-
1
-
-
15444350807
-
Selective inhibition of cell proliferation and BCR-ABL phosphorylation in acute lymphoblastic leukemia cells expressing Mr 190,000 BCR-ABL protein by a tyrosine kinase inhibitor (CGP-57148)
-
Beran M, Cao X, Estrov Z, et al: Selective inhibition of cell proliferation and BCR-ABL phosphorylation in acute lymphoblastic leukemia cells expressing Mr 190,000 BCR-ABL protein by a tyrosine kinase inhibitor (CGP-57148). Clin Cancer Res 4:1661-1672, 1998
-
(1998)
Clin Cancer Res
, vol.4
, pp. 1661-1672
-
-
Beran, M.1
Cao, X.2
Estrov, Z.3
-
2
-
-
0036566540
-
High frequency of point mutations clustered within the adenosine triphosphate-binding region of BCR/ABL in patients with chronic myeloid leukemia or Ph-positive acute lymphoblastic leukemia who develop imatinib (STI571) resistance
-
Branford S, Rudzki Z, Walsh S, et al: High frequency of point mutations clustered within the adenosine triphosphate-binding region of BCR/ABL in patients with chronic myeloid leukemia or Ph-positive acute lymphoblastic leukemia who develop imatinib (STI571) resistance. Blood 99:3472-3475, 2002
-
(2002)
Blood
, vol.99
, pp. 3472-3475
-
-
Branford, S.1
Rudzki, Z.2
Walsh, S.3
-
4
-
-
0031454003
-
CGP 57148, a tyrosine kinase inhibitor, inhibits the growth of cells expressing BCR-ABL, TEL-ABL and TEL-PDGFR fusion proteins
-
Carroll M, Ohno-Jones S, Tamura S, et al: CGP 57148, a tyrosine kinase inhibitor, inhibits the growth of cells expressing BCR-ABL, TEL-ABL and TEL-PDGFR fusion proteins. Blood 90:4947-4952, 1997
-
(1997)
Blood
, vol.90
, pp. 4947-4952
-
-
Carroll, M.1
Ohno-Jones, S.2
Tamura, S.3
-
5
-
-
0030853063
-
The tyrosine kinase inhibitor CGP57148B selectively inhibits the growth of BCR-ABL-positive cells
-
Deininger MW, Goldman JM, Lydon N, et al: The tyrosine kinase inhibitor CGP57148B selectively inhibits the growth of BCR-ABL-positive cells. Blood 90:3691-3698, 1997
-
(1997)
Blood
, vol.90
, pp. 3691-3698
-
-
Deininger, M.W.1
Goldman, J.M.2
Lydon, N.3
-
6
-
-
0037103424
-
Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors
-
Demetri GD, von Mehren M, Blanke CD, et al: Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors. N Engl J Med 347:472-480, 2002
-
(2002)
N Engl J Med
, vol.347
, pp. 472-480
-
-
Demetri, G.D.1
Von Mehren, M.2
Blanke, C.D.3
-
7
-
-
0034095603
-
The pyrido(2,3-d)pyrimidine derivative PD180970 inhibits p210Bcr-Abl tyrosine kinase and induces apoptosis of K562 leukemic cells
-
Dorsey JF, Jove R, Kraker AJ, et al: The pyrido(2,3-d)pyrimidine derivative PD180970 inhibits p210Bcr-Abl tyrosine kinase and induces apoptosis of K562 leukemic cells. Cancer Res 60:3127-3131, 2000
-
(2000)
Cancer Res
, vol.60
, pp. 3127-3131
-
-
Dorsey, J.F.1
Jove, R.2
Kraker, A.J.3
-
8
-
-
4243967053
-
A phase I study of the combination of gleevec (imatinib mesylate) with low dose Ara-C
-
Druker B, Kantarjian H, Talpaz M, et al: A phase I study of the combination of gleevec (imatinib mesylate) with low dose Ara-C. Blood 98:845a, 2001 (suppl 1, abstr)
-
(2001)
Blood
, vol.98
, Issue.SUPPL. 1 ABSTR.
