-
1
-
-
12944271053
-
Cancer statistics, 2005
-
Jemal, A.; Murray, T.; Ward, E.; Samuels, A.; Tiwari, R. C.; Ghafoor, A.; Feuer, E. J.; Thun, M. J. Cancer statistics, 2005. CA. Cancer J. Clin. 2005, 55, 10-30.
-
(2005)
CA. Cancer J. Clin.
, vol.55
, pp. 10-30
-
-
Jemal, A.1
Murray, T.2
Ward, E.3
Samuels, A.4
Tiwari, R.C.5
Ghafoor, A.6
Feuer, E.J.7
Thun, M.J.8
-
2
-
-
0034844617
-
Recent advances in the treatment of epithelial ovarian cancer
-
Harries, M.; Kaye, S. B. Recent advances in the treatment of epithelial ovarian cancer. Exp. Opin. Investig. Drugs 2001, 10, 1715-1724.
-
(2001)
Exp. Opin. Investig. Drugs
, vol.10
, pp. 1715-1724
-
-
Harries, M.1
Kaye, S.B.2
-
3
-
-
0037830009
-
Cervical cancer
-
Waggoner, S. E. Cervical cancer. Lancet 2003, 361, 2217-2225.
-
(2003)
Lancet
, vol.361
, pp. 2217-2225
-
-
Waggoner, S.E.1
-
4
-
-
0036181128
-
Current status and future innovations of hormonal agents, chemotherapy and investigational agents in endometrial cancer
-
Elit, L.; Hirte, H. Current status and future innovations of hormonal agents, chemotherapy and investigational agents in endometrial cancer. Curr. Opin. Obstet. Gynecol. 2002, 14, 67-73.
-
(2002)
Curr. Opin. Obstet. Gynecol.
, vol.14
, pp. 67-73
-
-
Elit, L.1
Hirte, H.2
-
5
-
-
0034523818
-
Pro-apoptotic cascade activates BID, which oligomerizes BAK or BAX into pores that result in the release of cytochrome c
-
Korsmeyer, S. J.; Wei, M. C.; Saito, M.; Weiler, S.; Oh, K. J.; Schlesinger, P. H. Pro-apoptotic cascade activates BID, which oligomerizes BAK or BAX into pores that result in the release of cytochrome c. Cell Death Differ. 2000, 7, 1166-1173.
-
(2000)
Cell Death Differ.
, vol.7
, pp. 1166-1173
-
-
Korsmeyer, S.J.1
Wei, M.C.2
Saito, M.3
Weiler, S.4
Oh, K.J.5
Schlesinger, P.H.6
-
6
-
-
0033582526
-
Distinct caspase cascades are initiated in receptor-mediated and chemical-induced apoptosis
-
Sun, X. M.; MacFarlane, M.; Zhuang, J.; Wolf, B. B.; Green, D. R.; Cohen, G. M. Distinct caspase cascades are initiated in receptor-mediated and chemical-induced apoptosis. J. Biol. Chem. 1999, 274, 5053-5060.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 5053-5060
-
-
Sun, X.M.1
MacFarlane, M.2
Zhuang, J.3
Wolf, B.B.4
Green, D.R.5
Cohen, G.M.6
-
7
-
-
0034278085
-
The IAP family: Endogenous caspase inhibitors with multiple biological activities
-
Yang, Y. L.; Li, X. M. The IAP family: endogenous caspase inhibitors with multiple biological activities. Cell Res. 2000, 10, 169-177.
-
(2000)
Cell Res.
, vol.10
, pp. 169-177
-
-
Yang, Y.L.1
Li, X.M.2
-
8
-
-
0036449793
-
Current status of the molecular mechanisms of anticancer drug-induced apoptosis. The contribution of molecular-level analysis to cancer chemotherapy
-
Kim, R.; Tanabe, K.; Uchida, Y.; Emi, M.; Inoue, H.; Toge, T. Current status of the molecular mechanisms of anticancer drug-induced apoptosis. The contribution of molecular-level analysis to cancer chemotherapy. Cancer Chemother. Pharmacol. 2002, 50, 343-352.
-
(2002)
Cancer Chemother. Pharmacol.
, vol.50
, pp. 343-352
-
-
Kim, R.1
Tanabe, K.2
Uchida, Y.3
Emi, M.4
Inoue, H.5
Toge, T.6
-
9
-
-
0030715323
-
Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade
-
Li, P.; Nijhawan, D.; Budihardjo, I.; Srinivasula, S. M.; Ahmad, M.; Alnemri, E. S.; Wang, X. Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell 1997, 91, 479-489.
-
(1997)
Cell
, vol.91
, pp. 479-489
-
-
Li, P.1
Nijhawan, D.2
Budihardjo, I.3
Srinivasula, S.M.4
Ahmad, M.5
Alnemri, E.S.6
Wang, X.7
-
10
-
-
0028335717
-
Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo
-
Miyashita, T.; Krajewski, S.; Krajewska, M.; Wang, H. G.; Lin, H. K.; Liebermann, D. A.; Hoffman, B.; Reed, J. C. Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo. Oncogene 1994, 9, 1799-1805.
-
(1994)
Oncogene
, vol.9
, pp. 1799-1805
-
-
Miyashita, T.1
Krajewski, S.2
Krajewska, M.3
Wang, H.G.4
Lin, H.K.5
Liebermann, D.A.6
Hoffman, B.7
Reed, J.C.8
-
11
-
-
85047696563
-
Regulation of the mitochondrial checkpoint in p53-mediated apoptosis confers resistance to cell death
-
Henry, H.; Thomas, A.; Shen, Y.; White, E. Regulation of the mitochondrial checkpoint in p53-mediated apoptosis confers resistance to cell death. Oncogene 2002, 21, 748-760.
-
(2002)
Oncogene
, vol.21
, pp. 748-760
-
-
Henry, H.1
Thomas, A.2
Shen, Y.3
White, E.4
-
12
-
-
0031689575
-
Chemosensitivity of human malignant glioma: Modulation by p53 gene transfer
-
Trepel, M.; Groscurth, P.; Malipiero, U.; Gulbins, E.; Dichgans, J.; Weller, M. Chemosensitivity of human malignant glioma: modulation by p53 gene transfer. J. Neurooncol. 1998, 39, 19-32.
-
(1998)
J. Neurooncol.
, vol.39
, pp. 19-32
-
-
Trepel, M.1
Groscurth, P.2
Malipiero, U.3
Gulbins, E.4
Dichgans, J.5
Weller, M.6
-
13
-
-
0037372013
-
Apoptosis and melanoma: Molecular mechanisms
-
Hussein, M. R.; Haemel, A. K.; Wood, G. S. Apoptosis and melanoma: molecular mechanisms. J. Pathol. 2003, 199, 275-288.
-
(2003)
J. Pathol.
, vol.199
, pp. 275-288
-
-
Hussein, M.R.1
Haemel, A.K.2
Wood, G.S.3
-
14
-
-
0037377269
-
The p53 tumor suppressor gene and nuclear protein: Basic science review and relevance in the management of bladder cancer
-
Smith, N. D.; Rubenstein, J. N.; Eggener, S. E.; Kozlowski, J. M. The p53 tumor suppressor gene and nuclear protein: basic science review and relevance in the management of bladder cancer. J. Urol. 2003, 169, 1219-1228.
-
(2003)
J. Urol.
, vol.169
, pp. 1219-1228
-
-
Smith, N.D.1
Rubenstein, J.N.2
Eggener, S.E.3
Kozlowski, J.M.4
-
15
-
-
0033024368
-
Clinical significance of apoptosis-related factors p53, Mdm2, and Bcl-2 in advanced ovarian cancer
-
Baekelandt, M.; Kristensen, G. B.; Nesland, J. M.; Trope, C. G.; Holm, R. Clinical significance of apoptosis-related factors p53, Mdm2, and Bcl-2 in advanced ovarian cancer. J. Clin. Oncol. 1999, 17, 2061.
-
(1999)
J. Clin. Oncol.
, vol.17
, pp. 2061
-
-
Baekelandt, M.1
Kristensen, G.B.2
Nesland, J.M.3
Trope, C.G.4
Holm, R.5
-
16
-
-
0034794290
-
Preliminary phase I results of G3139 (bcl-2 antisense oligonucleotide) therapy in combination with docetaxel in hormone-refractory prostate cancer
-
Tolcher, A. W. Preliminary phase I results of G3139 (bcl-2 antisense oligonucleotide) therapy in combination with docetaxel in hormone-refractory prostate cancer. Semin. Oncol. 2001, 28, 67-70.
-
(2001)
Semin. Oncol.
, vol.28
, pp. 67-70
-
-
Tolcher, A.W.1
-
17
-
-
0035869667
-
Synergistic chemosensitization and inhibition of progression to androgen independence by antisense Bcl-2 oligodeoxynucleotide and paclitaxel in the LNCaP prostate tumor model
-
Leung, S.; Miyake, H.; Zellweger, T.; Tolcher, A.; Gleave, M. E. Synergistic chemosensitization and inhibition of progression to androgen independence by antisense Bcl-2 oligodeoxynucleotide and paclitaxel in the LNCaP prostate tumor model. Int. J. Cancer 2001, 91, 846-850.
-
(2001)
Int. J. Cancer
, vol.91
, pp. 846-850
-
-
Leung, S.1
Miyake, H.2
Zellweger, T.3
Tolcher, A.4
Gleave, M.E.5
-
18
-
-
16444379884
-
Bcl-2 and CCND1/CDK4 expression levels predict the cellular effects of mTOR inhibitors in human ovarian carcinoma
-
Aguirre, D.; Boya, P.; Bellet, D.; Faivre, S.; Troalen, F.; Benard, J.; Saulnier, P.; Hopkins-Donaldson, S.; Zangemeister-Wittke, U.; Kroemer, G.; Raymond, E. Bcl-2 and CCND1/CDK4 expression levels predict the cellular effects of mTOR inhibitors in human ovarian carcinoma. Apoptosis 2004, 9, 797-805.
-
(2004)
Apoptosis
, vol.9
, pp. 797-805
-
-
Aguirre, D.1
Boya, P.2
Bellet, D.3
Faivre, S.4
Troalen, F.5
Benard, J.6
Saulnier, P.7
Hopkins-Donaldson, S.8
Zangemeister-Wittke, U.9
Kroemer, G.10
Raymond, E.11
-
19
-
-
0030950758
-
Abrogation of taxol-induced G2-M arrest and apoptosis in human ovarian cancer cells grown as multicellular tumor spheroids
-
Frankel, A.; Buckman, R.; Kerbel, R. S. Abrogation of taxol-induced G2-M arrest and apoptosis in human ovarian cancer cells grown as multicellular tumor spheroids. Cancer Res. 1997, 57, 2388-2393.
-
(1997)
Cancer Res.
, vol.57
, pp. 2388-2393
-
-
Frankel, A.1
Buckman, R.2
Kerbel, R.S.3
-
20
-
-
0025815451
-
Identification of p53 as a sequence-specific DNA-binding protein
-
Kern, S. E.; Kinzler, K. W.; Bruskin, A.; Jarosz, D.; Friedman, P.; Prives, C.; Vogelstein, B. Identification of p53 as a sequence-specific DNA-binding protein. Science 1991, 252, 1708-1711.
-
(1991)
Science
, vol.252
, pp. 1708-1711
-
-
Kern, S.E.1
Kinzler, K.W.2
Bruskin, A.3
Jarosz, D.4
Friedman, P.5
Prives, C.6
Vogelstein, B.7
-
21
-
-
0028824260
-
Adenovirus-based p53 gene therapy in ovarian cancer
-
Santoso, J. T.; Tang, D. C.; Lane, S. B.; Hung, J.; Reed, D. J.; Muller, C. Y.; Carbone, D. P.; Lucci, J. A., 3rd; Miller, D. S.; Mathis, J. M. Adenovirus-based p53 gene therapy in ovarian cancer. Gynecol. Oncol. 1995, 59, 171-178.
-
(1995)
Gynecol. Oncol.
, vol.59
, pp. 171-178
-
-
Santoso, J.T.1
Tang, D.C.2
Lane, S.B.3
Hung, J.4
Reed, D.J.5
Muller, C.Y.6
Carbone, D.P.7
Lucci III, J.A.8
Miller, D.S.9
Mathis, J.M.10
-
22
-
-
0026504107
-
Overexpression and mutation of p53 in endometrial carcinoma
-
Kohler, M. F.; Berchuck, A.; Davidoff, A. M.; Humphrey, P. A.; Dodge, R. K.; Iglehart, J. D.; Soper, J. T.; Clarke-Pearson, D. L.; Bast, R. C., Jr.; Marks, J. R. Overexpression and mutation of p53 in endometrial carcinoma. Cancer Res. 1992, 52, 1622-1627.
-
(1992)
Cancer Res.
, vol.52
, pp. 1622-1627
-
-
Kohler, M.F.1
Berchuck, A.2
Davidoff, A.M.3
Humphrey, P.A.4
Dodge, R.K.5
Iglehart, J.D.6
Soper, J.T.7
Clarke-Pearson, D.L.8
Bast Jr., R.C.9
Marks, J.R.10
-
23
-
-
0027818396
-
A retroviral wild-type p53 expression vector penetrates human lung cancer spheroids and inhibits growth by inducing apoptosis
-
Fujiwara, T.; Grimm, E. A.; Mukhopadhyay, T.; Cai, D. W.; Owen-Schaub, L. B.; Roth, J. A. A retroviral wild-type p53 expression vector penetrates human lung cancer spheroids and inhibits growth by inducing apoptosis. Cancer Res. 1993, 53, 4129-4133.
-
(1993)
Cancer Res.
, vol.53
, pp. 4129-4133
-
-
Fujiwara, T.1
Grimm, E.A.2
Mukhopadhyay, T.3
Cai, D.W.4
Owen-Schaub, L.B.5
Roth, J.A.6
-
24
-
-
85047697641
-
Phase I trial of adenovirus-mediated p53 gene therapy for recurrent glioma: Biological and clinical results
-
Lang, F. F.; Bruner, J. M.; Fuller, G. N.; Aldape, K.; Prados, M. D.; Chang, S.; Berger, M. S.; McDermott, M. W.; Kunwar, S. M.; Junck, L. R.; Chandler, W.; Zwiebel, J. A.; Kaplan, R. S.; Yung, W. K. Phase I trial of adenovirus-mediated p53 gene therapy for recurrent glioma: biological and clinical results. J. Clin. Oncol. 2003, 21, 2508-2518.
-
(2003)
J. Clin. Oncol.
, vol.21
, pp. 2508-2518
-
-
Lang, F.F.1
Bruner, J.M.2
Fuller, G.N.3
Aldape, K.4
Prados, M.D.5
Chang, S.6
Berger, M.S.7
McDermott, M.W.8
Kunwar, S.M.9
Junck, L.R.10
Chandler, W.11
Zwiebel, J.A.12
Kaplan, R.S.13
Yung, W.K.14
-
25
-
-
0347625437
-
INGN 201: Ad-p53, Ad5CMV-p53, Adenoviral p53, INGN 101, p53 gene therapy - Introgen, RPR/INGN 201
-
INGN 201: Ad-p53, Ad5CMV-p53, Adenoviral p53, INGN 101, p53 gene therapy - Introgen, RPR/INGN 201. Bio. Drugs 2003, 17, 216-222.
-
(2003)
Bio. Drugs
, vol.17
, pp. 216-222
-
-
-
26
-
-
0037627875
-
Why did p53 gene therapy fail in ovarian cancer?
-
Zeimet, A. G.; Marth, C. Why did p53 gene therapy fail in ovarian cancer? Lancet Oncol. 2003, 4, 415-422.
-
(2003)
Lancet Oncol.
, vol.4
, pp. 415-422
-
-
Zeimet, A.G.1
Marth, C.2
-
27
-
-
3543071097
-
A phase I study of Adp53 (INGN 201; ADVEXIN) for patients with platinum- and paclitaxel-resistant epithelial ovarian cancer
-
Wolf, J. K.; Bodurka, D. C.; Gano, J. B.; Deavers, M.; Ramondetta, L.; Ramirez, P. T.; Levenback, C.; Gershenson, D. M. A phase I study of Adp53 (INGN 201; ADVEXIN) for patients with platinum- and paclitaxel-resistant epithelial ovarian cancer. Gynecol. Oncol. 2004, 94, 442-448.
-
(2004)
Gynecol. Oncol.
, vol.94
, pp. 442-448
-
-
Wolf, J.K.1
Bodurka, D.C.2
Gano, J.B.3
Deavers, M.4
Ramondetta, L.5
Ramirez, P.T.6
Levenback, C.7
Gershenson, D.M.8
-
28
-
-
0036765911
-
Phenoxodiol (2H-1-benzopyran-7-0,1,3-(4-hydroxyphenyl)), a novel isoflavone derivative, inhibits DNA topoisomerase II by stabilizing the cleavable complex
-
Constantinou, A. I.; Husband, A. Phenoxodiol (2H-1-benzopyran-7-0,1,3-(4- hydroxyphenyl)), a novel isoflavone derivative, inhibits DNA topoisomerase II by stabilizing the cleavable complex. Anticancer Res. 2002, 22, 2581-2585.
-
(2002)
Anticancer Res.
, vol.22
, pp. 2581-2585
-
-
Constantinou, A.I.1
Husband, A.2
-
29
-
-
0037854571
-
Phenoxodiol - An isoflavone analog - Induces apoptosis in chemoresistant ovarian cancer cells
-
Kamsteeg, M.; Rutherford, T.; Sapi, E.; Hanczaruk, B.; Shahabi, S.; Flick, M.; Brown, D.; Mor, G. Phenoxodiol - an isoflavone analog - induces apoptosis in chemoresistant ovarian cancer cells. Oncogene 2003, 22, 2611-2620.
-
(2003)
Oncogene
, vol.22
, pp. 2611-2620
-
-
Kamsteeg, M.1
Rutherford, T.2
Sapi, E.3
Hanczaruk, B.4
Shahabi, S.5
Flick, M.6
Brown, D.7
Mor, G.8
-
30
-
-
19944430097
-
Resistance of ovarian carcinoma cells to docetaxel is XIAP dependent and reversible by phenoxodiol
-
Sapi, E.; Alvero, A. B.; Chen, W.; O'Malley, D.; Hao, X. Y.; Dwipoyono, B.; Garg, M.; Kamsteeg, M.; Rutherford, T.; Mor, G. Resistance of ovarian carcinoma cells to docetaxel is XIAP dependent and reversible by phenoxodiol. Oncol. Res. 2004, 14, 567-578.
-
(2004)
Oncol. Res.
, vol.14
, pp. 567-578
-
-
Sapi, E.1
Alvero, A.B.2
Chen, W.3
O'Malley, D.4
Hao, X.Y.5
Dwipoyono, B.6
Garg, M.7
Kamsteeg, M.8
Rutherford, T.9
Mor, G.10
-
32
-
-
0034777519
-
Ras signaling pathway proteins as therapeutic targets
-
Adjei, A. A. Ras signaling pathway proteins as therapeutic targets. Curr. Pharm. Des. 2001, 7, 1581-1594.
-
(2001)
Curr. Pharm. Des.
, vol.7
, pp. 1581-1594
-
-
Adjei, A.A.1
-
33
-
-
0027182705
-
p53 and Ki-ras gene mutations in epithelial ovarian neoplasms
-
Teneriello, M. G.; Ebina, M.; Linnoila, R. I.; Henry, M.; Nash, J. D.; Park, R. C.; Birrer, M. J. p53 and Ki-ras gene mutations in epithelial ovarian neoplasms. Cancer Res. 1993, 53, 3103-3108.
-
(1993)
Cancer Res.
, vol.53
, pp. 3103-3108
-
-
Teneriello, M.G.1
Ebina, M.2
Linnoila, R.I.3
Henry, M.4
Nash, J.D.5
Park, R.C.6
Birrer, M.J.7
-
34
-
-
16244398711
-
Biochip for K-ras Mutation Screening in Ovarian Cancer
-
Fabjani, G.; Kriegshaeuser, G.; Schuetz, A.; Prix, L.; Zeillinger, R. Biochip for K-ras Mutation Screening in Ovarian Cancer. Clin. Chem. 2005, 51, 784-787.
-
(2005)
Clin. Chem.
, vol.51
, pp. 784-787
-
-
Fabjani, G.1
Kriegshaeuser, G.2
Schuetz, A.3
Prix, L.4
Zeillinger, R.5
-
35
-
-
0032945849
-
Mutations and amplification of oncogenes in endometrial cancer
-
Niederacher, D.; An, H. X.; Cho, Y. J.; Hantschmann, P.; Bender, H. G.; Beckmann, M. W. Mutations and amplification of oncogenes in endometrial cancer. Oncology 1999, 56, 59-65.
