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Volumn 6, Issue 6, 2006, Pages 579-589

Heat-shock protein 60 as a tool for novel therapeutic strategies that target the induction of regulatory T cells in human arthritis

Author keywords

Antigen specific immunotherapy; Arthritis; Autoimmune disease; Heat shock protein 60; JIA; Regulatory T cell

Indexed keywords

CANCER GROWTH FACTOR; EPITOPE; GAMMA INTERFERON; HEAT SHOCK PROTEIN 60; INTERLEUKIN 10; INTERLEUKIN 11 RECEPTOR; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR ALPHA; INTERLEUKIN 4; INTERLEUKIN 5; MYELIN BASIC PROTEIN; TRANSCRIPTION FACTOR FOXP3;

EID: 33744809528     PISSN: 14712598     EISSN: None     Source Type: Journal    
DOI: 10.1517/14712598.6.6.579     Document Type: Review
Times cited : (17)

References (114)
  • 1
    • 0028201732 scopus 로고
    • Tolerance, danger, and the extended family
    • MATZING ER P: Tolerance, danger, and the extended family. Annu. Rev. Immunol. (1994) 12:991-1045.
    • (1994) Annu. Rev. Immunol. , vol.12 , pp. 991-1045
    • Matzinger, P.1
  • 3
    • 85047690395 scopus 로고    scopus 로고
    • Autoreactive T cell responses show proinflammatory polarization in diabetes but a regulatory phenotype in health
    • ARIF S, TREE TI, ASTILL TP et al: Autoreactive T cell responses show proinflammatory polarization in diabetes but a regulatory phenotype in health. J. Clin. Invest. (2004) 113:451-463.
    • (2004) J. Clin. Invest. , vol.113 , pp. 451-463
    • Arif, S.1    Tree, T.I.2    Astill, T.P.3
  • 4
    • 10344229958 scopus 로고    scopus 로고
    • Functional regulatory immune responses against human cartilage glycoprotein-39 in health versus proinflammatory responses in rheumatoid arthritis
    • VAN BILSEN JH, VANDONGEN H, LARD LR et al.: Functional regulatory immune responses against human cartilage glycoprotein-39 in health versus proinflammatory responses in rheumatoid arthritis. Proc. Natl. Acad. Sci. USA (2004) 101:17180-17185.
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 17180-17185
    • Van Bilsen, J.H.1    Vandongen, H.2    Lard, L.R.3
  • 5
    • 14844345227 scopus 로고    scopus 로고
    • CD4+ Tregs and immune control
    • FEHERVARI Z, SAKAGUCHI S: CD4+ Tregs and immune control. J. Clin. Invest. (2004) 114:1209-1217.
    • (2004) J. Clin. Invest. , vol.114 , pp. 1209-1217
    • Fehervari, Z.1    Sakaguchi, S.2
  • 6
    • 0035554676 scopus 로고    scopus 로고
    • Regulatory T cells in the control of immune pathology
    • MALOY KJ, POWRIE F: Regulatory T cells in the control of immune pathology. Nat. Immunol. (2001) 2:816-822.
    • (2001) Nat. Immunol. , vol.2 , pp. 816-822
    • Maloy, K.J.1    Powrie, F.2
  • 7
    • 0037364804 scopus 로고    scopus 로고
    • Natural versus adaptive regulatory T cells
    • BLUESTONE JA, ABBAS AK: Natural versus adaptive regulatory T cells. Nat. Rev. Immunol. (2003) 3:253-257. In this report, the authors make and elaborate on the principal distinction between natural and induced (adaptive) Tregs.
    • (2003) Nat. Rev. Immunol. , vol.3 , pp. 253-257
    • Bluestone, J.A.1    Abbas, A.K.2
  • 8
    • 16844365788 scopus 로고    scopus 로고
    • Naturally arising Foxp3-expressing CD25(+)CD4(+) regulatory T cells in immunological tolerance to self and non-self
    • SAKAGUCHI S: Naturally arising Foxp3-expressing CD25(+)CD4(+) regulatory T cells in immunological tolerance to self and non-self. Nat. Immunol. (2005) 6:345-352. Clear review of natural Tregs and their markers.
    • (2005) Nat. Immunol. , vol.6 , pp. 345-352
    • Sakaguchi, S.1
  • 11
    • 0028037782 scopus 로고
    • Regulatory T cell clones induced by oral tolerance: Suppression of autoimmune encephalomyelitis
    • CHEN Y, KUCHROO VX, INOBE J, HAFLER DA, WEINER HL: Regulatory T cell clones induced by oral tolerance: suppression of autoimmune encephalomyelitis. Science (1994) 265:1237-1240.
    • (1994) Science , vol.265 , pp. 1237-1240
    • Chen, Y.1    Kuchroo, V.X.2    Inobe, J.3    Hafler, D.A.4    Weiner, H.L.5
  • 12
    • 0037446531 scopus 로고    scopus 로고
    • Cutting edge: Cure of colitis by CD4+CD25+ regulatory T cells
    • MOTTET C, UHLIG HH, POWRIE F: Cutting edge: cure of colitis by CD4+CD25+ regulatory T cells. J. Immunol. (2003) 170:3939-3943.
    • (2003) J. Immunol. , vol.170 , pp. 3939-3943
    • Mottet, C.1    Uhlig, H.H.2    Powrie, F.3
  • 13
    • 12244285937 scopus 로고    scopus 로고
    • Regulatory T cells suppress tumor-specific CD8 T cell cytotoxicity through TGF-beta signals in vivo
    • CHEN ML, PITTET MJ, GORELIK L et al.: Regulatory T cells suppress tumor-specific CD8 T cell cytotoxicity through TGF-beta signals in vivo. Proc. Natl. Acad. Sci. USA (2005) 102:419-424.
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , pp. 419-424
    • Chen, M.L.1    Pittet, M.J.2    Gorelik, L.3
  • 14
    • 2442641572 scopus 로고    scopus 로고
    • Promotion of allograft survival by CD4+CD25+ regulatory T cells: Evidence for in vivo inhibition of effector cell proliferation
    • LEE MK, MOORE DJ, JARRETT BP et al.: Promotion of allograft survival by CD4+CD25+ regulatory T cells: evidence for in vivo inhibition of effector cell proliferation. J. Immunol. (2004) 172:6539-6544.
    • (2004) J. Immunol. , vol.172 , pp. 6539-6544
    • Lee, M.K.1    Moore, D.J.2    Jarrett, B.P.3
  • 15
    • 18944370310 scopus 로고    scopus 로고
    • CD4+CD25 + regulatory T cells restrain pathogenic responses during Leishmania amazonensis infection
    • JI J, MASTERSON J, SUN J, SOONG L: CD4+CD25 + regulatory T cells restrain pathogenic responses during Leishmania amazonensis infection. J. Immunol. (2005) 174:7147-7153.
    • (2005) J. Immunol. , vol.174 , pp. 7147-7153
    • Ji, J.1    Masterson, J.2    Sun, J.3    Soong, L.4
  • 16
    • 17044421326 scopus 로고    scopus 로고
    • Removal of regulatory T cell activity reverses hyporesponsiveness and leads to filanal parasite clearance in vivo
    • TAYLOR MD, LEGOFF L, HARRIS A, MALONE E, ALLEN JE, MAIZELS RM: Removal of regulatory T cell activity reverses hyporesponsiveness and leads to filanal parasite clearance in vivo. J. Immunol. (2005) 174:4924-4933.