-
-
Druker, B.1
Kantarjian, H.2
Talpaz, M.3
-
9
-
-
0002694995
-
STI571 (Gleevec/Glivec, imatinib) versus interferon (IFN) + cytarabine as initial therapy for patients with CML: Results of a randomized study
-
abstr
-
Druker BJ, for the IRIS (International Randomized IFN vs. STI571) Study Group: STI571 (Gleevec/Glivec, imatinib) versus interferon (IFN) + cytarabine as initial therapy for patients with CML: Results of a randomized study. Proc Am Soc Clin Onc 21:1a, 2002 (abstr)
-
(2002)
Proc Am Soc Clin Onc
, vol.21
-
-
Druker, B.J.1
-
10
-
-
0033987746
-
Lessons learned from the development of an abl tyrosine kinase inhibitor for chronic myelogenous leukemia
-
Druker BJ, Lydon NB: Lessons learned from the development of an abl tyrosine kinase inhibitor for chronic myelogenous leukemia. J Clin Invest 105:3-7, 2000
-
(2000)
J Clin Invest
, vol.105
, pp. 3-7
-
-
Druker, B.J.1
Lydon, N.B.2
-
12
-
-
0035810142
-
Activity of a specific inhibitor of the Bcr-Abl tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome
-
Druker BJ, Sawyers CL, Kantarjian H, et al: Activity of a specific inhibitor of the Bcr-Abl tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome. N Engl J Med 344:1038-1042, 2001
-
(2001)
N Engl J Med
, vol.344
, pp. 1038-1042
-
-
Druker, B.J.1
Sawyers, C.L.2
Kantarjian, H.3
-
13
-
-
0035810147
-
Efficacy and safety of a specific inhibitor of the Bcr-Abl tyrosine kinase in chronic myeloid leukemia
-
Druker BJ, Talpaz M, Resta D, et al: Efficacy and safety of a specific inhibitor of the Bcr-Abl tyrosine kinase in chronic myeloid leukemia. N Engl J Med 344:1031-1037, 2001
-
(2001)
N Engl J Med
, vol.344
, pp. 1031-1037
-
-
Druker, B.J.1
Talpaz, M.2
Resta, D.3
-
14
-
-
0029947186
-
Effects of a selective inhibitor of the ABL tyrosine kinase on the growth of BCR-ABL positive cells
-
Druker BJ, Tamura S, Buchdunger E, et al: Effects of a selective inhibitor of the ABL tyrosine kinase on the growth of BCR-ABL positive cells. Nat Med 2:561-566, 1996
-
(1996)
Nat Med
, vol.2
, pp. 561-566
-
-
Druker, B.J.1
Tamura, S.2
Buchdunger, E.3
-
15
-
-
0034665903
-
CGP57148B (STI-571) induces differentiation and apoptosis and sensitizes Bcr-Abl-positive human leukemia cells to apoptosis due to antileukemic drugs
-
Fang G, Kim CN, Perkins CL, et al: CGP57148B (STI-571) induces differentiation and apoptosis and sensitizes Bcr-Abl-positive human leukemia cells to apoptosis due to antileukemic drugs. Blood 96:2246-2253, 2000
-
(2000)
Blood
, vol.96
, pp. 2246-2253
-
-
Fang, G.1
Kim, C.N.2
Perkins, C.L.3
-
16
-
-
0031409736
-
Inhibition of the ABL kinase activity blocks the proliferation of BCR/ABL+ leukemic cells and induces apoptosis
-
Gambacorti-Passerini C, le Coutre P, Mologni L, et al: Inhibition of the ABL kinase activity blocks the proliferation of BCR/ABL+ leukemic cells and induces apoptosis. Blood Cells Mol Dis 23:380-394, 1997
-
(1997)
Blood Cells Mol Dis
, vol.23
, pp. 380-394
-
-
Gambacorti-Passerini, C.1
Le Coutre, P.2
Mologni, L.3
-
17
-
-
79960970804
-
In vitro effects of PS-341 alone and in combination with STI571 in Bcr-Abl positive cell lines both sensitive and resistant to STI571
-
Gatto SR, Scappini B, Verstovsek S, et al: In vitro effects of PS-341 alone and in combination with STI571 in Bcr-Abl positive cell lines both sensitive and resistant to STI571. Blood 98:101a, 2001 (suppl 1, abstr)
-
(2001)
Blood
, vol.98
, Issue.SUPPL. 1 ABSTR.
