Human CD4+CD25+ regulatory T cells

Seminars in Immunology

Volumn 16, Issue 2, 2004, Pages 89-98

  Baecher Allan, Clare ^a   Viglietta, Vissia ^a   Hafler, David A ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

CD25; Regulatory; Suppression

Indexed keywords

CD4 ANTIGEN; INTERLEUKIN 10; INTERLEUKIN 2 RECEPTOR; TRANSFORMING GROWTH FACTOR BETA;

AUTOIMMUNITY; CARCINOMA; CELL GROWTH; CELL ISOLATION; CELL SURFACE; CHRONIC DISEASE; COCULTURE; CYTOKINE PRODUCTION; ENDOCRINE DISEASE; ENTEROPATHY; GENETIC DISORDER; HUMAN; HUMAN CELL; IMMUNE DEFICIENCY; IMMUNOREGULATION; IMMUNOSTIMULATION; IN VITRO STUDY; INFECTION; LYMPH NODE; LYMPHOCYTE ACTIVATION; LYMPHOCYTE CULTURE; LYMPHOCYTE FUNCTION; LYMPHOCYTE SUBPOPULATION; MOUSE; NONHUMAN; PHENOTYPE; REVIEW; SIGNAL TRANSDUCTION; STIMULUS; T LYMPHOCYTE; THYMUS; UMBILICAL CORD BLOOD;

EID: 1242295285     PISSN: 10445323     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.smim.2003.12.005     Document Type: Article

References (33)