-
(1999)
Oncology
, vol.56
, pp. 59-65
-
-
Niederacher, D.1
An, H.X.2
Cho, Y.J.3
Hantschmann, P.4
Bender, H.G.5
Beckmann, M.W.6
-
36
-
-
0025184539
-
K-ras activation in neoplasms of the human female reproductive tract
-
Enomoto, T.; Inoue, M.; Perantoni, A. O.; Terakawa, N.; Tanizawa, O.; Rice, J. M. K-ras activation in neoplasms of the human female reproductive tract. Cancer Res. 1990, 50, 6139-6145.
-
(1990)
Cancer Res.
, vol.50
, pp. 6139-6145
-
-
Enomoto, T.1
Inoue, M.2
Perantoni, A.O.3
Terakawa, N.4
Tanizawa, O.5
Rice, J.M.6
-
37
-
-
1342279497
-
Transcriptional activation of H- and N-ras oncogenes in human cervical cancer
-
Mammas, I. N.; Zafiropoulos, A.; Koumantakis, E.; Sifakis, S.; Spandidos, D. A. Transcriptional activation of H- and N-ras oncogenes in human cervical cancer. Gynecol. Oncol. 2004, 92, 941-948.
-
(2004)
Gynecol. Oncol.
, vol.92
, pp. 941-948
-
-
Mammas, I.N.1
Zafiropoulos, A.2
Koumantakis, E.3
Sifakis, S.4
Spandidos, D.A.5
-
38
-
-
0035240617
-
Farnesyl transferase inhibitors: A novel targeted tnerapy for cancer
-
Johnston, S. R. Farnesyl transferase inhibitors: a novel targeted tnerapy for cancer. Lancet Oncol. 2001, 2, 18-26.
-
(2001)
Lancet Oncol.
, vol.2
, pp. 18-26
-
-
Johnston, S.R.1
-
39
-
-
16544382706
-
Dose-ranging pharmacodynamic study of tipifarnib (R115777) in patients with relapsed and refractory hematologic malignancies
-
Zimmerman, T. M.; Harlin, H.; Odenike, O. M.; Berk, S.; Sprague, E.; Karrison, T.; Stock, W.; Larson, R. A.; Ratain, M. J.; Gajewski, T. F. Dose-ranging pharmacodynamic study of tipifarnib (R115777) in patients with relapsed and refractory hematologic malignancies. J. Clin. Oncol. 2004, 22, 4816-4822.
-
(2004)
J. Clin. Oncol.
, vol.22
, pp. 4816-4822
-
-
Zimmerman, T.M.1
Harlin, H.2
Odenike, O.M.3
Berk, S.4
Sprague, E.5
Karrison, T.6
Stock, W.7
Larson, R.A.8
Ratain, M.J.9
Gajewski, T.F.10
-
40
-
-
0035383789
-
Clinical and biologic activity of the farnesyltransferase inhibitor R115777 in adults with refractory and relapsed acute leukemias: A phase 1 clinical-laboratory correlative trial
-
Karp, J. E.; Lancet, J. E.; Kaufmann, S. H.; End, D. W.; Wright, J. J.; Bol, K.; Horak, I.; Tidwell, M. L.; Liesveld, J.; Kottke, T. J.; Ange, D.; Buddharaju, L.; Gojo, I.; Highsmith, W. E.; Belly, R. T.; Hohl, R. J.; Rybak, M. E.; Thibault, A.; Rosenblatt, J. Clinical and biologic activity of the farnesyltransferase inhibitor R115777 in adults with refractory and relapsed acute leukemias: a phase 1 clinical-laboratory correlative trial. Blood 2001, 97, 3361-3369.
-
(2001)
Blood
, vol.97
, pp. 3361-3369
-
-
Karp, J.E.1
Lancet, J.E.2
Kaufmann, S.H.3
End, D.W.4
Wright, J.J.5
Bol, K.6
Horak, I.7
Tidwell, M.L.8
Liesveld, J.9
Kottke, T.J.10
Ange, D.11
Buddharaju, L.12
Gojo, I.13
Highsmith, W.E.14
Belly, R.T.15
Hohl, R.J.16
Rybak, M.E.17
Thibault, A.18
Rosenblatt, J.19
-
41
-
-
5444241523
-
Phase III double-blind placebo-controlled study of farnesyl transferase inhibitor R115777 in patients with refractory advanced colorectal cancer
-
Rao, S.; Cunningham, D.; de Gramont, A.; Scheithauer, W.; Smakal, M.; Humblet, Y.; Kourteva, G.; Iveson, T.; Andre, T.; Dostalova, J.; Illes, A.; Belly, R.; Perez-Ruixo, J. J.; Park, Y. C.; Palmer, P. A. Phase III double-blind placebo-controlled study of farnesyl transferase inhibitor R115777 in patients with refractory advanced colorectal cancer. J. Clin. Oncol. 2004, 22, 3950-3957.
-
(2004)
J. Clin. Oncol.
, vol.22
, pp. 3950-3957
-
-
Rao, S.1
Cunningham, D.2
De Gramont, A.3
Scheithauer, W.4
Smakal, M.5
Humblet, Y.6
Kourteva, G.7
Iveson, T.8
Andre, T.9
Dostalova, J.10
Illes, A.11
Belly, R.12
Perez-Ruixo, J.J.13
Park, Y.C.14
Palmer, P.A.15
-
42
-
-
0034784725
-
Discovery of a novel Raf kinase inhibitor
-
Lyons, J. F.; Wilhelm, S.; Hibner, B.; Bollag, G. Discovery of a novel Raf kinase inhibitor. Endocr. Relat. Cancer 2001, 8, 219-225.
-
(2001)
Endocr. Relat. Cancer
, vol.8
, pp. 219-225
-
-
Lyons, J.F.1
Wilhelm, S.2
Hibner, B.3
Bollag, G.4
-
43
-
-
4944249117
-
BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis
-
Wilhelm, S. M.; Carter, C.; Tang, L.; Wilkie, D.; McNabola, A.; Rong, H.; Chen, C.; Zhang, X.; Vincent, P.; McHugh, M.; Cao, Y.; Shujath, J.; Gawlak, S.; Eveleigh, D.; Rowley, B.; Liu, L.; Adnane, L.; Lynch, M.; Auclair, D.; Taylor, I.; Gedrich, R.; Voznesensky, A.; Riedl, B.; Post, L. E.; Bollag, G.; Trail, P. A. BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis. Cancer Res. 2004, 64, 7099-7109.
-
(2004)
Cancer Res.
, vol.64
, pp. 7099-7109
-
-
Wilhelm, S.M.1
Carter, C.2
Tang, L.3
Wilkie, D.4
McNabola, A.5
Rong, H.6
Chen, C.7
Zhang, X.8
Vincent, P.9
McHugh, M.10
Cao, Y.11
Shujath, J.12
Gawlak, S.13
Eveleigh, D.14
Rowley, B.15
Liu, L.16
Adnane, L.17
Lynch, M.18
Auclair, D.19
Taylor, I.20
Gedrich, R.21
Voznesensky, A.22
Riedl, B.23
Post, L.E.24
Bollag, G.25
Trail, P.A.26
more..
-
44
-
-
20044382799
-
Phase I clinical and pharmacokinetic study of the Novel Raf kinase and vascular endothelial growth factor receptor inhibitor BAY 43-9006 in patients with advanced refractory solid tumors
-
Strumberg, D.; Richly, H.; Hilger, R. A.; Schleucher, N.; Korfee, S.; Tewes, M.; Faghih, M.; Brendel, E.; Voliotis, D.; Haase, C. G.; Schwartz, B.; Awada, A.; Voigtmann, R.; Scheulen, M. E.; Seeber, S. Phase I clinical and pharmacokinetic study of the Novel Raf kinase and vascular endothelial growth factor receptor inhibitor BAY 43-9006 in patients with advanced refractory solid tumors. J. Clin. Oncol. 2005, 23, 965-972.
-
(2005)
J. Clin. Oncol.
, vol.23
, pp. 965-972
-
-
Strumberg, D.1
Richly, H.2
Hilger, R.A.3
Schleucher, N.4
Korfee, S.5
Tewes, M.6
Faghih, M.7
Brendel, E.8
Voliotis, D.9
Haase, C.G.10
Schwartz, B.11
Awada, A.12
Voigtmann, R.13
Scheulen, M.E.14
Seeber, S.15
-
45
-
-
10044232731
-
Prognostic significance of p53, Her-2, and EGFR overexpression in borderline and epithelial ovarian cancer
-
Nielsen, J. S.; Jakobsen, E.; Holund, B.; Bertelsen, K.; Jakobsen, A. Prognostic significance of p53, Her-2, and EGFR overexpression in borderline and epithelial ovarian cancer. Int. J. Gynecol. Cancer 2004, 14, 1086-1096.
-
(2004)
Int. J. Gynecol. Cancer
, vol.14
, pp. 1086-1096
-
-
Nielsen, J.S.1
Jakobsen, E.2
Holund, B.3
Bertelsen, K.4
Jakobsen, A.5
-
46
-
-
0037440042
-
Evaluation of monoclonal humanized anti-HER2 antibody, trastuzumab, in patients with recurrent or refractory ovarian or primary peritoneal carcinoma with overexpression of HER2: A phase II trial of the Gynecologic Oncology Group
-
Bookman, M. A.; Darcy, K. M.; Clarke-Pearson, D.; Boothby, R. A.; Horowitz, I. R. Evaluation of monoclonal humanized anti-HER2 antibody, trastuzumab, in patients with recurrent or refractory ovarian or primary peritoneal carcinoma with overexpression of HER2: a phase II trial of the Gynecologic Oncology Group. J. Clin. Oncol. 2003, 21, 283-290.
-
(2003)
J. Clin. Oncol.
, vol.21
, pp. 283-290
-
-
Bookman, M.A.1
Darcy, K.M.2
Clarke-Pearson, D.3
Boothby, R.A.4
Horowitz, I.R.5
-
47
-
-
0026231774
-
Expression of c-myc, epidermal growth factor receptor and c-erbB-2 in human endometrial carcinoma and cervical adenocarcinoma
-
Sato, S.; Ito, K.; Ozawa, N.; Yajima, A.; Sasano, H. Expression of c-myc, epidermal growth factor receptor and c-erbB-2 in human endometrial carcinoma and cervical adenocarcinoma. Tohoku J. Exp. Med. 1991, 165, 137-145.
-
(1991)
Tohoku J. Exp. Med.
, vol.165
, pp. 137-145
-
-
Sato, S.1
Ito, K.2
Ozawa, N.3
Yajima, A.4
Sasano, H.5
-
48
-
-
0030045523
-
Prognostic value of immunohistochemically detected HER-2/neu oncoprotein in endometrial cancer
-
Kohlberger, P.; Loesch, A.; Koelbl, H.; Breitenecker, G.; Kainz, C.; Gitsch, G. Prognostic value of immunohistochemically detected HER-2/neu oncoprotein in endometrial cancer. Cancer Lett. 1996, 98, 151-155.
-
(1996)
Cancer Lett.
, vol.98
, pp. 151-155
-
-
Kohlberger, P.1
Loesch, A.2
Koelbl, H.3
Breitenecker, G.4
Kainz, C.5
Gitsch, G.6
-
49
-
-
0027954973
-
Prognostic utility of epidermal growth factor receptor overexpression in endometrial adenocarcinoma
-
Khalifa, M. A.; Abdoh, A. A.; Mannel, R. S.; Haraway, S. D.; Walker, J. L.; Min, K. W. Prognostic utility of epidermal growth factor receptor overexpression in endometrial adenocarcinoma. Cancer 1994, 73, 370-376.
-
(1994)
Cancer
, vol.73
, pp. 370-376
-
-
Khalifa, M.A.1
Abdoh, A.A.2
Mannel, R.S.3
Haraway, S.D.4
Walker, J.L.5
Min, K.W.6
-
50
-
-
0009483341
-
Expression of epidermal growth factor receptor in carcinoma of the cervix
-
Kim, J. W.; Kim, Y. T.; Kim, D. K.; Song, C. H.; Lee, J. W. Expression of epidermal growth factor receptor in carcinoma of the cervix. Gynecol. Oncol. 1996, 60, 283-287.
-
(1996)
Gynecol. Oncol.
, vol.60
, pp. 283-287
-
-
Kim, J.W.1
Kim, Y.T.2
Kim, D.K.3
Song, C.H.4
Lee, J.W.5
-
51
-
-
0029954643
-
Evaluation of the prognostic significance of cathepsin D, epidermal growth factor receptor, and c-erbB-2 in early cervical squamous cell carcinoma. An immunohistochemical study
-
Kristensen, G. B.; Holm, R.; Abeler, V. M.; Trope, C. G. Evaluation of the prognostic significance of cathepsin D, epidermal growth factor receptor, and c-erbB-2 in early cervical squamous cell carcinoma. An immunohistochemical study. Cancer 1996, 78, 433-440.
-
(1996)
Cancer
, vol.78
, pp. 433-440
-
-
Kristensen, G.B.1
Holm, R.2
Abeler, V.M.3
Trope, C.G.4
-
52
-
-
0030851154
-
Quantitative determination of the epidermal growth factor receptor in cervical cancer and normal cervical epithelium by 2-color flow cytometry: Evidence for down-regulation in cervical cancer
-
Kimmig, R.; Pfeiffer, D.; Landsmann, H.; Hepp, H. Quantitative determination of the epidermal growth factor receptor in cervical cancer and normal cervical epithelium by 2-color flow cytometry: evidence for down-regulation in cervical cancer. Int. J. Cancer 1997, 74, 365-373.
-
(1997)
Int. J. Cancer
, vol.74
, pp. 365-373
-
-
Kimmig, R.1
Pfeiffer, D.2
Landsmann, H.3
Hepp, H.4
-
53
-
-
0033042754
-
Oncogene alterations in carcinomas of the uterine cervix: Overexpression of the epidermal growth factor receptor is associated with poor prognosis
-
Kersemaekers, A. M.; Fleuren, G. J.; Kenter, G. G.; Van den Broek, L. J.; Uljee, S. M.; Hermans, J.; Van de Vijver, M. J. Oncogene alterations in carcinomas of the uterine cervix: overexpression of the epidermal growth factor receptor is associated with poor prognosis. Clin. Cancer Res. 1999, 5, 577-586.
-
(1999)
Clin. Cancer Res.
, vol.5
, pp. 577-586
-
-
Kersemaekers, A.M.1
Fleuren, G.J.2
Kenter, G.G.3
Van Den Broek, L.J.4
Uljee, S.M.5
Hermans, J.6
Van De Vijver, M.J.7
-
54
-
-
0025073536
-
Expression of epidermal growth factor receptor and HER-2/neu in normal and neoplastic cervix, vulva, and vagina
-
Berchuck, A.; Rodriguez, G.; Kamel, A.; Soper, J. T.; Clarke-Pearson, D. L.; Bast, R. C., Jr. Expression of epidermal growth factor receptor and HER-2/neu in normal and neoplastic cervix, vulva, and vagina. Obstet. Gynecol. 1990, 76, 381-387.
-
(1990)
Obstet. Gynecol.
, vol.76
, pp. 381-387
-
-
Berchuck, A.1
Rodriguez, G.2
Kamel, A.3
Soper, J.T.4
Clarke-Pearson, D.L.5
Bast Jr., R.C.6
-
55
-
-
0347511895
-
Overexpression/amplification of HER-2/neu is uncommon in invasive carcinoma of the uterine cervix
-
Rosty, C.; Couturier, J.; Vincent-Salomon, A.; Genin, P.; Freneaux, P.; Sigal-Zafrani, B.; Sastre-Garau, X. Overexpression/amplification of HER-2/neu is uncommon in invasive carcinoma of the uterine cervix. Int. J. Gynecol. Pathol. 2004, 23, 13-17.
-
(2004)
Int. J. Gynecol. Pathol.
, vol.23
, pp. 13-17
-
-
Rosty, C.1
Couturier, J.2
Vincent-Salomon, A.3
Genin, P.4
Freneaux, P.5
Sigal-Zafrani, B.6
Sastre-Garau, X.7
-
56
-
-
4143076078
-
Targeting the epidermal growth factor receptor
-
El-Rayes, B. F.; LoRusso, P. M. Targeting the epidermal growth factor receptor. Br. J. Cancer 2004, 91, 418-424.
-
(2004)
Br. J. Cancer
, vol.91
, pp. 418-424
-
-
El-Rayes, B.F.1
LoRusso, P.M.2
-
57
-
-
0032851961
-
Nonclinical studies addressing the mechanism of action of trastuzumab (Herceptin)
-
Sliwkowski, M. X.; Lofgren, J. A.; Lewis, G. D.; Hotaling, T. E.; Fendly, B. M.; Fox, J. A. Nonclinical studies addressing the mechanism of action of trastuzumab (Herceptin). Semin. Oncol. 1999, 26, 60-70.
-
(1999)
Semin. Oncol.
, vol.26
, pp. 60-70
-
-
Sliwkowski, M.X.1
Lofgren, J.A.2
Lewis, G.D.3
Hotaling, T.E.4
Fendly, B.M.5
Fox, J.A.6
-
58
-
-
0037149539
-
Tumour biology: Herceptin acts as an anti-angiogenic cocktail
-
Izumi, Y.; Xu, L.; di Tomaso, E.; Fukumura, D.; Jain, R. K. Tumour biology: herceptin acts as an anti-angiogenic cocktail. Nature 2002, 416, 279-280.
-
(2002)
Nature
, vol.416
, pp. 279-280
-
-
Izumi, Y.1
Xu, L.2
Di Tomaso, E.3
Fukumura, D.4
Jain, R.K.5
-
59
-
-
0024337144
-
Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer
-
Slamon, D. J.; Godolphin, W.; Jones, L. A.; Holt, J. A.; Wong, S. G.; Keith, D. E.; Levin, W. J.; Stuart, S. G.; Udove, J.; Ullrich, A.; et al. Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer. Science 1989, 244, 707-712.
-
(1989)
Science
, vol.244
, pp. 707-712
-
-
Slamon, D.J.1
Godolphin, W.2
Jones, L.A.3
Holt, J.A.4
Wong, S.G.5
Keith, D.E.6
Levin, W.J.7
Stuart, S.G.8
Udove, J.9
Ullrich, A.10
-
60
-
-
0035869407
-
Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2
-
Slamon, D. J.; Leyland-Jones, B.; Shak, S.; Fuchs, H.; Paton, V.; Bajamonde, A.; Fleming, T.; Eiermann, W.; Wolter, J.; Pegram, M.; Baselga, J.; Norton, L. Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2. N. Engl. J. Med. 2001, 344, 783-792.
-
(2001)
N. Engl. J. Med.
, vol.344
, pp. 783-792
-
-
Slamon, D.J.1
Leyland-Jones, B.2
Shak, S.3
Fuchs, H.4
Paton, V.5
Bajamonde, A.6
Fleming, T.7
Eiermann, W.8
Wolter, J.9
Pegram, M.10
Baselga, J.11
Norton, L.12
-
61
-
-
11144357922
-
Cardiac safety of trastuzumab in combination with epirubicin and cyclophosphamide in women with metastatic breast cancer: Results of a phase I trial
-
Untch, M.; Eidtmann, H.; du Bois, A.; Meerpohl, H. G.; Thomssen, C.; Ebert, A.; Harbeck, N.; Jackisch, C.; Heilman, V.; Emons, G.; Wallwiener, D.; Wiese, W.; Blohmer, J. U.; Hoffken, K.; Kuhn, W.; Reichardt, P.; Muscholl, M.; Pauschinger, M.; Langer, B.; Luck, H. J. Cardiac safety of trastuzumab in combination with epirubicin and cyclophosphamide in women with metastatic breast cancer: results of a phase I trial. Eur. J. Cancer 2004, 40, 988-997.
-
(2004)
Eur. J. Cancer
, vol.40
, pp. 988-997
-
-
Untch, M.1
Eidtmann, H.2
Du Bois, A.3
Meerpohl, H.G.4
Thomssen, C.5
Ebert, A.6
Harbeck, N.7
Jackisch, C.8
Heilman, V.9
Emons, G.10
Wallwiener, D.11
Wiese, W.12
Blohmer, J.U.13
Hoffken, K.14
Kuhn, W.15
Reichardt, P.16
Muscholl, M.17
Pauschinger, M.18
Langer, B.19
Luck, H.J.20
more..
