;2902-2912. This paper demonstrates the role of APCs in mediating the suppression of anergic T cells.
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Taams, L.S.1
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52
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Anergic T cells act as suppressor cells in vitro and in vivo
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The authors demonstrate in vivo effects of anergic T cells on allograft survival.
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Chai JG, Bartok I, Chandler P, Vendetti S, Antoniou A, Dyson J, Lechler R Anergic T cells act as suppressor cells in vitro and in vivo. Eur J Immunol. 29:1999;686-692. The authors demonstrate in vivo effects of anergic T cells on allograft survival.
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Chai, J.G.1
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Anergy-associated T cell antigen presentation. A mechanism of infectious tolerance in experimental autoimmune encephalomyelitis
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Mannie MD, Rendall SK, Arnold PY, Nardella JP, White GA Anergy-associated T cell antigen presentation. A mechanism of infectious tolerance in experimental autoimmune encephalomyelitis. J Immunol. 157:1996;1062-1070.
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This is a demonstration that multiple phenotypes of anergic T cells may be induced under different conditions in vitro
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Evidence that the T cell repertoire of normal rats contains cells with the potential to cause diabetes. Characterization of the CD4+ T cell subset that inhibits this autoimmune potential
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Regulatory T cells in the control of autoimmunity: The essential role of transforming growth factor beta and interleukin 4 in the prevention of autoimmune thyroiditis in rats by peripheral CD4(+)CD45RC- cells and CD4(+)CD8(-) thymocytes
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This paper provides important experimental evidence for the immune regulatory role of IL-4 and TGF-β in an autoimmune thyroiditis model.
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Seddon B, Mason D Regulatory T cells in the control of autoimmunity: the essential role of transforming growth factor beta and interleukin 4 in the prevention of autoimmune thyroiditis in rats by peripheral CD4(+)CD45RC- cells and CD4(+)CD8(-) thymocytes. J Exp Med. 189:1999;279-288. This paper provides important experimental evidence for the immune regulatory role of IL-4 and TGF-β in an autoimmune thyroiditis model.
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Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases
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Sakaguchi S, Sakaguchi N, Asano M, Itoh M, Toda M Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J Immunol. 155:1995;1151-1164.
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60
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Immunologic self-tolerance maintained by CD25+CD4+ naturally anergic and suppressive T cells: Induction of autoimmune disease by breaking their anergic/suppressive state
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A functional study implicating the role of regulatory T cells in autoimmunity and suggesting that APCs might mediate immune suppression.
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