-
-
Gatto, S.R.1
Scappini, B.2
Verstovsek, S.3
-
18
-
-
0036090222
-
Primitive, quiescent, Philadelphia-positive stem cells from patients with chronic myeloid leukemia are insensitive to STI571 in vitro
-
Graham SM, Jorgensen HG, Allan E, et al: Primitive, quiescent, Philadelphia-positive stem cells from patients with chronic myeloid leukemia are insensitive to STI571 in vitro. Blood 99:319-325, 2002
-
(2002)
Blood
, vol.99
, pp. 319-325
-
-
Graham, S.M.1
Jorgensen, H.G.2
Allan, E.3
-
19
-
-
0036850514
-
Molecular and chromosomal mechanisms of resistance to imatinib (STI571) therapy
-
Hochhaus A, Kreil S, Corbin AS, et al: Molecular and chromosomal mechanisms of resistance to imatinib (STI571) therapy. Leukemia 16:2190-2196, 2002
-
(2002)
Leukemia
, vol.16
, pp. 2190-2196
-
-
Hochhaus, A.1
Kreil, S.2
Corbin, A.S.3
-
20
-
-
0036493544
-
Ph(+) acute lymphoblastic leukemia resistant to the tyrosine kinase inhibitor STI571 has a unique BCR-ABL gene mutation
-
Hofmann WK, Jones LC, Lemp NA, et al: Ph(+) acute lymphoblastic leukemia resistant to the tyrosine kinase inhibitor STI571 has a unique BCR-ABL gene mutation. Blood 99:1860-1862, 2001
-
(2001)
Blood
, vol.99
, pp. 1860-1862
-
-
Hofmann, W.K.1
Jones, L.C.2
Lemp, N.A.3
-
21
-
-
0037093082
-
Imatinib mesylate (STI571) inhibits growth of primitive malignant progenitors in chronic myelogenous leukemia through reversal of abnormally increased proliferation
-
Holtz MS, Slovak ML, Zhang F, et al: Imatinib mesylate (STI571) inhibits growth of primitive malignant progenitors in chronic myelogenous leukemia through reversal of abnormally increased proliferation. Blood 99:3792-3800, 2002
-
(2002)
Blood
, vol.99
, pp. 3792-3800
-
-
Holtz, M.S.1
Slovak, M.L.2
Zhang, F.3
-
22
-
-
0036683409
-
Overcoming STI571 resistance with the farnesyl transferase inhibitor SCH66336
-
Hoover RR, Mahon FX, Melo JV, et al: Overcoming STI571 resistance with the farnesyl transferase inhibitor SCH66336. Blood 100:1068-1071, 2002
-
(2002)
Blood
, vol.100
, pp. 1068-1071
-
-
Hoover, R.R.1
Mahon, F.X.2
Melo, J.V.3
-
23
-
-
0035313251
-
In vitro cytotoxic effects of a tyrosine kinase inhibitor STI571 in combination with commonly used antileukemic agents
-
Kano Y, Akutsu M, Tsunoda S, et al: In vitro cytotoxic effects of a tyrosine kinase inhibitor STI571 in combination with commonly used antileukemic agents. Blood 97:1999-2007, 2001
-
(2001)
Blood
, vol.97
, pp. 1999-2007
-
-
Kano, Y.1
Akutsu, M.2
Tsunoda, S.3
-
24
-
-
0003215157
-
High rates of early major and complete cytogenetic responses with imatinib mesylate therapy given at 400 mg or 800 mg orally daily in patients with newly diagnosed Philadelphia chromosome-positive chronic myeloid leukemia in chronic phase
-
abstr
-
Kantarjian H, Jorge C, O'Brien S, et al: High rates of early major and complete cytogenetic responses with imatinib mesylate therapy given at 400 mg or 800 mg orally daily in patients with newly diagnosed Philadelphia chromosome-positive chronic myeloid leukemia in chronic phase. Proc Am Soc Clin Oncol 21:261a, 2002 (abstr)
-
(2002)
Proc Am Soc Clin Oncol
, vol.21
-
-
Kantarjian, H.1
Jorge, C.2
O'Brien, S.3
-
25
-
-
0037186915
-
Hematologic and cytogenetic responses to imatinib mesylate in chronic myelogenous leukemia
-
Kantarjian H, Sawyers C, Hochhaus A, et al: Hematologic and cytogenetic responses to imatinib mesylate in chronic myelogenous leukemia. N Engl J Med 346:645-652, 2002
