메뉴 건너뛰기




Volumn 172, Issue 5, 2004, Pages 2795-2802

The T Cells Specific for the Carboxyl-Terminal Determinants of Self (Rat) Heat-Shock Protein 65 Escape Tolerance Induction and Are Involved in Regulation of Autoimmune Arthritis

Author keywords

[No Author keywords available]

Indexed keywords

HEAT SHOCK PROTEIN; HEAT SHOCK PROTEIN 65;

EID: 1342324756     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.172.5.2795     Document Type: Article
Times cited : (50)

References (60)
  • 1
    • 84961016706 scopus 로고
    • Development of arthritis, periarthritis and periostitis in rats given adjuvants
    • Pearson, C. M. 1956. Development of arthritis, periarthritis and periostitis in rats given adjuvants. Proc. Soc. Exp. Biol. Med. 91:95.
    • (1956) Proc. Soc. Exp. Biol. Med. , vol.91 , pp. 95
    • Pearson, C.M.1
  • 3
    • 0021335515 scopus 로고
    • Arthritis induced in rats by cloned T lymphocytes responsive to mycobacteria but not to collagen type II
    • Holoshitz, J., A. Matitiau, and I. R. Cohen. 1984. Arthritis induced in rats by cloned T lymphocytes responsive to mycobacteria but not to collagen type II. J. Clin. Invest. 73:211.
    • (1984) J. Clin. Invest. , vol.73 , pp. 211
    • Holoshitz, J.1    Matitiau, A.2    Cohen, I.R.3
  • 5
    • 0036418868 scopus 로고    scopus 로고
    • Immune regulation in adjuvant disease and other arthritis models: Relevance to pathogenesis of chronic arthritis
    • Waksman, B. H. 2002. Immune regulation in adjuvant disease and other arthritis models: relevance to pathogenesis of chronic arthritis. Scand. J. Immunol. 56:12.
    • (2002) Scand. J. Immunol. , vol.56 , pp. 12
    • Waksman, B.H.1
  • 6
    • 0030956660 scopus 로고    scopus 로고
    • Diversification of T cell responses to carboxy-terminal determinants within the 65-kD heat-shock protein is involved in regulation of autoimmune arthritis
    • Moudgil, K. D., T. T. Chang, H. Eradat, A. M. Chen, R. S. Gupta, E. Brahn, and E. E. Sercarz. 1997. Diversification of T cell responses to carboxy-terminal determinants within the 65-kD heat-shock protein is involved in regulation of autoimmune arthritis. J. Exp. Med. 185:1307.
    • (1997) J. Exp. Med. , vol.185 , pp. 1307
    • Moudgil, K.D.1    Chang, T.T.2    Eradat, H.3    Chen, A.M.4    Gupta, R.S.5    Brahn, E.6    Sercarz, E.E.7
  • 7
    • 0022499392 scopus 로고
    • T lymphocytes of rheumatoid arthritis patients show augmented reactivity to a fraction of mycobacteria cross-reactive with cartilage
    • Holoshitz, J., A. Klajman, I. Drucker, Z. Lapidot, A. Yaretzky, A. Frenkel, W. van Eden, and I. R. Cohen. 1986. T lymphocytes of rheumatoid arthritis patients show augmented reactivity to a fraction of mycobacteria cross-reactive with cartilage. Lancet 2:305.
    • (1986) Lancet , vol.2 , pp. 305
    • Holoshitz, J.1    Klajman, A.2    Drucker, I.3    Lapidot, Z.4    Yaretzky, A.5    Frenkel, A.6    Van Eden, W.7    Cohen, I.R.8
  • 8
    • 0024444150 scopus 로고
    • In vitro responses to a 65-kilodalton mycobacterial protein by synovial T cells from inflammatory arthritis patients
    • Gaston, J. S., P. F. Life, L. C. Bailey, and P. A. Bacon. 1989. In vitro responses to a 65-kilodalton mycobacterial protein by synovial T cells from inflammatory arthritis patients. J. Immunol. 143:2494.