    • (2005) J. Immunol. , vol.174 , pp. 4924-4933
    • Taylor, M.D.1    Legoff, L.2    Harris, A.3    Malone, E.4    Allen, J.E.5    Maizels, R.M.6
  • 17
    • 0029150110 scopus 로고
    • Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes-various autoimmune diseases
    • SAKAGUCHI S, SAKAGUCHI N, ASANO M, ITOH M, TODA M: Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes-various autoimmune diseases. J. Immunol. (1995) 155:1151-1164.
    • (1995) J. Immunol. , vol.155 , pp. 1151-1164
    • Sakaguchi, S.1    Sakaguchi, N.2    Asano, M.3    Itoh, M.4    Toda, M.5
  • 18
    • 0029788211 scopus 로고    scopus 로고
    • Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation
    • ASANO M, TODA M, SAKAGUCHI N, SAKAGUCHI S: Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation. J. Exp. Med. (1996) 184:387-396.
    • (1996) J. Exp. Med. , vol.184 , pp. 387-396
    • Asano, M.1    Toda, M.2    Sakaguchi, N.3    Sakaguchi, S.4
  • 19
    • 3543097547 scopus 로고    scopus 로고
    • Suppressor T cells in human diseases
    • BAECHER-ALLAN C, HAFLER DA: Suppressor T cells in human diseases. J. Exp. Med. (2004) 200:273-276. The authors present an elaborate overview of the role of natural Tregs in human disease.
    • (2004) J. Exp. Med. , vol.200 , pp. 273-276
    • Baecher-Allan, C.1    Hafler, D.A.2
  • 20
    • 2442618129 scopus 로고    scopus 로고
    • CD4+CD25(bright) regulatory T cells actively regulate inflammation in the joints of patients with the remitting form of juvenile idiopathic arthritis
    • DE KLEER IM, WEDDERBURN LR, TAAMS LS et al.: CD4+CD25(bright) regulatory T cells actively regulate inflammation in the joints of patients with the remitting form of juvenile idiopathic arthritis. J. Immunol. (2004) 172:6435-6443.
    • (2004) J. Immunol. , vol.172 , pp. 6435-6443
    • De Kleer, I.M.1    Wedderburn, L.R.2    Taams, L.S.3
  • 21
    • 0141518636 scopus 로고    scopus 로고
    • Immune regulation by CD4+CD25+ regulatory T cells: Implications for transplantation tolerance
    • TAAMS L, VUKMANOVIC-STEJIC M, SALMON M, AKBAR A: Immune regulation by CD4+CD25+ regulatory T cells: implications for transplantation tolerance. Transplant. Immunol. (2003) 11:277-285.
    • (2003) Transplant. Immunol. , vol.11 , pp. 277-285
    • Taams, L.1    Vukmanovic-Stejic, M.2    Salmon, M.3    Akbar, A.4
  • 22
    • 2342603958 scopus 로고    scopus 로고
    • Normal human pregnancy is associated with an elevation in the immune suppressive CD25+ CD4+ regulatory T-cell subset
    • SOMERSET DA, ZHENG Y, KILBY MD, SANSOM DM, DRAYSON MT: Normal human pregnancy is associated with an elevation in the immune suppressive CD25+ CD4+ regulatory T-cell subset. Immunology (2004) 112:38-43.
    • (2004) Immunology , vol.112 , pp. 38-43
    • Somerset, D.A.1    Zheng, Y.2    Kilby, M.D.3    Sansom, D.M.4    Drayson, M.T.5
  • 23
    • 0037099719 scopus 로고    scopus 로고
    • Infectious tolerance: Human CD25(+) regulatory T cells convey suppressor activity to conventional CD4(+) T helper cells
    • JONULEIT H, SCHMITT E, KAKIRMAN H, STASSEN M, KNOP J, ENK AH: Infectious tolerance: human CD25(+) regulatory T cells convey suppressor activity to conventional CD4(+) T helper cells. J. Exp. Med. (2002) 196:255-260.
    • (2002) J. Exp. Med. , vol.196 , pp. 255-260
    • Jonuleit, H.1    Schmitt, E.2    Kakirman, H.3    Stassen, M.4    Knop, J.5    Enk, A.H.6
  • 24
    • 0037099733 scopus 로고    scopus 로고
    • Human CD4(+)CD25(+) regulatory, contact-dependent T cells induce interleukin 10-producing, contact-independent type 1-like regulatory T cells [corrected]
    • DIECKMANN D, BRUETT CH, PLOETTNER H, LUTZ MB, SCHULERC: Human CD4(+)CD25(+) regulatory, contact-dependent T cells induce interleukin 10-producing, contact-independent type 1-like regulatory T cells [corrected]. J. Exp. Med. (2002) 196:247-253.
    • (2002) J. Exp. Med. , vol.196 , pp. 247-253
    • Dieckmann, D.1    Bruett, C.H.2    Ploettner, H.3    Lutz, M.B.4    Schuler, C.5
  • 25
    • 0037026003 scopus 로고    scopus 로고
    • Phenotype, localization, and mechanism of suppression of CD4(+)CD25(+) human thymocytes
    • ANNUNZIATO F, COSMI L, LIOTTA F et al.: Phenotype, localization, and mechanism of suppression of CD4(+)CD25(+) human thymocytes. J. Exp. Med. (2002) 196:379-387.
    • (2002) J. Exp. Med. , vol.196 , pp. 379-387
    • Annunziato, F.1    Cosmi, L.2    Liotta, F.3
  • 26
    • 0036886390 scopus 로고    scopus 로고
    • The role of IL-10 and TGF-beta in the differentiation and effector function of T regulatory cells
    • LEVINGS MK, BACCHETTA R, SCHULZ U, RONCAROLO MG: The role of IL-10 and TGF-beta in the differentiation and effector function of T regulatory cells. Int. Arch. Allergy Immunol. (2002) 129:263-276.
    • (2002) Int. Arch. Allergy Immunol. , vol.129 , pp. 263-276
    • Levings, M.K.1    Bacchetta, R.2    Schulz, U.3    Roncarolo, M.G.4
  • 30
    • 0346969978 scopus 로고    scopus 로고
    • Induction of FoxP3 and acquisition of T regulatory activity by stimulated human CD4+
    • WALKER MR, KASPROWICZ DJ, GERSUK VH et al: Induction of FoxP3 and acquisition of T regulatory activity by stimulated human CD4+. J. Clin. Invest. (2003) 112:1437-1443.
    • (2003) J. Clin. Invest. , vol.112 , pp. 1437-1443
    • Walker, M.R.1    Kasprowicz, D.J.2    Gersuk, V.H.3
  • 31
    • 0842278639 scopus 로고    scopus 로고
    • Antigen nonspecific suppression of T cell responses by activated stimulation-refractory CD4+ T cells
    • DUTHOIT CT, NGUYEN P, GEIGERTL: Antigen nonspecific suppression of T cell responses by activated stimulation-refractory CD4+ T cells. J. Immunol. (2004) 172:2238-2246.
    • (2004) J. Immunol. , vol.172 , pp. 2238-2246
    • Duthoit, C.T.1    Nguyen, P.2    Geiger, T.L.3
  • 32
    • 0348223787 scopus 로고    scopus 로고
    • Conversion of peripheral CD4+CD25-naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3
    • CHEN W, JIN W, HARDEGEN N et al.: Conversion of peripheral CD4+CD25-naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3. J. Exp. Med. (2003) 198:1875-1886.