-
(2002)
N Engl J Med
, vol.346
, pp. 645-652
-
-
Kantarjian, H.1
Sawyers, C.2
Hochhaus, A.3
-
26
-
-
0037194613
-
Phosphatidylinositol-3 kinase inhibitors enhance the anti-leukemia effect of STI571
-
Klejman A, Rushen L, Morrione A, et al: Phosphatidylinositol-3 kinase inhibitors enhance the anti-leukemia effect of STI571. Oncogene 21:5868-5876, 2002
-
(2002)
Oncogene
, vol.21
, pp. 5868-5876
-
-
Klejman, A.1
Rushen, L.2
Morrione, A.3
-
27
-
-
79960971244
-
Preclinical evaluation of the efficacy of STI571 in combination with a variety of novel anticancer agents
-
La Rosée P, Johnson K, Moseson EM, et al: Preclinical evaluation of the efficacy of STI571 in combination with a variety of novel anticancer agents. Blood 98:839a, 2001 (suppl 1, abstr)
-
(2001)
Blood
, vol.98
, Issue.SUPPL. 1 ABSTR.
-
-
La Rosée, P.1
Johnson, K.2
Moseson, E.M.3
-
28
-
-
0036320754
-
In vitro studies of the combination of imatinib mesylate (Gleevec) and arsenic trioxide (Trisenox) in chronic myelogenous leukemia
-
La Rosee P, Johnson K, O'Dwyer ME, et al: In vitro studies of the combination of imatinib mesylate (Gleevec) and arsenic trioxide (Trisenox) in chronic myelogenous leukemia. Exp Hematol 30:729-737, 2002
-
(2002)
Exp Hematol
, vol.30
, pp. 729-737
-
-
La Rosee, P.1
Johnson, K.2
O'Dwyer, M.E.3
-
29
-
-
0036045378
-
Insights from preclinical studies for new combination treatment regimens with the Bcr-Abl kinase inhibitor imatinib mesylate (Gleevec/Glivec) in chronic myelogenous leukemia: A translational perspective
-
La Rosee P, O'Dwyer ME, Druker BJ: Insights from preclinical studies for new combination treatment regimens with the Bcr-Abl kinase inhibitor imatinib mesylate (Gleevec/Glivec) in chronic myelogenous leukemia: A translational perspective. Leukemia 16:1213-1219, 2002
-
(2002)
Leukemia
, vol.16
, pp. 1213-1219
-
-
La Rosee, P.1
O'Dwyer, M.E.2
Druker, B.J.3
-
30
-
-
0033585504
-
In vivo eradication of human BCR/ABL-positive leukemia cells with an ABL kinase inhibitor
-
le Coutre P, Mologni L, Cleris L, et al: In vivo eradication of human BCR/ABL-positive leukemia cells with an ABL kinase inhibitor. J Natl Cancer Inst 91:163-168, 1999
-
(1999)
J Natl Cancer Inst
, vol.91
, pp. 163-168
-
-
Le Coutre, P.1
Mologni, L.2
Cleris, L.3
-
31
-
-
0025348013
-
Tyrosine kinase activity and transformation potency of bcr-abl oncogene products
-
Lugo TG, Pendergast AM, Muller AJ, et al: Tyrosine kinase activity and transformation potency of bcr-abl oncogene products. Science 247:1079-1082, 1990
-
(1990)
Science
, vol.247
, pp. 1079-1082
-
-
Lugo, T.G.1
Pendergast, A.M.2
Muller, A.J.3
-
32
-
-
0036159844
-
Effects of combinations of therapeutic agents on the proliferation of progenitor cells in chronic myeloid leukaemia
-
Marley SB, Davidson RJ, Goldman JM, et al: Effects of combinations of therapeutic agents on the proliferation of progenitor cells in chronic myeloid leukaemia. Br J Haematol 116:162-165, 2002
-
(2002)
Br J Haematol
, vol.116
, pp. 162-165
-
-
Marley, S.B.1
Davidson, R.J.2
Goldman, J.M.3
-
33
-
-
0037079720
-
Effects of the Bcr/abl kinase inhibitors STI571 and adaphostin (NSC 680410) on chronic myelogenous leukemia cells in vitro
-
Mow BM, Chandra J, Svingen PA, et al: Effects of the Bcr/abl kinase inhibitors STI571 and adaphostin (NSC 680410) on chronic myelogenous leukemia cells in vitro. Blood 99:664-671, 2002
