A gene expression profile of Alzheimer’s disease

DNA and Cell Biology

Volumn 20, Issue 11, 2001, Pages 683-695

  Loring, Jeanne F ^a,b   Wen, X ^a   Lee, J M ^c   Seilhamer, Jeff ^a   Somogyi, R ^a,d  

^a Department of Life Sciences   (United States)

^b Arcos Bioscience   (United States)

^c LOYOLA UNIVERSITY MEDICAL CENTER   (United States)

^d Molecular Mining Corporation   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; COMPLEMENTARY DNA; PROTEIN;

AGED; ALZHEIMER DISEASE; AMYGDALOID NUCLEUS; ARTICLE; BRAIN REGION; CALCIUM BINDING; CELL ADHESION; CELL PROLIFERATION; CINGULATE GYRUS; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION FUNCTION; CYTOSKELETON; DNA SEQUENCE; ENERGY; FEMALE; GENE EXPRESSION PROFILING; GENE FUNCTION; HUMAN; HUMAN TISSUE; INFLAMMATION; MALE; PRIORITY JOURNAL; PROTEIN SYNTHESIS; SIGNAL TRANSDUCTION; STRESS; SYNAPSE VESICLE;

ALZHEIMER DISEASE; BRAIN; DNA, COMPLEMENTARY; GENE EXPRESSION PROFILING; HUMANS; NUCLEIC ACID HYBRIDIZATION; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS;

EID: 0035692472     PISSN: 10445498     EISSN: None     Source Type: Journal    
DOI: 10.1089/10445490152717541     Document Type: Article

References (142)