1. Taams L.S., Smith J., Rustin M.H., Salmon M., Poulter L.W., Akbar A.N. Human anergic/suppressive CD4(+)CD25(+) T cells: a highly differentiated and apoptosis-prone population. Eur. J. Immunol. 31:2001;1122-1131.
2. Dieckmann D., Plottner H., Berchtold S., Berger T., Schuler G. Ex vivo isolation and characterization of CD4(+)CD25(+) T cells with regulatory properties from human blood. J. Exp. Med. 193:2001;1303-1310.
3. Jonuleit H., Schmitt E., Stassen M., Tuettenberg A., Knop J., Enk A.H. Identification and functional characterization of human CD4(+)CD25(+) T cells with regulatory properties isolated from peripheral blood. J. Exp. Med. 193:2001;1285-1294.
4. Taylor P.A., Noelle R.J., Blazar B.R. CD4(+)CD25(+) immune regulatory cells are required for induction of tolerance to alloantigen via costimulatory blockade. J. Exp. Med. 193:2001;1311-1318.
5. Stephens L.A., Mottet C., Mason D., Powrie F. Human CD4(+)CD25(+) thymocytes and peripheral T cells have immune suppressive activity in vitro. Eur. J. Immunol. 31:2001;1247-1254.
6. Baecher-Allan C., Brown J.A., Freeman G.J., Hafler D.A. CD4+CD25 high regulatory cells in human peripheral blood. J. Immunol. 167:2001;1245-1253.
7. Wing K., Lindgren S., Kollberg G., Lundgren A., Harris R.A., Rudin A.et al. CD4 T cell activation by myelin oligodendrocyte glycoprotein is suppressed by adult but not cord blood CD25+ T cells. Eur. J. Immunol. 33:2003;579-587.
8. Baecher-Allan C., Viglietta V., Hafler D.A. Inhibition of human CD4(+)CD25(+high) regulatory T cell function. J. Immunol. 169:2002;6210-6217.
9. Cao D., Malmstrom V., Baecher-Allan C., Hafler D., Klareskog L., Trollmo C. Isolation and functional characterization of regulatory CD25 bright CD4+ T cells from the target organ of patients with rheumatoid arthritis. Eur. J. Immunol. 33:2003;215-223.
10. Lepault F., Gagnerault M.C. Characterization of peripheral regulatory CD4+ T cells that prevent diabetes onset in nonobese diabetic mice. J. Immunol. 164:2000;240-247.
11. Read S., Mauze S., Asseman C., Bean A., Coffman R., Powrie F. CD38+ CD45RB(low) CD4+ T cells: a population of T cells with immune regulatory activities in vitro. Eur. J. Immunol. 28:1998;3435-3447.
12. Lundgren A., Suri-Payer E., Enarsson K., Svennerholm A.M., Lundin B.S. Helicobacter pylori-specific CD4+ CD25high regulatory T cells suppress memory T-cell responses to H. pylori in infected individuals. Infect. Immun. 71:2003;1755-1762.
13. Ng W.F., Duggan P.J., Ponchel F., Matarese G., Lombardi G., Edwards A.D.et al. Human CD4(+)CD25(+) cells: a naturally occurring population of regulatory T cells. Blood. 98:2001;2736-2744.
14. Levings M.K., Sangregorio R., Roncarolo M.G. Human CD25(+)CD4(+) T regulatory cells suppress naive and memory T cell proliferation and can be expanded in vitro without loss of function. J. Exp. Med. 193:2001;1295-1302.
15. Levings M.K., Sangregorio R., Sartirana C., Moschin A.L., Battaglia M., Orban P.C.et al. Human CD25+CD4+ T suppressor cell clones produce transforming growth regulatory cells. J. Exp. Med. 196:2002;1335-1346.
16. Thornton A.M., Shevach E.M. CD4+CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production. J. Exp. Med. 188:1998;287-296.
17. Annunziato F., Cosmi L., Liotta F., Lazzeri E., Manetti R., Vanini V.et al. Phenotype, localization, and mechanism of suppression of CD4+CD25+ human thymocytes. J. Exp. Med. 196:2002;379-387.
18. Akbar A.N., Taams L.S., Salmon M., Vukmanovic-Stejic M. The peripheral generation of CD4+ CD25+ regulatory T cells. Immunology. 109:2003;319-325.
19. Taams L.S., Vukmanovic-Stejic M., Smith J., Dunne P.J., Fletcher J.M., Plunkett F.J.et al. Antigen-specific T cell suppression by human CD4+CD25+ regulatory T cells. Eur. J. Immunol. 32:2002;1621-1630.
20. Asano M., Toda M., Sakaguchi N., Sakaguchi S. Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation. J. Exp. Med. 184:1996;387-396.
21. Fukuma K., Sakaguchi S., Kuribayashi K., Chen W.L., Morishita R., Sekita K.et al. Immunologic and clinical studies on murine experimental autoimmune gastritis induced by neonatal thymectomy. Gastroenterology. 94:1988;274-283.
22. Dieckmann D., Bruett C.H., Ploettner H., Lutz M.B., Schuler G. Human CD4+CD25+ regulatory, contact-dependent T Cells induce interleukin 10-producing, contact-independent type 1-like regulatory T Cells. J. Exp. Med. 196:2002;247-253.
23. Jonuleit H., Schmitt E., Kakirman H., Stassen M., Knop J., Enk A.H. Infectious tolerance: human CD25(+) regulatory T cells convey suppressor activity to conventional CD4(+) T helper cells. J. Exp. Med. 196:2002;255-260.
24. Liyanage U.K., Moore T.T., Joo H.G., Tanaka Y., Herrmann V., Doherty G. et al. Prevalence of regulatory T cells is increased in peripheral blood and tumor microenvironment of patients with pancreas or breast adenocarcinoma. J. Immunol. 169:2002;2756-2761.
25. Woo E.Y., Yeh H., Chu C.S., Schlienger K., Carroll R.G., Riley J.L.et al. Cutting edge: regulatory T cells from lung cancer patients directly inhibit autologous T cell proliferation. J. Immunol. 168:2002;4272-4276.
26. Wildin R.S., Smyk-Pearson S., Filipovich A.H. Clinical and molecular features of the immunodysregulation, polyendocrinopthy, enteropathy, X linked (IPEX) syndrome. J. Med. Genet. 39:2002;537-545.
27. Hori S., Nomura T., Sakaguchi S. Control of regulatory T cell development by the transcription factor Foxp3. Science. 299:2003;1057-1061.
28. Fontenot J.D., Gavin M.A., Rudensky A.Y. Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Nat. Immunol. 4:2003;330-336.
29. Chatenoud L. CD3-specific antibody-induced active tolerance: from bench to bedside. Nat. Rev. Immunol. 3:2003;123-132.
30. Tommasini A., Ferrari S., Moratto D., Badolato R., Boniotto M., Pirulli D.et al. X-chromosome inactivation analysis in a female carrier of FOXP3 mutation. Clin. Exp. Immunol. 130:2002;127-130.
31. Bennett C.L., Brunkow M.E., Ramsdell F., O'Briant K.C., Zhu Q., Fuleihan R.L.et al. A rare polyadenylation signal mutation of the FOXP3 gene (. AAUAAA→AAUGAA ) leads to the IPEX syndrome Immunogenetics. 53:2001;435-439.
32. Gambineri E., Torgerson T.R., Ochs H.D. TI - immune dysregulation, polyendocrinopathy, enteropathy, and X-linked inheritance (IPEX), a syndrome of systemic autoimmunity caused by mutations of FOXP3, a critical regulator of T-cell homeostasis. Curr. Opin. Rheumatol. 15:2003;430-435.
33. Smyk-Pearson S.K., Bakke A.C., Held P.K., Wildin R.S. Rescue of the autoimmune scurfy mouse by partial bone marrow transplantation or by injection with T-enriched splenocytes. Clin. Exp. Immunol. 133:2003;193-199.