-
62
-
-
2442645508
-
Phase II trial of trastuzumab followed by weekly paclitaxel/carboplatin as first-line treatment for patients with metastatic breast cancer
-
Burris, H., 3rd; Yardley, D.; Jones, S.; Houston, G.; Broome, C.; Thompson, D.; Greco, F. A.; White, M.; Hainsworth, J. Phase II trial of trastuzumab followed by weekly paclitaxel/carboplatin as first-line treatment for patients with metastatic breast cancer. J. Clin. Oncol. 2004, 22, 1621-1629.
-
(2004)
J. Clin. Oncol.
, vol.22
, pp. 1621-1629
-
-
Burris III, H.1
Yardley, D.2
Jones, S.3
Houston, G.4
Broome, C.5
Thompson, D.6
Greco, F.A.7
White, M.8
Hainsworth, J.9
-
63
-
-
0037434791
-
Structure of the extracellular region of HER2 alone and in complex with the Herceptin Fab
-
Cho, H. S.; Mason, K.; Ramyar, K. X.; Stanley, A. M.; Gabelli, S. B.; Denney, D. W., Jr.; Leahy, D. J. Structure of the extracellular region of HER2 alone and in complex with the Herceptin Fab. Nature 2003, 421, 756-760.
-
(2003)
Nature
, vol.421
, pp. 756-760
-
-
Cho, H.S.1
Mason, K.2
Ramyar, K.X.3
Stanley, A.M.4
Gabelli, S.B.5
Denney Jr., D.W.6
Leahy, D.J.7
-
64
-
-
20244378677
-
Phase I clinical study of pertuzumab, a novel HER dimerization inhibitor, in patients with advanced cancer
-
Agus, D. B.; Gordon, M. S.; Taylor, C.; Natale, R. B.; Karlan, B.; Mendelson, D. S.; Press, M. F.; Allison, D. E.; Sliwkowski, M. X.; Lieberman, G.; Kelsey, S. M.; Fyfe, G. Phase I clinical study of pertuzumab, a novel HER dimerization inhibitor, in patients with advanced cancer. J. Clin. Oncol. 2005, 23, 2534-2543.
-
(2005)
J. Clin. Oncol.
, vol.23
, pp. 2534-2543
-
-
Agus, D.B.1
Gordon, M.S.2
Taylor, C.3
Natale, R.B.4
Karlan, B.5
Mendelson, D.S.6
Press, M.F.7
Allison, D.E.8
Sliwkowski, M.X.9
Lieberman, G.10
Kelsey, S.M.11
Fyfe, G.12
-
65
-
-
0034779291
-
The EGFR as a target for anticancer therapy - Focus on cetuximab
-
Baselga, J. The EGFR as a target for anticancer therapy - focus on cetuximab. Eur. J. Cancer 2001, 37(Suppl 4), S16-22.
-
(2001)
Eur. J. Cancer
, vol.37
, Issue.4 SUPPL.
-
-
Baselga, J.1
-
66
-
-
2142641698
-
Phase II trial of cetuximab in patients with refractory colorectal cancer that expresses the epidermal growth factor receptor
-
Saltz, L. B.; Meropol, N. J.; Loehrer, P. J., Sr.; Needle, M. N.; Kopit, J.; Mayer, R. J. Phase II trial of cetuximab in patients with refractory colorectal cancer that expresses the epidermal growth factor receptor. J. Clin. Oncol. 2004, 22, 1201-1208.
-
(2004)
J. Clin. Oncol.
, vol.22
, pp. 1201-1208
-
-
Saltz, L.B.1
Meropol, N.J.2
Loehrer Sr., P.J.3
Needle, M.N.4
Kopit, J.5
Mayer, R.J.6
-
67
-
-
0035117355
-
Development of ABX-EGF, a fully human anti-EGF receptor monoclonal antibody, for cancer therapy
-
Yang, X. D.; Jia, X. C.; Corvalan, J. R.; Wang, P.; Davis, C. G. Development of ABX-EGF, a fully human anti-EGF receptor monoclonal antibody, for cancer therapy. Crit. Rev. Oncol. Hematol. 2001, 38, 17-23.
-
(2001)
Crit. Rev. Oncol. Hematol.
, vol.38
, pp. 17-23
-
-
Yang, X.D.1
Jia, X.C.2
Corvalan, J.R.3
Wang, P.4
Davis, C.G.5
-
68
-
-
4143050397
-
Safety, pharmacokinetics, and activity of ABX-EGF, a fully human anti-epidermal growth factor receptor monoclonal antibody in patients with metastatic renal cell cancer
-
Rowinsky, E. K.; Schwartz, G. H.; Gollob, J. A.; Thompson, J. A.; Vogelzang, N. J.; Figlin, R.; Bukowski, R.; Haas, N.; Lockbaum, P.; Li, Y. P.; Arends, R.; Foon, K. A.; Schwab, G.; Dutcher, J. Safety, pharmacokinetics, and activity of ABX-EGF, a fully human anti-epidermal growth factor receptor monoclonal antibody in patients with metastatic renal cell cancer. J. Clin. Oncol. 2004, 22, 3003-3015.
-
(2004)
J. Clin. Oncol.
, vol.22
, pp. 3003-3015
-
-
Rowinsky, E.K.1
Schwartz, G.H.2
Gollob, J.A.3
Thompson, J.A.4
Vogelzang, N.J.5
Figlin, R.6
Bukowski, R.7
Haas, N.8
Lockbaum, P.9
Li, Y.P.10
Arends, R.11
Foon, K.A.12
Schwab, G.13
Dutcher, J.14
-
69
-
-
0037439578
-
Anticancer drugs of tomorrow: Apoptotic pathways as targets for drug design
-
Los, M.; Burek, C. J.; Stroh, C.; Benedyk, K.; Hug, H.; Mackiewicz, A. Anticancer drugs of tomorrow: apoptotic pathways as targets for drug design. Drug Discov. Today 2003, 8, 67-77.
-
(2003)
Drug Discov. Today
, vol.8
, pp. 67-77
-
-
Los, M.1
Burek, C.J.2
Stroh, C.3
Benedyk, K.4
Hug, H.5
Mackiewicz, A.6
-
70
-
-
2342624080
-
EGFR mutations in lung cancer: Correlation with clinical response to gefitinib therapy
-
Paez, J. G.; Janne, P. A.; Lee, J. C.; Tracy, S.; Greulich, H.; Gabriel, S.; Herman, P.; Kaye, F. J.; Lindeman, N.; Boggon, T. J.; Naoki, K.; Sasaki, H.; Fujii, Y.; Eck, M. J.; Sellers, W. R.; Johnson, B. E.; Meyerson, M. EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy. Science 2004, 304, 1497-1500.
-
(2004)
Science
, vol.304
, pp. 1497-1500
-
-
Paez, J.G.1
Janne, P.A.2
Lee, J.C.3
Tracy, S.4
Greulich, H.5
Gabriel, S.6
Herman, P.7
Kaye, F.J.8
Lindeman, N.9
Boggon, T.J.10
Naoki, K.11
Sasaki, H.12
Fujii, Y.13
Eck, M.J.14
Sellers, W.R.15
Johnson, B.E.16
Meyerson, M.17
-
71
-
-
33646221982
-
Tyrosine kinase inhibitors in endometrial cancer
-
Leslie, K. K.; Laidler, L.; Albitar, L.; Davies, S.; Holmes, A.; Nguyen, T.; Bolnick, J.; Dai, D. Tyrosine kinase inhibitors in endometrial cancer. Int. J. Gynecol. Cancer 2005, 15, 409-411.
-
(2005)
Int. J. Gynecol. Cancer
, vol.15
, pp. 409-411
-
-
Leslie, K.K.1
Laidler, L.2
Albitar, L.3
Davies, S.4
Holmes, A.5
Nguyen, T.6
Bolnick, J.7
Dai, D.8
-
72
-
-
8444221534
-
Administration of CI-1033, an irreversible pan-erbB tyrosine kinase inhibitor, is feasible on a 7-day on, 7-day off schedule: A phase I pharmacokinetic and food effect study
-
Calvo, E.; Tolcher, A. W.; Hammond, L. A.; Patnaik, A.; de Bono, J. S.; Eiseman, I. A.; Olson, S. C.; Lenehan, P. F.; McCreery, H.; Lorusso, P.; Rowinsky, E. K. Administration of CI-1033, an irreversible pan-erbB tyrosine kinase inhibitor, is feasible on a 7-day on, 7-day off schedule: a phase I pharmacokinetic and food effect study. Clin. Cancer Res. 2004, 10, 7112-7120.
-
(2004)
Clin. Cancer Res.
, vol.10
, pp. 7112-7120
-
-
Calvo, E.1
Tolcher, A.W.2
Hammond, L.A.3
Patnaik, A.4
De Bono, J.S.5
Eiseman, I.A.6
Olson, S.C.7
Lenehan, P.F.8
McCreery, H.9
Lorusso, P.10
Rowinsky, E.K.11
-
73
-
-
0035476866
-
The characterization of novel, dual ErbB-2/EGFR, tyrosine kinase inhibitors: Potential therapy for cancer
-
Rusnak, D. W.; Affleck, K.; Cockerill, S. G.; Stubberfield, C.; Harris, R.; Page, M.; Smith, K. J.; Guntrip, S. B.; Carter, M. C.; Shaw, R. J.; Jowett, A.; Stables, J.; Topley, P.; Wood, E. R.; Brignola, P. S.; Kadwell, S. H.; Reep, B. R.; Mullin, R. J.; Alligood, K. J.; Keith, B. R.; Crosby, R. M.; Murray, D. M.; Knight, W. B.; Gilmer, T. M.; Lackey, K. The characterization of novel, dual ErbB-2/EGFR, tyrosine kinase inhibitors: potential therapy for cancer. Cancer Res. 2001, 61, 7196-7203.
-
(2001)
Cancer Res.
, vol.61
, pp. 7196-7203
-
-
Rusnak, D.W.1
Affleck, K.2
Cockerill, S.G.3
Stubberfield, C.4
Harris, R.5
Page, M.6
Smith, K.J.7
Guntrip, S.B.8
Carter, M.C.9
Shaw, R.J.10
Jowett, A.11
Stables, J.12
Topley, P.13
Wood, E.R.14
Brignola, P.S.15
Kadwell, S.H.16
Reep, B.R.17
Mullin, R.J.18
Alligood, K.J.19
Keith, B.R.20
Crosby, R.M.21
Murray, D.M.22
Knight, W.B.23
Gilmer, T.M.24
Lackey, K.25
more..
-
74
-
-
0035553174
-
The effects of the novel, reversible epidermal growth factor receptor/ErbB-2 tyrosine kinase inhibitor, GW2016, on the growth of human normal and tumor-derived cell lines in vitro and in vivo
-
Rusnak, D. W.; Lackey, K.; Affleck, K.; Wood, E. R.; Alligood, K. J.; Rhodes, N.; Keith, B. R.; Murray, D. M.; Knight, W. B.; Mullin, R. J.; Gilmer, T. M. The effects of the novel, reversible epidermal growth factor receptor/ErbB-2 tyrosine kinase inhibitor, GW2016, on the growth of human normal and tumor-derived cell lines in vitro and in vivo. Mol. Cancer Ther. 2001, 1, 85-94.
-
(2001)
Mol. Cancer Ther.
, vol.1
, pp. 85-94
-
-
Rusnak, D.W.1
Lackey, K.2
Affleck, K.3
Wood, E.R.4
Alligood, K.J.5
Rhodes, N.6
Keith, B.R.7
Murray, D.M.8
Knight, W.B.9
Mullin, R.J.10
Gilmer, T.M.11
-
75
-
-
4644289313
-
A unique structure for epidermal growth factor receptor bound to GW572016 (Lapatinib): Relationships among protein conformation, inhibitor off-rate, and receptor activity in tumor cells
-
Wood, E. R.; Truesdale, A. T.; McDonald, O. B.; Yuan, D.; Hassell, A.; Dickerson, S. H.; Ellis, B.; Pennisi, C.; Horne, E.; Lackey, K.; Alligood, K. J.; Rusnak, D. W.; Gilmer, T. M.; Shewchuk, L. A unique structure for epidermal growth factor receptor bound to GW572016 (Lapatinib): relationships among protein conformation, inhibitor off-rate, and receptor activity in tumor cells. Cancer Res. 2004, 64, 6652-6659.
-
(2004)
Cancer Res.
, vol.64
, pp. 6652-6659
-
-
Wood, E.R.1
Truesdale, A.T.2
McDonald, O.B.3
Yuan, D.4
Hassell, A.5
Dickerson, S.H.6
Ellis, B.7
Pennisi, C.8
Horne, E.9
Lackey, K.10
Alligood, K.J.11
Rusnak, D.W.12
Gilmer, T.M.13
Shewchuk, L.14
-
76
-
-
0037254419
-
Imatinib alone and in combination for chronic myeloid leukemia
-
Druker, B. J. Imatinib alone and in combination for chronic myeloid leukemia. Semin. Hematol. 2003, 40, 50-58.
-
(2003)
Semin. Hematol.
, vol.40
, pp. 50-58
-
-
Druker, B.J.1
-
77
-
-
10744233716
-
Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia
-
O'Brien, S. G.; Guilhot, F.; Larson, R. A.; Gathmann, I.; Baccarani, M.; Cervantes, F.; Cornelissen, J. J.; Fischer, T.; Hochhaus, A.; Hughes, T.; Lechner, K.; Nielsen, J. L.; Rousselot, P.; Reiffers, J.; Saglio, G.; Shepherd, J.; Simonsson, B.; Gratwohl, A.; Goldman, J. M.; Kantarjian, H.; Taylor, K.; Verhoef, G.; Bolton, A. E.; Capdeville, R.; Druker, B. J. Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia. N. Engl. J. Med. 2003, 348, 994-1004.
-
(2003)
N. Engl. J. Med.
, vol.348
, pp. 994-1004
-
-
O'Brien, S.G.1
Guilhot, F.2
Larson, R.A.3
Gathmann, I.4
Baccarani, M.5
Cervantes, F.6
Cornelissen, J.J.7
Fischer, T.8
Hochhaus, A.9
Hughes, T.10
Lechner, K.11
Nielsen, J.L.12
Rousselot, P.13
Reiffers, J.14
Saglio, G.15
Shepherd, J.16
Simonsson, B.17
Gratwohl, A.18
Goldman, J.M.19
Kantarjian, H.20
Taylor, K.21
Verhoef, G.22
Bolton, A.E.23
Capdeville, R.24
Druker, B.J.25
more..
-
78
-
-
0141528828
-
Chronic myeloid leukemia - Advances in biology and new approaches to treatment
-
Goldman, J. M.; Melo, J. V. Chronic myeloid leukemia - advances in biology and new approaches to treatment. N. Engl. J. Med. 2003, 349, 1451-1464.
-
(2003)
N. Engl. J. Med.
, vol.349
, pp. 1451-1464
-
-
Goldman, J.M.1
Melo, J.V.2
-
79
-
-
0036795899
-
Approval summary: Imatinib mesylate in the treatment of metastatic and/or unresectable malignant gastrointestinal stromal tumors
-
Dagher, R.; Cohen, M.; Williams, G.; Rothmann, M.; Gobburu, J.; Robbie, G.; Rahman, A.; Chen, G.; Staten, A.; Griebel, D.; Pazdur, R. Approval summary: imatinib mesylate in the treatment of metastatic and/or unresectable malignant gastrointestinal stromal tumors. Clin. Cancer Res. 2002, 8, 3034-3038.
-
(2002)
Clin. Cancer Res.
, vol.8
, pp. 3034-3038
-
-
Dagher, R.1
Cohen, M.2
Williams, G.3
Rothmann, M.4
Gobburu, J.5
Robbie, G.6
Rahman, A.7
Chen, G.8
Staten, A.9
Griebel, D.10
Pazdur, R.11
-
80
-
-
0041570242
-
Expression of c-ABL, c-KIT, and platelet-derived growth factor receptor-beta in ovarian serous carcinoma and normal ovarian surface epithelium
-
Schmandt, R. E.; Broaddus, R.; Lu, K. H.; Shvartsman, H.; Thornton, A.; Malpica, A.; Sun, C.; Bodurka, D. C.; Gershenson, D. M. Expression of c-ABL, c-KIT, and platelet-derived growth factor receptor-beta in ovarian serous carcinoma and normal ovarian surface epithelium. Cancer 2003, 98, 758-764.
-
(2003)
Cancer
, vol.98
, pp. 758-764
-
-
Schmandt, R.E.1
Broaddus, R.2
Lu, K.H.3
Shvartsman, H.4
Thornton, A.5
Malpica, A.6
Sun, C.7
Bodurka, D.C.8
Gershenson, D.M.9
-
81
-
-
4644293414
-
Expression of imatinib mesylate-targeted kinases in endometrial carcinoma
-
Slomovitz, B. M.; Broaddus, R. R.; Schmandt, R.; Wu, W.; Oh, J. C.; Ramondetta, L. M.; Burke, T. W.; Gershenson, D. M.; Lu, K. H. Expression of imatinib mesylate-targeted kinases in endometrial carcinoma. Gynecol. Oncol. 2004, 95, 32-36.
-
(2004)
Gynecol. Oncol.
, vol.95
, pp. 32-36
-
-
Slomovitz, B.M.1
Broaddus, R.R.2
Schmandt, R.3
Wu, W.4
Oh, J.C.5
Ramondetta, L.M.6
Burke, T.W.7
Gershenson, D.M.8
Lu, K.H.9
-
82
-
-
0029012625
-
HER-2/neu-targeting cancer therapy via adenovirus-mediated E1A delivery in an animal model
-
Zhang, Y.; Yu, D.; Xia, W.; Hung, M. C. HER-2/neu-targeting cancer therapy via adenovirus-mediated E1A delivery in an animal model. Oncogene 1995, 10, 1947-1954.
-
(1995)
Oncogene
, vol.10
, pp. 1947-1954
-
-
Zhang, Y.1
Yu, D.2
Xia, W.3
Hung, M.C.4
-
83
-
-
2442484655
-
A multicenter Phase I gene therapy clinical trial involving intraperitoneal administration of E1A-lipid complex in patients with recurrent epithelial ovarian cancer overexpressing HER-2/neu oncogene
-
Madhusudan, S.; Tamir, A.; Bates, N.; Flanagan, E.; Gore, M. E.; Barton, D. P.; Harper, P.; Seckl, M.; Thomas, H.; Lemoine, N. R.; Charnock, M.; Habib, N. A.; Lechler, R.; Nicholls, J.; Pignatelli, M.; Ganesan, T. S. A multicenter Phase I gene therapy clinical trial involving intraperitoneal administration of E1A-lipid complex in patients with recurrent epithelial ovarian cancer overexpressing HER-2/neu oncogene. Clin. Cancer Res. 2004, 10, 2986-2996.
-
(2004)
Clin. Cancer Res.
, vol.10
, pp. 2986-2996
-
-
Madhusudan, S.1
Tamir, A.2
Bates, N.3
Flanagan, E.4
Gore, M.E.5
Barton, D.P.6
Harper, P.7
Seckl, M.8
Thomas, H.9
Lemoine, N.R.10
Charnock, M.11
Habib, N.A.12
Lechler, R.13
Nicholls, J.14
Pignatelli, M.15
Ganesan, T.S.16
-
84
-
-
0031768405
-
Safety study and characterization of E1A-liposome complex gene-delivery protocol in an ovarian cancer model
-
Xing, X.; Zhang, S.; Chang, J. Y.; Tucker, S. D.; Chen, H.; Huang, L.;Hung, M. C. Safety study and characterization of E1A-liposome complex gene-delivery protocol in an ovarian cancer model. Gene Ther. 1998, 5, 1538-1544.
-
(1998)
Gene Ther.
, vol.5
, pp. 1538-1544
-
-
Xing, X.1
Zhang, S.2
Chang, J.Y.3
Tucker, S.D.4
Chen, H.5
Huang, L.6
Hung, M.C.7
-
85
-
-
0034722888
-
The rapamycin-sensitive signal transduction pathway as a target for cancer therapy
-
Hidalgo, M.; Rowinsky, E. K. The rapamycin-sensitive signal transduction pathway as a target for cancer therapy. Oncogene 2000, 19, 6680-6686.
-
(2000)
Oncogene
, vol.19
, pp. 6680-6686
-
-
Hidalgo, M.1
Rowinsky, E.K.2
-
86
-
-
0030936323
-
PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer
-
Li, J.; Yen, C.; Liaw, D.; Podsypanina, K.; Bose, S.; Wang, S. I.; Puc, J.; Miliaresis, C.; Rodgers, L.; McCombie, R.; Bigner, S. H.; Giovanella, B. C.; Ittmann, M.; Tycko, B.; Hibshoosh, H.; Wigler, M. H.; Parsons, R. PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. Science 1997, 275, 1943-1947.