    • (1989) J. Immunol. , vol.143 , pp. 2494
    • Gaston, J.S.1    Life, P.F.2    Bailey, L.C.3    Bacon, P.A.4
  • 9
    • 0026560801 scopus 로고
    • Peptide recognition, T cell receptor usage and HLA restriction elements of human heat-shock protein (hsp) 60 and mycobacterial 65-kDa hsp-reactive T cell clones from rheumatoid synovial fluid
    • Quayle, A. J., K. B. Wilson, S. G. Li, J. Kjeldsen-Kragh, F. Oftung, T. Shinnick, M. Sioud, O. Forre, J. D. Capra, and J. B. Natvig. 1992. Peptide recognition, T cell receptor usage and HLA restriction elements of human heat-shock protein (hsp) 60 and mycobacterial 65-kDa hsp-reactive T cell clones from rheumatoid synovial fluid. Eur. J. Immunol. 22:1315.
    • (1992) Eur. J. Immunol. , vol.22 , pp. 1315
    • Quayle, A.J.1    Wilson, K.B.2    Li, S.G.3    Kjeldsen-Kragh, J.4    Oftung, F.5    Shinnick, T.6    Sioud, M.7    Forre, O.8    Capra, J.D.9    Natvig, J.B.10
  • 10
    • 0026502769 scopus 로고
    • Prevention of adjuvant arthritis in rats by a nonapeptide from the 65-kD mycobacterial heat shock protein: Specificity and mechanism
    • Yang, X. D., J. Gasser, and U. Feige. 1992. Prevention of adjuvant arthritis in rats by a nonapeptide from the 65-kD mycobacterial heat shock protein: specificity and mechanism. Clin. Exp. Immunol. 87:99.
    • (1992) Clin. Exp. Immunol. , vol.87 , pp. 99
    • Yang, X.D.1    Gasser, J.2    Feige, U.3
  • 11
    • 0028346838 scopus 로고
    • Differential rat T cell recognition of cathepsin D-released fragments of mycobacterial 65 kDa heat-shock protein after immunization with either the recombinant protein or whole mycobacteria
    • van Noort, J. M., S. M. Anderton, J. P. Wagenaar, M. H. Wauben, C. van Holten, and C. J. Boog. 1994. Differential rat T cell recognition of cathepsin D-released fragments of mycobacterial 65 kDa heat-shock protein after immunization with either the recombinant protein or whole mycobacteria. Int. Immunol. 6:603.
    • (1994) Int. Immunol. , vol.6 , pp. 603
    • Van Noort, J.M.1    Anderton, S.M.2    Wagenaar, J.P.3    Wauben, M.H.4    Van Holten, C.5    Boog, C.J.6
  • 12
    • 0028900289 scopus 로고
    • Activation of T cells recognizing self 60-kD heat shock protein can protect against experimental arthritis
    • Anderton, S. M., R. van der Zee, B. Prakken, A. Noordzij, and W. van Eden. 1995. Activation of T cells recognizing self 60-kD heat shock protein can protect against experimental arthritis. J. Exp. Med. 181:943.
    • (1995) J. Exp. Med. , vol.181 , pp. 943
    • Anderton, S.M.1    Van Der Zee, R.2    Prakken, B.3    Noordzij, A.4    Van Eden, W.5
  • 13
    • 0031786797 scopus 로고    scopus 로고
    • Diversification of response to hsp65 during the course of autoimmune arthritis is regulatory rather than pathogenic
    • Moudgil, K. D. 1998. Diversification of response to hsp65 during the course of autoimmune arthritis is regulatory rather than pathogenic. Immunol. Rev. 164:175.
    • (1998) Immunol. Rev. , vol.164 , pp. 175
    • Moudgil, K.D.1
  • 14
    • 0037097641 scopus 로고    scopus 로고
    • Resistance to adjuvant arthritis is due to protective antibodies against heat shock protein surface epitopes and the induction of IL-10 secretion
    • Ulmansky, R., C. J. Cohen, F. Szafer, E. Moallem, Z. G. Fridlender, Y. Kashi, and Y. Naparstek. 2002. Resistance to adjuvant arthritis is due to protective antibodies against heat shock protein surface epitopes and the induction of IL-10 secretion. J. Immunol. 168:6463.
