Development of small molecule Hsp90 inhibitors: Utilizing both forward and reverse chemical genomics for drug identification

Current Medicinal Chemistry

Volumn 10, Issue 9, 2003, Pages 733-739

  Neckers, Len ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Benzoquinone ansamycins; Geldanamycin; Heat shock protein 90; Kinase inhibitors; Molecular chaperones; Molecularly targeted therapeutics; Novobiocin; Radicicol

Indexed keywords

ADENOSINE TRIPHOSPHATE; ANSAMYCIN DERIVATIVE; ANTINEOPLASTIC AGENT; BCR ABL PROTEIN; BENZOQUINONE DERIVATIVE; CHAPERONE; HEAT SHOCK PROTEIN 90; HEAT SHOCK PROTEIN 90 INHIBITOR; HELIX LOOP HELIX PROTEIN; NOVOBIOCIN; ONCOPROTEIN; PROTEIN INHIBITOR; PROTEIN KINASE B; PROTEIN P53; RADICICOL; RAF PROTEIN; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; BINDING SITE; CANCER GROWTH; CARBOXY TERMINAL SEQUENCE; CELL SURVIVAL; DRUG IDENTIFICATION; DRUG PROTEIN BINDING; DRUG SCREENING; DRUG STRUCTURE; DRUG TARGETING; EXPERIMENTAL MODEL; GENE MUTATION; GENE OVEREXPRESSION; GENOMICS; HUMAN; HUMAN CELL; MOLECULAR BIOLOGY; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN STABILITY; REVIEW; SIGNAL TRANSDUCTION;

ANIMALS; ANTI-BACTERIAL AGENTS; ANTINEOPLASTIC AGENTS; BENZOQUINONES; DRUG DESIGN; EPITOPES; GENOMICS; HSP90 HEAT-SHOCK PROTEINS; HUMANS; LACTAMS, MACROCYCLIC; LACTONES; MACROLIDES; NOVOBIOCIN; NUCLEOTIDES; PROTEIN BINDING; RIFABUTIN;

EID: 0037265586     PISSN: 09298673     EISSN: None     Source Type: Journal    
DOI: 10.2174/0929867033457818     Document Type: Review

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