-
(1997)
Science
, vol.275
, pp. 1943-1947
-
-
Li, J.1
Yen, C.2
Liaw, D.3
Podsypanina, K.4
Bose, S.5
Wang, S.I.6
Puc, J.7
Miliaresis, C.8
Rodgers, L.9
McCombie, R.10
Bigner, S.H.11
Giovanella, B.C.12
Ittmann, M.13
Tycko, B.14
Hibshoosh, H.15
Wigler, M.H.16
Parsons, R.17
-
87
-
-
0030761409
-
Mutations in PTEN are frequent in endometrial carcinoma but rare in other common gynecological malignancies
-
Tashiro, H.; Blazes, M. S.; Wu, R.; Cho, K. R.; Bose, S.; Wang, S. I.; Li, J.; Parsons, R.; Ellenson, L. H. Mutations in PTEN are frequent in endometrial carcinoma but rare in other common gynecological malignancies. Cancer Res. 1997, 57, 3935-3940.
-
(1997)
Cancer Res.
, vol.57
, pp. 3935-3940
-
-
Tashiro, H.1
Blazes, M.S.2
Wu, R.3
Cho, K.R.4
Bose, S.5
Wang, S.I.6
Li, J.7
Parsons, R.8
Ellenson, L.H.9
-
88
-
-
0034802755
-
PTEN mutation located only outside exons 5, 6, and 7 is an independent predictor of favorable survival in endometrial carcinomas
-
Minaguchi, T.; Yoshikawa, H.; Oda, K.; Ishino, T.; Yasugi, T.; Onda, T.; Nakagawa, S.; Matsumoto, K.; Kawana, K.; Taketani, Y. PTEN mutation located only outside exons 5, 6, and 7 is an independent predictor of favorable survival in endometrial carcinomas. Clin. Cancer Res. 2001, 7, 2636-2642.
-
(2001)
Clin. Cancer Res.
, vol.7
, pp. 2636-2642
-
-
Minaguchi, T.1
Yoshikawa, H.2
Oda, K.3
Ishino, T.4
Yasugi, T.5
Onda, T.6
Nakagawa, S.7
Matsumoto, K.8
Kawana, K.9
Taketani, Y.10
-
89
-
-
4143111260
-
AKT and mTOR phosphorylation is frequently detected in ovarian cancer and can be targeted to disrupt ovarian tumor cell growth
-
Altomare, D. A.; Wang, H. Q.; Skele, K. L.; De Rienzo, A.; Klein-Szanto, A. J.; Godwin, A. K.; Testa, J. R. AKT and mTOR phosphorylation is frequently detected in ovarian cancer and can be targeted to disrupt ovarian tumor cell growth. Oncogene 2004, 23, 5853-5857.
-
(2004)
Oncogene
, vol.23
, pp. 5853-5857
-
-
Altomare, D.A.1
Wang, H.Q.2
Skele, K.L.3
De Rienzo, A.4
Klein-Szanto, A.J.5
Godwin, A.K.6
Testa, J.R.7
-
90
-
-
18144399578
-
mTOR-targeted therapy of cancer with rapamycin derivatives
-
Vignot, S.; Faivre, S.; Aguirre, D.; Raymond, E. mTOR-targeted therapy of cancer with rapamycin derivatives. Ann. Oncol. 2005, 16, 525-537.
-
(2005)
Ann. Oncol.
, vol.16
, pp. 525-537
-
-
Vignot, S.1
Faivre, S.2
Aguirre, D.3
Raymond, E.4
-
91
-
-
17944368972
-
An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity in Pten+/- mice
-
Podsypanina, K.; Lee, R. T.; Politis, C.; Hennessy, I.; Crane, A.; Puc, J.; Neshat, M.; Wang, H.; Yang, L.; Gibbons, J.; Frost, P.; Dreisbach, V.; Blenis, J.; Gaciong, Z.; Fisher, P.; Sawyers, C.; Hedrick-Ellenson, L.; Parsons, R. An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity in Pten+/- mice. Proc. Natl. Acad. Sci. USA 2001, 98, 10320-10325.
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 10320-10325
-
-
Podsypanina, K.1
Lee, R.T.2
Politis, C.3
Hennessy, I.4
Crane, A.5
Puc, J.6
Neshat, M.7
Wang, H.8
Yang, L.9
Gibbons, J.10
Frost, P.11
Dreisbach, V.12
Blenis, J.13
Gaciong, Z.14
Fisher, P.15
Sawyers, C.16
Hedrick-Ellenson, L.17
Parsons, R.18
-
92
-
-
2942735384
-
Safety and pharmacokinetics of escalated doses of weekly intravenous infusion of CCI-779, a novel mTOR inhibitor, in patients with cancer
-
Raymond, E.; Alexandre, J.; Faivre, S.; Vera, K.; Materman, E.; Boni, J.; Leister, C.; Korth-Bradley, J.; Hanauske, A.; Armand, J. P. Safety and pharmacokinetics of escalated doses of weekly intravenous infusion of CCI-779, a novel mTOR inhibitor, in patients with cancer. J. Clin. Oncol. 2004, 22, 2336-2347.
-
(2004)
J. Clin. Oncol.
, vol.22
, pp. 2336-2347
-
-
Raymond, E.1
Alexandre, J.2
Faivre, S.3
Vera, K.4
Materman, E.5
Boni, J.6
Leister, C.7
Korth-Bradley, J.8
Hanauske, A.9
Armand, J.P.10
-
93
-
-
1542398693
-
Randomized phase II study of multiple dose levels of CCI-779, a novel mammalian target of rapamycin kinase inhibitor, in patients with advanced refractory renal cell carcinoma
-
Atkins, M. B.; Hidalgo, M.; Stadler, W. M.; Logan, T. F.; Dutcher, J. P.; Hudes, G. R.; Park, Y.; Liou, S. H.; Marshall, B.; Boni, J. P.; Dukart, G.; Sherman, M. L. Randomized phase II study of multiple dose levels of CCI-779, a novel mammalian target of rapamycin kinase inhibitor, in patients with advanced refractory renal cell carcinoma. J. Clin. Oncol. 2004, 22, 909-918.
-
(2004)
J. Clin. Oncol.
, vol.22
, pp. 909-918
-
-
Atkins, M.B.1
Hidalgo, M.2
Stadler, W.M.3
Logan, T.F.4
Dutcher, J.P.5
Hudes, G.R.6
Park, Y.7
Liou, S.H.8
Marshall, B.9
Boni, J.P.10
Dukart, G.11
Sherman, M.L.12
-
94
-
-
0030798245
-
Histone acetylation in chromatin structure and transcription
-
Grunstein, M. Histone acetylation in chromatin structure and transcription. Nature 1997, 389, 349-352.
-
(1997)
Nature
, vol.389
, pp. 349-352
-
-
Grunstein, M.1
-
95
-
-
0034617261
-
Histone deacetylases specifically down-regulate p53-dependent gene activation
-
Juan, L. J.; Shia, W. J.; Chen, M. H.; Yang, W. M.; Seto, E.; Lin, Y. S.; Wu, C. W. Histone deacetylases specifically down-regulate p53-dependent gene activation. J. Biol. Chem. 2000, 275, 20436-20443.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 20436-20443
-
-
Juan, L.J.1
Shia, W.J.2
Chen, M.H.3
Yang, W.M.4
Seto, E.5
Lin, Y.S.6
Wu, C.W.7
-
96
-
-
0242637101
-
Direct acetylation of the estrogen receptor alpha hinge region by p300 regulates transactivation and hormone sensitivity
-
Wang, C.; Fu, M.; Angeletti, R. H.; Siconolfi-Baez, L.; Reutens, A. T.; Albanese, C.; Lisanti, M. P.; Katzenellenbogen, B. S.; Kato, S.; Hopp, T.; Fuqua, S. A.; Lopez, G. N.; Kushner, P. J.; Pestell, R. G. Direct acetylation of the estrogen receptor alpha hinge region by p300 regulates transactivation and hormone sensitivity. J. Biol. Chem. 2001, 276, 18375-18383.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 18375-18383
-
-
Wang, C.1
Fu, M.2
Angeletti, R.H.3
Siconolfi-Baez, L.4
Reutens, A.T.5
Albanese, C.6
Lisanti, M.P.7
Katzenellenbogen, B.S.8
Kato, S.9
Hopp, T.10
Fuqua, S.A.11
Lopez, G.N.12
Kushner, P.J.13
Pestell, R.G.14
-
97
-
-
0037127259
-
Methylation of promoter proximal-transcribed sequences of an embryonic globin gene inhibits transcription in primary erythroid cells and promotes formation of a cell type-specific methyl cytosine binding complex
-
Singal, R.; Wang, S. Z.; Sargent, T.; Zhu, S. Z.; Ginder, G. D. Methylation of promoter proximal-transcribed sequences of an embryonic globin gene inhibits transcription in primary erythroid cells and promotes formation of a cell type-specific methyl cytosine binding complex. J. Biol. Chem. 2002, 277, 1897-1905.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 1897-1905
-
-
Singal, R.1
Wang, S.Z.2
Sargent, T.3
Zhu, S.Z.4
Ginder, G.D.5
-
98
-
-
0037068385
-
Methyl-CpG binding proteins and cancer: Are MeCpGs more important than MBDs?
-
Prokhortchouk, E.; Hendrich, B. Methyl-CpG binding proteins and cancer: are MeCpGs more important than MBDs? Oncogene 2002, 21, 5394-5399.
-
(2002)
Oncogene
, vol.21
, pp. 5394-5399
-
-
Prokhortchouk, E.1
Hendrich, B.2
-
99
-
-
0031892481
-
DNA methylation as a target for drug design
-
Bender, C. M.; Zingg, J. M.; Jones, P. A. DNA methylation as a target for drug design. Pharm. Res. 1998, 15, 175-187.
-
(1998)
Pharm. Res.
, vol.15
, pp. 175-187
-
-
Bender, C.M.1
Zingg, J.M.2
Jones, P.A.3
-
100
-
-
0035099160
-
Primary ovarian carcinomas display multiple methylator phenotypes involving known tumor suppressor genes
-
Strathdee, G.; Appleton, K.; Illand, M.; Millan, D. W.; Sargent, J.; Paul, J.; Brown, R. Primary ovarian carcinomas display multiple methylator phenotypes involving known tumor suppressor genes. Am. J. Pathol. 2001, 158, 1121-1127.
-
(2001)
Am. J. Pathol.
, vol.158
, pp. 1121-1127
-
-
Strathdee, G.1
Appleton, K.2
Illand, M.3
Millan, D.W.4
Sargent, J.5
Paul, J.6
Brown, R.7
-
101
-
-
0030796349
-
Induction of caspase-3 protease activity and apoptosis by butyrate and trichostatin A (inhibitors of histone deacetylase): Dependence on protein synthesis and synergy with a mitochondrial/cytochrome c-dependent pathway
-
Medina, V.; Edmonds, B.; Young, G. P.; James, R.; Appleton, S.; Zalewski, P. D. Induction of caspase-3 protease activity and apoptosis by butyrate and trichostatin A (inhibitors of histone deacetylase): dependence on protein synthesis and synergy with a mitochondrial/cytochrome c-dependent pathway. Cancer Res. 1997, 57, 3697-3707.
-
(1997)
Cancer Res.
, vol.57
, pp. 3697-3707
-
-
Medina, V.1
Edmonds, B.2
Young, G.P.3
James, R.4
Appleton, S.5
Zalewski, P.D.6
-
102
-
-
0032539890
-
A class of hybrid polar inducers of transformed cell differentiation inhibits histone deacetylases
-
Richon, V. M.; Emiliani, S.; Verdin, E.; Webb, Y.; Breslow, R.; Rifkind, R. A.; Marks, P. A. A class of hybrid polar inducers of transformed cell differentiation inhibits histone deacetylases. Proc. Natl. Acad. Sci. USA 1998, 95, 3003-3007.
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 3003-3007
-
-
Richon, V.M.1
Emiliani, S.2
Verdin, E.3
Webb, Y.4
Breslow, R.5
Rifkind, R.A.6
Marks, P.A.7
-
103
-
-
0035755974
-
Histone deacetylases and cancer: Causes and therapies
-
Marks, P.; Rifkind, R. A.; Richon, V. M.; Breslow, R.; Miller, T.; Kelly, W. K. Histone deacetylases and cancer: causes and therapies. Nat. Rev. Cancer 2001, 1, 194-202.
-
(2001)
Nat. Rev. Cancer
, vol.1
, pp. 194-202
-
-
Marks, P.1
Rifkind, R.A.2
Richon, V.M.3
Breslow, R.4
Miller, T.5
Kelly, W.K.6
-
104
-
-
0036014986
-
Histone deacetylases as therapeutic targets in hematologic malignancies
-
Melnick, A.; Licht, J. D. Histone deacetylases as therapeutic targets in hematologic malignancies. Curr. Opin. Hematol. 2002, 9, 322-332.
-
(2002)
Curr. Opin. Hematol.
, vol.9
, pp. 322-332
-
-
Melnick, A.1
Licht, J.D.2
-
105
-
-
0032563871
-
Fungal metabolite FR901228 inhibits c-Myc and Fas ligand expression
-
Wang, R.; Brunner, T.; Zhang, L.; Shi, Y. Fungal metabolite FR901228 inhibits c-Myc and Fas ligand expression. Oncogene 1998, 17, 1503-1508.
-
(1998)
Oncogene
, vol.17
, pp. 1503-1508
-
-
Wang, R.1
Brunner, T.2
Zhang, L.3
Shi, Y.4
-
106
-
-
0031768386
-
Effects of a novel antitumor depsipeptide, FR901228, on human breast cancer cells
-
Rajgolikar, G.; Chan, K. K.; Wang, H. C. Effects of a novel antitumor depsipeptide, FR901228, on human breast cancer cells. Breast Cancer Res. Treat. 1998, 51, 29-38.
-
(1998)
Breast Cancer Res. Treat.
, vol.51
, pp. 29-38
-
-
Rajgolikar, G.1
Chan, K.K.2
Wang, H.C.3
-
107
-
-
0033822112
-
P21-dependent g(1)arrest with downregulation of cyclin D1 and upregulation of cyclin e by the histone deacetylase inhibitor FR901228
-
Sandor, V.; Senderowicz, A.; Mertins, S.; Sackett, D.; Sausville, E.; Blagosklonny, M. V.; Bates, S. E. P21-dependent g(1)arrest with downregulation of cyclin D1 and upregulation of cyclin E by the histone deacetylase inhibitor FR901228. Br. J. Cancer 2000, 83, 817-825.
-
(2000)
Br. J. Cancer
, vol.83
, pp. 817-825
-
-
Sandor, V.1
Senderowicz, A.2
Mertins, S.3
Sackett, D.4
Sausville, E.5
Blagosklonny, M.V.6
Bates, S.E.7
-
108
-
-
0028500561
-
Action of FR901228, a novel antitumor bicyclic depsipeptide produced by Chromobacterium violaceum no. 968, on Ha-ras transformed NIH3T3 cells
-
Ueda, H.; Nakajima, H.; Hori, Y.; Goto, T.; Okuhara, M. Action of FR901228, a novel antitumor bicyclic depsipeptide produced by Chromobacterium violaceum no. 968, on Ha-ras transformed NIH3T3 cells. Biosci. Biotechnol. Biochem. 1994, 58, 1579-1583.
-
(1994)
Biosci. Biotechnol. Biochem.
, vol.58
, pp. 1579-1583
-
-
Ueda, H.1
Nakajima, H.2
Hori, Y.3
Goto, T.4
Okuhara, M.5
-
109
-
-
0036301281
-
Phase I trial of the histone deacetylase inhibitor, depsipeptide (FR901228, NSC 630176), in patients with refractory neoplasms
-
Sandor, V.; Bakke, S.; Robey, R. W.; Kang, M. H.; Blagosklonny, M. V.; Bender, J.; Brooks, R.; Piekarz, R. L.; Tucker, E.; Figg, W. D.; Chan, K. K.; Goldspiel, B.; Fojo, A. T.; Balcerzak, S. P.; Bates, S. E. Phase I trial of the histone deacetylase inhibitor, depsipeptide (FR901228, NSC 630176), in patients with refractory neoplasms. Clin. Cancer Res. 2002, 8, 718-728.
-
(2002)
Clin. Cancer Res.
, vol.8
, pp. 718-728
-
-
Sandor, V.1
Bakke, S.2
Robey, R.W.3
Kang, M.H.4
Blagosklonny, M.V.5
Bender, J.6
Brooks, R.7
Piekarz, R.L.8
Tucker, E.9
Figg, W.D.10
Chan, K.K.11
Goldspiel, B.12
Fojo, A.T.13
Balcerzak, S.P.14
Bates, S.E.15
-
110
-
-
18644379905
-
A phase I trial of depsipeptide (FR901228) in patients with advanced cancer
-
Marshall, J. L.; Rizvi, N.; Kauh, J.; Dahut, W.; Figuera, M.; Kang, M. H.; Figg, W. D.; Wainer, I.; Chaissang, C.; Li, M. Z.; Hawkins, M. J. A phase I trial of depsipeptide (FR901228) in patients with advanced cancer. J. Exp. Ther. Oncol. 2002, 2, 325-332.
-
(2002)
J. Exp. Ther. Oncol.
, vol.2
, pp. 325-332
-
-
Marshall, J.L.1
Rizvi, N.2
Kauh, J.3
Dahut, W.4
Figuera, M.5
Kang, M.H.6
Figg, W.D.7
Wainer, I.8
Chaissang, C.9
Li, M.Z.10
Hawkins, M.J.11
-
111
-
-
19944432566
-
A phase 1 and pharmacodynamic study of depsipeptide (FK228) in chronic lymphocytic leukemia and acute myeloid leukemia
-
Byrd, J. C.; Marcucci, G.; Parthun, M. R.; Xiao, J. J.; Klisovic, R. B.; Moran, M.; Lin, T. S.; Liu, S.; Sklenar, A. R.; Davis, M. E.; Lucas, D. M.; Fischer, B.; Shank, R.; Tejaswi, S. L.; Binkley, P.; Wright, J.; Chan, K. K.; Grever, M. R. A phase 1 and pharmacodynamic study of depsipeptide (FK228) in chronic lymphocytic leukemia and acute myeloid leukemia. Blood 2005, 105, 959-967.
-
(2005)
Blood
, vol.105
, pp. 959-967
-
-
Byrd, J.C.1
Marcucci, G.2
Parthun, M.R.3
Xiao, J.J.4
Klisovic, R.B.5
Moran, M.6
Lin, T.S.7
Liu, S.8
Sklenar, A.R.9
Davis, M.E.10
Lucas, D.M.11
Fischer, B.12
Shank, R.13
Tejaswi, S.L.14
Binkley, P.15
Wright, J.16
Chan, K.K.17
Grever, M.R.18
-
112
-
-
0037068379
-
5-Azacytidine and 5-aza-2′-deoxycytidine as inhibitors of DNA methylation: Mechanistic studies and their implications for cancer therapy
-
Christman, J. K. 5-Azacytidine and 5-aza-2′-deoxycytidine as inhibitors of DNA methylation: mechanistic studies and their implications for cancer therapy. Oncogene 2002, 21, 5483-5495.
-
(2002)
Oncogene
, vol.21
, pp. 5483-5495
-
-
Christman, J.K.1
-
113
-
-
0034326784
-
Reversal of drug resistance in human tumor xenografts by 2′-deoxy-5-azacytidine-induced demethylation of the hMLH1 gene promoter
-
Plumb, J. A.; Strathdee, G.; Sludden, J.; Kaye, S. B.; Brown, R. Reversal of drug resistance in human tumor xenografts by 2′-deoxy-5-azacytidine- induced demethylation of the hMLH1 gene promoter. Cancer Res. 2000, 60, 6039-6044.
-
(2000)
Cancer Res.
, vol.60
, pp. 6039-6044
-
-
Plumb, J.A.1
Strathdee, G.2
Sludden, J.3
Kaye, S.B.4
Brown, R.5
-
114
-
-
0034106513
-
A phase I trial of cisplatin plus decitabine, a new DNA-hypomethylating agent, in patients with advanced solid tumors and a follow-up early phase II evaluation in patients with inoperable non-small cell lung cancer
-
Schwartsmann, G.; Schunemann, H.; Gorini, C. N.; Filho, A. F.; Garbino, C.; Sabini, G.; Muse, I.; DiLeone, L.; Mans, D. R. A phase I trial of cisplatin plus decitabine, a new DNA-hypomethylating agent, in patients with advanced solid tumors and a follow-up early phase II evaluation in patients with inoperable non-small cell lung cancer. Invest. New Drugs 2000, 18, 83-91.