    • (2003) J. Exp. Med. , vol.198 , pp. 1875-1886
    • Chen, W.1    Jin, W.2    Hardegen, N.3
  • 34
    • 19944369378 scopus 로고    scopus 로고
    • Expression of FOXP3 mRNA is not confined to CD4+CD25+ T regulatory cells in humans
    • MORGAN ME, VAN BILSEN JH, BAKKER AM et al.: Expression of FOXP3 mRNA is not confined to CD4+CD25+ T regulatory cells in humans. Hum. Immunol. (2005) 66:13-20.
    • (2005) Hum. Immunol. , vol.66 , pp. 13-20
    • Morgan, M.E.1    Van Bilsen, J.H.2    Bakker, A.M.3
  • 35
    • 0037361819 scopus 로고    scopus 로고
    • Antigen-induced regulatory T cells in autoimmunity
    • VON HERRATH MG, HARRISON LC: Antigen-induced regulatory T cells in autoimmunity. Nat. Rev. Immunol. (2003) 3:223-232. Excellent overview of the role of induced Tregs in autoimmune disease.
    • (2003) Nat. Rev. Immunol. , vol.3 , pp. 223-232
    • Von Herrath, M.G.1    Harrison, L.C.2
  • 36
    • 0030035509 scopus 로고    scopus 로고
    • Induction of circulating myelin basic protein and proteolipid prorein-specific transforming growth factor-beta1-secreting Th3 T cells by oral administration of myelin in multiple sclerosis patients
    • FUKAURA H, KENT SC, PIETRUSEWICZ MJ, KHOURY SJ, WEINER HL, HAFLER DA: Induction of circulating myelin basic protein and proteolipid prorein-specific transforming growth factor-beta1-secreting Th3 T cells by oral administration of myelin in multiple sclerosis patients. J. Clin. Invest. (1996) 98:70-77.
    • (1996) J. Clin. Invest. , vol.98 , pp. 70-77
    • Fukaura, H.1    Kent, S.C.2    Pietrusewicz, M.J.3    Khoury, S.J.4    Weiner, H.L.5    Hafler, D.A.6
  • 37
    • 0030704726 scopus 로고    scopus 로고
    • A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitis
    • GROUX H, O'GARRA A, BIGLER M et al: A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitis. Nature (1997) 389:737-742.
    • (1997) Nature , vol.389 , pp. 737-742
    • Groux, H.1    O'Garra, A.2    Bigler, M.3
  • 38
    • 1242345130 scopus 로고    scopus 로고
    • Antigen-specific regulatory T cells-their induction and role in infection
    • MILLS KH, MCGUIRK P: Antigen-specific regulatory T cells-their induction and role in infection. Semin. Immunol. (2004) 16:107-117.
    • (2004) Semin. Immunol. , vol.16 , pp. 107-117
    • Mills, K.H.1    Mcguirk, P.2
  • 39
    • 0033975024 scopus 로고    scopus 로고
    • Inhibition of Th1 development and treatment of chronic-relapsing experimental allergic encephalomyelitis by a non-hypercalcemic analogue of 1,25-dihydroxyvitamin D(3)
    • MATTNER F, SMIROLDO S, GALBIATI F et al.: Inhibition of Th1 development and treatment of chronic-relapsing experimental allergic encephalomyelitis by a non-hypercalcemic analogue of 1,25-dihydroxyvitamin D(3). Eur. J. Immunol. (2000) 30:498-508.
    • (2000) Eur. J. Immunol. , vol.30 , pp. 498-508
    • Mattner, F.1    Smiroldo, S.2    Galbiati, F.3
  • 40
    • 12844274909 scopus 로고    scopus 로고
    • Differentiation of Tr1 cells by immature dendritic cells requires IL-10 but not CD25+CD4+ Tr cells
    • LEVINGS MK, GREGORI S, TRESOLDI E, CAZZANIGA S, BONINI C, RONCAROLO MG: Differentiation of Tr1 cells by immature dendritic cells requires IL-10 but not CD25+CD4+ Tr cells. Blood (2005) 105:1162-1169.
    • (2005) Blood , vol.105 , pp. 1162-1169
    • Levings, M.K.1    Gregori, S.2    Tresoldi, E.3    Cazzaniga, S.4    Bonini, C.5    Roncarolo, M.G.6
  • 41
    • 2142752959 scopus 로고    scopus 로고
    • Type 1 T regulatory cells and their relationship with CD4+CD25+ T regulatory cells
    • RONCAROLO MG, GREGORI S, LEVINGS M: Type 1 T regulatory cells and their relationship with CD4+CD25+ T regulatory cells. Novartis Found. Symp. (2003) 252:115-127.
    • (2003) Novartis Found. Symp. , vol.252 , pp. 115-127
    • Roncarolo, M.G.1    Gregori, S.2    Levings, M.3
  • 42
    • 0037018104 scopus 로고    scopus 로고
    • In vitro generation of interleukin 10-producing regulatory CD4(+) T cells is induced by immunosuppressive drugs and inhibited by T helper type 1 (Th1)- and Th2-inducing cytokines
    • BARRAT FJ, CUA DJ, BOONSTRA A et al.: In vitro generation of interleukin 10-producing regulatory CD4(+) T cells is induced by immunosuppressive drugs and inhibited by T helper type 1 (Th1)- and Th2-inducing cytokines. J. Exp. Med. (2002) 195:603-616.
    • (2002) J. Exp. Med. , vol.195 , pp. 603-616
    • Barrat, F.J.1    Cua, D.J.2    Boonstra, A.3
  • 43
    • 0038278670 scopus 로고    scopus 로고
    • Role of interleukin-10 in the induction and function of natural and antigen-induced regulatory T cells
    • WRAITH DC: Role of interleukin-10 in the induction and function of natural and antigen-induced regulatory T cells. J. Autoimmun. (2003) 20:273-275.
    • (2003) J. Autoimmun. , vol.20 , pp. 273-275
    • Wraith, D.C.1
  • 44
    • 0038617550 scopus 로고    scopus 로고
    • The role of interleukin 10 in the control of autoimmunity
    • RONCAROLO MG, BATTAGLIA M, GREGORI S: The role of interleukin 10 in the control of autoimmunity. J. Autoimmun. (2003) 20:269-272.
    • (2003) J. Autoimmun. , vol.20 , pp. 269-272
    • Roncarolo, M.G.1    Battaglia, M.2    Gregori, S.3
  • 46
    • 0037310355 scopus 로고    scopus 로고
    • Role for IL-10 in suppression mediated by peptide-induced regulatory T cells in vivo
    • SUNDSTEDT A, O'NEILL EJ, NICOLSON KS, WRAITH DC: Role for IL-10 in suppression mediated by peptide-induced regulatory T cells in vivo. J. Immunol. (2003) 170:1240-1248.
    • (2003) J. Immunol. , vol.170 , pp. 1240-1248
    • Sundstedt, A.1    O'Neill, E.J.2    Nicolson, K.S.3    Wraith, D.C.4
  • 47
    • 0032821774 scopus 로고    scopus 로고
    • Peptide-induced T cell regulation of experimental autoimmune encephalomyelitis: A role for IL-10
    • BURKHART C, LIU GY, ANDERTON SM, METZLER B, WRAITH DC: Peptide-induced T cell regulation of experimental autoimmune encephalomyelitis: a role for IL-10. Int. Immunol. (1999) 11(10):1625-1634.