1. Increased density of metallothionein I/II immunopositive cortical glial cells in the early stages of Alzheimer’s disease
2. Sequences required for delivery and localization of the ADP/ATP translocator to the mitochondrial inner membrane
3. The expression of several mitochondrial and nuclear genes encoding the subunits of electron transport chain enzyme complexes, cytochrome C oxidase, and NADH dehydrogenase, in different brain regions in Alzheimer’s disease
4. Basic local alignment search tool
5. Phosphatidylinositol phosphate kinases, a multifaceted family of signaling enzymes
6. Immunolocalization of cytosolic aspartate aminotransferase (cAAT) in axon terminals that form synapses in the rat cerebellar cortex: A study at the electron microscopic level
7. Increased expression and subcellular translocation of the mitogen activated protein kinase kinase and mitogen-activated protein kinase in Alzheimer’s disease
8. Human fetal hippocampal development II: The neuronal cytoskeleton
9. The microglial cell: A historical review
10. Mitochondrial dysfunction in neurodegenerative diseases
11. Alzheimer’s disease and oxidative stress: Implications for novel therapeutic approaches
12. Regional and cellular distribution of neural visinin-like protein immunoreactivities (VILIP-1 and VILIP-3) in human brain
13. Activities of key glycolytic enzymes in the brains of patients with Alzheimer’s disease
14. A family of human phosphodiesterases homologous to the dunce learning and memory gene product of Drosophila melanogaster are potential targets for antidepressant drugs
15. Extracellular matrix components and amyloid in neuritic plaques of Alzheimer’s disease
16. An evaluation of the role of mitochondria in neurodegenerative diseases: Mitochondrial mutations and oxidative pathology, protective nuclear responses, and cell death in neurodegeneration
17. The novel components of the Arabidopsis light signaling pathway may define a group of general developmental regulators shared by both animal and plant kingdoms
18. The primary structure of rat ribosomal protein L23
19. Isolation and characterization of human TR3 receptor: A member of steroid receptor superfamily
20. Role of the proteasome in Alzheimer’s disease
21. Human homologues of the bacterial heat-shock protein DnaJ are preferentially expressed in neurons
22. Isolation and characterization of a novel gene expressed in multiple cancers
23. Familial dementia caused by polymerization of mutant neuroserpin
24. The importance of inflammatory mechanisms for the development of Alzheimer’s disease
25. Cloning, analysis, and chromosomal localization of myoxin (MYH12), the human homologue to the mouse dilute gene
26. Cloning, sequencing, gene organization, and localization of the human ribosomal protein RPL23A gene
27. Microglia induce CD4 T lymphocyte final effector function and death
28. Enzymes of ketone body utilization in human tissues: Protein and messenger RNA levels of succinylcoenzyme A (CoA):3-ketoacid CoA transferase and mitochondrial and cytosolic acetoacetyl-CoA thiolases
29. Molecular cloning and characterization of human keratan sulfate Gal-6-sulfotransferase
30. Inflammatory pathogenesis in Alzheimer’s disease: Biological mechanisms and cognitive sequelae
31. The E2 antigen, a 32 kD glycoprotein involved in T-cell adhesion processes, is the MIC2 gene product
32. A murine neural-specific homolog corrects cholinergic defects in Caenorhabditis elegans unc-18 mutants
33. Cloning and tissue expression of two putative steroid membrane receptors
34. Structural features of the human gene for muscle-specific enolase: Differential splicing in the 5′-untranslated sequence generates two forms of mRNA
35. Oxidative stress and a key metabolic enzyme in Alzheimer brains, cultured cells, and an animal model of chronic oxidative deficits
36. Identification and characterization of multiple forms of bovine brain N-myristoyltransferase
37. Phosphorylation of microtubule-associated protein tau is regulated by protein phosphatase 2A in mammalian brain: Implications for neurofibrillary degeneration in Alzheimer’s disease
38. Microglia and immune activation in Alzheimer’s disease
39. Role of cyclin G-associated kinase in uncoating clathrin-coated vesicles from non-neuronal cells
40. Alzheimer’s disease and inflammation: A review of cellular and therapeutic mechanisms
41. Prefoldin-nascent chain complexes in the folding of cytoskeletal proteins
42. CI-ATPase and Na+/K(+)-ATPase activities in Alzheimer’s disease brains
43. Human alpha-endosulfine, a possible regulator of sulfonylurea-sensitive KATP channel: Molecular cloning, expression and biological properties
44. Role of glycogen synthase kinase-3beta in neuronal apoptosis induced by trophic withdrawal
45. Complementary DNA encoding core protein II of human mitochondrial cytochrome bc1 complex: Substantial diversity in deduced primary structure from its yeast counterpart
46. Purification and partial amino acid sequence of a novel protein of the reticulocalbin family
47. The linkage of Kennedy’s neuron disease to ARA24, the first identified androgen receptor polyglutamine region-associated coactivator