-
(2000)
Invest. New Drugs
, vol.18
, pp. 83-91
-
-
Schwartsmann, G.1
Schunemann, H.2
Gorini, C.N.3
Filho, A.F.4
Garbino, C.5
Sabini, G.6
Muse, I.7
DiLeone, L.8
Mans, D.R.9
-
115
-
-
0031945210
-
A phase II study of 5-aza-2′deoxycytidine (decitabine) in hormone independent metastatic (D2) prostate cancer
-
Thibault, A.; Figg, W. D.; Bergan, R. C.; Lush, R. M.; Myers, C. E.; Tompkins, A.; Reed, E.; Samid, D. A phase II study of 5-aza- 2′deoxycytidine (decitabine) in hormone independent metastatic (D2) prostate cancer. Tumori. 1998, 84, 87-89.
-
(1998)
Tumori.
, vol.84
, pp. 87-89
-
-
Thibault, A.1
Figg, W.D.2
Bergan, R.C.3
Lush, R.M.4
Myers, C.E.5
Tompkins, A.6
Reed, E.7
Samid, D.8
-
116
-
-
0031000513
-
Dihydro-5-azacytidine in malignant mesothelioma. A phase II trial demonstrating activity accompanied by cardiac toxicity
-
Cancer and Leukemia Group B
-
Yogelzang, N. J.; Herndon, J. E., 2nd; Cirrincione, C.; Harmon, D. C.; Antman, K. H.; Corson, J. M.; Suzuki, Y.; Citron, M. L.; Green, M. R. Dihydro-5-azacytidine in malignant mesothelioma. A phase II trial demonstrating activity accompanied by cardiac toxicity. Cancer and Leukemia Group B. Cancer 1997, 79, 2237-2242.
-
(1997)
Cancer
, vol.79
, pp. 2237-2242
-
-
Yogelzang, N.J.1
Herndon II, J.E.2
Cirrincione, C.3
Harmon, D.C.4
Antman, K.H.5
Corson, J.M.6
Suzuki, Y.7
Citron, M.L.8
Green, M.R.9
-
117
-
-
17444452612
-
Low-dose 5-aza-2′-deoxycytidine, a DNA hypomethylating agent, for the treatment of high-risk myelodysplastic syndrome: A multicenter phase II study in elderly patients
-
Wijermans, P.; Lubbert, M.; Verhoef, G.; Bosly, A.; Ravoet, C.; Andre, M.; Ferrant, A. Low-dose 5-aza-2′-deoxycytidine, a DNA hypomethylating agent, for the treatment of high-risk myelodysplastic syndrome: a multicenter phase II study in elderly patients. J. Clin. Oncol. 2000, 18, 956-962.
-
(2000)
J. Clin. Oncol.
, vol.18
, pp. 956-962
-
-
Wijermans, P.1
Lubbert, M.2
Verhoef, G.3
Bosly, A.4
Ravoet, C.5
Andre, M.6
Ferrant, A.7
-
118
-
-
10744233452
-
Phase 1 study of low-dose prolonged exposure schedules of the hypomethylating agent 5-aza-2′-deoxycytidine (decitabine) in hematopoietic malignancies
-
Issa, J. P.; Garcia-Manero, G.; Giles, F. J.; Mannari, R.; Thomas, D.; Faderl, S.; Bayar, E.; Lyons, J.; Rosenfeld, C. S.; Cortes, J.; Kantarjian, H. M. Phase 1 study of low-dose prolonged exposure schedules of the hypomethylating agent 5-aza-2′-deoxycytidine (decitabine) in hematopoietic malignancies. Blood 2004, 103, 1635-1640.
-
(2004)
Blood
, vol.103
, pp. 1635-1640
-
-
Issa, J.P.1
Garcia-Manero, G.2
Giles, F.J.3
Mannari, R.4
Thomas, D.5
Faderl, S.6
Bayar, E.7
Lyons, J.8
Rosenfeld, C.S.9
Cortes, J.10
Kantarjian, H.M.11
-
119
-
-
0036794950
-
Phase II trial of cisplatin plus decitabine, a new DNA hypomethylating agent, in patients with advanced squamous cell carcinoma of the cervix
-
Pohlmann, P.; DiLeone, L. P.; Cancella, A. I.; Caldas, A. P.; Dal Lago, L.; Campos, O., Jr.; Monego, E.; Rivoire, W.; Schwartsmann, G. Phase II trial of cisplatin plus decitabine, a new DNA hypomethylating agent, in patients with advanced squamous cell carcinoma of the cervix. Am. J. Clin. Oncol. 2002, 25, 496-501.
-
(2002)
Am. J. Clin. Oncol.
, vol.25
, pp. 496-501
-
-
Pohlmann, P.1
Dileone, L.P.2
Cancella, A.I.3
Caldas, A.P.4
Dal Lago, L.5
Campos Jr., O.6
Monego, E.7
Rivoire, W.8
Schwartsmann, G.9
-
120
-
-
0043240182
-
Ovarian cancer: Strategies for overcoming resistance to chemotherapy
-
Agarwal, R.; Kaye, S. B. Ovarian cancer: strategies for overcoming resistance to chemotherapy. Nat. Rev. Cancer 2003, 3, 502-516.
-
(2003)
Nat. Rev. Cancer
, vol.3
, pp. 502-516
-
-
Agarwal, R.1
Kaye, S.B.2
-
121
-
-
0029781344
-
Peptide and lipid growth factors decrease cis-diamminedichloroplatinum- induced cell death in human ovarian cancer cells
-
Frankel, A.; Mills, G. B. Peptide and lipid growth factors decrease cis-diamminedichloroplatinum-induced cell death in human ovarian cancer cells. Clin. Cancer Res. 1996, 2, 1307-1313.
-
(1996)
Clin. Cancer Res.
, vol.2
, pp. 1307-1313
-
-
Frankel, A.1
Mills, G.B.2
-
122
-
-
0029863194
-
Design, synthesis, and evaluation of latent alkylating agents activated by glutathione S-transferase
-
Satyam, A.; Hocker, M. D.; Kane-Maguire, K. A.; Morgan, A. S.; Villar, H. O.; Lyttle, M. H. Design, synthesis, and evaluation of latent alkylating agents activated by glutathione S-transferase. J. Med. Chem. 1996, 39, 1736-1747.
-
(1996)
J. Med. Chem.
, vol.39
, pp. 1736-1747
-
-
Satyam, A.1
Hocker, M.D.2
Kane-Maguire, K.A.3
Morgan, A.S.4
Villar, H.O.5
Lyttle, M.H.6
-
123
-
-
0031011245
-
Activity of TER286 against human tumor colony-forming units
-
Izbicka, E.; Lawrence, R.; Cerna, C.; Von Hoff, D. D.;Sanderson, P. E. Activity of TER286 against human tumor colony-forming units. Anticancer Drugs 1997, 8, 345-348.
-
(1997)
Anticancer Drugs
, vol.8
, pp. 345-348
-
-
Izbicka, E.1
Lawrence, R.2
Cerna, C.3
Von Hoff, D.D.4
Sanderson, P.E.5
-
124
-
-
0034644522
-
Signal transduction by the JNK group of MAP kinases
-
Davis, R. J. Signal transduction by the JNK group of MAP kinases. Cell 2000, 103, 239-252.
-
(2000)
Cell
, vol.103
, pp. 239-252
-
-
Davis, R.J.1
-
125
-
-
0035212589
-
The ups and downs of MEK kinase interactions
-
Hagemann, C.; Blank, J. L. The ups and downs of MEK kinase interactions. Cell Signal. 2001, 13, 863-875.
-
(2001)
Cell Signal.
, vol.13
, pp. 863-875
-
-
Hagemann, C.1
Blank, J.L.2
-
126
-
-
2542517093
-
Phase 1 study of TLK286 (Telcyta) administered weekly in advanced malignancies
-
Rosen, L. S.; Laxa, B.; Boulos, L.; Wiggins, L.; Keck, J. G.; Jameson, A. J.; Parra, R.; Patel, K.; Brown, G. L. Phase 1 study of TLK286 (Telcyta) administered weekly in advanced malignancies. Clin. Cancer Res. 2004, 10, 3689-3698.
-
(2004)
Clin. Cancer Res.
, vol.10
, pp. 3689-3698
-
-
Rosen, L.S.1
Laxa, B.2
Boulos, L.3
Wiggins, L.4
Keck, J.G.5
Jameson, A.J.6
Parra, R.7
Patel, K.8
Brown, G.L.9
-
127
-
-
22544443334
-
Multi-institutional phase 2 study of TLK286 (TELCYTA, a glutathione S-transferase P1-1 activated glutathione analog prodrug) in patients with platinum and paclitaxel refractory or resistant ovarian cancer
-
Kavanagh, J. J.; Gershenson, D. M.; Choi, H.; Lewis, L.; Patel, K.; Brown, G. L.; Garcia, A.; Spriggs, D. R. Multi-institutional phase 2 study of TLK286 (TELCYTA, a glutathione S-transferase P1-1 activated glutathione analog prodrug) in patients with platinum and paclitaxel refractory or resistant ovarian cancer. Int. J. Gynecol. Cancer 2005, 15, 593-600.
-
(2005)
Int. J. Gynecol. Cancer
, vol.15
, pp. 593-600
-
-
Kavanagh, J.J.1
Gershenson, D.M.2
Choi, H.3
Lewis, L.4
Patel, K.5
Brown, G.L.6
Garcia, A.7
Spriggs, D.R.8
-
128
-
-
0032740801
-
Drug resistance-associated markers P-glycoprotein, multidrug resistance-associated protein 1, multidrug resistance-associated protein 2, and lung resistance protein as prognostic factors in ovarian carcinoma
-
Arts, H. J.; Katsaros, D.; de Vries, E. G.; Massobrio, M.; Genta, F.; Danese, S.; Arisio, R.; Scheper, R. J.; Kool, M.; Scheffer, G. L.; Willemse, P. H.; van der Zee, A. G.; Suurmeijer, A. J. Drug resistance-associated markers P-glycoprotein, multidrug resistance-associated protein 1, multidrug resistance-associated protein 2, and lung resistance protein as prognostic factors in ovarian carcinoma. Clin. Cancer Res. 1999, 5, 2798-2805.
-
(1999)
Clin. Cancer Res.
, vol.5
, pp. 2798-2805
-
-
Arts, H.J.1
Katsaros, D.2
De Vries, E.G.3
Massobrio, M.4
Genta, F.5
Danese, S.6
Arisio, R.7
Scheper, R.J.8
Kool, M.9
Scheffer, G.L.10
Willemse, P.H.11
Van Der Zee, A.G.12
Suurmeijer, A.J.13
-
129
-
-
0028241990
-
P-glycoprotein, HER-2/neu, and mutant p53 expression in human gynecologic tumors
-
Schneider, J.; Rubio, M. P.; Barbazan, M. J.; Rodriguez-Escudero, F. J.; Seizinger, B. R.; Castresana, J. S. P-glycoprotein, HER-2/neu, and mutant p53 expression in human gynecologic tumors. J. Natl. Cancer Inst. 1994, 86, 850-855.
-
(1994)
J. Natl. Cancer Inst.
, vol.86
, pp. 850-855
-
-
Schneider, J.1
Rubio, M.P.2
Barbazan, M.J.3
Rodriguez-Escudero, F.J.4
Seizinger, B.R.5
Castresana, J.S.6
-
130
-
-
0034053339
-
P-glycoprotein expression is a marker for chemotherapy resistance and prognosis in advanced ovarian cancer
-
Baekelandt, M. M.; Holm, R.; Nesland, J. M.; Trope, C. G.; Kristensen, G. B. P-glycoprotein expression is a marker for chemotherapy resistance and prognosis in advanced ovarian cancer. Anticancer Res. 2000, 20, 1061-1067.
-
(2000)
Anticancer Res.
, vol.20
, pp. 1061-1067
-
-
Baekelandt, M.M.1
Holm, R.2
Nesland, J.M.3
Trope, C.G.4
Kristensen, G.B.5
-
131
-
-
0035215395
-
Proteasome inhibition in cancer: Development of PS-341
-
Adams, J. Proteasome inhibition in cancer: development of PS-341. Semin. Oncol. 2001, 28, 613-619.
-
(2001)
Semin. Oncol.
, vol.28
, pp. 613-619
-
-
Adams, J.1
-
132
-
-
0242496212
-
Molecular sequelae of proteasome inhibition in human multiple myeloma cells
-
Mitsiades, N.; Mitsiades, C. S.; Poulaki, V.; Chauhan, D.; Fanourakis, G.; Gu, X.; Bailey, C.; Joseph, M.; Libermann, T. A.; Treon, S. P.; Munshi, N. C.; Richardson, P. G.; Hideshima, T.; Anderson, K. C. Molecular sequelae of proteasome inhibition in human multiple myeloma cells. Proc. Natl. Acad. Sci. USA 2002, 99, 14374-14379.
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 14374-14379
-
-
Mitsiades, N.1
Mitsiades, C.S.2
Poulaki, V.3
Chauhan, D.4
Fanourakis, G.5
Gu, X.6
Bailey, C.7
Joseph, M.8
Libermann, T.A.9
Treon, S.P.10
Munshi, N.C.11
Richardson, P.G.12
Hideshima, T.13
Anderson, K.C.14
-
133
-
-
0037325976
-
Human papillomavirus-induced carcinogenesis and the ubiquitin-proteasome system
-
Scheffner, M.; Whitaker, N. J. Human papillomavirus-induced carcinogenesis and the ubiquitin-proteasome system. Semin Cancer Biol. 2003, 13, 59-67.
-
(2003)
Semin Cancer Biol.
, vol.13
, pp. 59-67
-
-
Scheffner, M.1
Whitaker, N.J.2
-
134
-
-
0141596941
-
Overview: Translating Hsp90 biology into Hsp90 drugs
-
Workman, P. Overview: translating Hsp90 biology into Hsp90 drugs. Curr. Cancer Drug Targets 2003, 3, 297-300.
-
(2003)
Curr. Cancer Drug Targets
, vol.3
, pp. 297-300
-
-
Workman, P.1
-
135
-
-
0037194413
-
Dentification of heat shock protein 90 and other proteins as tumour antigens by serological screening of an ovarian carcinoma expression library
-
Luo, L. Y.; Herrera, I.; Soosaipillai, A.; Diamandis, E. P. Identification of heat shock protein 90 and other proteins as tumour antigens by serological screening of an ovarian carcinoma expression library. Br. J. Cancer 2002, 87, 339-343.
-
(2002)
Br. J. Cancer
, vol.87
, pp. 339-343
-
-
Luo, L.Y.1
Herrera, I.2
Soosaipillai, A.3
Diamandis, E.P.I.4
-
136
-
-
0035866032
-
Over-expression of heat shock proteins in carcinogenic endometrium
-
Wataba, K.; Saito, T.; Fukunaka, K.; Ashihara, K.; Nishimura, M.; Kudo, R. Over-expression of heat shock proteins in carcinogenic endometrium. Int. J. Cancer 2001, 91, 448-456.
-
(2001)
Int. J. Cancer
, vol.91
, pp. 448-456
-
-
Wataba, K.1
Saito, T.2
Fukunaka, K.3
Ashihara, K.4
Nishimura, M.5
Kudo, R.6
-
137
-
-
2942692143
-
Phase I trial of the proteasome inhibitor bortezomib in patients with advanced solid tumors with observations in androgen-independent prostate cancer
-
Papandreou, C. N.; Daliani, D. D.; Nix, D.; Yang, H.; Madden, T.; Wang, X.; Pien, C. S.; Millikan, R. E.; Tu, S. M.; Pagliaro, L.; Kim, J.; Adams, J.; Elliott, P.; Esseltine, D.; Petrusich, A.; Dieringer, P.; Perez, C.; Logothetis, C. J. Phase I trial of the proteasome inhibitor bortezomib in patients with advanced solid tumors with observations in androgen-independent prostate cancer. J. Clin. Oncol. 2004, 22, 2108-2121.
-
(2004)
J. Clin. Oncol.
, vol.22
, pp. 2108-2121
-
-
Papandreou, C.N.1
Daliani, D.D.2
Nix, D.3
Yang, H.4
Madden, T.5
Wang, X.6
Pien, C.S.7
Millikan, R.E.8
Tu, S.M.9
Pagliaro, L.10
Kim, J.11
Adams, J.12
Elliott, P.13
Esseltine, D.14
Petrusich, A.15
Dieringer, P.16
Perez, C.17
Logothetis, C.J.18
-
138
-
-
0037252480
-
High-dose therapy and immunomodulatory drugs in multiple myeloma
-
Barlogie, B.; Shaughnessy, J.; Zangari, M.; Tricot, G. High-dose therapy and immunomodulatory drugs in multiple myeloma. Semin Oncol. 2002, 29, 26-33.
-
(2002)
Semin Oncol.
, vol.29
, pp. 26-33
-
-
Barlogie, B.1
Shaughnessy, J.2
Zangari, M.3
Tricot, G.4
-
139
-
-
0034820022
-
Cell cycle regulation in the G1 phase: A promising target for the development of new chemotherapeutic anticancer agents
-
Owa, T.; Yoshino, H.; Yoshimatsu, K.; Nagasu, T. Cell cycle regulation in the G1 phase: a promising target for the development of new chemotherapeutic anticancer agents. Curr. Med. Chem. 2001, 8, 1487-1503.
-
(2001)
Curr. Med. Chem.
, vol.8
, pp. 1487-1503
-
-
Owa, T.1
Yoshino, H.2
Yoshimatsu, K.3
Nagasu, T.4
-
140
-
-
0037973279
-
A phase 2 study of bortezomib in relapsed, refractory myeloma
-
Richardson, P. G.; Barlogie, B.; Berenson, J.; Singhal, S.; Jagannath, S.; Irwin, D.; Rajkumar, S. V.; Srkalovic, G.; Alsina, M.; Alexanian, R.; Siegel, D.; Orlowski, R. Z.; Kuter, D.; Limentani, S. A.; Lee, S.; Hideshima, T.; Esseltine, D. L.; Kauffman, M.; Adams, J.; Schenkein, D. P.; Anderson, K. C. A phase 2 study of bortezomib in relapsed, refractory myeloma. N. Engl. J. Med. 2003, 348, 2609-2617.
-
(2003)
N. Engl. J. Med.
, vol.348
, pp. 2609-2617
-
-
Richardson, P.G.1
Barlogie, B.2
Berenson, J.3
Singhal, S.4
Jagannath, S.5
Irwin, D.6
Rajkumar, S.V.7
Srkalovic, G.8
Alsina, M.9
Alexanian, R.10
Siegel, D.11
Orlowski, R.Z.12
Kuter, D.13
Limentani, S.A.14
Lee, S.15
Hideshima, T.16
Esseltine, D.L.17
Kauffman, M.18
Adams, J.19
Schenkein, D.P.20
Anderson, K.C.21
more..
-
141
-
-
2442510143
-
Phase II trial of PS-341 in patients with renal cell cancer: A University of Chicago phase II consortium study
-
Davis, N. B.; Taber, D. A.; Ansari, R. H.; Ryan, C. W.; George, C.; Vokes, E. E.; Vogelzang, N. J.; Stadler, W. M. Phase II trial of PS-341 in patients with renal cell cancer: a University of Chicago phase II consortium study. J. Clin. Oncol. 2004, 22, 115-119.
-
(2004)
J. Clin. Oncol.
, vol.22
, pp. 115-119
-
-
Davis, N.B.1
Taber, D.A.2
Ansari, R.H.3
Ryan, C.W.4
George, C.5
Vokes, E.E.6
Vogelzang, N.J.7
Stadler, W.M.8
-
142
-
-
0029056501
-
Preclinical pharmacologic evaluation of geldanamycin as an antitumor agent
-
Supko, J. G.; Hickman, R. L.; Grever, M. R.; Malspeis, L. Preclinical pharmacologic evaluation of geldanamycin as an antitumor agent. Cancer Chemother. Pharmacol. 1995, 36, 305-315.
-
(1995)
Cancer Chemother. Pharmacol.
, vol.36
, pp. 305-315
-
-
Supko, J.G.1
Hickman, R.L.2
Grever, M.R.3
Malspeis, L.4
-
143
-
-
0037265586
-
Development of small molecule Hsp90 inhibitors: Utilizing both forward and reverse chemical genomics for drug identification
-
Neckers, L. Development of small molecule Hsp90 inhibitors: utilizing both forward and reverse chemical genomics for drug identification. Curr. Med. Chem. 2003, 10, 733-739.
