PTEN mutation located only outside exons 5, 6, and 7 is an independent predictor of favorable survival in endometrial carcinomas

Clinical Cancer Research

Volumn 7, Issue 9, 2001, Pages 2636-2642

  Minaguchi, T ^a   Yoshikawa, H ^a   Oda, K ^a   Ishino, T ^a   Yasugi, T ^a   Onda, T ^a   Nakagawa, S ^a   Matsumoto, K ^a   Kawana, K ^a   Taketani, Y ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

DNA;

ADULT; AGED; ARTICLE; CANCER SURVIVAL; DNA SEQUENCE; ENDOMETRIUM CARCINOMA; EXON; FEMALE; GENE MUTATION; GYNECOLOGIC CANCER; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROGNOSIS; SINGLE STRAND CONFORMATION POLYMORPHISM; TUMOR SUPPRESSOR GENE;

ADULT; AGED; DNA MUTATIONAL ANALYSIS; DNA, NEOPLASM; ENDOMETRIAL NEOPLASMS; EXONS; FEMALE; HUMANS; MIDDLE AGED; MUTATION; NEOPLASM STAGING; PHOSPHORIC MONOESTER HYDROLASES; POLYMORPHISM, SINGLE-STRANDED CONFORMATIONAL; PREDICTIVE VALUE OF TESTS; PROGNOSIS; PTEN PHOSPHOHYDROLASE; SURVIVAL ANALYSIS; TUMOR SUPPRESSOR PROTEINS;

EID: 0034802755     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (27)

1. Uterine cancer
2. Allelic loss on chromosome 17p and p53 mutations in human endometrial carcinoma of the uterus
3. K-ras activation in neoplasms of the human female reproductive tract
4. β-catenin mutation in carcinoma of the uterine endometrium
5. Mutations in PTEN are frequent in endometrial carcinoma but rare in other common gynecological malignancies
6. PTEN/MMAC1 mutations in endometrial cancers
7. PTEN is frequently mutated in primary endometrial carcinomas
8. PTEN a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer
9. Identification of a candidate tumor suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers
10. Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome
11. Germline mutations in PTEN are present in Bannayan-Zonana syndrome
12. Frequent inactivation of PTEN/MMAC1 in primary prostate cancer
13. Disruption of the MMAC1/PTEN gene by deletion or mutation is a frequent event in malignant melanoma
14. The multiple roles of PTEN in tumor suppression
15. PTEN gene mutations are seen in high-grade but not in low-grade gliomas
16. Differential expression of MMAC/PTEN in glioblastoma multiforme: Relationship to localization and prognosis
17. Loss of PTEN expression in paraffin-embedded primary prostate cancer correlates with high Gleason score and advanced stage
18. PTEN mutation in endometrial cancers is associated with favorable clinical and pathologic characteristics
19. Racial disparity in the frequency of PTEN mutations, but not microsatellite instability, in advanced endometrial cancers
20. FIGO stages: 1988 revisions
21. Histological typing of female genital tract tumors
22. Infrequent genetic alterations of the PTEN/MMAC1 gene in Japanese patients with primary cancers of the breast, lung, pancreas, kidney, and ovary
23. Nonparametric estimation from incomplete observations
24. Regression models and life-tables
25. Crystal structure of the PTEN tumor suppressor: Implications for its phosphoinositide phosphatase activity and membrane association
26. Mutational spectra of PTEN/MMAC1 gene: A tumor suppressor with lipid phosphatase activity
27. Endometrial carcinoma