48. Expression of s-laminin and laminin in the developing rat central nervous system
49. Extracellular signal regulated kinases: Localization of protein and mRNA in the human hippocampal formation in Alzheimer’s disease
50. Possible role of tau protein kinases in pathogenesis of Alzheimer’s disease
51. Identification of a specific effector of the small GTP-binding protein Rap2
52. Molecular characterization and tissue distribution of ZO-2, a tight junction protein homologous to ZO-1 and the Drosophila discs-large tumor suppressor protein
53. Characterization and chromosomal localization of PTP-NP-2, a new isoform of protein tyrosine phosphatase-like receptor, expressed on synaptic boutons
54. Molecular characterization of seizure-related genes isolated by differential screening
55. Genomic structure of human microtubule-associated protein 2 (MAP-2) and characterization of additional MAP-2 isoforms
56. Molecular characterization of the type 2 phosphatidic acid phosphatase
57. Impaired proteasome function in Alzheimer’s disease
58. Transforming growth factor-beta-stimulated clone-22 is a member of a family of leucine zipper proteins that can homo- and heterodimerize and has transcriptional repressor activity
59. Brain cytochrome oxidase in Alzheimer’s disease
60. Molecular cloning of a novel calcium-binding protein structurally related to hippocalcin from human brain and chromosomal mapping of its gene
61. Embryonic genes expressed in Alzheimer’s disease brains
62. cDNA cloning, tissue distribution, and chromosomal localization of myelodysplasia/myeloid leukemia factor 2 (MLF2)
63. Mitochondria from Alzheimer’s fibroblasts show decreased uptake of calcium and increased sensitivity to free radicals
64. cDNA cloning of a neural visinin-like Ca(2+)-binding protein
65. Loss of inositol 1, 4, 5-trisphosphate receptor sites and decreased PKC levels correlate with staging of Alzheimer’s disease neurofibrillary pathology
66. Moesin: A member of the protein 4.1-talin-ezrin family of proteins
67. A novel cDNA encoding a human homologue of ribosomal protein L29
68. Coordinate IGF-I and IGFBP5 gene expression in perinatal rat brain after hypoxia-ischemia
69. Molecular cloning and expression of the transformation sensitive epithelial marker stratifin: A member of a protein family that has been involved in the protein kinase C signaling pathway
70. Molecular cloning of two alternatively spliced forms of human phosphatidic acid phosphatase cDNAs that are differentially expressed in normal and tumor cells
71. The human heat-shock protein family: Expression of a novel heat-inducible HSP70 (HSP70B’) and isolation of its cDNA and genomic DNA
72. The human NADH:ubiquinone oxidoreductase NDUFS5 (15 kDa) subunit: Cdna cloning, chromosomal localization, tissue distribution and the absence of mutations in isolated complex I-deficient patients
73. Decreased glutathione transferase activity in brain and ventricular fluid in Alzheimer’s disease
74. Decreased base excision repair and increased helicase activity in Alzheimer’s disease brain
75. Microglia in diffuse plaques in hereditary cerebral hemorrhage with amyloidosis (Dutch): An immunohistochemical study
76. Oxidative alterations in Alzheimer’s disease
77. Expression of the human groEL stress-protein homologue in the brain and spinal cord
78. Tob, a novel protein that interacts with p185erbB2, is associated with anti-proliferative activity
79. Adducin is an in vivo substrate for protein kinase C: Phosphorylation in the MARCKS-related domain inhibits activity in promoting spectrin-actin complexes and occurs in many cells, including dendritic spines of neurons
80. Human chondroitin 6-sulfotransferase: Cloning, gene structure, and chromosomal localization
81. Apolipoprotein E4 isoform-specific actions on neuronal cells in culture
82. The Consortium to Establish a Registry for Alzheimer’s Disease (CERAD) II: Standardization of the neuropathologic assessment of Alzheimer’s disease
83. Molecular cloning of a novel thyroid hormone-responsive gene, ZAKI-4, in human skin fibroblasts
84. Protein kinase C-zeta activity but not level is decreased in Alzheimer’s disease microvessels
85. Elongation factor-1alpha stabilizes microtubules in a calcium/calmodulin-dependent manner
86. Heat-shock 70 messenger RNA levels in human brain: Correlation with agonal fever
87. Interleukin-1 and the immunogenetics of Alzheimer disease
88. Synaptopodin: An actin-associated protein in telencephalic dendrites and renal podocytes
89. Elevated connexin43 immunoreactivity at sites of amyloid plaques in Alzheimer’s disease
90. Beta-NAP, a cerebellar degeneration antigen, is a neuron-specific vesicle coat protein
91. Molecular cloning and characterization of a transcription factor for the C-type natriuretic peptide gene promoter
92. Expression of stromal cell-derived factor-1 and CXCR4 chemokine receptor mRNAs in cultured rat glial and neuronal cells
93. Expression and characterization of human FKBP52, an immunophilin that associates with the 90-kDa heat shock protein and is a component of steroid receptor complexes