-
(2003)
Curr. Med. Chem.
, vol.10
, pp. 733-739
-
-
Neckers, L.1
-
144
-
-
20044384168
-
Phase I trial of 17-allylamino-17-demethoxygeldanamycin in patients with advanced cancer
-
Goetz, M. P.; Toft, D.; Reid, J.; Ames, M.; Stensgard, B.; Safgren, S.; Adjei, A. A.; Sloan, J.; Atherton, P.; Vasile, V.; Salazaar, S.; Adjei, A.; Croghan, G.; Erlichman, C. Phase I trial of 17-allylamino-17- demethoxygeldanamycin in patients with advanced cancer. J. Clin. Oncol. 2005, 23, 1078-1087.
-
(2005)
J. Clin. Oncol.
, vol.23
, pp. 1078-1087
-
-
Goetz, M.P.1
Toft, D.2
Reid, J.3
Ames, M.4
Stensgard, B.5
Safgren, S.6
Adjei, A.A.7
Sloan, J.8
Atherton, P.9
Vasile, V.10
Salazaar, S.11
Adjei, A.12
Croghan, G.13
Erlichman, C.14
-
145
-
-
0033399453
-
Anticancer drug targets: Cell cycle and checkpoint control
-
Shapiro, G. I.; Harper, J. W. Anticancer drug targets: cell cycle and checkpoint control. J. Clin. Invest. 1999, 104, 1645-1653.
-
(1999)
J. Clin. Invest.
, vol.104
, pp. 1645-1653
-
-
Shapiro, G.I.1
Harper, J.W.2
-
147
-
-
2342639645
-
VX-680, a potent and selective small-molecule inhibitor of the Aurora kinases, suppresses tumor growth in vivo
-
Harrington, E. A.; Bebbington, D.; Moore, J.; Rasmussen, R. K.; Ajose-Adeogun, A. O.; Nakayama, T.; Graham, J. A.; Demur, C.; Hercend, T.; Diu-Hercend, A.; Su, M.; Golec, J. M.; Miller, K. M. VX-680, a potent and selective small-molecule inhibitor of the Aurora kinases, suppresses tumor growth in vivo. Nat. Med. 2004, 10, 262-267.
-
(2004)
Nat. Med.
, vol.10
, pp. 262-267
-
-
Harrington, E.A.1
Bebbington, D.2
Moore, J.3
Rasmussen, R.K.4
Ajose-Adeogun, A.O.5
Nakayama, T.6
Graham, J.A.7
Demur, C.8
Hercend, T.9
Diu-Hercend, A.10
Su, M.11
Golec, J.M.12
Miller, K.M.13
-
148
-
-
16344376622
-
Frequent overexpression of STK15/Aurora-A/BTAK and chromosomal instability in tumorigenic cell cultures derived from human ovarian cancer
-
Hu, W.; Kavanagh, J. J.; Deaver, M.; Johnston, D. A.; Freedman, R. S.; Verschraegen, C. F.; Sen, S. Frequent overexpression of STK15/Aurora-A/BTAK and chromosomal instability in tumorigenic cell cultures derived from human ovarian cancer. Oncol. Res. 2005, 15, 49-57.
-
(2005)
Oncol. Res.
, vol.15
, pp. 49-57
-
-
Hu, W.1
Kavanagh, J.J.2
Deaver, M.3
Johnston, D.A.4
Freedman, R.S.5
Verschraegen, C.F.6
Sen, S.7
-
149
-
-
0013057087
-
Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochores
-
Ditchfield, C.; Johnson, V. L.; Tighe, A.; Ellston, R.; Haworth, C.; Johnson, T.; Mortlock, A.; Keen, N.; Taylor, S. S. Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochores. J. Cell Biol. 2003, 161, 267-280.
-
(2003)
J. Cell Biol.
, vol.161
, pp. 267-280
-
-
Ditchfield, C.1
Johnson, V.L.2
Tighe, A.3
Ellston, R.4
Haworth, C.5
Johnson, T.6
Mortlock, A.7
Keen, N.8
Taylor, S.S.9
-
150
-
-
0037373258
-
G1 tetraploidy checkpoint and the suppression of tumorigenesis
-
Margolis, R. L.; Lohez, O. D.; Andreassen, P. R. G1 tetraploidy checkpoint and the suppression of tumorigenesis. J. Cell Biochem. 2003, 88, 673-683.
-
(2003)
J. Cell Biochem.
, vol.88
, pp. 673-683
-
-
Margolis, R.L.1
Lohez, O.D.2
Andreassen, P.R.3
-
151
-
-
9144251019
-
Phosphorylation by aurora kinase a induces Mdm2-mediated destabilization and inhibition of p53
-
Katayama, H.; Sasai, K.; Kawai, H.; Yuan, Z. M.; Bondaruk, J.; Suzuki, F.; Fujii, S.; Arlinghaus, R. B.; Czerniak, B. A.; Sen, S. Phosphorylation by aurora kinase A induces Mdm2-mediated destabilization and inhibition of p53. Nat. Genet. 2004, 36, 55-62.
-
(2004)
Nat. Genet.
, vol.36
, pp. 55-62
-
-
Katayama, H.1
Sasai, K.2
Kawai, H.3
Yuan, Z.M.4
Bondaruk, J.5
Suzuki, F.6
Fujii, S.7
Arlinghaus, R.B.8
Czerniak, B.A.9
Sen, S.10
-
152
-
-
0035055595
-
Mechanisms of action of flavopiridol
-
Sedlacek, H. H. Mechanisms of action of flavopiridol. Crit. Rev. Oncol. Hematol. 2001, 38, 139-170.
-
(2001)
Crit. Rev. Oncol. Hematol.
, vol.38
, pp. 139-170
-
-
Sedlacek, H.H.1
-
153
-
-
3042536038
-
Preclinical and clinical development of the cyclin-dependent kinase inhibitor flavopiridol
-
Shapiro, G. I. Preclinical and clinical development of the cyclin-dependent kinase inhibitor flavopiridol. Clin. Cancer Res. 2004, 10, 4270s-4275s.
-
(2004)
Clin. Cancer Res.
, vol.10
-
-
Shapiro, G.I.1
-
154
-
-
10744230675
-
A Phase II trial of flavopiridol (NSC #649890) in patients with previously untreated metastatic androgenin-dependent prostate cancer
-
Liu, G.; Gandara, D. R.; Lara, P. N., Jr.; Raghavan, D.; Doroshow, J. H.; Twardowski, P.; Kantoff, P.; Oh, W.; Kim, K.; Wilding, G. A Phase II trial of flavopiridol (NSC #649890) in patients with previously untreated metastatic androgenin-dependent prostate cancer. Clin. Cancer Res. 2004, 10, 924-928.
-
(2004)
Clin. Cancer Res.
, vol.10
, pp. 924-928
-
-
Liu, G.1
Gandara, D.R.2
Lara Jr., P.N.3
Raghavan, D.4
Doroshow, J.H.5
Twardowski, P.6
Kantoff, P.7
Oh, W.8
Kim, K.9
Wilding, G.10
-
155
-
-
0038745560
-
Flavopiridol, a cyclin-dependent kinase inhibitor, enhances radiosensitivity of ovarian carcinoma cells
-
Raju, U.; Nakata, E.; Mason, K. A.; Ang, K. K.; Milas, L. Flavopiridol, a cyclin-dependent kinase inhibitor, enhances radiosensitivity of ovarian carcinoma cells. Cancer Res. 2003, 63, 3263-3267.
-
(2003)
Cancer Res.
, vol.63
, pp. 3263-3267
-
-
Raju, U.1
Nakata, E.2
Mason, K.A.3
Ang, K.K.4
Milas, L.5
-
156
-
-
0031932603
-
Cross-talk between peptide growth factor and estrogen receptor signaling pathways
-
Smith, C. L. Cross-talk between peptide growth factor and estrogen receptor signaling pathways. Biol. Reprod. 1998, 58, 627-632.
-
(1998)
Biol. Reprod.
, vol.58
, pp. 627-632
-
-
Smith, C.L.1
-
157
-
-
0028886694
-
Activation of the estrogen receptor through phosphorylation by mitogen-activated protein kinase
-
Kato, S.; Endoh, H.; Masuhiro, Y.; Kitamoto, T.; Uchiyama, S.; Sasaki, H.; Masushige, S.; Gotoh, Y.; Nishida, E.; Kawashima, H.; Metzger, D.; Chambon, P. Activation of the estrogen receptor through phosphorylation by mitogen-activated protein kinase. Science 1995, 270, 1491-1494.
-
(1995)
Science
, vol.270
, pp. 1491-1494
-
-
Kato, S.1
Endoh, H.2
Masuhiro, Y.3
Kitamoto, T.4
Uchiyama, S.5
Sasaki, H.6
Masushige, S.7
Gotoh, Y.8
Nishida, E.9
Kawashima, H.10
Metzger, D.11
Chambon, P.12
-
158
-
-
0035971181
-
Phosphatidylinositol 3-kinase/AKT-mediated activation of estrogen receptor alpha: A new model for anti-estrogen resistance
-
Campbell, R. A.; Bhat-Nakshatri, P.; Patel, N. M.; Constantinidou, D.; Ali, S.; Nakshatri, H. Phosphatidylinositol 3-kinase/AKT-mediated activation of estrogen receptor alpha: a new model for anti-estrogen resistance. J. Biol. Chem. 2001, 276, 9817-9824.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 9817-9824
-
-
Campbell, R.A.1
Bhat-Nakshatri, P.2
Patel, N.M.3
Constantinidou, D.4
Ali, S.5
Nakshatri, H.6
-
159
-
-
0029877913
-
Activation of the unliganded estrogen receptor by EGF involves the MAP kinase pathway and direct phosphorylation
-
Bunone, G.; Briand, P. A.; Miksicek, R. J.; Picard, D. Activation of the unliganded estrogen receptor by EGF involves the MAP kinase pathway and direct phosphorylation. EMBO J. 1996, 15, 2174-2183.
-
(1996)
EMBO J.
, vol.15
, pp. 2174-2183
-
-
Bunone, G.1
Briand, P.A.2
Miksicek, R.J.3
Picard, D.4
-
160
-
-
0032537396
-
Tamoxifen for early breast cancer: An overview of the randomised trials
-
Early Breast Cancer Trialists' Collaborative Group
-
Tamoxifen for early breast cancer: an overview of the randomised trials. Early Breast Cancer Trialists' Collaborative Group. Lancet 1998, 351, 1451-1467.
-
(1998)
Lancet
, vol.351
, pp. 1451-1467
-
-
-
161
-
-
0036166523
-
Tamoxifen therapy for ovarian cancer in the adjuvant and advanced settings: Systematic review of the literature and implications for future research
-
Perez-Gracia, J. L.; Carrasco, E. M. Tamoxifen therapy for ovarian cancer in the adjuvant and advanced settings: systematic review of the literature and implications for future research. Gynecol. Oncol. 2002, 84, 201-209.
-
(2002)
Gynecol. Oncol.
, vol.84
, pp. 201-209
-
-
Perez-Gracia, J.L.1
Carrasco, E.M.2
-
162
-
-
0026032112
-
Endocrine factors in common epithelial ovarian cancer
-
Rao, B. R.; Slotman, B. J. Endocrine factors in common epithelial ovarian cancer. Endocr. Rev. 1991, 12, 14-26.
-
(1991)
Endocr. Rev.
, vol.12
, pp. 14-26
-
-
Rao, B.R.1
Slotman, B.J.2
-
163
-
-
0025935370
-
Responsiveness of patients with advanced ovarian carcinoma to tamoxifen. A Gynecologic Oncology Group study of second-line therapy in 105 patients
-
Hatch, K. D.; Beecham, J. B.; Blessing, J. A.; Creasman, W. T. Responsiveness of patients with advanced ovarian carcinoma to tamoxifen. A Gynecologic Oncology Group study of second-line therapy in 105 patients. Cancer 1991, 68, 269-271.
-
(1991)
Cancer
, vol.68
, pp. 269-271
-
-
Hatch, K.D.1
Beecham, J.B.2
Blessing, J.A.3
Creasman, W.T.4
-
164
-
-
0031712804
-
Intratumoral aromatase in human breast, endometrial, and ovarian malignancies
-
Sasano, H.; Harada, N. Intratumoral aromatase in human breast, endometrial, and ovarian malignancies. Endocr. Rev. 1998, 19, 593-607.
-
(1998)
Endocr. Rev.
, vol.19
, pp. 593-607
-
-
Sasano, H.1
Harada, N.2
-
165
-
-
0027278685
-
Local aromatase activity in human breast tissues
-
Thijssen, J. H.; Daroszewski, J.; Milewicz, A.; Blankenstein, M. A. Local aromatase activity in human breast tissues. J. Steroid Biochem. Mol. Biol. 1993, 44, 577-582.
-
(1993)
J. Steroid Biochem. Mol. Biol.
, vol.44
, pp. 577-582
-
-
Thijssen, J.H.1
Daroszewski, J.2
Milewicz, A.3
Blankenstein, M.A.4
-
166
-
-
0036421058
-
Anti-tumor effects of letrozole
-
Miller, W. R.; Anderson, T. J.; Dixon, J. M. Anti-tumor effects of letrozole. Cancer Invest. 2002, 20(Suppl 2), 15-21.
-
(2002)
Cancer Invest.
, vol.20
, Issue.2 SUPPL.
, pp. 15-21
-
-
Miller, W.R.1
Anderson, T.J.2
Dixon, J.M.3
-
167
-
-
0028873380
-
Aromatase in human endometrial carcinoma and hyperplasia. Immunohistochemical, in situ hybridization, and biochemical studies
-
Watanabe, K.; Sasano, H.; Harada, N.; Ozaki, M.; Niikura, H.; Sato, S.; Yajima, A. Aromatase in human endometrial carcinoma and hyperplasia. Immunohistochemical, in situ hybridization, and biochemical studies. Am. J. Pathol. 1995, 146, 491-500.
-
(1995)
Am. J. Pathol.
, vol.146
, pp. 491-500
-
-
Watanabe, K.1
Sasano, H.2
Harada, N.3
Ozaki, M.4
Niikura, H.5
Sato, S.6
Yajima, A.7
-
168
-
-
0037157603
-
Anastrozole alone or in combination with tamoxifen versus tamoxifen alone for adjuvant treatment of postmenopausal women with early breast cancer: First results of the ATAC randomised trial
-
Baum, M.; Budzar, A. U.; Cuzick, J.; Forbes, J.; Houghton, J. H.; Klijn, J. G.; Sahmoud, T. Anastrozole alone or in combination with tamoxifen versus tamoxifen alone for adjuvant treatment of postmenopausal women with early breast cancer: first results of the ATAC randomised trial. Lancet 2002, 359, 2131-2139.
-
(2002)
Lancet
, vol.359
, pp. 2131-2139
-
-
Baum, M.1
Budzar, A.U.2
Cuzick, J.3
Forbes, J.4
Houghton, J.H.5
Klijn, J.G.6
Sahmoud, T.7
-
169
-
-
0142181118
-
Anastrozole alone or in combination with tamoxifen versus tamoxifen alone for adjuvant treatment of postmenopausal women with early-stage breast cancer: Results of the ATAC (Arimidex, Tamoxifen Alone or in Combination) trial efficacy and safety update analyses
-
Baum, M.; Buzdar, A.; Cuzick, J.; Forbes, J.; Houghton, J.; Howell, A.; Sahmoud, T. Anastrozole alone or in combination with tamoxifen versus tamoxifen alone for adjuvant treatment of postmenopausal women with early-stage breast cancer: results of the ATAC (Arimidex, Tamoxifen Alone or in Combination) trial efficacy and safety update analyses. Cancer 2003, 98, 1802-1810.
-
(2003)
Cancer
, vol.98
, pp. 1802-1810
-
-
Baum, M.1
Buzdar, A.2
Cuzick, J.3
Forbes, J.4
Houghton, J.5
Howell, A.6
Sahmoud, T.7
-
170
-
-
12144290117
-
Phase II trial of anastrozole in women with asymptomatic mullerian cancer
-
del Carmen, M. G.; Fuller, A. F.; Matulonis, U.; Horick, N. K.; Goodman, A.; Duska, L. R.; Penson, R.; Campos, S.; Roche, M.;Seiden, M. V. Phase II trial of anastrozole in women with asymptomatic mullerian cancer. Gynecol. Oncol. 2003, 91, 596-602.
-
(2003)
Gynecol. Oncol.
, vol.91
, pp. 596-602
-
-
Del Carmen, M.G.1
Fuller, A.F.2
Matulonis, U.3
Horick, N.K.4
Goodman, A.5
Duska, L.R.6
Penson, R.7
Campos, S.8
Roche, M.9
Seiden, M.V.10
-
171
-
-
7444259675
-
A randomized trial of letrozole in postmenopausal women after five years of tamoxifen therapy for early-stage breast cancer
-
Goss, P. E.; Ingle, J. N.; Martino, S.; Robert, N. J.; Muss, H. B.; Piccart, M. J.; Castiglione, M.; Tu, D.; Shepherd, L. E.; Pritchard, K. I.; Livingston, R. B.; Davidson, N. E.; Norton, L.; Perez, E. A.; Abrams, J. S.; Therasse, P.; Palmer, M. J.; Pater, J. L. A randomized trial of letrozole in postmenopausal women after five years of tamoxifen therapy for early-stage breast cancer. N. Engl. J. Med. 2003, 349, 1793-1802.
-
(2003)
N. Engl. J. Med.
, vol.349
, pp. 1793-1802
-
-
Goss, P.E.1
Ingle, J.N.2
Martino, S.3
Robert, N.J.4
Muss, H.B.5
Piccart, M.J.6
Castiglione, M.7
Tu, D.8
Shepherd, L.E.9
Pritchard, K.I.10
Livingston, R.B.11
Davidson, N.E.12
Norton, L.13
Perez, E.A.14
Abrams, J.S.15
Therasse, P.16
Palmer, M.J.17
Pater, J.L.18
-
172
-
-
0035992369
-
CA125 response is associated with estrogen receptor expression in a phase II trial of letrozole in ovarian cancer: Identification of an endocrine-sensitive subgroup
-
Bowman, A.; Gabra, H.; Langdon, S. P.; Lessells, A.; Stewart, M.; Young, A.; Smyth, J. F. CA125 response is associated with estrogen receptor expression in a phase II trial of letrozole in ovarian cancer: identification of an endocrine-sensitive subgroup. Clin. Cancer Res. 2002, 8, 2233-2239.
-
(2002)
Clin. Cancer Res.
, vol.8
, pp. 2233-2239
-
-
Bowman, A.1
Gabra, H.2
Langdon, S.P.3
Lessells, A.4
Stewart, M.5
Young, A.6
Smyth, J.F.7
-
173
-
-
2342545914
-
Hormonal therapy with letrozole for relapsed epithelial ovarian cancer. Long-term results of a phase II study
-
Papadimitriou, C. A.; Markaki, S.; Siapkaras, J.; Vlachos, G.; Efstathiou, E.; Grimani, I.; Hamilos, G.; Zorzou, M.; Dimopoulos, M. A. Hormonal therapy with letrozole for relapsed epithelial ovarian cancer. Long-term results of a phase II study. Oncology 2004, 66, 112-117.
-
(2004)
Oncology
, vol.66
, pp. 112-117
-
-
Papadimitriou, C.A.1
Markaki, S.2
Siapkaras, J.3
Vlachos, G.4
Efstathiou, E.5
Grimani, I.6
Hamilos, G.7
Zorzou, M.8
Dimopoulos, M.A.9
-
174
-
-
0026726506
-
Exemestane (FCE 24304), a new steroidal aromatase inhibitor
-
di Salle, E.; Ornati, G.; Giudici, D.; Lassus, M.; Evans, T. R.;Coombes, R. C. Exemestane (FCE 24304), a new steroidal aromatase inhibitor. J. Steroid Biochem. Mol. Biol. 1992, 43, 137-143.
-
(1992)
J. Steroid Biochem. Mol. Biol.
, vol.43
, pp. 137-143
-
-
Di Salle, E.1
Ornati, G.2
Giudici, D.3
Lassus, M.4
Evans, T.R.5
Coombes, R.C.6
-
175
-
-
0019800997
-
Inactivation of aromatase in vitro by 4-hydroxy-4-androstene-3,17-dione and 4-acetoxy-4-androstene-3,17-dione and sustained effects in vivo
-
Brodie, A. M.; Garrett, W. M.; Hendrickson, J. R.; Tsai-Morris, C. H.; Marcotte, P. A.; Robinson, C. H. Inactivation of aromatase in vitro by 4-hydroxy-4-androstene-3,17-dione and 4-acetoxy-4-androstene-3,17-dione and sustained effects in vivo. Steroids 1981, 38, 693-702.