    • (1999) Int. Immunol. , vol.11 , Issue.10 , pp. 1625-1634
    • Burkhart, C.1    Liu, G.Y.2    Anderton, S.M.3    Metzler, B.4    Wraith, D.C.5
  • 48
    • 2942642383 scopus 로고    scopus 로고
    • In vitro-expanded antigen-specific regulatory T cells suppress autoimmune diabetes
    • TANG Q, HENRIKSEN KJ, BI M et al.: In vitro-expanded antigen-specific regulatory T cells suppress autoimmune diabetes. J. Exp. Med. (2004) 199:1455-1465.
    • (2004) J. Exp. Med. , vol.199 , pp. 1455-1465
    • Tang, Q.1    Henriksen, K.J.2    Bi, M.3
  • 49
    • 2942692039 scopus 로고    scopus 로고
    • CD25+ CD4+ T cells, expanded with dendritic cells presenting a single autoantigenic peptide, suppress autoimmune diabetes
    • TARBELL KV, YAMAZAKI S, OLSON K, TOY P, STEINMAN RM: CD25+ CD4+ T cells, expanded with dendritic cells presenting a single autoantigenic peptide, suppress autoimmune diabetes. J. Exp. Med. (2004) 199:1467-1477.
    • (2004) J. Exp. Med. , vol.199 , pp. 1467-1477
    • Tarbell, K.V.1    Yamazaki, S.2    Olson, K.3    Toy, P.4    Steinman, R.M.5
  • 50
  • 51
    • 17144374934 scopus 로고    scopus 로고
    • Regulatory T-cell therapy: Is it ready for the clinic?
    • BLUESTONE JA: Regulatory T-cell therapy: is it ready for the clinic? Nat. Rev. Immunol. (2005) 5:343-349.
    • (2005) Nat. Rev. Immunol. , vol.5 , pp. 343-349
    • Bluestone, J.A.1
  • 52
    • 0042235547 scopus 로고    scopus 로고
    • Heat shock proteins as regulators of the immune response
    • POCKLEY AG: Heat shock proteins as regulators of the immune response. Lancet (2003) 362:469-476.
    • (2003) Lancet , vol.362 , pp. 469-476
    • Pockley, A.G.1
  • 54
    • 0024522738 scopus 로고
    • Primary structure of a human mitochondrial protein homologous to the bacterial and plant chaperonins and to the 65-kilodalton mycobacterial antigen
    • JINDAL S, DUDANI AK, SINGH B, HARLEY CB, GUPTA RS: Primary structure of a human mitochondrial protein homologous to the bacterial and plant chaperonins and to the 65-kilodalton mycobacterial antigen. Mol. Cell. Biol. (1989) 9:2279-2283.
    • (1989) Mol. Cell. Biol. , vol.9 , pp. 2279-2283
    • Jindal, S.1    Dudani, A.K.2    Singh, B.3    Harley, C.B.4    Gupta, R.S.5
  • 55
    • 0025249304 scopus 로고
    • Heat shock proteins and the immune response
    • KAUFFMANN SH: Heat shock proteins and the immune response. Immunol. Today (1990) 11:129-136.
    • (1990) Immunol. Today , vol.11 , pp. 129-136
    • Kauffmann, S.H.1
  • 56
    • 0023234075 scopus 로고
    • Enumeration of T cells reactive with Mycobacterium tuberculosis organisms and specific for the recombinant mycobacterial 64-kDa protein
    • KAUFMANN SH, VATH U, THOLE JE, VAN EMBDEN JD, EMMRICH F: Enumeration of T cells reactive with Mycobacterium tuberculosis organisms and specific for the recombinant mycobacterial 64-kDa protein. Eur. J. Immunol. (1987) 17:351-357.
    • (1987) Eur. J. Immunol. , vol.17 , pp. 351-357
    • Kaufmann, S.H.1    Vath, U.2    Thole, J.E.3    Van Embden, J.D.4    Emmrich, F.5
  • 57
    • 0032877283 scopus 로고    scopus 로고
    • Identification of immunoreactive proteins of Chlamydia trachomatis by western blot analysis of a two-dimensional electrophoresis map with patient sera
    • SANCHEZ-CAMPILLO M, BINI L, COMANDUCCI M et al.: Identification of immunoreactive proteins of Chlamydia trachomatis by western blot analysis of a two-dimensional electrophoresis map with patient sera. Electrophoresis (1999) 20:2269-2279.
    • (1999) Electrophoresis , vol.20 , pp. 2269-2279
    • Sanchez-Campillo, M.1    Bini, L.2    Comanducci, M.3
  • 58
    • 6544263852 scopus 로고    scopus 로고
    • Stress proteins in fungal diseases
    • MATTHEWS RC, MARESCA B, BURNIE JP et al.: Stress proteins in fungal diseases. Med. Mycol. (1998) 36(Suppl. 1):45-51.
    • (1998) Med. Mycol. , vol.36 , Issue.SUPPL. 1 , pp. 45-51
    • Matthews, R.C.1    Maresca, B.2    Burnie, J.P.3
  • 59
    • 0031664697 scopus 로고    scopus 로고
    • Molecular mimicry and immune-mediated diseases
    • OLDSTONE MB: Molecular mimicry and immune-mediated diseases. FASEB J. (1998) 12:1255-1265.
    • (1998) FASEB J. , vol.12 , pp. 1255-1265
    • Oldstone, M.B.1
  • 60
    • 17144417382 scopus 로고    scopus 로고
    • Heat-shock proteins induce T-cell regulation of chronic inflammation
    • VAN EDEN W, VAN DER ZEE R, PRAKKEN B: Heat-shock proteins induce T-cell regulation of chronic inflammation. Nat. Rev. Immunol. (2005) 5:318-330. This review links immune reactivity to HSPs with induction of tolerogenic immune responses, and is an elegant overview of the role of HSPs in immune regulation.
    • (2005) Nat. Rev. Immunol. , vol.5 , pp. 318-330
    • Van Eden, W.1    Van Der Zee, R.2    Prakken, B.3
  • 61
    • 0028900289 scopus 로고
    • Activation of T-cells recognizing self 60 kDa heat shock protein can protect against experimental arthritis
    • ANDERTON SM, VAN DER ZEE R, PRAKKEN B, NOORDZIJ A, VAN EDEN W: Activation of T-cells recognizing self 60 kDa heat shock protein can protect against experimental arthritis. J. Exp. Med. (1995) 181:943-952. In this study, the authors demonstrate for the first time that autoimmune responses to conserved sequences of self-HSPs can indeed protect against autoimmune disease, and is based on T cell crossreactivity between the microbial and rat HSP peptide.
    • (1995) J. Exp. Med. , vol.181 , pp. 943-952
    • Anderton, S.M.1    Van Der Zee, R.2    Prakken, B.3    Noordzij, A.4    Van Eden, W.5
  • 62
    • 0037105543 scopus 로고    scopus 로고
    • Inhibition of adjuvant arthritis by a DNA vaccine encoding human heat shock protein 60
    • QUINTANA FJ, CARMI P, MOR F, COHEN IR: Inhibition of adjuvant arthritis by a DNA vaccine encoding human heat shock protein 60. J. Immunol. (2002) 169(6):3422-3428.