94. Structure of the carboxy-terminal LIM domain from the cysteine rich protein CRP
95. MHC class II-positive microglia in human brain: Association with Alzheimer lesions
96. Activation of neuronal extracellular receptor kinase (ERK) in Alzheimer disease links oxidative stress to abnormal phosphorylation
97. Alpha2-macroglobulin enhances the clearance of endogenous soluble beta-amyloid peptide via low-density lipoprotein receptor-related protein in cortical neurons
98. Molecular cloning of LMO41, a new human LIM domain gene
99. The role of cell cycle-mediated events in Alzheimer’s disease
100. Regulation of eukaryotic messenger RNA turnover
101. Stress proteins as molecular markers of neurotoxicity
102. Cloning of human erythroid dematin reveals another member of the villin family
103. Association and colocalization of the Kvbeta1 and Kvbeta2 beta-subunits with Kv1 alpha-subunits in mammalian brain K+ channel complexes
104. Isolation of cDNAs from a mouse astroglial cell line by a subtracted cDNA library
105. On the stability of messenger RNA and ribosomal RNA in the brains of control human subjects and patients with Alzheimer’s disease
106. A 19-kDa protein belonging to a new family is expressed in the Golgi apparatus of neural cells
107. The 56-59-kilodalton protein identified in untransformed steroid receptor complexes is a unique protein that exists in cytosol in a complex with both the 70- and 90-kilodalton heat shock proteins
108. BIT, an immune antigen receptor like molecule in the brain
109. Coat proteins regulating membrane traffic
110. Localization of two potassium channel beta subunit genes, KCNA1B and KCNA2B
111. Isolation, tissue expression, and chromosomal assignment of human RGS5, a novel G-protein signaling regulator gene
112. AHNAK, a protein that binds and activates phospholipase C-gamma1 in the presence of arachidonic acid
113. Sequence and expression of seven new tetraspans
114. Neuronal death in cultured murine cortical cells is induced by inhibition of GAPDH and triosephosphate isomerase
115. Human alanyl-tRNA synthetase: Conservation in evolution of catalytic core and microhelix recognition
116. Functional alterations in Alzheimer’s disease: Selective loss of mitochondrial-encoded cytochrome oxidase mRNA in the hippocampal formation
117. Widespread peroxynitrite-mediated damage in Alzheimer’s disease
118. The cloning and expression of a human creatine transporter
119. Co-amplification of MYCN and a DEAD box gene (DDX1) in primary neuroblastoma
120. Selective regional loss of exocytotic presynaptic vesicle proteins in Alzheimer’s disease brains
121. Increased levels of apolipoprotein D in cerebrospinal fluid and hippocampus of Alzheimer’s patients
122. Functionally distinct isoforms of dynactin are expressed in human neurons
123. Activity-dependent pH shifts in hippocampal slices from normal and carbonic anhydrase II-deficient mice
124. Paired helical filament tau in Alzheimer’s disease: The kinase connection
125. Cloning, mapping, expression, function, and mutation analyses of the human ortholog of the hamster putative tumor suppressor gene Doc-1
126. Pre-foldin, a chaperone that delivers unfolded proteins to cytosolic chaperonin
127. Phosphatidate phosphohydrolase in purified rat brain myelin
128. Synthesis and release of l-serine by rat astroglia-rich primary cultures
129. MAPKKK6, a novel mitogen-activated protein kinase kinase kinase that associates with MAPKKK5
130. A presumed DNA helicase encoded by ERCC-3 is involved in the human repair disorders xeroderma pigmentosum and Cockayne’s syndrome
131. In silico-initiated cloning and molecular characterization of a novel human member of the L1 gene family of neural cell adhesion molecules
132. The endoplasmic reticulum calcium-binding protein of 55 kDa is a novel EF-hand protein retained in the endoplasmic reticulum by a carboxyl-terminal His-Asp-Glu-Leu motif
133. Human T and B lymphocytes express a structurally conserved focal adhesion kinase, pp125FAK
134. The human homologue of the mouse t-complex gene, TCP1, is located on chromosome 6 but is not near the HLA region
135. Protein-protein interactions between the testis brain RNA-binding protein and the transitional endoplasmic reticulum ATPase, a cytoskeletal gamma actin and Trax in male germ cells and the brain
136. Cloning and expression of cDNA encoding a human ubiquitin-conjugating enzyme similar to the Drosophila bendless gene product
137. Up-regulated production and activation of the complement system in Alzheimer’s disease brain
138. The Hsp56 component of steroid receptor complexes binds to immobilized FK506 and shows homology to FKBP-12 and FKBP-13
139. Heat-shock protein 70 levels in brain of patients with Down syndrome and Alzheimer’s disease
140. An evaluation of the performance of cDNA microarrays for detecting changes in global mRNA expression
141. The human Rab genes encode a family of GTP-binding proteins related to yeast YPT1 and SEC4 products involved in secretion
142. Recombinant SFD isoforms activate vacuolar proton pumps