    • (2002) J. Immunol. , vol.168 , pp. 6463
    • Ulmansky, R.1    Cohen, C.J.2    Szafer, F.3    Moallem, E.4    Fridlender, Z.G.5    Kashi, Y.6    Naparstek, Y.7
  • 15
    • 0036630358 scopus 로고    scopus 로고
    • The thymus and negative selection
    • Sprent, J., and H. Kishimoto. 2002. The thymus and negative selection. Immunol. Rev. 185:126.
    • (2002) Immunol. Rev. , vol.185 , pp. 126
    • Sprent, J.1    Kishimoto, H.2
  • 17
    • 0035185362 scopus 로고    scopus 로고
    • Thymus and tolerance: Is regulation the major function of the thymus?
    • Durkin, H. G., and B. H. Waksman. 2001. Thymus and tolerance: is regulation the major function of the thymus? Immunol. Rev. 182:33.
    • (2001) Immunol. Rev. , vol.182 , pp. 33
    • Durkin, H.G.1    Waksman, B.H.2
  • 20
    • 0025074415 scopus 로고
    • Nucleotide sequence of rat hsp60 (chaperonin, GroEL homolog) cDNA
    • Venner, T. J., and R. S. Gupta. 1990. Nucleotide sequence of rat hsp60 (chaperonin, GroEL homolog) cDNA. Nucleic Acids Res. 18:5309.
    • (1990) Nucleic Acids Res. , vol.18 , pp. 5309
    • Venner, T.J.1    Gupta, R.S.2
  • 21
    • 0025038041 scopus 로고
    • A mycobacterial 65-kD heat shock protein induces antigen-specific suppression of adjuvant arthritis, but is not itself arthritogenic
    • Billingham, M. E., S. Carney, R. Butler, and M. J. Colston. 1990. A mycobacterial 65-kD heat shock protein induces antigen-specific suppression of adjuvant arthritis, but is not itself arthritogenic. J. Exp. Med. 171:339.
    • (1990) J. Exp. Med. , vol.171 , pp. 339
    • Billingham, M.E.1    Carney, S.2    Butler, R.3    Colston, M.J.4
  • 22
    • 0028299971 scopus 로고
    • Differential mycobacterial 65-kDa heat shock protein T cell epitope recognition after adjuvant arthritis-inducing or protective immunization protocols
    • Anderton, S. M., R. van der Zee, A. Noordzij, and W. van Eden. 1994. Differential mycobacterial 65-kDa heat shock protein T cell epitope recognition after adjuvant arthritis-inducing or protective immunization protocols. J. Immunol. 152:3656.
    • (1994) J. Immunol. , vol.152 , pp. 3656
    • Anderton, S.M.1    Van Der Zee, R.2    Noordzij, A.3    Van Eden, W.4
  • 23
    • 0029905739 scopus 로고    scopus 로고
    • Suppression of adjuvant arthritis in rats by induction of oral tolerance to mycobacterial 65-kDa heat shock protein
    • Haque, M. A., S. Yoshino, S. Inada, H. Nomaguchi, O. Tokunaga, and O. Kohashi. 1996. Suppression of adjuvant arthritis in rats by induction of oral tolerance to mycobacterial 65-kDa heat shock protein. Eur. J. Immunol. 26:2650.
    • (1996) Eur. J. Immunol. , vol.26 , pp. 2650
    • Haque, M.A.1    Yoshino, S.2    Inada, S.3    Nomaguchi, H.4    Tokunaga, O.5    Kohashi, O.6
  • 24
    • 0031055339 scopus 로고    scopus 로고
    • Protection of rats from adjuvant arthritis by immunization with naked DNA encoding for mycobacterial heat shock protein 65
    • Ragno, S., M. J. Colston, D. B. Lowrie, V. R. Winrow, D. R. Blake, and R. Tascon. 1997. Protection of rats from adjuvant arthritis by immunization with naked DNA encoding for mycobacterial heat shock protein 65. Arthritis Rheum. 40:277.