    • (2002) J. Immunol. , vol.169 , Issue.6 , pp. 3422-3428
    • Quintana, F.J.1    Carmi, P.2    Mor, F.3    Cohen, I.R.4
  • 63
    • 0035887917 scopus 로고    scopus 로고
    • Induction of IL-10 and inhibition of experimental arthritis are specific features of microbial heat shock proteins that are absent for other evolutionarily conserved immunodominant proteins
    • PRAKKEN BJ, WENDLING U, VAN DER ZEE R, RUTTEN VP, KUIS W, VAN EDEN W: Induction of IL-10 and inhibition of experimental arthritis are specific features of microbial heat shock proteins that are absent for other evolutionarily conserved immunodominant proteins. J. Immunol. (2001) 167(8):4147-4153.
    • (2001) J. Immunol. , vol.167 , Issue.8 , pp. 4147-4153
    • Prakken, B.J.1    Wendling, U.2    Van Der Zee, R.3    Rutten, V.P.4    Kuis, W.5    Van Eden, W.6
  • 64
  • 66
    • 0030960632 scopus 로고    scopus 로고
    • Hsp60 peptide therapy of NOD mouse diabetes induces a Th2 cytokine burst and downregulates autoimmumty to various β-cell antigens
    • ELIAS D, ABLAMUNITS V, BIRK OS, CARMI P, KÖNEN-WAISMAN S, COHEN IR: Hsp60 peptide therapy of NOD mouse diabetes induces a Th2 cytokine burst and downregulates autoimmumty to various β-cell antigens. Diabetes (1997) 46:758-764.
    • (1997) Diabetes , vol.46 , pp. 758-764
    • Elias, D.1    Ablamunits, V.2    Birk, O.S.3    Carmi, P.4    Könen-Waisman, S.5    Cohen, I.R.6
  • 67
    • 0032191586 scopus 로고    scopus 로고
    • Heat shock proteins and experimental autoimmune encephalomyelitis. II: Environmental infection and extra-neuraxial inflammation alter the course of chronic relapsing encephalomyelitis
    • BIRNBAUM G, KOTILINEK L, MILLER SD et al.: Heat shock proteins and experimental autoimmune encephalomyelitis. II: environmental infection and extra-neuraxial inflammation alter the course of chronic relapsing encephalomyelitis. J. NeuroImmunol. (1998) 90:149-161.
    • (1998) J. NeuroImmunol. , vol.90 , pp. 149-161
    • Birnbaum, G.1    Kotilinek, L.2    Miller, S.D.3
  • 68
    • 0034163391 scopus 로고    scopus 로고
    • A conserved mycobacterial heat shock protein (hsp) 70 sequence prevents adjuvant arthritis upon nasal administration and induces IL-10-producing T cells that cross-react with the mammalian self-hsp70 homologue
    • WENDLING U, PAUL L, VAN DER ZEE R, PRAKKEN B, SINGH M, VAN EDEN W: A conserved mycobacterial heat shock protein (hsp) 70 sequence prevents adjuvant arthritis upon nasal administration and induces IL-10-producing T cells that cross-react with the mammalian self-hsp70 homologue. J. Immunol (2000) 164:2711-2717.
    • (2000) J. Immunol , vol.164 , pp. 2711-2717
    • Wendling, U.1    Paul, L.2    Van Der Zee, R.3    Prakken, B.4    Singh, M.5    Van Eden, W.6
  • 69
    • 0025844958 scopus 로고
    • Recognition of human 60 kD heat shock protein by mononuclear cells from patients with juvenile chronic arthritis
    • DE GRAEFF-MEEDER ER, VAN DER ZEE R, RIJKERS GT et al: Recognition of human 60 kD heat shock protein by mononuclear cells from patients with juvenile chronic arthritis. Lancet (1991) 337:1368-1372.
    • (1991) Lancet , vol.337 , pp. 1368-1372
    • De Graeff-Meeder, E.R.1    Van Der Zee, R.2    Rijkers, G.T.3
  • 71
    • 0032703133 scopus 로고    scopus 로고
    • Depressed proliferative responses by peripheral blood mononuclear cells from early arthritis patients to mycobacterial heat shock protein 60
    • RAMAGE JM, GASTON JS: Depressed proliferative responses by peripheral blood mononuclear cells from early arthritis patients to mycobacterial heat shock protein 60. Rheumatology (Oxford) (1999) 38:631-635.
    • (1999) Rheumatology (Oxford) , vol.38 , pp. 631-635
    • Ramage, J.M.1    Gaston, J.S.2
  • 72
    • 0033106415 scopus 로고    scopus 로고
    • T cell proliferative responses of type 1 Diabetes patients and healthy individuals to human hsp60 and its peptides
    • ABULAFIA-LAPID R, ELIAS D, RAZ I, KEREN-ZUR Y, ATLAN H, COHEN IR: T cell proliferative responses of type 1 Diabetes patients and healthy individuals to human hsp60 and its peptides. J. Autoimmun. (1999) 12:121-129.
    • (1999) J. Autoimmun. , vol.12 , pp. 121-129
    • Abulafia-Lapid, R.1    Elias, D.2    Raz, I.3    Keren-Zur, Y.4    Atlan, H.5    Cohen, I.R.6
  • 73
    • 10744232300 scopus 로고    scopus 로고
    • Interaction of antibodies against cytomegalovirus with heat-shock protein 60 in pathogenesis of atherosclerosis
    • BASON C, CORROCHER R, LUNARDI C et al.: Interaction of antibodies against cytomegalovirus with heat-shock protein 60 in pathogenesis of atherosclerosis. Lancet (2003) 362:1971-1977.
    • (2003) Lancet , vol.362 , pp. 1971-1977
    • Bason, C.1    Corrocher, R.2    Lunardi, C.3
  • 74
    • 0035253485 scopus 로고    scopus 로고
    • The human endoplasmic reticulum molecular chaperone BiP is an autoantigen for rheumatoid arthritis and prevents the induction of experimental arthritis
    • CORRIGALL VM, BODMAN-SMITH MD, FIFE MS et al: The human endoplasmic reticulum molecular chaperone BiP is an autoantigen for rheumatoid arthritis and prevents the induction of experimental arthritis. J. Immunol. (2001) 166:1492-1498.
    • (2001) J. Immunol. , vol.166 , pp. 1492-1498
    • Corrigall, V.M.1    Bodman-Smith, M.D.2    Fife, M.S.3
  • 75
    • 0038082251 scopus 로고    scopus 로고
    • Cytokines and juvenile idiopathic arthritis
    • WOO P: Cytokines and juvenile idiopathic arthritis. Curr. Rheumatol. Rep. (2002) 4:452-457.
    • (2002) Curr. Rheumatol. Rep. , vol.4 , pp. 452-457
    • Woo, P.1
  • 76
    • 10744230484 scopus 로고    scopus 로고
    • International League of Associations for Rheumatology classification of juvenile idiopathic arthritis: Second revision, Edmonton, 2001
    • PETTY RE, SOUTHWOOD TR, MANNERS P et al.: International League of Associations for Rheumatology classification of juvenile idiopathic arthritis: second revision, Edmonton, 2001. J. Rheumatol. (2004) 31:390-392.
    • (2004) J. Rheumatol. , vol.31 , pp. 390-392
    • Petty, R.E.1    Southwood, T.R.2    Manners, P.3
  • 77
    • 0034986387 scopus 로고    scopus 로고
    • Hereditary predisposition to low interleukin-10 production in children with extended oligoarticular juvenile idiopathic arthritis
    • CRAWLEY E, KON S, WOO P: Hereditary predisposition to low interleukin-10 production in children with extended oligoarticular juvenile idiopathic arthritis. Rheumatology (Oxford) (2001) 40:574-578.