-
(2002)
Blood
, vol.99
, pp. 664-671
-
-
Mow, B.M.1
Chandra, J.2
Svingen, P.A.3
-
34
-
-
0035126944
-
Cotreatment with STI-571 enhances tumor necrosis factor alpha-related apoptosis-inducing ligand (TRAIL or apo-2L)-induced apoptosis of Bcr-Abl-positive human acute leukemia cells
-
Nimmanapalli R, Porosnicu M, Nguyen D, et al: Cotreatment with STI-571 enhances tumor necrosis factor alpha-related apoptosis-inducing ligand (TRAIL or apo-2L)-induced apoptosis of Bcr-Abl-positive human acute leukemia cells. Clin Cancer Res 7:350-357, 2001
-
(2001)
Clin Cancer Res
, vol.7
, pp. 350-357
-
-
Nimmanapalli, R.1
Porosnicu, M.2
Nguyen, D.3
-
35
-
-
79960970508
-
PEGIntron and STI571 combination evaluation study (PISCES) in chronic phase chronic myeloid leukaemia
-
O'Brien SG, Vallance SE, Craddock C, et al: PEGIntron and STI571 combination evaluation study (PISCES) in chronic phase chronic myeloid leukaemia. Blood 98:846a, 2001 (suppl 1, abstr)
-
(2001)
Blood
, vol.98
, Issue.SUPPL. 1 ABSTR.
-
-
O'Brien, S.G.1
Vallance, S.E.2
Craddock, C.3
-
36
-
-
0036720397
-
The impact of clonal evolution on response to imatinib mesylate (STI571) in accelerated phase CML
-
O'Dwyer ME, Mauro MJ, Kurilik, G, et al: The impact of clonal evolution on response to imatinib mesylate (STI571) in accelerated phase CML. Blood 100:1628-1633, 2002
-
(2002)
Blood
, vol.100
, pp. 1628-1633
-
-
O'Dwyer, M.E.1
Mauro, M.J.2
Kurilik, G.3
-
37
-
-
79960970988
-
Preliminary evaluation of the combination of imatinib mesylate (Gleevec) in combination with low dose interferon-alpha for the treatment of chronic phase CML
-
O'Dwyer ME, Mauro MJ, Kuyl J, et al: Preliminary evaluation of the combination of imatinib mesylate (Gleevec) in combination with low dose interferon-alpha for the treatment of chronic phase CML. Blood 98:846a, 2001 (suppl 1, abstr)
-
(2001)
Blood
, vol.98
, Issue.SUPPL. 1 ABSTR
-
-
O'Dwyer, M.E.1
Mauro, M.J.2
Kuyl, J.3
-
38
-
-
0035871874
-
ARG tyrosine kinase activity is inhibited by STI571
-
Okuda K, Weisberg E, Gilliland DG, et al: ARG tyrosine kinase activity is inhibited by STI571. Blood 97:2440-2448, 2001
-
(2001)
Blood
, vol.97
, pp. 2440-2448
-
-
Okuda, K.1
Weisberg, E.2
Gilliland, D.G.3
-
39
-
-
0037105560
-
A phase II study of imatinib mesylate (Glivec) in patients with relapsed or refractory Philadelphia chromosome positive acute lymphoid leukemias
-
Ottmann OG, Druker BJ, Sawyers CL, et al: A phase II study of imatinib mesylate (Glivec) in patients with relapsed or refractory Philadelphia chromosome positive acute lymphoid leukemias. Blood 100:1965-1971, 2002
-
(2002)
Blood
, vol.100
, pp. 1965-1971
-
-
Ottmann, O.G.1
Druker, B.J.2
Sawyers, C.L.3
-
40
-
-
0034743735
-
Co-treatment with As2O3 enhances selective cytotoxic effects of STI-571 against Bcr-Abl-positive acute leukemia cells
-
Porosnicu M, Nimmanapalli R, Nguyen D, et al: Co-treatment with As2O3 enhances selective cytotoxic effects of STI-571 against Bcr-Abl-positive acute leukemia cells. Leukemia 15:772-778, 2001
-
(2001)
Leukemia
, vol.15
, pp. 772-778
-
-
Porosnicu, M.1
Nimmanapalli, R.2
Nguyen, D.3
-
41
-
-
0036682481
-
Several types of mutations of the Abl gene can be found in chronic myeloid leukemia patients resistant to STI571, and they can pre-exist to the onset of treatment
-