    • (1997) Arthritis Rheum. , vol.40 , pp. 277
    • Ragno, S.1    Colston, M.J.2    Lowrie, D.B.3    Winrow, V.R.4    Blake, D.R.5    Tascon, R.6
  • 25
    • 0037105543 scopus 로고    scopus 로고
    • Inhibition of adjuvant arthritis by a DNA vaccine encoding human heat shock protein 60
    • Quintana, F. J., P. Carmi, F. Mor, and I. R. Cohen. 2002. Inhibition of adjuvant arthritis by a DNA vaccine encoding human heat shock protein 60. J. Immunol. 169:3422.
    • (2002) J. Immunol. , vol.169 , pp. 3422
    • Quintana, F.J.1    Carmi, P.2    Mor, F.3    Cohen, I.R.4
  • 26
    • 0034671574 scopus 로고    scopus 로고
    • Highly autoproliferative T cells specific for 60-kDa heat shock protein produce IL-4/IL-10 and IFN-γ and are protective in adjuvant arthritis
    • Paul, A. G., P. J. van Kooten, W. van Eden, and R. van der Zee. 2000. Highly autoproliferative T cells specific for 60-kDa heat shock protein produce IL-4/ IL-10 and IFN-γ and are protective in adjuvant arthritis. J. Immunol. 165:7270.
    • (2000) J. Immunol. , vol.165 , pp. 7270
    • Paul, A.G.1    Van Kooten, P.J.2    Van Eden, W.3    Van Der Zee, R.4
  • 27
    • 0027377220 scopus 로고
    • Modulation of adjuvant arthritis in Lewis rats by recombinant vaccinia virus expressing the human 60-kilodalton heat shock protein
    • Lopez-Guerrero, J. A., J. P. Lopez-Bote, M. A. Ortiz, R. S. Gupta, E. Paez, and C. Bernabeu. 1993. Modulation of adjuvant arthritis in Lewis rats by recombinant vaccinia virus expressing the human 60-kilodalton heat shock protein. Infect. Immun. 61:4225.
    • (1993) Infect. Immun. , vol.61 , pp. 4225
    • Lopez-Guerrero, J.A.1    Lopez-Bote, J.P.2    Ortiz, M.A.3    Gupta, R.S.4    Paez, E.5    Bernabeu, C.6
  • 28
    • 0028079811 scopus 로고
    • Therapeutic effect of recombinant vaccinia virus expressing the 60-kd heat-shock protein on adjuvant arthritis
    • Lopez-Guerrero, J. A., M. A. Ortiz, E. Paez, C. Bernabeu, and J. P. Lopez-Bote. 1994. Therapeutic effect of recombinant vaccinia virus expressing the 60-kd heat-shock protein on adjuvant arthritis. Arthritis Rheum. 37:1462.
    • (1994) Arthritis Rheum. , vol.37 , pp. 1462
    • Lopez-Guerrero, J.A.1    Ortiz, M.A.2    Paez, E.3    Bernabeu, C.4    Lopez-Bote, J.P.5
  • 29
    • 0024311503 scopus 로고
    • Molecular cloning of a Chinese hamster mitochondrial protein related to the "chaperonin" family of bacterial and plant proteins
    • Picketts, D. J., C. S. Mayanil, and R. S. Gupta. 1989. Molecular cloning of a Chinese hamster mitochondrial protein related to the "chaperonin" family of bacterial and plant proteins. J. Biol. Chem. 264:12001.
