Preliminary studies of a novel bifunctional metal chelator targeting Alzheimer's amyloidogenesis

Experimental Gerontology

Volumn 39, Issue 11-12 SPEC. ISS., 2004, Pages 1641-1649

  Dedeoglu, Alpaslan ^a,b   Cormier, Kerry ^a,b   Payton, Sandra ^c   Tseitlin, Katya A ^c   Kremsky, Jonathan N ^d   Lai, Li ^e   Li, Xiaohua ^e   Moir, Robert D ^c   Tanzi, Rudolph E ^c   Bush, Ashley I ^c   Kowall, Neil W ^a,b   Rogers, Jack T ^c   Huang, Xudong ^c  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

^d Prime Organics Inc   (United States)

^e HARVARD MEDICAL SCHOOL   (United States)

Author keywords

A amyloid; Alzheimer's disease; Amyloid precursor protein (APP); Metal chelator; Metals

Indexed keywords

[[(4 BENZOTHIAZOL 2 YLPHENYLCARBAMOYL)METHYL][2 [[2 [[(4 BENZOTHIAZOL 2 YLPHENYLCARBAMOYL)METHYL]CARBOXYMETHYLAMINO]ETHYL]CARBOXYMETHYLAMINO]ETHYL] AMINO]ACETIC ACID; AMIDE; AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[1-40]; COPPER; IRON; METAL CHELATE; UNCLASSIFIED DRUG; ZINC;

ALZHEIMER DISEASE; AMYLOIDOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; BRAIN DYSFUNCTION; CHELATION THERAPY; CHEMICAL BOND; CHEMICAL MODEL; CONFERENCE PAPER; CONTROLLED STUDY; COVALENT BOND; DRUG DESIGN; DRUG EFFECT; DRUG MECHANISM; DRUG PROTEIN BINDING; DRUG SYNTHESIS; DRUG TARGETING; FEMALE; GEOMETRY; GLYCOPROTEIN SYNTHESIS; HUMAN; HUMAN CELL; IN VITRO STUDY; LIPOPHILICITY; MOLECULE; MOUSE; NEUROBLASTOMA CELL; NEUROTOXICITY; NONHUMAN; PATHOGENESIS; PHARMACOPHORE; PRIORITY JOURNAL; PROTEIN BINDING; RAT; TOXICOKINETICS; TRANSGENIC MOUSE;

AGED; ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOIDOSIS; ANIMALS; BRAIN; BRAIN CHEMISTRY; BRAIN NEOPLASMS; CELL LINE, TUMOR; CHELATING AGENTS; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; METALS; MICE; MICE, TRANSGENIC; NEUROBLASTOMA; PEPTIDE FRAGMENTS;

ANIMALIA; MUS MUSCULUS;

EID: 9744219638     PISSN: 05315565     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exger.2004.08.016     Document Type: Conference Paper

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