    • (2001) Rheumatology (Oxford) , vol.40 , pp. 574-578
    • Crawley, E.1    Kon, S.2    Woo, P.3
  • 78
    • 0031809101 scopus 로고    scopus 로고
    • Contrasting cytokine profiles in the synovium of different forms of juvenile rheumatoid arthritis and juvenile spondyloarthropathy: Prominence of interleukin 4 in restricted disease
    • MURRAY KJ, GROM AA, THOMPSON SD, LIEUWEN D, PASSO MH, GLASS DN: Contrasting cytokine profiles in the synovium of different forms of juvenile rheumatoid arthritis and juvenile spondyloarthropathy: prominence of interleukin 4 in restricted disease. J. Rheumatol. (1998) 25:1388-1398.
    • (1998) J. Rheumatol. , vol.25 , pp. 1388-1398
    • Murray, K.J.1    Grom, A.A.2    Thompson, S.D.3    Lieuwen, D.4    Passo, M.H.5    Glass, D.N.6
  • 79
    • 0035336426 scopus 로고    scopus 로고
    • Chemokine receptor CCR4 on CD4+ T cells in juvenile rheumatoid arthritis synovial fluid defines a subset of cells with increased IL-4:IFN-gamma mRNA ratios
    • THOMPSON SD, LUYRINK LK, GRAHAM TB et al.: Chemokine receptor CCR4 on CD4+ T cells in juvenile rheumatoid arthritis synovial fluid defines a subset of cells with increased IL-4:IFN-gamma mRNA ratios. J. Immunol. (2001) 166:6899-6906.
    • (2001) J. Immunol. , vol.166 , pp. 6899-6906
    • Thompson, S.D.1    Luyrink, L.K.2    Graham, T.B.3
  • 80
    • 0035903307 scopus 로고    scopus 로고
    • Unique chemotactic response profile and specific expression of chemokine receptors CCR4 and CCR8 by CD4(+)CD25(+) regulatory T cells
    • IELLEM A, MARIANI M, LANG R et al.: Unique chemotactic response profile and specific expression of chemokine receptors CCR4 and CCR8 by CD4(+)CD25(+) regulatory T cells. J. Exp. Med. (2001) 194:847-853.
    • (2001) J. Exp. Med. , vol.194 , pp. 847-853
    • Iellem, A.1    Mariani, M.2    Lang, R.3
  • 81
    • 22344432319 scopus 로고    scopus 로고
    • Coexpression of CD25 and CD27 identifies FoxP3+ regulatory T cells in inflamed synovia
    • RUPRECHT CR, GATTORNO M, FERLITO F et al.: Coexpression of CD25 and CD27 identifies FoxP3+ regulatory T cells in inflamed synovia. J. Exp. Med. (2005) 201:1793-1803.
    • (2005) J. Exp. Med. , vol.201 , pp. 1793-1803
    • Ruprecht, C.R.1    Gattorno, M.2    Ferlito, F.3
  • 82
    • 0027373940 scopus 로고
    • Responses to Gram-negative enteric bacterial antigens by synovial T cells from patients with juvenile chronic arthritis: Recognition of heat shock protein hsp60
    • LIFE R HASSEL A, WILLIAMS K et al.: Responses to Gram-negative enteric bacterial antigens by synovial T cells from patients with juvenile chronic arthritis: recognition of heat shock protein hsp60. J. Rheumatol. (1993) 20:1388-1396.
    • (1993) J. Rheumatol. , vol.20 , pp. 1388-1396
    • Life, R.1    Hassel, A.2    Williams, K.3
  • 83
    • 0028231446 scopus 로고
    • Immune responses to the Escherichia coli dnaJ heat shock protein in juvenile rheumatoid arthritis and their correlation with disease activity
    • ALBANI S, RAVELLI A, MASSA M et al.: Immune responses to the Escherichia coli dnaJ heat shock protein in juvenile rheumatoid arthritis and their correlation with disease activity. J. Pediatr. (1994) 124:561-565.
    • (1994) J. Pediatr. , vol.124 , pp. 561-565
    • Albani, S.1    Ravelli, A.2    Massa, M.3
  • 84
    • 0028909538 scopus 로고
    • Juvenile chronic arthritis: T cell reactivity to human HSP60 in patients with a favourable course of arthritis
    • DE GRAEFF-MEEDER ER, VAN EDEN W, RIJKERS GT et al.: Juvenile chronic arthritis: T cell reactivity to human HSP60 in patients with a favourable course of arthritis. J. Clin. Invest. (1995) 95:934-940.
    • (1995) J. Clin. Invest. , vol.95 , pp. 934-940
    • De Graeff-Meeder, E.R.1    Van Eden, W.2    Rijkers, G.T.3
  • 85
    • 0029911403 scopus 로고    scopus 로고
    • Autoreactivity to human heat-shock protein 60 predicts disease remission in oligoarticular juvenile rheumatoid arthritis
    • PRAKKEN AB, VAN EDEN W, RIJKERS GT et al.: Autoreactivity to human heat-shock protein 60 predicts disease remission in oligoarticular juvenile rheumatoid arthritis. Arthritis Rheum. (1996) 39:1826-1832.
    • (1996) Arthritis Rheum. , vol.39 , pp. 1826-1832
    • Prakken, A.B.1    Van Eden, W.2    Rijkers, G.T.3
  • 86
    • 0038681274 scopus 로고    scopus 로고
    • The spontaneous remission of juvenile idiopathic arthritis is characterized by CD30+ T cells directed to human heat-shock protein 60 capable of producing the regulatory cytokine interleukin-10
    • DE KLEER IM, KAMPHUIS SM, RIJKERS GT et al.: The spontaneous remission of juvenile idiopathic arthritis is characterized by CD30+ T cells directed to human heat-shock protein 60 capable of producing the regulatory cytokine interleukin-10. Arthritis Rheum. (2003) 48:2001-2010.
    • (2003) Arthritis Rheum. , vol.48 , pp. 2001-2010
    • De Kleer, I.M.1    Kamphuis, S.M.2    Rijkers, G.T.3
  • 87
    • 0032055915 scopus 로고    scopus 로고
    • Several common HLA-DR types share largely overlapping peptide binding repertoires
    • SOUTHWOOD S, SIDNEY J, KONDO A et al.: Several common HLA-DR types share largely overlapping peptide binding repertoires. J. Immunol. (1998) 160:3363-3373.
    • (1998) J. Immunol. , vol.160 , pp. 3363-3373
    • Southwood, S.1    Sidney, J.2    Kondo, A.3
  • 88
    • 0034671889 scopus 로고    scopus 로고
    • Tools of the trade in vaccine design
    • SETTE A: Tools of the trade in vaccine design. Science (2000) 290:2074-2075.
    • (2000) Science , vol.290 , pp. 2074-2075
    • Sette, A.1
  • 89
    • 21844457408 scopus 로고    scopus 로고
    • Tolerogenic immune responses to novel T-cell epitopes from heat-shock protein 60 in juvenile idiopathic arthritis
    • KAMPHUIS S, KUIS W, DE JAGER W et al.: Tolerogenic immune responses to novel T-cell epitopes from heat-shock protein 60 in juvenile idiopathic arthritis. Lancet (2005) 366:50-56. This study identifies immunomodulatory HSP peptides that are good candidates for antigen-specific immune therapy in JIA.