-
(1981)
Steroids
, vol.38
, pp. 693-702
-
-
Brodie, A.M.1
Garrett, W.M.2
Hendrickson, J.R.3
Tsai-Morris, C.H.4
Marcotte, P.A.5
Robinson, C.H.6
-
176
-
-
10744223655
-
A randomized trial of exemestane after two to three years of tamoxifen therapy in postmenopausal women with primary breast cancer
-
Coombes, R. C.; Hall, E.; Gibson, L. J.; Paridaens, R.; Jassem, J.; Delozier, T.; Jones, S. E.; Alvarez, I.; Bertelli, G.; Ortmann, O.; Coates, A. S.; Bajetta, E.; Dodwell, D.; Coleman, R. E.; Fallowfield, L. J.; Mickiewicz, E.; Andersen, J.; Lonning, P. E.; Cocconi, G.; Stewart, A.; Stuart, N.; Snowdon, C. F.; Carpentieri, M.; Massimini, G.; Bliss, J. M. A randomized trial of exemestane after two to three years of tamoxifen therapy in postmenopausal women with primary breast cancer. N. Engl. J. Med. 2004, 350, 1081-1092.
-
(2004)
N. Engl. J. Med.
, vol.350
, pp. 1081-1092
-
-
Coombes, R.C.1
Hall, E.2
Gibson, L.J.3
Paridaens, R.4
Jassem, J.5
Delozier, T.6
Jones, S.E.7
Alvarez, I.8
Bertelli, G.9
Ortmann, O.10
Coates, A.S.11
Bajetta, E.12
Dodwell, D.13
Coleman, R.E.14
Fallowfield, L.J.15
Mickiewicz, E.16
Andersen, J.17
Lonning, P.E.18
Cocconi, G.19
Stewart, A.20
Stuart, N.21
Snowdon, C.F.22
Carpentieri, M.23
Massimini, G.24
Bliss, J.M.25
more..
-
177
-
-
0037011660
-
A phase I trial to assess the pharmacology of the new oestrogen receptor antagonist fulvestrant on the endometrium in healthy postmenopausal volunteers
-
Addo, S.; Yates, R. A.; Laight, A. A phase I trial to assess the pharmacology of the new oestrogen receptor antagonist fulvestrant on the endometrium in healthy postmenopausal volunteers. Br. J. Cancer 2002, 87, 1354-1359.
-
(2002)
Br. J. Cancer
, vol.87
, pp. 1354-1359
-
-
Addo, S.1
Yates, R.A.2
Laight, A.3
-
178
-
-
0030016280
-
Pharmacokinetics, pharmacological and anti-tumour effects of the specific anti-oestrogen ICI 182780 in women with advanced breast cancer
-
Howell, A.; DeFriend, D. J.; Robertson, J. F.; Blamey, R. W.; Anderson, L.; Anderson, E.; Sutcliffe, F. A.; Walton, P. Pharmacokinetics, pharmacological and anti-tumour effects of the specific anti-oestrogen ICI 182780 in women with advanced breast cancer. Br. J. Cancer 1996, 74, 300-308.
-
(1996)
Br. J. Cancer
, vol.74
, pp. 300-308
-
-
Howell, A.1
DeFriend, D.J.2
Robertson, J.F.3
Blamey, R.W.4
Anderson, L.5
Anderson, E.6
Sutcliffe, F.A.7
Walton, P.8
-
179
-
-
0037102126
-
Double-blind, randomized trial comparing the efficacy and tolerability of fulvestrant versus anastrozole in postmenopausal women with advanced breast cancer progressing on prior endocrine therapy: Results of a North American trial
-
Osborne, C. K.; Pippen, J.; Jones, S. E.; Parker, L. M.; Ellis, M.; Come, S.; Gertler, S. Z.; May, J. T.; Burton, G.; Dimery, I.; Webster, A.; Morris, C.; Elledge, R.; Buzdar, A. Double-blind, randomized trial comparing the efficacy and tolerability of fulvestrant versus anastrozole in postmenopausal women with advanced breast cancer progressing on prior endocrine therapy: results of a North American trial. J. Clin. Oncol. 2002, 20, 3386-3395.
-
(2002)
J. Clin. Oncol.
, vol.20
, pp. 3386-3395
-
-
Osborne, C.K.1
Pippen, J.2
Jones, S.E.3
Parker, L.M.4
Ellis, M.5
Come, S.6
Gertler, S.Z.7
May, J.T.8
Burton, G.9
Dimery, I.10
Webster, A.11
Morris, C.12
Elledge, R.13
Buzdar, A.14
-
180
-
-
0037102121
-
Fulvestrant, formerly ICI 182,780, is as effective as anastrozole in postmenopausal women with advanced breast cancer progressing after prior endocrine treatment
-
Howell, A.; Robertson, J. F.; Quaresma Albano, J.; Aschermannova, A.; Mauriac, L.; Kleeberg, U. R.; Vergote, I.; Erikstein, B.; Webster, A.; Morris, C. Fulvestrant, formerly ICI 182,780, is as effective as anastrozole in postmenopausal women with advanced breast cancer progressing after prior endocrine treatment. J. Clin. Oncol. 2002, 20, 3396-3403.
-
(2002)
J. Clin. Oncol.
, vol.20
, pp. 3396-3403
-
-
Howell, A.1
Robertson, J.F.2
Quaresma Albano, J.3
Aschermannova, A.4
Mauriac, L.5
Kleeberg, U.R.6
Vergote, I.7
Erikstein, B.8
Webster, A.9
Morris, C.10
-
181
-
-
0002947450
-
Oral medroxyprogesterone acetate in advanced or recurrent endometrial carcinoma: Results of therapy and correlation with estrogen and progesterone receptor levels-the Gynecologic Oncology Group experience
-
Baulier, E.; Iacobelli, S.; McGuire, W.; Eds.; New York: Parthenon Publishers
-
Thigpen, J. T.; Blessing, J. A.; DiSaia, P. Oral medroxyprogesterone acetate in advanced or recurrent endometrial carcinoma: results of therapy and correlation with estrogen and progesterone receptor levels-the Gynecologic Oncology Group experience. In Endocrinology and Malignancy; Baulier, E.; Iacobelli, S.; McGuire, W.; Eds.; New York: Parthenon Publishers. 1986, 446-454.
-
(1986)
Endocrinology and Malignancy
, pp. 446-454
-
-
Thigpen, J.T.1
Blessing, J.A.2
DiSaia, P.3
-
182
-
-
0033003177
-
Oral medroxyprogesterone acetate in the treatment of advanced or recurrent endometrial carcinoma: A dose-response study by the Gynecologic Oncology Group
-
Thigpen, J. T.; Brady, M. F.; Alvarez, R. D.; Adelson, M. D.; Homesley, H. D.; Manetta, A.; Soper, J. T.; Given, F. T. Oral medroxyprogesterone acetate in the treatment of advanced or recurrent endometrial carcinoma: a dose-response study by the Gynecologic Oncology Group. J. Clin. Oncol. 1999, 17, 1736-1744.
-
(1999)
J. Clin. Oncol.
, vol.17
, pp. 1736-1744
-
-
Thigpen, J.T.1
Brady, M.F.2
Alvarez, R.D.3
Adelson, M.D.4
Homesley, H.D.5
Manetta, A.6
Soper, J.T.7
Given, F.T.8
-
183
-
-
0031870833
-
The pivotal role of VEGF in tumor angiogenesis: Molecular facts and therapeutic opportunities
-
Siemeister, G.; Martiny-Baron, G.; Marme, D. The pivotal role of VEGF in tumor angiogenesis: molecular facts and therapeutic opportunities. Cancer Metastas. Rev. 1998, 17, 241-248.
-
(1998)
Cancer Metastas. Rev.
, vol.17
, pp. 241-248
-
-
Siemeister, G.1
Martiny-Baron, G.2
Marme, D.3
-
184
-
-
14644440555
-
Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis
-
Hicklin, D. J.; Ellis, L. M. Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis. J. Clin. Oncol. 2005, 23, 1011-1027.
-
(2005)
J. Clin. Oncol.
, vol.23
, pp. 1011-1027
-
-
Hicklin, D.J.1
Ellis, L.M.2
-
185
-
-
0042624638
-
Vascular endothelial growth factor (VEGF) expression in primary tumors and peritoneal metastases from patients with advanced ovarian carcinoma
-
Gadducci, A.; Viacava, P.; Cosio, S.; Cecchetti, D.; Fanelli, G.; Fanucchi, A.; Teti, G.; Genazzani, A. R. Vascular endothelial growth factor (VEGF) expression in primary tumors and peritoneal metastases from patients with advanced ovarian carcinoma. Anticancer Res. 2003, 23, 3001-3008.
-
(2003)
Anticancer Res.
, vol.23
, pp. 3001-3008
-
-
Gadducci, A.1
Viacava, P.2
Cosio, S.3
Cecchetti, D.4
Fanelli, G.5
Fanucchi, A.6
Teti, G.7
Genazzani, A.R.8
-
186
-
-
0030817612
-
Expression of vascular endothelial growth factor (VEGF) in epithelial ovarian neoplasms: Correlation with clinicopathology and patient survival, and analysis of serum VEGF levels
-
Yamamoto, S.; Konishi, I.; Mandai, M.; Kuroda, H.; Komatsu, T.; Nanbu, K.; Sakahara, H.; Mori, T. Expression of vascular endothelial growth factor (VEGF) in epithelial ovarian neoplasms: correlation with clinicopathology and patient survival, and analysis of serum VEGF levels. Br. J. Cancer 1997, 76, 1221-1227.
-
(1997)
Br. J. Cancer
, vol.76
, pp. 1221-1227
-
-
Yamamoto, S.1
Konishi, I.2
Mandai, M.3
Kuroda, H.4
Komatsu, T.5
Nanbu, K.6
Sakahara, H.7
Mori, T.8
-
187
-
-
0036605759
-
Thalidomide in solid malignancies
-
Eisen, T. Thalidomide in solid malignancies. J. Clin. Oncol. 2002, 20, 2607-2609.
-
(2002)
J. Clin. Oncol.
, vol.20
, pp. 2607-2609
-
-
Eisen, T.1
-
188
-
-
0037097595
-
Apoptotic signaling induced by immunomodulatory thalidomide analogs in human multiple myeloma cells: Therapeutic implications
-
Mitsiades, N.; Mitsiades, C. S.; Poulaki, V.; Chauhan, D.; Richardson, P. G.; Hideshima, T.; Munshi, N. C.; Treon, S. P.; Anderson, K. C. Apoptotic signaling induced by immunomodulatory thalidomide analogs in human multiple myeloma cells: therapeutic implications. Blood 2002, 99, 4525-4530.
-
(2002)
Blood
, vol.99
, pp. 4525-4530
-
-
Mitsiades, N.1
Mitsiades, C.S.2
Poulaki, V.3
Chauhan, D.4
Richardson, P.G.5
Hideshima, T.6
Munshi, N.C.7
Treon, S.P.8
Anderson, K.C.9
-
189
-
-
0037308584
-
A novel subclass of thalidomide analogue with anti-solid tumor activity in which caspase-dependent apoptosis is associated with altered expression of bcl-2 family proteins
-
Marriott, J. B.; Clarke, I. A.; Czajka, A.; Dredge, K.; Childs, K.; Man, H. W.; Schafer, P.; Govinda, S.; Muller, G. W.; Stirling, D. I.; Dalgleish, A. G. A novel subclass of thalidomide analogue with anti-solid tumor activity in which caspase-dependent apoptosis is associated with altered expression of bcl-2 family proteins. Cancer Res. 2003, 63, 593-599.
-
(2003)
Cancer Res.
, vol.63
, pp. 593-599
-
-
Marriott, J.B.1
Clarke, I.A.2
Czajka, A.3
Dredge, K.4
Childs, K.5
Man, H.W.6
Schafer, P.7
Govinda, S.8
Muller, G.W.9
Stirling, D.I.10
Dalgleish, A.G.11
-
190
-
-
0036839013
-
Immunomodulatory drug CC-5013 overcomes drug resistance and is well tolerated in patients with relapsed multiple myeloma
-
Richardson, P. G.; Schlossman, R. L.; Weller, E.; Hideshima, T.; Mitsiades, C.; Davies, F.; LeBlanc, R.; Catley, L. P.; Doss, D.; Kelly, K.; McKenney, M.; Mechlowicz, J.; Freeman, A.; Deocampo, R.; Rich, R.; Ryoo, J. J.; Chauhan, D.; Balinski, K.; Zeldis, J.; Anderson, K. C. Immunomodulatory drug CC-5013 overcomes drug resistance and is well tolerated in patients with relapsed multiple myeloma. Blood 2002, 100, 3063-3067.
-
(2002)
Blood
, vol.100
, pp. 3063-3067
-
-
Richardson, P.G.1
Schlossman, R.L.2
Weller, E.3
Hideshima, T.4
Mitsiades, C.5
Davies, F.6
LeBlanc, R.7
Catley, L.P.8
Doss, D.9
Kelly, K.10
McKenney, M.11
Mechlowicz, J.12
Freeman, A.13
Deocampo, R.14
Rich, R.15
Ryoo, J.J.16
Chauhan, D.17
Balinski, K.18
Zeldis, J.19
Anderson, K.C.20
more..
-
191
-
-
11144355748
-
Phase I study to determine the safety, tolerability and immunostimulatory activity of thalidomide analogue CC-5013 in patients with metastatic malignant melanoma and other advanced cancers
-
Bartlett, J. B.; Michael, A.; Clarke, I. A.; Dredge, K.; Nicholson, S.; Kristeleit, H.; Polychronis, A.; Pandha, H.; Muller, G. W.; Stirling, D. I.; Zeldis, J.; Dalgleish, A. G. Phase I study to determine the safety, tolerability and immunostimulatory activity of thalidomide analogue CC-5013 in patients with metastatic malignant melanoma and other advanced cancers. Br. J. Cancer 2004, 90, 955-961.
-
(2004)
Br. J. Cancer
, vol.90
, pp. 955-961
-
-
Bartlett, J.B.1
Michael, A.2
Clarke, I.A.3
Dredge, K.4
Nicholson, S.5
Kristeleit, H.6
Polychronis, A.7
Pandha, H.8
Muller, G.W.9
Stirling, D.I.10
Zeldis, J.11
Dalgleish, A.G.12
-
192
-
-
0037083545
-
Ovarian and papillary-serous peritoneal carcinoma: Pilot study with thalidomide
-
Abramson, N.; Stokes, P. K.; Luke, M.; Marks, A. R.; Harris, J. M. Ovarian and papillary-serous peritoneal carcinoma: pilot study with thalidomide. J. Clin. Oncol. 2002, 20, 1147-1149.
-
(2002)
J. Clin. Oncol.
, vol.20
, pp. 1147-1149
-
-
Abramson, N.1
Stokes, P.K.2
Luke, M.3
Marks, A.R.4
Harris, J.M.5
-
193
-
-
0027197245
-
Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo
-
Kim, K. J.; Li, B.; Winer, J.; Armanini, M.; Gillett, N.; Phillips, H. S.; Ferrara, N. Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo. Nature 1993, 362, 841-844.
-
(1993)
Nature
, vol.362
, pp. 841-844
-
-
Kim, K.J.1
Li, B.2
Winer, J.3
Armanini, M.4
Gillett, N.5
Phillips, H.S.6
Ferrara, N.7
-
194
-
-
2542561964
-
Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer
-
Hurwitz, H.; Fehrenbacher, L.; Novotny, W.; Cartwright, T.; Hainsworth, J.; Heim, W.; Berlin, J.; Baron, A.; Griffing, S.; Holmgren, E.; Ferrara, N.; Fyfe, G.; Rogers, B.; Ross, R.; Kabbinavar, F. Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N. Engl. J. Med. 2004, 350, 2335-2342.
-
(2004)
N. Engl. J. Med.
, vol.350
, pp. 2335-2342
-
-
Hurwitz, H.1
Fehrenbacher, L.2
Novotny, W.3
Cartwright, T.4
Hainsworth, J.5
Heim, W.6
Berlin, J.7
Baron, A.8
Griffing, S.9
Holmgren, E.10
Ferrara, N.11
Fyfe, G.12
Rogers, B.13
Ross, R.14
Kabbinavar, F.15
-
195
-
-
11844254414
-
Normalization of tumor vasculature: An emerging concept in antiangiogenic therapy
-
Jain, R. K. Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy. Science 2005, 307, 58-62.
-
(2005)
Science
, vol.307
, pp. 58-62
-
-
Jain, R.K.1
-
197
-
-
0034655182
-
PTK787/ZK 222584, a novel and potent inhibitor of vascular endothelial growth factor receptor tyrosine kinases, impairs vascular endothelial growth factor-induced responses and tumor growth after oral administration
-
Wood, J. M.; Bold, G.; Buchdunger, E.; Cozens, R.; Ferrari, S.; Frei, J.; Hofmann, F.; Mestan, J.; Mett, H.; O'Reilly, T.; Persohn, E.; Rosel, J.; Schnell, C.; Stover, D.; Theuer, A.; Towbin, H.; Wenger, F.; Woods-Cook, K.; Menrad, A.; Siemeister, G.; Schirner, M.; Thierauch, K. H.; Schneider, M. R.; Drevs, J.; Martiny-Baron, G.; Totzke, F. PTK787/ZK 222584, a novel and potent inhibitor of vascular endothelial growth factor receptor tyrosine kinases, impairs vascular endothelial growth factor-induced responses and tumor growth after oral administration. Cancer Res. 2000, 60, 2178-2189.
-
(2000)
Cancer Res.
, vol.60
, pp. 2178-2189
-
-
Wood, J.M.1
Bold, G.2
Buchdunger, E.3
Cozens, R.4
Ferrari, S.5
Frei, J.6
Hofmann, F.7
Mestan, J.8
Mett, H.9
O'Reilly, T.10
Persohn, E.11
Rosel, J.12
Schnell, C.13
Stover, D.14
Theuer, A.15
Towbin, H.16
Wenger, F.17
Woods-Cook, K.18
Menrad, A.19
Siemeister, G.20
Schirner, M.21
Thierauch, K.H.22
Schneider, M.R.23
Drevs, J.24
Martiny-Baron, G.25
Totzke, F.26
more..
-
198
-
-
0020559574
-
A radioimmunoassay using a monoclonal antibody to monitor the course of epithelial ovarian cancer
-
Bast, R. C., Jr.; Klug, T. L.; St John, E.; Jenison, E.; Niloff, J. M.; Lazarus, H.; Berkowitz, R. S.; Leavitt, T.; Griffiths, C. T.; Parker, L.; Zurawski, V. R., Jr.; Knapp, R. C. A radioimmunoassay using a monoclonal antibody to monitor the course of epithelial ovarian cancer. N. Engl. J. Med. 1983, 309, 883-887.
-
(1983)
N. Engl. J. Med.
, vol.309
, pp. 883-887
-
-
Bast Jr., R.C.1
Klug, T.L.2
St John, E.3
Jenison, E.4
Niloff, J.M.5
Lazarus, H.6
Berkowitz, R.S.7
Leavitt, T.8
Griffiths, C.T.9
Parker, L.10
Zurawski Jr., V.R.11
Knapp, R.C.12
-
199
-
-
0037388367
-
TRANCE- and CD40 ligand-matured dendritic cells reveal MHC class I-restricted T cells specific for autologous tumor in late-stage ovarian cancer patients
-
Schlienger, K.; Chu, C. S.; Woo, E. Y.; Rivers, P. M.; Toll, A. J.; Hudson, B.; Maus, M. V.; Riley, J. L.; Choi, Y.; Coukos, G.; Kaiser, L. R.; Rubin, S. C.; Levine, B. L.; Carroll, R. G.; June, C. H. TRANCE- and CD40 ligand-matured dendritic cells reveal MHC class I-restricted T cells specific for autologous tumor in late-stage ovarian cancer patients. Clin. Cancer Res. 2003, 9, 1517-1527.
-
(2003)
Clin. Cancer Res.