    • (1989) J. Biol. Chem. , vol.264 , pp. 12001
    • Picketts, D.J.1    Mayanil, C.S.2    Gupta, R.S.3
  • 30
    • 0026091843 scopus 로고
    • Temperature-induced stress abrogates co-stimulatory function in antigen-presenting cells
    • Kuperberg, G., J. Ellis, J. Marcinkiewicz, and B. M. Chain. 1991. Temperature-induced stress abrogates co-stimulatory function in antigen-presenting cells. Eur. J. Immunol. 21:2791.
    • (1991) Eur. J. Immunol. , vol.21 , pp. 2791
    • Kuperberg, G.1    Ellis, J.2    Marcinkiewicz, J.3    Chain, B.M.4
  • 31
    • 0027439013 scopus 로고
    • An autoantigenic T cell epitope forms unstable complexes with class II MHC: A novel route for escape from tolerance induction
    • Fairchild, P. J., R. Wildgoose, E. Atherton, S. Webb, and D. C. Wraith. 1993. An autoantigenic T cell epitope forms unstable complexes with class II MHC: a novel route for escape from tolerance induction. Int. Immunol. 5:1151.
    • (1993) Int. Immunol. , vol.5 , pp. 1151
    • Fairchild, P.J.1    Wildgoose, R.2    Atherton, E.3    Webb, S.4    Wraith, D.C.5
  • 32
    • 0034089844 scopus 로고    scopus 로고
    • HLA transgenic mice as models of human autoimmune diseases
    • Das, P., R. Abraham, and C. David. 2000. HLA transgenic mice as models of human autoimmune diseases. Rev. Immunogenet. 2:105.
    • (2000) Rev. Immunogenet. , vol.2 , pp. 105
    • Das, P.1    Abraham, R.2    David, C.3
  • 33
    • 0034490074 scopus 로고    scopus 로고
    • Autoimmunity versus tolerance: Analysis using transgenic mice
    • Taneja, V., and C. S. David. 2000. Autoimmunity versus tolerance: analysis using transgenic mice. Hum. Immunol. 61:1383.
    • (2000) Hum. Immunol. , vol.61 , pp. 1383
    • Taneja, V.1    David, C.S.2
  • 34
    • 0035795102 scopus 로고    scopus 로고
    • Mice resistant to experimental autoimmune encephalomyelitis have increased thymic expression of myelin basic protein and increased MBP specific T cell tolerance
    • Liu, H., A. J. MacKenzie-Graham, S. Kim, and R. R. Voskuhl. 2001. Mice resistant to experimental autoimmune encephalomyelitis have increased thymic expression of myelin basic protein and increased MBP specific T cell tolerance. J. Neuroimmunol. 115:118.
    • (2001) J. Neuroimmunol. , vol.115 , pp. 118
    • Liu, H.1    MacKenzie-Graham, A.J.2    Kim, S.3    Voskuhl, R.R.4
  • 35
    • 0036219003 scopus 로고    scopus 로고
    • T cell response in experimental autoimmune encephalomyelitis (EAE): Role of self and cross-reactive antigens in shaping, tuning, and regulating the autopathogenic T cell repertoire
    • Kuchroo, V. K., A. C. Anderson, H. Waldner, M. Munder, E. Bettelli, and L. B. Nicholson. 2002. T cell response in experimental autoimmune encephalomyelitis (EAE): role of self and cross-reactive antigens in shaping, tuning, and regulating the autopathogenic T cell repertoire. Annu. Rev. Immunol. 20:101.
    • (2002) Annu. Rev. Immunol. , vol.20 , pp. 101
    • Kuchroo, V.K.1    Anderson, A.C.2    Waldner, H.3    Munder, M.4    Bettelli, E.5    Nicholson, L.B.6
  • 37
    • 0032707791 scopus 로고    scopus 로고
    • MHC structure and autoimmune T cell repertoire development
    • Ridgway, W. M., and C. G. Fathman. 1999. MHC structure and autoimmune T cell repertoire development. Curr. Opin. Immunol. 11:638.
    • (1999) Curr. Opin. Immunol. , vol.11 , pp. 638
    • Ridgway, W.M.1    Fathman, C.G.2
  • 38
    • 0034020884 scopus 로고    scopus 로고
    • Positive selection for autoimmunity
    • Datta, S. K. 2000. Positive selection for autoimmunity. Nat. Med. 6:259.