Roche-Lestienne C, Soenen-Cornu V, Grardel-Duflos N, et al: Several types of mutations of the Abl gene can be found in chronic myeloid leukemia patients resistant to STI571, and they can pre-exist to the onset of treatment. Blood 100:1014-1018, 2002
-
(2002)
Blood
, vol.100
, pp. 1014-1018
-
-
Roche-Lestienne, C.1
Soenen-Cornu, V.2
Grardel-Duflos, N.3
-
42
-
-
79960971563
-
Effects of aminopeptidase inhibitors on STI571 resistant cell lines
-
Sawafuji K, Miyakawa Y, Weisberg E, et al: Effects of aminopeptidase inhibitors on STI571 resistant cell lines. Blood 98:309a, 2001 (suppl I, abstr)
-
(2001)
Blood
, vol.98
, Issue.SUPPL. I ABSTR.
-
-
Sawafuji, K.1
Miyakawa, Y.2
Weisberg, E.3
-
43
-
-
0037093092
-
Imatinib induces hematologic and cytogenetic responses in patients with chronic myeloid leukemia in myeloid blast crisis: Results of a phase II study
-
Sawyers CL, Hochhaus A, Feldman E, et al: Imatinib induces hematologic and cytogenetic responses in patients with chronic myeloid leukemia in myeloid blast crisis: Results of a phase II study. Blood 99:3530-3539, 2002
-
(2002)
Blood
, vol.99
, pp. 3530-3539
-
-
Sawyers, C.L.1
Hochhaus, A.2
Feldman, E.3
-
44
-
-
0001686739
-
Multiple BCR-ABL kinase domain mutations confer polyclonal resistance to the tyrosine kinase inhibitor imatinib (STI571) in chronic phase and blast crisis chronic myeloid leukemia
-
Shah NP, Nicoll JM, Nagar B, et al: Multiple BCR-ABL kinase domain mutations confer polyclonal resistance to the tyrosine kinase inhibitor imatinib (STI571) in chronic phase and blast crisis chronic myeloid leukemia. Cancer Cell 2:117-125, 2002
-
(2002)
Cancer Cell
, vol.2
, pp. 117-125
-
-
Shah, N.P.1
Nicoll, J.M.2
Nagar, B.3
-
45
-
-
0035313531
-
Comparison of effects of the tyrosine kinase inhibitors AG957, AG490, and STI571 on BCR-ABL-expressing cells, demonstrating synergy between AG490 and STI571
-
Sun X, Layton JE, Elefanty A, et al: Comparison of effects of the tyrosine kinase inhibitors AG957, AG490, and STI571 on BCR-ABL-expressing cells, demonstrating synergy between AG490 and STI571. Blood 97:2008-2015, 2001
-
(2001)
Blood
, vol.97
, pp. 2008-2015
-
-
Sun, X.1
Layton, J.E.2
Elefanty, A.3
-
46
-
-
0037085785
-
Imatinib induces durable hematologic and cytogenetic responses in patients with accelerated phase chronic myeloid leukemia: Results of a phase 2 study
-
Talpaz M, Silver RT, Druker BJ, et al: Imatinib induces durable hematologic and cytogenetic responses in patients with accelerated phase chronic myeloid leukemia: Results of a phase 2 study. Blood 99:1928-1937, 2002
-
(2002)
Blood
, vol.99
, pp. 1928-1937
-
-
Talpaz, M.1
Silver, R.T.2
Druker, B.J.3
-
47
-
-
0034330931
-
Efficacy of an Abl tyrosine kinase inhibitor in conjunction with other antileukemic agents against Bcr-Abl positive cells
-
Thiesing JT, Ohno-Jones S, Kolibaba KS, et al: Efficacy of an Abl tyrosine kinase inhibitor in conjunction with other antileukemic agents against Bcr-Abl positive cells. Blood 96:3195-3199, 2000
-
(2000)
Blood
, vol.96
, pp. 3195-3199
-
-
Thiesing, J.T.1
Ohno-Jones, S.2
Kolibaba, K.S.3
-
48
-
-
0000443909
-
Strong synergism of different signal transduction inhibitors in chronic myelogenous leukemia
-
Topaly J, Schad M, Zeller WJ, et al: Strong synergism of different signal transduction inhibitors in chronic myelogenous leukemia. Blood 98:617a, 2001 (suppl 1, abstr)
-
(2001)
Blood
, vol.98
, Issue.SUPPL. 1 ABSTR.