    • (2005) Lancet , vol.366 , pp. 50-56
    • Kamphuis, S.1    Kuis, W.2    De Jager, W.3
  • 90
    • 0023927111 scopus 로고
    • Suppression of experimental autoimmune encephalomyelitis by the oral administration of myelin basic protein
    • BITAR DM, WHITACRE CC: Suppression of experimental autoimmune encephalomyelitis by the oral administration of myelin basic protein. Cell. Immunol. (1988) 112:364-370.
    • (1988) Cell. Immunol. , vol.112 , pp. 364-370
    • Bitar, D.M.1    Whitacre, C.C.2
  • 91
    • 0031966915 scopus 로고    scopus 로고
    • Hierarchy in the ability of T cell epitopes to induce peripheral tolerance to antigens from myelin
    • ANDERTON SM, WRAITH DC: Hierarchy in the ability of T cell epitopes to induce peripheral tolerance to antigens from myelin. Eur. J. Immunol. (1998) 28:1251-1261.
    • (1998) Eur. J. Immunol. , vol.28 , pp. 1251-1261
    • Anderton, S.M.1    Wraith, D.C.2
  • 92
    • 0031927667 scopus 로고    scopus 로고
    • Inhibition of experimental autoimmune encephalomyelitis in Lewis rats by nasal administration of encephalitogenic MBP peptides: Synergistic effects of MBP 68-86 and 87-99
    • LIU JQ, BAI XF, SHI FD et al.: Inhibition of experimental autoimmune encephalomyelitis in Lewis rats by nasal administration of encephalitogenic MBP peptides: synergistic effects of MBP 68-86 and 87-99. Int. Immunol. (1998) 10:1139-1148.
    • (1998) Int. Immunol. , vol.10 , pp. 1139-1148
    • Liu, J.Q.1    Bai, X.F.2    Shi, F.D.3
  • 93
    • 0029962104 scopus 로고    scopus 로고
    • Mucosal tolerance and suppression of collagen-induced arthritis (CIA) induced by nasal inhalation of synthetic peptide 184-198 of bovine type II collagen (CII) expressing a dominant T cell epitope
    • STAINES NA, HARPER N, WARD FJ, MALMSTRÖM V, HOLMDAHL R, BANSAL S: Mucosal tolerance and suppression of collagen-induced arthritis (CIA) induced by nasal inhalation of synthetic peptide 184-198 of bovine type II collagen (CII) expressing a dominant T cell epitope. Clin. Exp. Immunol. (1996) 103:368-375.
    • (1996) Clin. Exp. Immunol. , vol.103 , pp. 368-375
    • Staines, N.A.1    Harper, N.2    Ward, F.J.3    Malmström, V.4    Holmdahl, R.5    Bansal, S.6
  • 94
    • 0030953059 scopus 로고    scopus 로고
    • Peptide induced nasal tolerance for a mycobacterial hsp60 T cell epitope in rats suppresses both adjuvant arthritis and non-microbially induced experimental arthritis
    • PRAKKEN BJ, VAN DER ZEE R, ANDERTON SM, VAN KOOTEN PJ, KUIS W VAN EDEN W: Peptide induced nasal tolerance for a mycobacterial hsp60 T cell epitope in rats suppresses both adjuvant arthritis and non-microbially induced experimental arthritis. Proc. Natl. Acad. Sci. USA (1997) 94:3284-3289.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 3284-3289
    • Prakken, B.J.1    Van Der Zee, R.2    Anderton, S.M.3    Van Kooten, P.J.4    Kuis, W.5    Van Eden, W.6
  • 95
    • 0029923430 scopus 로고    scopus 로고
    • Nasal administration of glutamate decarboxylase (GAD65) peptides induces Th2 responses and prevents murine insulin-dependent diabetes
    • TIAN Y, ATKINSON MA, CLARE-SALZLER M et al.: Nasal administration of glutamate decarboxylase (GAD65) peptides induces Th2 responses and prevents murine insulin-dependent diabetes. J. Exp. Med. (1996) 183:1561-1567.
    • (1996) J. Exp. Med. , vol.183 , pp. 1561-1567
    • Tian, Y.1    Ma, A.2    Clare-Salzler, M.3
  • 96
    • 0030069688 scopus 로고    scopus 로고
    • Protection of nonobese diabetic mice from diabetes by intranasal or subcutaneous administration of insulin peptide B-(9-23)
    • DANIEL D, WEGMANN DR: Protection of nonobese diabetic mice from diabetes by intranasal or subcutaneous administration of insulin peptide B-(9-23). Proc. Natl. Acad. Sci. USA (1996) 93:956-960.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 956-960
    • Daniel, D.1    Wegmann, D.R.2
  • 97
    • 0030578412 scopus 로고    scopus 로고
    • Antigen-driven peripheral immune tolerance:suppression of experimental autoimmune encephalomyelitis and collagen-induced arthritis by aerosol administration of myelin basic protein or type II collagen
    • AL-SABBAGH A, NELSON PA, AKSELBAND Y, SOBEL RA, WEINER HL: Antigen-driven peripheral immune tolerance:suppression of experimental autoimmune encephalomyelitis and collagen-induced arthritis by aerosol administration of myelin basic protein or type II collagen. Cell. Immunol. (1996) 171:111-119.
    • (1996) Cell. Immunol. , vol.171 , pp. 111-119
    • Al-Sabbagh, A.1    Nelson, P.A.2    Akselband, Y.3    Sobel, R.A.4    Weiner, H.L.5
  • 99
    • 0032403567 scopus 로고    scopus 로고
    • Oral delivery of group a streptococcal cell walls augments circulating TGF-beta and suppresses streptococcal cell wall arthritis
    • CHEN W, JIN W, COOK M, WEINER HL, WAHL SM: Oral delivery of group A streptococcal cell walls augments circulating TGF-beta and suppresses streptococcal cell wall arthritis. J. Immunol. (1998) 161:6297-6304.
    • (1998) J. Immunol. , vol.161 , pp. 6297-6304
    • Chen, W.1    Jin, W.2    Cook, M.3    Weiner, H.L.4    Wahl, S.M.5
  • 100
    • 0030791484 scopus 로고    scopus 로고
    • Transgenic plants expressing autoantigens fed to mice to induce oral immune tolerance
    • MA SW, ZHAO DL, YIN ZQ et al.: Transgenic plants expressing autoantigens fed to mice to induce oral immune tolerance. Nat. Med. (1997) 3:793-796.
    • (1997) Nat. Med. , vol.3 , pp. 793-796
    • Ma, S.W.1    Zhao, D.L.2    Yin, Z.Q.3
  • 101
    • 1842732158 scopus 로고    scopus 로고
    • Induction of oral tolerance to prevent diabetes with transgenic plants requires glutamic acid decarboxylase (GAD) and IL-4
    • MA S, HUANG Y, YIN Z, MENASSA R, BRANDLE JE, JEVNIKAR AM: Induction of oral tolerance to prevent diabetes with transgenic plants requires glutamic acid decarboxylase (GAD) and IL-4. Proc. Natl. Acad. Sci. USA (2004) 101:5680-5685.
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 5680-5685
    • Ma, S.1    Huang, Y.2    Yin, Z.3    Menassa, R.4    Brandle, J.E.5    Jevnikar, A.M.6
  • 102
    • 3042847542 scopus 로고    scopus 로고
    • Immune therapy for autoimmune diseases
    • STEINMAN L: Immune therapy for autoimmune diseases. Science (2004) 305:212-216.