    • (2000) Nat. Med. , vol.6 , pp. 259
    • Datta, S.K.1
  • 41
    • 0033151524 scopus 로고    scopus 로고
    • Determinant hierarchy: Shaping of the self-directed T cell repertoire, and induction of autoimmunity
    • Moudgil, K. D. 1999. Determinant hierarchy: shaping of the self-directed T cell repertoire, and induction of autoimmunity. Immunol. Lett. 68:251.
    • (1999) Immunol. Lett. , vol.68 , pp. 251
    • Moudgil, K.D.1
  • 42
    • 0033579881 scopus 로고    scopus 로고
    • Interleukin 12 protects from a T helper type 1-mediated autoimmune disease, experimental autoimmune uveitis, through a mechanism involving interferon γ, nitric oxide, and apoptosis
    • Tarrant, T. K., P. B. Silver, J. L. Wahlsten, L. V. Rizzo, C. C. Chan, B. Wiggert, and R. R. Caspi. 1999. Interleukin 12 protects from a T helper type 1-mediated autoimmune disease, experimental autoimmune uveitis, through a mechanism involving interferon γ, nitric oxide, and apoptosis. J. Exp. Med. 189:219.
    • (1999) J. Exp. Med. , vol.189 , pp. 219
    • Tarrant, T.K.1    Silver, P.B.2    Wahlsten, J.L.3    Rizzo, L.V.4    Chan, C.C.5    Wiggert, B.6    Caspi, R.R.7
  • 43
    • 0037514387 scopus 로고    scopus 로고
    • IL-12 administration accelerates autoimmune diabetes in both wild-type and IFN-γ-deficient nonobese diabetic mice, revealing pathogenic and protective effects of IL-12-induced IFN-γ
    • Trembleau, S., G. Penna, S. Gregori, N. Giarratana, and L. Adorini. 2003. IL-12 administration accelerates autoimmune diabetes in both wild-type and IFN-γ-deficient nonobese diabetic mice, revealing pathogenic and protective effects of IL-12-induced IFN-γ. J. Immunol. 170:5491.
    • (2003) J. Immunol. , vol.170 , pp. 5491
    • Trembleau, S.1    Penna, G.2    Gregori, S.3    Giarratana, N.4    Adorini, L.5
  • 47
    • 0035909925 scopus 로고    scopus 로고
    • Interleukin-12 receptor/STAT4 signaling is required for the development of autoimmune myocarditis in mice by an interferon-γ-independent pathway
    • Afanasyeva, M., Y. Wang, Z. Kaya, E. A. Stafford, K. M. Dohmen, A. A. Sadighi Akha, and N. R. Rose. 2001. Interleukin-12 receptor/STAT4 signaling is required for the development of autoimmune myocarditis in mice by an interferon-γ-independent pathway. Circulation 104:3145.
    • (2001) Circulation , vol.104 , pp. 3145
    • Afanasyeva, M.1    Wang, Y.2    Kaya, Z.3    Stafford, E.A.4    Dohmen, K.M.5    Sadighi Akha, A.A.6    Rose, N.R.7
  • 49
    • 0036345337 scopus 로고    scopus 로고
    • Origin of regulatory T cells with known specificity for antigen
    • Apostolou, I., A. Sarukhan, L. Klein, and H. von Boehmer. 2002. Origin of regulatory T cells with known specificity for antigen. Nat Immunol. 3:756.
    • (2002) Nat. Immunol. , vol.3 , pp. 756
    • Apostolou, I.1    Sarukhan, A.2    Klein, L.3    Von Boehmer, H.4
  • 50
    • 0032829384 scopus 로고    scopus 로고
    • Significance of endogenous heat shock protein in adjuvant arthritis
    • Miyata, M., H. Sato, Y. Sato, E. Kodama, and R. Kasukawa. 1999. Significance of endogenous heat shock protein in adjuvant arthritis. J. Rheumatol. 26:2210.