-
-
Topaly, J.1
Schad, M.2
Zeller, W.J.3
-
49
-
-
0035080416
-
Synergistic activity of the new ABL-specific tyrosine kinase inhibitor STI571 and chemotherapeutic drugs on BCR-ABL-positive chronic myelogenous leukemia cells
-
Topaly J, Zeller WJ, Fruehauf S: Synergistic activity of the new ABL-specific tyrosine kinase inhibitor STI571 and chemotherapeutic drugs on BCR-ABL-positive chronic myelogenous leukemia cells. Leukemia 15:342-347, 2001
-
(2001)
Leukemia
, vol.15
, pp. 342-347
-
-
Topaly, J.1
Zeller, W.J.2
Fruehauf, S.3
-
50
-
-
0035960428
-
Safety and efficacy of imatinib (STI571) in metastatic gastrointestinal stromal tumours: A phase I study
-
van Oosterom AT, Judson I, Verweij J, et al: Safety and efficacy of imatinib (STI571) in metastatic gastrointestinal stromal tumours: A phase I study. Lancet 358:1421-1423, 2001
-
(2001)
Lancet
, vol.358
, pp. 1421-1423
-
-
Van Oosterom, A.T.1
Judson, I.2
Verweij, J.3
-
51
-
-
0035122485
-
Induction of apoptosis in chronic myelogenous leukemia cells through nuclear entrapment of BCR-ABL tyrosine kinase
-
Vigneri P, Wang JY: Induction of apoptosis in chronic myelogenous leukemia cells through nuclear entrapment of BCR-ABL tyrosine kinase. Nat Med 7:228-234, 2001
-
(2001)
Nat Med
, vol.7
, pp. 228-234
-
-
Vigneri, P.1
Wang, J.Y.2
-
52
-
-
0037045583
-
BCR-ABL gene mutations in relation to clinical resistance of Philadelphia-chromosome-positive leukaemia to STI571: A prospective study
-
von Bubnoff N, Schneller F, Peschel C, et al: BCR-ABL gene mutations in relation to clinical resistance of Philadelphia-chromosome-positive leukaemia to STI571: A prospective study. Lancet 359:487-491, 2002
-
(2002)
Lancet
, vol.359
, pp. 487-491
-
-
Von Bubnoff, N.1
Schneller, F.2
Peschel, C.3
-
53
-
-
0036142963
-
Pharmacologic mitogen-activated protein/extracellular signal-regulated kinase kinase/mitogen-activated protein kinase inhibitors interact synergistically with STI571 to induce apoptosis in Bcr/Abl-expressing human leukemia cells
-
Yu C, Krystal G, Varticovksi L, et al: Pharmacologic mitogen-activated protein/extracellular signal-regulated kinase kinase/mitogen-activated protein kinase inhibitors interact synergistically with STI571 to induce apoptosis in Bcr/Abl-expressing human leukemia cells. Cancer Res 62:188-199, 2002
-
(2002)
Cancer Res
, vol.62
, pp. 188-199
-
-
Yu, C.1
Krystal, G.2
Varticovksi, L.3
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