    • (2004) Science , vol.305 , pp. 212-216
    • Steinman, L.1
  • 103
    • 0033571116 scopus 로고    scopus 로고
    • Activation of T cells recognizing an epitope of heat-shock protein 70 can protect against rat adjuvant arthritis
    • TANAKA S, KIMURA Y, MITANI A et al.: Activation of T cells recognizing an epitope of heat-shock protein 70 can protect against rat adjuvant arthritis. J. Immunol. (1999) 163:5560-5565.
    • (1999) J. Immunol. , vol.163 , pp. 5560-5565
    • Tanaka, S.1    Kimura, Y.2    Mitani, A.3
  • 104
    • 1342324756 scopus 로고    scopus 로고
    • The T cells specific for the carboxyl-terminal determinants of self (rat) heat-shock protein 65 escape tolerance induction and are involved in regulation of autoimmune arthritis
    • DURAI M, GUPTA RS, MOUDGIL KD: The T cells specific for the carboxyl-terminal determinants of self (rat) heat-shock protein 65 escape tolerance induction and are involved in regulation of autoimmune arthritis. J. Immunol. (2004) 172:2795-2802.
    • (2004) J. Immunol. , vol.172 , pp. 2795-2802
    • Durai, M.1    Gupta, R.S.2    Moudgil, K.D.3
  • 105
    • 14544294320 scopus 로고    scopus 로고
    • Current issues in the treatment of human diseases by mucosal tolerance
    • WEINER HL: Current issues in the treatment of human diseases by mucosal tolerance. Ann. NY Acad. Sci. (2004) 1029:211-224.
    • (2004) Ann. NY Acad. Sci. , vol.1029 , pp. 211-224
    • Weiner, H.L.1
  • 106
    • 0027670271 scopus 로고
    • Effects of oral administration of type II collagen on rheumatoid arthritis
    • TRENTHAM DE, DYNESIUS-TRENTHAM RA, ORAV JE el al.: Effects of oral administration of type II collagen on rheumatoid arthritis. Science (1993) 261:1727-1730.
    • (1993) Science , vol.261 , pp. 1727-1730
    • Trentham, D.E.1    Dynesius-Trentham, R.A.2    Orav, J.E.3
  • 107
    • 0027467440 scopus 로고
    • Double-blind pilot trial of oral tolerization with myelin antigens in multiple sclerosis
    • WEINER HL, MACKIN GA, MATSUI M et al.: Double-blind pilot trial of oral tolerization with myelin antigens in multiple sclerosis. Science (1993) 259:1321-1324.
    • (1993) Science , vol.259 , pp. 1321-1324
    • Weiner, H.L.1    Mackin, G.A.2    Matsui, M.3
  • 108
    • 0033000532 scopus 로고    scopus 로고
    • Lack of efficacy of oral bovine type II collagen added to existing therapy in rheumatoid arthritis
    • MCKOWN KM, CARBONE LD, KAPLAN SB et al.: Lack of efficacy of oral bovine type II collagen added to existing therapy in rheumatoid arthritis. Arthritis Rheum. (1999) 42:1204-1208.
    • (1999) Arthritis Rheum. , vol.42 , pp. 1204-1208
    • Mckown, K.M.1    Carbone, L.D.2    Kaplan, S.B.3
  • 109
    • 0033846982 scopus 로고    scopus 로고
    • No effect of oral insulin on residual beta-cell function in recent-onset type I diabetes (the IMDIAB VII)
    • IMDIAB Group
    • POZZILLI P, PITOCCO D, VISALLI N et al.: No effect of oral insulin on residual beta-cell function in recent-onset type I diabetes (the IMDIAB VII). IMDIAB Group. Diabetologia (2000) 43:1000-1004.
    • (2000) Diabetologia , vol.43 , pp. 1000-1004
    • Pozzilli, P.1    Pitocco, D.2    Visalli, N.3
  • 110
    • 0035944844 scopus 로고    scopus 로고
    • Beta-cell function in new-onset type 1 diabetes and immunomodulation with a heat-shock protein peptide (DiaPep277): A randomised, double-blind, Phase II trial
    • RAZI, ELIAS D, AVRON A, TAMIR M, METZGER M, COHEN IR: Beta-cell function in new-onset type 1 diabetes and immunomodulation with a heat-shock protein peptide (DiaPep277): a randomised, double-blind, Phase II trial. Lancet (2001) 358:1749-1753. Report of a successful Phase II randomised controlled trial with an HSP peptide in diabetes.
    • (2001) Lancet , vol.358 , pp. 1749-1753
    • Raz, I.1    Elias, D.2    Avron, A.3    Tamir, M.4    Metzger, M.5    Cohen, I.R.6
  • 111
    • 0033791462 scopus 로고    scopus 로고
    • Induction of a non-encephalitogenic type 2 T helper-cell autoimmune response in multiple sclerosis after administration of an altered peptide ligand in a placebo-controlled, randomized Phase II trial
    • KAPPOS L, COMI G, PANITCH H et al.: Induction of a non-encephalitogenic type 2 T helper-cell autoimmune response in multiple sclerosis after administration of an altered peptide ligand in a placebo-controlled, randomized Phase II trial. Nat. Med. (2000) 6:1176-1182. First randomised controlled trial of antigen-specific immunotherapy in an autoimmune disease. Halted due to hypersensitivity reactions; secondary analysis, however, did show clinical benefit and Th2 immune deviation in the patients treated with the APL.
    • (2000) Nat. Med. , vol.6 , pp. 1176-1182
    • Kappos, L.1    Comi, G.2    Panitch, H.3
  • 112
    • 0033786776 scopus 로고    scopus 로고
    • Encephalitogenic potential of the myelin basic protein peptide (amino acids 83-99) in multiple sclerosis: Results of a Phase II clinical trial with an altered peptide ligand
    • BIELEKOVA B, GOODWIN B, RICHERT N et al.: Encephalitogenic potential of the myelin basic protein peptide (amino acids 83-99) in multiple sclerosis: results of a Phase II clinical trial with an altered peptide ligand. Nat. Med. (2000) 6:1167-1175.
    • (2000) Nat. Med. , vol.6 , pp. 1167-1175
    • Bielekova, B.1    Goodwin, B.2    Richert, N.3
  • 113
    • 12144289938 scopus 로고    scopus 로고
    • Epitope-specific immunotherapy induces immune deviation of proinflammatory T cells in rheumatoid arthritis
    • PRAKKEN BJ, SAMODAL R, LE TD et al: Epitope-specific immunotherapy induces immune deviation of proinflammatory T cells in rheumatoid arthritis. Proc. Natl. Acad. Sci. USA (2004) 101:4228-4233. Report of a Phase I trial in rheumatoid arthritis with an HSP peptide that successfully induced antigen-specific immune deviation.
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 4228-4233
    • Prakken, B.J.1    Samodal, R.2    Le, T.D.3
  • 114
    • 0036481263 scopus 로고    scopus 로고
    • Epitope spreading in immune-mediated diseases: Implications for immunotherapy
    • VANDERLUGT C, MILLER SD: Epitope spreading in immune-mediated diseases: implications for immunotherapy. Nat. Rev. Immunol. (2002) 2:85-95.
    • (2002) Nat. Rev. Immunol. , vol.2 , pp. 85-95
    • Vanderlugt, C.1    Miller, S.D.2


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