, vol.9
, pp. 1517-1527
-
-
Schlienger, K.1
Chu, C.S.2
Woo, E.Y.3
Rivers, P.M.4
Toll, A.J.5
Hudson, B.6
Maus, M.V.7
Riley, J.L.8
Choi, Y.9
Coukos, G.10
Kaiser, L.R.11
Rubin, S.C.12
Levine, B.L.13
Carroll, R.G.14
June, C.H.15
-
200
-
-
0037375713
-
The use of dendritic cells in cancer immunotherapy
-
Schuler, G.; Schuler-Thurner, B.; Steinman, R. M. The use of dendritic cells in cancer immunotherapy. Curr. Opin. Immunol. 2003, 15, 138-147.
-
(2003)
Curr. Opin. Immunol.
, vol.15
, pp. 138-147
-
-
Schuler, G.1
Schuler-Thurner, B.2
Steinman, R.M.3
-
201
-
-
0023636771
-
The E6-E7 region of human papillomavirus type 18 is sufficient for transformation of NIH 3T3 and rat-1 cells
-
Bedell, M. A.; Jones, K. H.; Laimins, L. A. The E6-E7 region of human papillomavirus type 18 is sufficient for transformation of NIH 3T3 and rat-1 cells. J. Virol. 1987, 61, 3635-3640.
-
(1987)
J. Virol.
, vol.61
, pp. 3635-3640
-
-
Bedell, M.A.1
Jones, K.H.2
Laimins, L.A.3
-
202
-
-
0028810340
-
Evaluation of seroreactivity to human papillomavirus type 16 virus-like particles in an incident case-control study of cervical neoplasia
-
Wideroff, L.; Schiffman, M. H.; Nonnenmacher, B.; Hubbert, N.; Kirnbauer, R.; Greer, C. E.; Lowy, D.; Lorincz, A. T.; Manos, M. M.; Glass, A. G.; et al. Evaluation of seroreactivity to human papillomavirus type 16 virus-like particles in an incident case-control study of cervical neoplasia. J. Infect. Dis. 1995, 172, 1425-1430.
-
(1995)
J. Infect. Dis.
, vol.172
, pp. 1425-1430
-
-
Wideroff, L.1
Schiffman, M.H.2
Nonnenmacher, B.3
Hubbert, N.4
Kirnbauer, R.5
Greer, C.E.6
Lowy, D.7
Lorincz, A.T.8
Manos, M.M.9
Glass, A.G.10
-
203
-
-
0028080322
-
Human papillomavirus types 6 and 11 have antigenically distinct strongly immunogenic conformationally dependent neutralizing epitopes
-
Christensen, N. D.; Kirnbauer, R.; Schiller, J. T.; Ghim, S. J.; Schlegel, R.; Jenson, A. B.; Kreider, J. W. Human papillomavirus types 6 and 11 have antigenically distinct strongly immunogenic conformationally dependent neutralizing epitopes. Virology 1994, 205, 329-335.
-
(1994)
Virology
, vol.205
, pp. 329-335
-
-
Christensen, N.D.1
Kirnbauer, R.2
Schiller, J.T.3
Ghim, S.J.4
Schlegel, R.5
Jenson, A.B.6
Kreider, J.W.7
-
204
-
-
0042206882
-
Papillomavirus vaccines in clinical trials
-
Galloway, D. A. Papillomavirus vaccines in clinical trials. Lancet Infect. Dis. 2003, 3, 469-475.
-
(2003)
Lancet Infect. Dis.
, vol.3
, pp. 469-475
-
-
Galloway, D.A.1
-
205
-
-
0037153042
-
A controlled trial of a human papillomavirus type 16 vaccine
-
Koutsky, L. A.; Ault, K. A.; Wheeler, C. M.; Brown, D. R.; Barr, E.; Alvarez, F. B.; Chiacchierini, L. M.; Jansen, K. U. A controlled trial of a human papillomavirus type 16 vaccine. N. Engl. J. Med. 2002, 347, 1645-1651.
-
(2002)
N. Engl. J. Med.
, vol.347
, pp. 1645-1651
-
-
Koutsky, L.A.1
Ault, K.A.2
Wheeler, C.M.3
Brown, D.R.4
Barr, E.5
Alvarez, F.B.6
Chiacchierini, L.M.7
Jansen, K.U.8
-
206
-
-
8444249386
-
Efficacy of a bivalent L1 virus-like particle vaccine in prevention of infection with human papillomavirus types 16 and 18 in young women: A randomised controlled trial
-
Harper, D. M.; Franco, E. L.; Wheeler, C.; Ferris, D. G.; Jenkins, D.; Schuind, A.; Zahaf, T.; Innis, B.; Naud, P.; De Carvalho, N. S.; Roteli-Martins, C. M.; Teixeira, J.; Blatter, M. M.; Korn, A. P.; Quint, W.; Dubin, G. Efficacy of a bivalent L1 virus-like particle vaccine in prevention of infection with human papillomavirus types 16 and 18 in young women: a randomised controlled trial. Lancet 2004, 364, 1757-1765.
-
(2004)
Lancet
, vol.364
, pp. 1757-1765
-
-
Harper, D.M.1
Franco, E.L.2
Wheeler, C.3
Ferris, D.G.4
Jenkins, D.5
Schuind, A.6
Zahaf, T.7
Innis, B.8
Naud, P.9
De Carvalho, N.S.10
Roteli-Martins, C.M.11
Teixeira, J.12
Blatter, M.M.13
Korn, A.P.14
Quint, W.15
Dubin, G.16
-
207
-
-
15444362351
-
Viable adenovirus vaccine prototypes: High-level production of a papillomavirus capsid antigen from the major late transcriptional unit
-
Berg, M.; Difatta, J.; Hoiczyk, E.; Schlegel, R.; Ketner, G. Viable adenovirus vaccine prototypes: high-level production of a papillomavirus capsid antigen from the major late transcriptional unit. Proc. Natl. Acad. Sci. USA 2005, 102, 4590-4595.
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 4590-4595
-
-
Berg, M.1
Difatta, J.2
Hoiczyk, E.3
Schlegel, R.4
Ketner, G.5
-
208
-
-
0031747870
-
Anti-idiotype induction therapy: Anti-CA125 antibodies (Ab3) mediated tumor killing in patients treated with Ovarex mAb B43.13 (Ab1)
-
Schultes, B. C.; Baum, R. P.; Niesen, A.; Noujaim, A. A.; Madiyalakan, R. Anti-idiotype induction therapy: anti-CA125 antibodies (Ab3) mediated tumor killing in patients treated with Ovarex mAb B43.13 (Ab1). Cancer Immunol. Immunother. 1998, 46, 201-212.
-
(1998)
Cancer Immunol. Immunother.
, vol.46
, pp. 201-212
-
-
Schultes, B.C.1
Baum, R.P.2
Niesen, A.3
Noujaim, A.A.4
Madiyalakan, R.5
-
209
-
-
0013370513
-
Immunomodulation with antibodies: Clinical application in ovarian cancer and other malignancies
-
Nicodemus, C. F.; Schultes, B. C.; Hamilton, B. L. Immunomodulation with antibodies: clinical application in ovarian cancer and other malignancies. Exp. Rev. Vaccines 2002, 1, 35-48.
-
(2002)
Exp. Rev. Vaccines
, vol.1
, pp. 35-48
-
-
Nicodemus, C.F.1
Schultes, B.C.2
Hamilton, B.L.3
-
210
-
-
0038336598
-
Immune responses to murine monoclonal antibody-B43.13 correlate with prolonged survival of women with recurrent ovarian cancer
-
Mobus, V. J.; Baum, R. P.; Bolle, M.; Kreienberg, R.; Noujaim, A. A.; Schultes, B. C.; Nicodemus, C. F. Immune responses to murine monoclonal antibody-B43.13 correlate with prolonged survival of women with recurrent ovarian cancer. Am. J. Obstet. Gynecol. 2003, 189, 28-36.
-
(2003)
Am. J. Obstet. Gynecol.
, vol.189
, pp. 28-36
-
-
Mobus, V.J.1
Baum, R.P.2
Bolle, M.3
Kreienberg, R.4
Noujaim, A.A.5
Schultes, B.C.6
Nicodemus, C.F.7
-
211
-
-
4444383336
-
Randomized, placebo-controlled study of oregovomab for consolidation of clinical remission in patients with advanced ovarian cancer
-
Berek, J. S.; Taylor, P. T.; Gordon, A.; Cunningham, M. J.; Finkler, N.; Orr, J., Jr.; Rivkin, S.; Schultes, B. C.; Whiteside, T. L.; Nicodemus, C. F. Randomized, placebo-controlled study of oregovomab for consolidation of clinical remission in patients with advanced ovarian cancer. J. Clin. Oncol. 2004, 22, 3507-3516.
-
(2004)
J. Clin. Oncol.
, vol.22
, pp. 3507-3516
-
-
Berek, J.S.1
Taylor, P.T.2
Gordon, A.3
Cunningham, M.J.4
Finkler, N.5
Orr Jr., J.6
Rivkin, S.7
Schultes, B.C.8
Whiteside, T.L.9
Nicodemus, C.F.10
-
212
-
-
0033838826
-
Immunotherapy of a human papillomavirus (HPV) type 16 E7-expressing tumour by administration of fusion protein comprising Mycobacterium bovis bacille Calmette-Guerin (BCG) hsp65 and HPV16 E7
-
Chu, N. R.; Wu, H. B.; Wu, T.; Boux, L. J.; Siegel, M. I.; Mizzen, L. A. Immunotherapy of a human papillomavirus (HPV) type 16 E7-expressing tumour by administration of fusion protein comprising Mycobacterium bovis bacille Calmette-Guerin (BCG) hsp65 and HPV16 E7. Clin. Exp. Immunol. 2000, 121, 216-225.
-
(2000)
Clin. Exp. Immunol.
, vol.121
, pp. 216-225
-
-
Chu, N.R.1
Wu, H.B.2
Wu, T.3
Boux, L.J.4
Siegel, M.I.5
Mizzen, L.A.6
-
213
-
-
0036114412
-
Activity of HspE7, a Novel Immunotherapy, in Patients with Anogenital Warts
-
Goldstone, S. E.; Palefsky, J. M.; Winnett, M. T.; Neefe, J. R. Activity of HspE7, a Novel Immunotherapy, in Patients with Anogenital Warts. Dis. Colon Rectum 2001, 45, 502-507.
-
(2001)
Dis. Colon Rectum
, vol.45
, pp. 502-507
-
-
Goldstone, S.E.1
Palefsky, J.M.2
Winnett, M.T.3
Neefe, J.R.4
-
214
-
-
0030891198
-
LY231514, a pyrrolo[2,3-d]pyrimidine-based antifolate that inhibits multiple folate-requiring enzymes
-
Shih, C.; Chen, V. J.; Gossett, L. S.; Gates, S. B.; MacKellar, W. C.; Habeck, L. L.; Shackelford, K. A.; Mendelsohn, L. G.; Soose, D. J.; Patel, V. F.; Andis, S. L.; Bewley, J. R.; Rayl, E. A.; Moroson, B. A.; Beardsley, G. P.; Kohler, W.; Ratnam, M.; Schultz, R. M. LY231514, a pyrrolo[2,3-d]pyrimidine- based antifolate that inhibits multiple folate-requiring enzymes. Cancer Res. 1997, 57, 1116-1123.
-
(1997)
Cancer Res.
, vol.57
, pp. 1116-1123
-
-
Shih, C.1
Chen, V.J.2
Gossett, L.S.3
Gates, S.B.4
MacKellar, W.C.5
Habeck, L.L.6
Shackelford, K.A.7
Mendelsohn, L.G.8
Soose, D.J.9
Patel, V.F.10
Andis, S.L.11
Bewley, J.R.12
Rayl, E.A.13
Moroson, B.A.14
Beardsley, G.P.15
Kohler, W.16
Ratnam, M.17
Schultz, R.M.18
-
215
-
-
0036562507
-
Homocysteine and methylmalonic acid: Markers to predict and avoid toxicity from pemetrexed therapy
-
Niyikiza, C.; Baker, S. D.; Seitz, D. E.; Walling, J. M.; Nelson, K.; Rusthoven, J. J.; Stabler, S. P.; Paoletti, P.; Calvert, A. H.; Allen, R. H. Homocysteine and methylmalonic acid: markers to predict and avoid toxicity from pemetrexed therapy. Mol. Cancer Ther. 2002, 1, 545-552.
-
(2002)
Mol. Cancer Ther.
, vol.1
, pp. 545-552
-
-
Niyikiza, C.1
Baker, S.D.2
Seitz, D.E.3
Walling, J.M.4
Nelson, K.5
Rusthoven, J.J.6
Stabler, S.P.7
Paoletti, P.8
Calvert, A.H.9
Allen, R.H.10
-
216
-
-
0035985288
-
Phase II trial of pemetrexed disodium (ALIMTA, LY231514) in chemotherapy-naive patients with advanced non-small-cell lung cancer
-
Clarke, S. J.; Abratt, R.; Goedhals, L.; Boyer, M. J.; Millward, M. J.;Ackland, S. P. Phase II trial of pemetrexed disodium (ALIMTA, LY231514) in chemotherapy-naive patients with advanced non-small-cell lung cancer. Ann. Oncol. 2002, 13, 737-741.
-
(2002)
Ann. Oncol.
, vol.13
, pp. 737-741
-
-
Clarke, S.J.1
Abratt, R.2
Goedhals, L.3
Boyer, M.J.4
Millward, M.J.5
Ackland, S.P.6
-
217
-
-
0032908148
-
Multitargeted antifolate LY231514 as firstline chemotherapy for patients with advanced non-small-cell lung cancer: A phase II study
-
National Cancer Institute of Canada Clinical Trials Group
-
Rusthoven, J. J.; Eisenhauer, E.; Butts, C.; Gregg, R.; Dancey, J.; Fisher, B.; Iglesias, J. Multitargeted antifolate LY231514 as firstline chemotherapy for patients with advanced non-small-cell lung cancer: A phase II study. National Cancer Institute of Canada Clinical Trials Group. J. Clin. Oncol. 1999, 17, 1194.
-
(1999)
J. Clin. Oncol.
, vol.17
, pp. 1194
-
-
Rusthoven, J.J.1
Eisenhauer, E.2
Butts, C.3
Gregg, R.4
Dancey, J.5
Fisher, B.6
Iglesias, J.7
-
218
-
-
0033993714
-
Phase I and pharmacologic study of sequences of gemcitabine and the multitargeted antifolate agent in patients with advanced solid tumors
-
Adjei, A. A.; Erlichman, C.; Sloan, J. A.; Reid, J. M.; Pitot, H. C.; Goldberg, R. M.; Peethambaram, P.; Atherton, P.; Hanson, L. J.; Alberts, S. R.;Jett, J. Phase I and pharmacologic study of sequences of gemcitabine and the multitargeted antifolate agent in patients with advanced solid tumors. J. Clin. Oncol. 2000, 18, 1748-1757.
-
(2000)
J. Clin. Oncol.
, vol.18
, pp. 1748-1757
-
-
Adjei, A.A.1
Erlichman, C.2
Sloan, J.A.3
Reid, J.M.4
Pitot, H.C.5
Goldberg, R.M.6
Peethambaram, P.7
Atherton, P.8
Hanson, L.J.9
Alberts, S.R.10
Jett, J.11
-
219
-
-
0001348880
-
MTA (LY231514) in advanced carinoma of the cervix
-
Goedhals, L.; van Wijk, A. L. MTA (LY231514) in advanced carinoma of the cervix. Ann. Oncol. 1998, 9(Suppl 2), 339a.
-
(1998)
Ann. Oncol.
, vol.9
, Issue.2 SUPPL.
-
-
Goedhals, L.1
Van Wijk, A.L.2
-
220
-
-
0029049468
-
Epothilones, a new class of microtubule-stabilizing agents with a taxol-like mechanism of action
-
Bollag, D. M.; McQueney, P. A.; Zhu, J.; Hensens, O.; Koupal, L.; Liesch, J.; Goetz, M.; Lazarides, E.; Woods, C. M. Epothilones, a new class of microtubule-stabilizing agents with a taxol-like mechanism of action. Cancer Res. 1995, 55, 2325-2333.
-
(1995)
Cancer Res.
, vol.55
, pp. 2325-2333
-
-
Bollag, D.M.1
McQueney, P.A.2
Zhu, J.3
Hensens, O.4
Koupal, L.5
Liesch, J.6
Goetz, M.7
Lazarides, E.8
Woods, C.M.9
-
221
-
-
0034895987
-
BMS-247550: A novel epothilone analog with a mode of action similar to paclitaxel but possessing superior antitumor efficacy
-
Lee, F. Y.; Borzilleri, R.; Fairchild, C. R.; Kim, S. H.; Long, B. H.; Reventos-Suarez, C.; Vite, G. D.; Rose, W. C.; Kramer, R. A. BMS-247550: a novel epothilone analog with a mode of action similar to paclitaxel but possessing superior antitumor efficacy. Clin. Cancer Res. 2001, 7, 1429-1437.
-
(2001)
Clin. Cancer Res.
, vol.7
, pp. 1429-1437
-
-
Lee, F.Y.1
Borzilleri, R.2
Fairchild, C.R.3
Kim, S.H.4
Long, B.H.5
Reventos-Suarez, C.6
Vite, G.D.7
Rose, W.C.8
Kramer, R.A.9
-
222
-
-
3442898528
-
A phase II trial of the epothilone B analog, BMS-247550, in patients with previously treated advanced colorectal cancer
-
Eng, C.; Kindler, H. L.; Nattam, S.; Ansari, R. H.; Kasza, K.; Wade-Oliver, K.; Vokes, E. E. A phase II trial of the epothilone B analog, BMS-247550, in patients with previously treated advanced colorectal cancer. Ann. Oncol. 2004, 15, 928-932.
-
(2004)
Ann. Oncol.
, vol.15
, pp. 928-932
-
-
Eng, C.1
Kindler, H.L.2
Nattam, S.3
Ansari, R.H.4
Kasza, K.5
Wade-Oliver, K.6
Vokes, E.E.7
-
223
-
-
0032903928
-
In vitro pharmacology of cryptophycin 52 (LY355703) in human tumor cell lines
-
Wagner, M. M.; Paul, D. C.; Shih, C.; Jordan, M. A.; Wilson, L.; Williams, D. C. In vitro pharmacology of cryptophycin 52 (LY355703) in human tumor cell lines. Cancer Chemother. Pharmacol. 1999, 43, 115-125.
-
(1999)
Cancer Chemother. Pharmacol.
, vol.43
, pp. 115-125
-
-
Wagner, M.M.1
Paul, D.C.2
Shih, C.3
Jordan, M.A.4
Wilson, L.5
Williams, D.C.6
-
224
-
-
0036023410
-
Phase I trial of the cryptophycin analogue LY355703 administered as an intravenous infusion on a day 1 and 8 schedule every 21 days
-
Stevenson, J. P.; Sun, W.; Gallagher, M.; Johnson, R.; Vaughn, D.; Schuchter, L.; Algazy, K.; Hahn, S.; Enas, N.; Ellis, D.; Thornton, D.;O'Dwyer, P. J. Phase I trial of the cryptophycin analogue LY355703 administered as an intravenous infusion on a day 1 and 8 schedule every 21 days. Clin. Cancer Res. 2002, 8, 2524-2529.
-
(2002)
Clin. Cancer Res.
, vol.8
, pp. 2524-2529
-
-
Stevenson, J.P.1
Sun, W.2
Gallagher, M.3
Johnson, R.4
Vaughn, D.5
Schuchter, L.6
Algazy, K.7
Hahn, S.8
Enas, N.9
Ellis, D.10
Thornton, D.11
O'Dwyer, P.J.12
-
225
-
-
0037316411
-
Phase 2 study of cryptophycin 52 (LY355703) in patients previously treated with platinum based chemotherapy for advanced non-small cell lung cancer
-
Edelman, M. J.; Gandara, D. R.; Hausner, P.; Israel, V.; Thornton, D.; DeSanto, J.; Doyle, L. A. Phase 2 study of cryptophycin 52 (LY355703) in patients previously treated with platinum based chemotherapy for advanced non-small cell lung cancer. Lung Cancer 2003, 39, 197-199.
-
(2003)
Lung Cancer
, vol.39
, pp. 197-199
-
-
Edelman, M.J.1
Gandara, D.R.2
Hausner, P.3
Israel, V.4
Thornton, D.5
Desanto, J.6
Doyle, L.A.7
-
226
-
-
12144255062
-
Combinations of endocrine and biological agents: Present status of therapeutic and presurgical investigations
-
Johnston, S. R. Combinations of endocrine and biological agents: present status of therapeutic and presurgical investigations. Clin. Cancer Res. 2005, 11, 889s-899s.
-
(2005)
Clin. Cancer Res.
, vol.11
-
-
Johnston, S.R.1
|