    • (1999) J. Rheumatol. , vol.26 , pp. 2210
    • Miyata, M.1    Sato, H.2    Sato, Y.3    Kodama, E.4    Kasukawa, R.5
  • 52
    • 0025210457 scopus 로고
    • Presence of human 65 kD heat shock protein (hsp) in inflamed joints and subcutaneous nodules of RA patients
    • Karlsson-Parra, A., K. Soderstrom, M. Ferm, J. Ivanyi, R. Kiessling, and L. Klareskog. 1990. Presence of human 65 kD heat shock protein (hsp) in inflamed joints and subcutaneous nodules of RA patients. Scand. J. Immunol. 31:283.
    • (1990) Scand. J. Immunol. , vol.31 , pp. 283
    • Karlsson-Parra, A.1    Soderstrom, K.2    Ferm, M.3    Ivanyi, J.4    Kiessling, R.5    Klareskog, L.6
  • 55
    • 0025975832 scopus 로고
    • Single amino acid substitution alters T cell determinant selection during antigen processing of Staphylococcus aureus nuclease
    • Liu, Z. R., K. P. Williams, Y. H. Chang, and J. A. Smith. 1991. Single amino acid substitution alters T cell determinant selection during antigen processing of Staphylococcus aureus nuclease. J. Immunol. 146:438.
    • (1991) J. Immunol. , vol.146 , pp. 438
    • Liu, Z.R.1    Williams, K.P.2    Chang, Y.H.3    Smith, J.A.4
  • 56
    • 0027524738 scopus 로고
    • Dominant determinants in hen eggwhite lysozyme correspond to the cryptic determinants within its self-homologue, mouse lysozyme: Implications in shaping of the T cell repertoire and autoimmunity
    • Moudgil, K. D., and E. E. Sercarz. 1993. Dominant determinants in hen eggwhite lysozyme correspond to the cryptic determinants within its self-homologue, mouse lysozyme: implications in shaping of the T cell repertoire and autoimmunity. J. Exp. Med. 178:2131.
    • (1993) J. Exp. Med. , vol.178 , pp. 2131
    • Moudgil, K.D.1    Sercarz, E.E.2
  • 57
    • 0026642137 scopus 로고
    • Identification of an immunodominant type-II collagen peptide recognized by T cells in H-2q mice: Self tolerance at the level of determinant selection
    • Michaelsson, E., M. Andersson, A. Engstrom, and R. Holmdahl. 1992. Identification of an immunodominant type-II collagen peptide recognized by T cells in H-2q mice: self tolerance at the level of determinant selection. Eur. J. Immunol. 22:1819.
    • (1992) Eur. J. Immunol. , vol.22 , pp. 1819
    • Michaelsson, E.1    Andersson, M.2    Engstrom, A.3    Holmdahl, R.4
  • 58
    • 0027479452 scopus 로고
    • The inability to process a self-peptide allows autoreactive T cells to escape tolerance
    • Mamula, M. J. 1993. The inability to process a self-peptide allows autoreactive T cells to escape tolerance. J. Exp. Med. 177:567.
    • (1993) J. Exp. Med. , vol.177 , pp. 567
    • Mamula, M.J.1
  • 59
    • 0026439389 scopus 로고
    • The cognitive paradigm and the immunological homunculus
    • Cohen, I. R. 1992. The cognitive paradigm and the immunological homunculus. Immunol. Today. 13:490.
    • (1992) Immunol. Today , vol.13 , pp. 490
    • Cohen, I.R.1
  • 60
    • 0036035624 scopus 로고    scopus 로고
    • Peptide therapy for type I diabetes: The immunological homunculus and the rationale for vaccination
    • Cohen, I. R. 2002. Peptide therapy for type I diabetes: the immunological homunculus and the rationale for vaccination. Diabetologia 45:1468.
    • (2002) Diabetologia , vol.45 , pp. 1468
    • Cohen, I.R.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.